Medicated diet composition based on attribute characteristics of five-element heart in traditional Chinese medicine as well as preparation method and application of medicated diet composition

Abstract

The invention provides a medicated diet composition based on attribute characteristics of five elements in traditional Chinese medicine as well as a preparation method and application thereof, and belongs to the field of traditional Chinese medicines. The medicated diet composition is prepared from the following raw material medicines in parts by weight: 8-12 parts of fried spina date seeds, 8-12 parts of longan aril, 8-12 parts of Chinese wolfberry fruits, 4-6 parts of mulberries, 1.5-2.5 parts of cinnamon, 8-12 parts of Chinese dates, 8-12 parts of red beans, 8-12 parts of coix seeds, 8-12 parts of poria cocos, 1.5-2.5 parts of licorice roots and 2.5-3.5 parts of lucid ganoderma. Based on the five-element characteristics of the five-element heart attribute of traditional Chinese medicine, all the medicines supplement each other, the number of red blood cells can be effectively reduced, the content of hemoglobin is reduced, and the medicated diet composition has an excellent effect on improving nutritional anemia. Meanwhile, all the medicines in the medicated diet composition are homologous in medicine and food, so that the medicated diet composition can be prepared into various forms of medicated diets, such as decoction, even seasonings, especially hotpot condiments, the acceptability of the public can be improved, the public can improve alimentary anemia in daily diet, and the medicated diet composition has a good application prospect.

Description

Technical Field

[0001] The present invention belongs to the field of traditional Chinese medicine, and in particular relates to a medicinal diet composition based on the five elements of traditional Chinese medicine and the characteristics of the heart property, as well as a preparation method and use thereof. Background Art

[0002] Anemia is a common blood disease, the main feature of which is a decrease in the number of red blood cells in the peripheral blood, resulting in insufficient oxygen supply to tissues and organs. The diagnostic criteria for anemia vary from population to population. In addition to being affected by factors such as age, gender, and altitude, it is also determined by clinicians. The global prevalence of anemia is as high as 24.8%, affecting the health of 1.62 billion people. The causes of anemia can be attributed to: reduced or insufficient red blood cell production, excessive red blood cell destruction, and blood loss, and may be affected by factors such as dietary habits, long-term and excessive exposure to chemicals, viral infections, chronic diseases, or malignant tumors.

[0003] Nutritional anemia is a type of anemia, which refers to a disease caused by a relative or absolute reduction in nutrients necessary for the body to produce blood, such as iron, folic acid, vitamin D, etc., which leads to insufficient hemoglobin formation or red blood cell production, resulting in low hematopoietic function. It is common in infants and young children aged 6 months to 2 years, pregnant or lactating women, and patients with poor nutrient absorption caused by gastrointestinal diseases.

[0004] Nutritional anemia can generally be improved by adjusting diet, drug therapy, and blood transfusion therapy. Adjusting diet can be alleviated by eating iron-rich foods, such as beef, chicken, and animal offal, and eating more foods rich in vitamin C to promote iron absorption, while limiting the intake of foods that affect iron absorption. Drug treatment can use iron supplements, such as ferrous sulfate tablets, Angelica Blood-Replenishing Oral Liquid, and Ferrous Lactate Oral Liquid. In addition, blood transfusion therapy is also an important means to improve nutritional anemia. However, drug treatment may cause side effects such as nausea, vomiting, and blackening of teeth, while blood transfusion therapy may cause complications such as non-hemolytic fever reactions, urticaria and allergic reactions, hemolytic reactions, circulatory overload, bacterial contamination reactions, and disease transmission. Therefore, improving nutritional anemia by adjusting diet is an important and safe means.

