Testing device for controlled impact brain trauma animal model

Abstract

The invention provides a test device for a controlled impact brain trauma animal model. The test device comprises a device base, the placement frame is fixed on the device base, a side fixing plate is arranged on the placement frame, an experiment table is arranged on the inner side of the side fixing plate, and the experiment table is fixed through a fixing assembly arranged on the side fixing plate; the adjusting plate is arranged on the placing frame, the upper end face of the adjusting plate is in contact connection with a positioning plate arranged on the upper end face of the placing frame, an elastic piece is arranged on the adjusting plate, and the end of the elastic piece is connected with a positioning assembly; the adjusting seat is arranged on the device base and can horizontally move; the device has the advantages that the death rate of animals can be reduced, the strength can be grasped, and an impact brain injury model can be accurately made.

Description

Technical Field

[0001] The invention relates to the technical field of test devices for simulating impact brain trauma, and in particular to a test device for a controlled impact brain trauma animal model. Background Art

[0002] At present, medical workers' research on the sequelae of brain trauma, the recovery time of brain injury, and the behavior and emotional response patterns of animals after injury is mainly completed manually. They use hand hammers to hit the injured part, which is easy to be inaccurate and sometimes even hurt themselves. Generally, mice are used for impact tests on brain injuries. During the animal impact test, the animal needs to be anesthetized, the head is fixed, and then the animal's cerebral cortex is quickly impacted with an impact device.

[0003] The patent publication number CN217723793U was retrieved, and the patent name is a public material of a brain trauma animal head model impact experiment device, and specifically discloses an animal head model impact experiment device for brain trauma, including a support frame, a top plate of the support frame is provided with an impact experiment device, the impact experiment device includes an electric push rod fixedly installed on the top plate of the support frame, a fixed rod is fixedly installed at the end of the telescopic shaft of the electric push rod, a storage assembly is provided on the fixed rod, the storage assembly includes a fixed sleeve which is sleeved on the fixed rod and rotatably connected with the fixed rod, a limit plate is fixedly installed on the annular side surface of the fixed sleeve, a rectangular hole connected to the outside is provided in the limit plate, a weight is provided in the rectangular hole, a micro motor is fixedly installed on the bottom surface of the fixed sleeve, a baffle is fixedly installed at the end of the output shaft of the micro motor, and the baffle is located below the rectangular hole. The impact test device provided by the present invention ensures that when in use, the electric push rod can be used to work, and the telescopic shaft on the push rod can be extended or shortened to adjust the height of the baffle and the weight placed on the baffle. In addition, the micro motor is used to drive the baffle to rotate. The weight is no longer supported by the baffle under the blocking effect of the limit plate, and the weight will fall smoothly, which is conducive to the impact test operation and convenient to use. The defect of the conventional impact test device that it is inconvenient to adjust the falling height of the heavy object when in use, which will affect the experimental effect and bring inconvenience to the user, is solved.

[0004] Through the analysis of the above-mentioned public materials, it can be known that the impact test device cannot effectively control the force, increases the animal mortality rate, is inconvenient to operate, and the animals cannot be fixed. Summary of the invention

[0005] In view of this, the present invention provides a test device for a controlled impact brain injury animal model, which can not only reduce the animal mortality rate, but also control the strength and accurately make an impact brain injury model.

[0006] In order to solve the above technical problems, the present invention provides a test device for a controlled impact brain injury animal model, comprising:

[0007] Device base;

[0008] A placement rack, the placement rack is fixed on the device base, the placement rack is provided with a side fixing plate, the inner side of the side fixing plate is provided with a laboratory table, and is fixed by a fixing component provided on the side fixing plate;

[0009] An adjustment plate, wherein the adjustment plate is arranged on the placement rack, the upper end surface of the adjustment plate is in contact with a positioning plate arranged on the upper end surface of the placement rack, the adjustment plate is provided with an elastic sheet, and the end of the elastic sheet is connected to a positioning assembly;

[0010] An adjustment seat, which is arranged on the device base and can move horizontally;

[0011] A support mechanism, the support mechanism comprising a vertical rod arranged on the adjustment seat, a locking block arranged on the vertical rod, the locking block connected to a cross bar, an adjustment block installed on the cross bar, a vertically arranged sliding rod connected to the adjustment block, a connecting shaft sleeve arranged on the sliding rod, a striking block installed on the connecting shaft sleeve, and a striker arranged at the lower end of the striking block;

[0012] A winch, wherein the winch is arranged on the adjusting block, the winch is connected with a pull rope, and the lower end of the pull rope is connected to the connecting shaft sleeve;

[0013] The brake is arranged on the adjusting block, and the pull rope passes through the brake.