[0005] TCM believes that nutritional anemia is mainly caused by deficiency of spleen and kidney. Spleen is the foundation of acquired constitution, responsible for transporting and transforming water and grain essence to produce blood; kidney stores essence, responsible for bone and marrow production, and sufficient essence can be transformed into blood. Therefore, when spleen and stomach are weak and cannot transport water and grain essence well, or when kidney deficiency and essence are insufficient, blood production can be reduced and anemia can be formed. TCM treatment of nutritional anemia will adopt the method of tonifying the spleen and replenishing qi to produce blood, and help blood production by improving nutrition and promoting absorption. Using Chinese medicine for both medicinal and edible purposes to prepare medicated diet is a method of TCM to improve nutritional anemia. Some commonly used medicated diet recipes include Rehmannia pig liver soup, red dates, fungus and longan soup, etc. If more medicated diets with good effects on improving anemia and different forms can be provided and combined with daily diet, it will not only benefit the health of anemia patients, but also improve the adaptability of anemia patients, which is of great significance to anemia patients. Summary of the invention

[0006] The purpose of the present invention is to provide a medicinal diet composition based on the five elements of traditional Chinese medicine and the characteristics of the heart property, as well as a preparation method and use thereof.

[0007] The present invention provides a medicinal diet composition, which is prepared from raw materials in the following weight ratio:

[0008] Stir-fried sour jujube kernel 8-12 parts, longan pulp 8-12 parts, wolfberry 8-12 parts, mulberry 4-6 parts, cinnamon 1.5-2.5 parts, jujube 8-12 parts, red bean 8-12 parts, coix seed 8-12 parts, poria cocos 8-12 parts, licorice 1.5-2.5 parts, ganoderma lucidum 2.5-3.5 parts.

[0009] Furthermore, the aforementioned medicinal diet composition is prepared from raw materials in the following weight ratio:

[0010] Stir-fry 10 parts of sour jujube kernels, 10 parts of longan pulp, 10 parts of wolfberries, 5 parts of mulberries, 2 parts of cinnamon, 10 parts of jujubes, 10 parts of red beans, 10 parts of coix seeds, 10 parts of Poria cocos, 2 parts of licorice, and 3 parts of Ganoderma lucidum.

[0011] Furthermore, the aforementioned medicinal diet composition is a food, health food or pharmaceutical preparation prepared by using the powder of the raw material medicine in the aforementioned weight ratio, or the water and / or organic solvent extract of the raw material medicine as the active ingredient, and adding food, health food or pharmaceutically acceptable excipients or auxiliary ingredients.

[0012] Further, the food is a seasoning; and / or the pharmaceutical preparation is an oral preparation;

[0013] Preferably, the food is hot pot soup base.

[0014] The present invention also provides a method for preparing the aforementioned medicinal diet composition, which comprises the following steps: taking raw materials of various weight proportions, directly powdering them, or adding water or organic solvents for extraction, and then adding food, health food or pharmaceutically acceptable excipients or auxiliary ingredients to obtain food, health food or pharmaceutical preparations.

[0015] The present invention also provides use of the above-mentioned medicinal diet composition in preparing a health food for improving nutritional anemia.

[0016] The present invention also provides use of the aforementioned medicinal diet composition in preparing food; preferably, the food is a seasoning; more preferably, the food is a hot pot base.

[0017] The present invention also provides the use of the aforementioned medicinal diet composition in preparing a drug for improving anemia;

[0018] Preferably, the drug is a drug for improving the reduction of red blood cell count and hemoglobin content;

[0019] More preferably, the drug is a drug for improving nutritional anemia.

[0020] The present invention also provides a food, which comprises the above-mentioned medicinal diet composition;

[0021] Preferably, the food is a seasoning; more preferably, the food is a hot pot base.

[0022] The present invention also provides a health food for improving nutritional anemia, which is prepared by using the above-mentioned medicinal diet composition as an active ingredient and adding an auxiliary material or auxiliary ingredient acceptable to health food;

[0023] Alternatively, a drug for improving anemia is prepared by using the aforementioned medicinal diet composition as an active ingredient and adding pharmaceutically acceptable excipients or auxiliary ingredients.

[0024] The medicinal diet composition of the present invention is adapted from the "heart-boosting soup" in "Shoushibaoyuan" written by Gong Tingxian in the Ming Dynasty. Summer corresponds to the "heart" of the five internal organs. The heart-boosting soup has the effects of nourishing blood and calming the mind, and calming the mind. This recipe is adapted from the original recipe of the "heart-boosting soup". In the recipe, longan meat belongs to the heart and spleen meridians, and has the effects of nourishing the heart and spleen, nourishing blood and calming the mind. Lycium barbarum belongs to the liver and kidney meridians. It has the effects of nourishing the liver and kidney and benefiting essence. Lycium barbarum and longan meat are compatible, nourishing heart blood, calming the mind, nourishing kidney water, making the heart and kidney intersect, and water and fire are in harmony as the monarch medicine. Coix seeds, Poria cocos, mulberry, stir-fried spiny jujube seeds, and red beans nourish the middle and replenish qi. Qi is the leader of blood. It is easy to replenish qi but difficult to replenish blood. Therefore, while replenishing heart blood, it replenishes the middle and replenishes qi, so that qi and blood are transformed into active, and it is a minister medicine to help the monarch medicine to nourish blood and nourish the heart. Cinnamon bark belongs to the heart, kidney, spleen and liver meridians, and has the effects of replenishing fire and yang, guiding fire back to the origin, dispelling cold and relieving pain, warming the meridians and promoting blood circulation. It is also a ministerial drug. Jujube, licorice and ganoderma lucidum are the guiding drugs, which replenish the middle and benefit the qi and harmonize the other drugs. The whole prescription replenishes without stagnation, and contains replenishment in movement. All the drugs work together to replenish blood and nourish the heart, and calm the mind and tranquilize the nerves.

[0025] Compared with the prior art, the present invention has the following beneficial effects:

[0026] The present invention provides a medicinal diet composition based on the characteristics of the five elements of traditional Chinese medicine. The medicinal diet composition is based on the five elements of the five elements of traditional Chinese medicine. The medicinal flavors complement each other, can effectively improve the reduction of red blood cell count and hemoglobin content, and have excellent effects on improving nutritional anemia. At the same time, the medicinal flavors in the medicinal diet composition of the present invention are both medicinal and edible, and can be prepared into various forms of medicinal diets, such as decoctions, or even seasonings, especially hot pot bases, which can improve public acceptance and allow the public to improve nutritional anemia in their daily diet, and have good application prospects.

[0027] Obviously, according to the above contents of the present invention, in accordance with common technical knowledge and customary means in the art, without departing from the above basic technical ideas of the present invention, other various forms of modification, replacement or change may be made.

[0028] The above contents of the present invention are further described in detail below through specific implementation methods in the form of embodiments. However, this should not be understood as the scope of the above subject matter of the present invention being limited to the following examples. All technologies realized based on the above contents of the present invention belong to the scope of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Figure 1 These are the GC-MS results of the volatile flavor substances in the prepared red pot hot pot base.

[0030] Figure 2 For red pot hot pot base ( Figure 2 3D waterfall chart showing the comparison of volatile flavor substances between No. 1 in the table and other commercially available hot pot bases (No. 2-10). DETAILED DESCRIPTION

[0031] The raw materials and equipment used in the specific embodiments of the present invention are all known products and are obtained by purchasing commercially available products.

[0032] Example 1: Preparation of the medicinal diet composition of the present invention

[0033] Recipe: stir-fried sour jujube kernel 10g, longan pulp 10g, wolfberry 10g, mulberry 5g, cinnamon 2g, jujube 10g, red bean 10g, coix seed 10g, poria 10g, licorice 2g, ganoderma lucidum 3g.

[0034] Preparation method: Weigh the weight of each raw material according to the formula, decoct it with 4 times the volume of water for 3 times, boil it for 1 hour each time, combine the filtrate, concentrate it to 2.05g raw material / mL at normal pressure, and store it at -20℃ for future use.

[0035] Example 2: Preparation of the medicinal diet composition of the present invention

[0036] Recipe: stir-fried sour jujube kernel 8g, longan pulp 8g, wolfberry 8g, mulberry 4g, cinnamon 1.5g, jujube 8g, red bean 8g, coix seed 8g, poria 8g, licorice 1.5g, and ganoderma lucidum 2.5g.

[0037] Preparation method: Weigh the weight of each raw material according to the formula, decoct it with 4 times the volume of water for 3 times, boil it for 1 hour each time, combine the filtrate, concentrate it to 2.05g raw material / mL at normal pressure, and store it at -20℃ for future use.