[0014] Furthermore, the placement rack is U-shaped, and the side fixing plates are fixedly arranged on the upper end surface of the placement rack, and are parallel to each other and have corresponding positions. The fixing assembly includes a fixing plate arranged on the end surface of the side fixing rack, and the fixing plate is arranged horizontally. A threaded hole is arranged on the fixing plate, and an adjusting bolt B is connected through the threaded hole. The lower end surface of the adjusting bolt B contacts the connection test bench.

[0015] Furthermore, the adjustment plate is horizontally arranged and slidably connected to the placement rack. The slideway is the space formed by the placement rack and the positioning plate. The positioning plate is fixedly connected to the placement rack. Bolts are arranged on the positioning plate for fixing the adjustment plate.

[0016] Furthermore, the positioning assembly includes an adjusting bolt A arranged on the elastic sheet, the adjusting bolt A is threadedly connected to the elastic sheet, and the lower end of the adjusting bolt A is connected to a bracket, which is arc-shaped and used to fix the head of the animal model.

[0017] Furthermore, the locking block is provided with bolts and is fixed to the vertical pole by the bolts. The cross bar and the locking block are connected by a shaft sleeve, and a groove is provided to prevent the cross bar from rotating.

[0018] Furthermore, the adjustment block and the cross bar are connected by a sleeve, and the groove is used to prevent the cross bar from rotating. The adjustment block and the slide bar are connected by a sleeve, and there is a clearance fit between the slide bar and the adjustment block. The slide bar is lifted upward under the action of the pull rope.

[0019] Furthermore, a brake block is provided inside the brake, a wing plate is installed on the side of the brake block, a threaded hole is provided on the wing plate, a screw is connected to the threaded hole, the screw is connected to a motor, the motor is fixed on the outer casing of the brake, and the pull rope is provided in the middle space between the two brake blocks and vertically passes through the space.

[0020] Furthermore, a frosted surface is provided on the inner side surface of the brake block, the frosted surface is arc-shaped and concave inward, and the pull rope is arranged between the frosted surfaces.

[0021] The beneficial effects of the above technical solution of the present invention are as follows:

[0022] 1. The purpose of the craniocerebral injury impact test is to observe the subsequent changes in the animal's activities. Through this device, the mortality rate of experimental animals during the experiment is reduced.

[0023] 2. It can control the force and accurately make a brain injury model. By installing a brake, the firing pin can be controlled instantaneously. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 It is a structural schematic diagram of the present invention;

[0025] Figure 2 for Figure 1 A magnified view of middle;

[0026] Figure 3 is a schematic diagram of the internal structure of the brake;

[0027] In the figure: 1. device base; 2. placement rack; 3. laboratory table; 4. side fixing plate; 5. bracket; 6. adjustment plate; 7. positioning plate; 8. adjustment seat; 9. vertical pole; 10. locking block; 11. cross bar; 12. adjustment block; 13. slide bar; 14. winch; 15. brake; 16. pull rope; 17. connecting sleeve; 18. impact block; 19. striker; 20. fixing plate; 21. elastic sheet; 22. bracket; 23. adjusting bolt A; 24. adjusting bolt B; 25. brake block; 26. wing plate; 27. screw; 28. motor; 29. ​​frosted surface. DETAILED DESCRIPTION

[0028] To make the purpose, technical solution and advantages of the embodiments of the present invention more clear, the following will be combined with the appended drawings of the embodiments of the present invention. Figure 1-3 , the technical scheme of the embodiment of the present invention is clearly and completely described. Obviously, the described embodiment is a part of the embodiment of the present invention, not all of the embodiments. Based on the described embodiment of the present invention, all other embodiments obtained by ordinary technicians in this field belong to the scope of protection of the present invention.

[0029] like Figure 1-3 As shown:

[0030] A test device for an animal model of controlled impact brain trauma, comprising a device base 1; a placement frame 2, the placement frame 2 is fixed to the device base 1, the placement frame 2 is provided with a side fixing plate 4, the inner side of the side fixing plate 4 is provided with a laboratory table 3, and is fixed by a fixing component arranged on the side fixing plate 4; an adjustment plate 6, the adjustment plate 6 is arranged on the placement frame 2, the upper end surface of the adjustment plate 6 is in contact with a positioning plate 7 arranged on the upper end surface of the placement frame 2, the adjustment plate 6 is provided with an elastic sheet 21, and the end of the elastic sheet 21 is connected to a positioning component; an adjustment seat 8, the adjustment seat 8 is arranged on the device base 1 and can move horizontally; a supporting mechanism, the supporting mechanism It includes a vertical rod 9 arranged on an adjustment seat 8, the vertical rod 9 is provided with a locking block 10, the locking block 10 is connected to a cross bar 11, the cross bar 11 is installed with an adjustment block 12, the adjustment block 12 is connected to a vertically arranged sliding rod 13, the sliding rod 13 is provided with a connecting sleeve 17, the connecting sleeve 17 is installed with a striking block 18, and the lower end of the striking block 18 is provided with a striker 19; a winch 14, the winch 14 is arranged on the adjustment block 12, the winch 14 is connected with a pull rope 16, and the lower end of the pull rope 16 is connected to the connecting sleeve 17; a brake 15, the brake 15 is arranged on the adjustment block 12, and the pull rope 16 runs through the brake 15.