[0038] Example 3: Preparation of the medicinal diet composition of the present invention

[0039] Recipe: stir-fried sour jujube kernel 12g, longan pulp 12g, wolfberry 12g, mulberry 6g, cinnamon 2.5g, jujube 12g, red bean 12g, coix seed 12g, poria 12g, licorice 2.5g, ganoderma lucidum 3.5g.

[0040] Preparation method: Weigh the weight of each raw material according to the formula, decoct it with 4 times the volume of water for 3 times, boil it for 1 hour each time, combine the filtrate, concentrate it to 2.05g raw material / mL at normal pressure, and store it at -20℃ for future use.

[0041] Example 4: Preparation of the medicinal diet composition of the present invention for hot pot soup base

[0042] 1. Selection of medicinal materials (material selection): Select medicinal materials without mildew and insect pests. The types and amounts of medicinal materials used are the same as those in Example 1.

[0043] 2. Cleaning: Clean the medicinal materials. No impurities should be contained after cleaning to make the medicinal materials clean.

[0044] 3. Powdering: crush the medicinal materials.

[0045] 4. Soaking: Place the crushed herbs in a clean stainless steel barrel, and pour in water about 3 times the weight of the herbs to soak until they are saturated with water.

[0046] 5. Boil the base health-preserving juice: add a certain proportion (about 3 times) of water to the soaked medicinal materials, boil for 2-23 hours, separate the medicinal diet mud and the medicinal diet soup, and the obtained medicinal diet soup is named health-preserving soup; take the obtained medicinal diet mud and stir-fry, and the stir-frying process is as follows:

[0047] Add 20-100g of cooking oil to a wok, heat to 80-100°C, take 8-30g of Pixian bean paste and stir-fry until the aroma of the bean paste overflows, keep the oil temperature unchanged, take the above-obtained medicinal diet puree and add it, stir-fry for 10min-30min to obtain the fried medicinal diet puree.

[0048] Then the fried medicinal food puree is mixed with the health-preserving soup to obtain a mixed juice.

[0049] 6. Base material coloring process: Take about 4 times the weight of the medicinal diet mud pepper, crush it, pour it into the edible oil slowly heated over a low fire, the amount of edible oil is about 5% (volume ratio) of the health-preserving soup, the oil temperature is controlled at about 150-160°C, stir-fry for 5-10 minutes, and the red pepper oil is obtained;

[0050] Pour the red chili oil into the mixed juice obtained in step 5, mix well to obtain the soup base.

[0051] 7. Boil and package: 7. Boil and concentrate the soup base obtained in step 6 at 100° C. under normal pressure until there is no obvious water vapor, cool and sterilize, and package to obtain the red pot hot pot base.

[0052] The volatile flavor substances of the red pot hot pot base were detected. The GC-MS results of the volatile flavor substances of the prepared red pot hot pot base were as follows: Figure 1 As shown, red pot hot pot base ( Figure 2 The 3D waterfall diagram shows the comparison of volatile flavor substances between NO.1 in the table and other commercially available hot pot bases (NO.6-10). Figure 2 shown.

[0053] Depend on Figure 1 and Figure 2 The results show that the hot pot soup base obtained by using the composition of Example 1 of the present invention has as many as 70 volatile flavor substances. Compared with the hot pot soup base available on the market, it has more volatile flavor types.

[0054] The acceptance test received feedback from 102 consumers in total, and the results of the 9-point pleasure scale method are shown in Table 1 below. In this test, 20 people expressed that they liked the above five-element medicinal hot pot soup base very much, accounting for 19.61% of the total number of people; 31 people expressed that they liked it very much, accounting for 30.39% of the total number of people; 13 people expressed that they liked it and 32 people expressed that they liked it and were just average, accounting for 12.75% and 31.37% of the total number of people, respectively. This shows that the hot pot soup base prepared by the medicinal diet composition of the present invention (Example 1 group) has a relatively good public acceptance.

[0055] Table 1. Results of the 9-point hedonic scale method for the red soup medicinal hot pot base prepared from the composition of Example 1

[0056]

[0057] The beneficial effects of the present invention are demonstrated below through specific test examples.

[0058] Test Example 1: Effect of the medicinal diet composition of the present invention on improving anemia

[0059] 1. Experimental Materials

[0060] (1) Experimental animals

[0061] KM mice, 50, half male and half female, weighing 18-22 g, were purchased from Sibeifu (Beijing) Biotechnology Co., Ltd., Animal Production License No.: SCXK (Beijing) 2019-0010. KM mice were raised in the SPF Animal Laboratory of the Animal Experiment Center of Sichuan Academy of Traditional Chinese Medicine, Animal Use License No.: SYXK (Sichuan) 2023-0100.

[0062] (2) Experimental drugs

[0063] Cyclophosphamide for injection was purchased from Baxter Oncology Gmbh with the national medicine approval number HJ20160467.

[0064] Chinese medicinal materials: stir-fried sour jujube kernel, longan pulp, wolfberry, mulberry, cinnamon, jujube, red bean, coix seed, Poria cocos, licorice, Ganoderma lucidum, Sichuan Guoqiang Chinese Medicine Pieces Co., Ltd.

[0065] Sample group 1: stir-fried spiny jujube seeds 10g, longan pulp 8g, wolfberry 7g, mulberry 5g, ganoderma lucidum 3g. Weigh the weight of each raw material according to the formula, decoct with 4 times the volume of water for 3 times, boil for 1 hour each time, combine the filtrate, concentrate to 2.05g crude drug / mL at normal pressure, and store at -20℃ for later use.

[0066] Sample group 2: 2g cinnamon bark, 10g jujube, 10g red bean, 10g coix seed, 10g poria, 2g licorice, 3g ganoderma. Weigh the weight of each raw material according to the formula, decoct it 3 times with 4 times the volume of water, boil it for 1 hour each time, combine the filtrate, concentrate it to 2.05g crude drug / mL under normal pressure, and store it at -20℃ for later use.

[0067] Sample group 3 (Example 1 group): stir-fried spiny jujube seeds 10g, longan pulp 10g, wolfberry 10g, mulberry 5g, cinnamon 2g, jujube 10g, red bean 10g, coix seed 10g, Poria 10g, licorice 2g, ganoderma lucidum 3g. According to the formula, weigh the weight of each raw material, decoct 3 times with 4 times the volume of water, boil 1h each time, combine the filtrate, concentrate to 2.05g crude drug / mL at normal pressure, and store at -20℃ for later use.

[0068] 2. Experimental methods

[0069] After 3 days of adaptive feeding, the mice were randomly divided into 5 groups according to their body weight, with 10 mice in each group. The groups and drug administration are shown in Table 2.

[0070] Table 2. Grouping of mice and administration of drugs

[0071]

[0072] On the first day of the experiment, except for the mice in the normal group (control group), the rest of the mice were intraperitoneally injected with 20mg / mL cyclophosphamide solution 0.1mL / 10g body weight. On the 1st to 7th days of the experiment, each dosing group (sample groups 1 to 3) was gavaged with the corresponding drug at 0.2mL / 10g body weight every day. The dosage of the three dosing groups remained consistent at 41.0g of native drug / kg, which is 30 times the human dose; the normal group and the model group were given an equal volume of distilled water. On the 7th day of the experiment, 0.5h after the administration, blood was collected from the canthal venous plexus of mice in each group, and the number of red blood cells and hemoglobin content were determined using a blood cell analyzer. The results were tested using t test.

[0073] 3. Experimental results

[0074] The results of red blood cell count and hemoglobin content are shown in Table 3.

[0075] Table 3. Red blood cell count and hemoglobin content of mice in each group

[0076]

[0077] Note: a indicates a significant difference compared with the normal group (control group) (p<0.01); b indicates a significant difference compared with the model group (p<0.01); c indicates a significant difference between sample group 3 and sample group 1 (p<0.05); d indicates a significant difference between sample group 3 and sample group 2 (p<0.05).