[0031] In this embodiment, the device base 1 is a planar structure, which is placed on the operating table. A placement rack 2 is set on the upper end surface of the device base 1. The placement rack 2 is used to place the test animal. After the test animal is anesthetized, it is manually placed on the experimental table 3, and then the head can be fixed through the elastic sheet 21, and the forelimbs of the test animal can be fixed through the fixing assembly. An adjustment seat 8 is set on one side of the placement rack 2, and a support mechanism is set on the adjustment seat 8. The function of the support mechanism is to support the impact component, specifically, including a vertical rod 9, a locking block 10 is set on the vertical rod 9, and the locking block 10 is used for positioning. A cross bar 11 is set on the locking block 10, and an adjustment block 12 is set on the cross bar 11. A winch 14 is set on the adjustment block 12. The function of the winch 14 is to lift the connecting sleeve 17, and a collision block 18 is set on the connecting sleeve 17. A striker 19 is installed at the lower end of the collision block 18, and the striker 19 is used to impact the skull of the test animal. When striking, controlling the force is the key. If the striking is too great, the mortality rate of the test animals will increase. Because a brake 15 is provided on the adjusting block 12, the striker 19 can be braked instantaneously.

[0032] The placement rack 2 is U-shaped, and the side fixing plates 4 are fixedly arranged on the upper end surface of the placement rack 2, and are parallel to each other and have corresponding positions. The fixing assembly includes a fixing plate 20 arranged on the end surface of the side fixing rack. The fixing plate 20 is arranged horizontally, and a threaded hole is arranged on the fixing plate 20, and an adjusting bolt B24 is connected through the threaded hole. The lower end surface of the adjusting bolt B24 contacts the connection test bench 3.

[0033] In this embodiment, the placement rack 2 is U-shaped and horizontally arranged on the device base 1. A side fixing plate 4 is arranged on the placement rack 2, and a fixing component is installed on the side fixing plate 4. A fixing plate 20 is arranged in the middle position of the side fixing plate 4. A threaded hole is arranged on the fixing plate 20, and an adjusting bolt B24 is connected to the fixing plate 20. By screwing and adjusting the adjusting bolt B24, the experimental table 3 can be fixed, so that the purpose of replacing the experimental table 3 can be achieved.

[0034] The adjustment plate 6 is horizontally arranged and slidably connected to the placement rack 2. The slideway is the space formed by the placement rack 2 and the positioning plate 7. The positioning plate 7 is fixedly connected to the placement rack 2. Bolts are arranged on the positioning plate 7 for fixing the adjustment plate 6.

[0035] In this embodiment, the adjustment plate 6 is arranged horizontally, and the adjustment plate 6 can manually adjust the horizontal position, so that the position can be adjusted for different test animals and the head can be fixed more conveniently.

[0036] The positioning assembly includes an adjusting bolt A23 disposed on the elastic sheet 21, the adjusting bolt A23 is threadedly connected to the elastic sheet 21, and the lower end of the adjusting bolt A23 is connected to a bracket 22, the bracket 22 is arc-shaped and is used to fix the head of the animal model.

[0037] In this embodiment, the positioning assembly includes an adjusting bolt A23, which is disposed on the elastic sheet 21 and can be screwed for adjustment. A bracket 22 is detachably connected to the lower end of the adjusting bolt A23, and the bracket 22 is used to fix the head.

[0038] The locking block 10 is provided with bolts and is fixed to the vertical rod 9 by bolts. The cross bar 11 and the locking block 10 are connected by a shaft sleeve, and a groove is provided to prevent the cross bar 11 from rotating.

[0039] In this embodiment, bolts are provided on the side of the locking block 10 , the bottom of the bolts contacts the connecting vertical pole 9 , and the grooves are through grooves reserved when processing the vertical pole 9 and the cross bar 11 .

[0040] The adjusting block 12 is connected to the cross bar 11 by a sleeve, and the groove prevents the cross bar 11 from rotating. The adjusting block 12 is connected to the slide bar 13 by a sleeve, and there is a clearance fit between the slide bar 13 and the adjusting block 12. The slide bar 13 is lifted upward under the action of the pull rope 16.