[0078] The results in Table 2 show that compared with the mice in the normal group, the number of red blood cells and the hemoglobin content of the mice in the model group were significantly reduced. After taking the drugs in each group, it was found that at the same dose, the Chinese medicine composition of sample group 1 and sample group 2 could not improve the reduction of the number of red blood cells and the hemoglobin content, while the Chinese medicine composition of sample group 3 could effectively improve the reduction of the number of red blood cells and the hemoglobin content.

[0079] 4. Experimental conclusion

[0080] The Chinese medicine composition of the present invention can effectively improve the reduction of red blood cell count and hemoglobin content, and can be used to improve anemia.

[0081] In summary, the present invention provides a medicinal diet composition based on the characteristics of the five elements of traditional Chinese medicine. The medicinal diet composition is based on the five elements of the five elements of traditional Chinese medicine. The medicinal flavors complement each other and can effectively improve the reduction of red blood cell count and hemoglobin content. It is used to improve nutritional anemia. Excellent effect. At the same time, the medicinal flavors in the medicinal diet composition of the present invention are both medicinal and edible, and can be prepared into various forms of medicinal diets, such as decoctions, or even seasonings, especially hot pot bases, which can improve public acceptance and allow the public to improve nutritional anemia in their daily diet, and has good application prospects.

Claims

1. A medicinal diet composition, characterized in that: It is prepared from raw materials in the following weight ratio: Stir-fried sour jujube kernel 8-12 parts, longan pulp 8-12 parts, wolfberry 8-12 parts, mulberry 4-6 parts, cinnamon 1.5-2.5 parts, jujube 8-12 parts, red bean 8-12 parts, coix seed 8-12 parts, poria cocos 8-12 parts, licorice 1.5-2.5 parts, ganoderma lucidum 2.5-3.5 parts.

2. The medicinal diet composition according to claim 1, characterized in that: It is prepared from raw materials in the following weight ratio: Stir-fry 10 parts of sour jujube kernels, 10 parts of longan pulp, 10 parts of wolfberries, 5 parts of mulberries, 2 parts of cinnamon, 10 parts of jujubes, 10 parts of red beans, 10 parts of coix seeds, 10 parts of Poria cocos, 2 parts of licorice, and 3 parts of Ganoderma lucidum.

3. The medicinal diet composition according to claim 1 or 2, characterized in that: It is a food, health food or pharmaceutical preparation prepared by taking the powder of the raw material medicine of the weight ratio, or the water and / or organic solvent extract of the raw material medicine as the active ingredient, and adding food, health food or pharmaceutically acceptable auxiliary materials or auxiliary ingredients.

4. The medicinal diet composition according to claim 3, characterized in that: The food is a seasoning; and / or the pharmaceutical preparation is an oral preparation; Preferably, the food is hot pot soup base.

5. The method for preparing the medicinal diet composition according to any one of claims 1 to 4, characterized in that: The method comprises the following steps: taking raw materials of various weight proportions, directly grinding them into powder, or adding water or organic solvent for extraction, and then adding auxiliary materials or auxiliary components acceptable to food, health food or medicine to obtain food, health food or medicine preparation.

6. Use of the medicinal diet composition according to any one of claims 1 to 4 in preparing a health food for improving nutritional anemia.

7. Use of the medicinal diet composition according to any one of claims 1 to 4 in preparing food; preferably, the food is a seasoning; more preferably, the food is a hot pot base.

8. Use of the medicinal diet composition according to any one of claims 1 to 4 in preparing a drug for improving anemia; Preferably, the drug is a drug for improving the reduction of red blood cell count and hemoglobin content; More preferably, the drug is a drug for improving nutritional anemia.

9. A food, characterized in that: It comprises the medicinal diet composition according to any one of claims 1 to 4; Preferably, the food is a seasoning; more preferably, the food is a hot pot base.

10. A health food for improving nutritional anemia, characterized in that: It is prepared by using the medicinal diet composition described in any one of claims 1 to 4 as an active ingredient and adding excipients or auxiliary ingredients acceptable to health food; Alternatively, a drug for improving anemia, characterized in that it is prepared by using the medicinal diet composition according to any one of claims 1 to 4 as an active ingredient and adding pharmaceutically acceptable excipients or auxiliary ingredients.

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