[0041] In this embodiment, the adjusting block 12 and the sliding rod 13 are connected by a shaft sleeve, and a groove is also provided between the sliding rod 13 and the adjusting block 12 to prevent the sliding rod 13 from rotating when it is lifted or lowered.

[0042] A brake block 25 is provided inside the brake 15, and a wing plate 26 is installed on the side of the brake block 25. A threaded hole is provided on the wing plate 26, and the threaded hole is connected to a screw rod 27. The screw rod 27 is connected to a motor, and the motor is fixed on the outer shell of the brake 15. The pull rope 16 is set in the middle space between the two brake blocks 25 and vertically passes through the space.

[0043] In this embodiment, there are two brake blocks 25 with a gap in between, which is used for the passage of the pull rope 16. The motor-driven screw 27 rotates, and the rotation of the screw 27 drives the brake blocks 25 to move inward. In this design, the threads on the screw 27 are set in forward and reverse directions, and the two brake blocks 25 move to the middle position or move to both sides synchronously.

[0044] A frosted surface 29 is disposed on the inner side surface of the brake block 25 . The frosted surface 29 is arc-shaped and inwardly concave. The pull rope 16 is disposed between the frosted surfaces 29 .

[0045] In this embodiment, the frosted surface 29 can improve the durability of the device and also enhance the instantaneous braking effect.

[0046] Working method (or working principle) of the present invention:

[0047] When the present technology is working, the test animal is first anesthetized, and then the anesthetized test animal is placed on the experimental table 3, the forelimbs are fixed by the fixing assembly, and the head is fixed by the elastic sheet 21 and the adjusting bolt A23. Specifically, after the adjusting bolt A23 is connected to the elastic sheet 21, the bracket 22 is installed at the bottom of the adjusting bolt A23, and the direction is adjusted so that the arc bracket 22 can clamp the head of the main test animal, and then the head of the test animal is dehaired, the skin is cut open, and the skull and brain are exposed. Then, after operating the adjustment mechanism and adjusting the position of the striker 19, the motor is controlled to release the pull rope 16, and the striker 19 strikes the skull and brain under the action of gravity, and then the skin of the test animal is sutured to observe the subsequent changes of the animal.

[0048] In the present invention, unless otherwise clearly stipulated and limited, for example, it can be a fixed connection, a detachable connection, or an integrated one; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements. Unless otherwise clearly defined, for ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to the specific circumstances.

Claims

1. A test device for a controlled impact brain injury animal model, characterized in that: It includes a device base (1); A placement rack (2), the placement rack (2) being fixed to the device base (1), the placement rack (2) being provided with a side fixing plate (4), the inner side of the side fixing plate (4) being provided with a laboratory table (3), and being fixed by a fixing component provided on the side fixing plate (4); An adjustment plate (6), the adjustment plate (6) being arranged on the placement rack (2), the upper end surface of the adjustment plate (6) being in contact with and connected to a positioning plate (7) arranged on the upper end surface of the placement rack (2), the adjustment plate (6) being provided with an elastic sheet (21), the end of the elastic sheet (21) being connected to a positioning assembly; An adjustment seat (8), the adjustment seat (8) being arranged on the device base (1) and being capable of horizontal movement; A support mechanism, the support mechanism comprising a vertical rod (9) arranged on an adjustment seat (8), a locking block (10) being arranged on the vertical rod (9), the locking block (10) being connected to a cross bar (11), an adjustment block (12) being installed on the cross bar (11), a vertically arranged sliding rod (13) being connected to the adjustment block (12), a connecting shaft sleeve (17) being arranged on the sliding rod (13), a striking block (18) being installed on the connecting shaft sleeve (17), and a striker (19) being arranged at the lower end of the striking block (18); A winch (14), wherein the winch (14) is arranged on the adjustment block (12), the winch (14) is connected to a pull rope (16), and the lower end of the pull rope (16) is connected to a connecting shaft sleeve (17); A brake (15), wherein the brake (15) is arranged on the adjustment block (12), and the pull rope (16) passes through the brake (15).

2. The test device for a controlled impact brain injury animal model according to claim 1, characterized in that: The placement rack (2) is U-shaped, the side fixing plates (4) are fixedly arranged on the upper end surface of the placement rack (2), and are parallel to each other and have corresponding positions. The fixing assembly includes a fixing plate (20) arranged on the end surface of the side fixing rack, the fixing plate (20) is arranged horizontally, a threaded hole is arranged on the fixing plate (20), and an adjusting bolt B (24) is connected through the threaded hole, and the lower end surface of the adjusting bolt B (24) contacts the connection test bench (3).

3. The test device for a controlled impact brain injury animal model according to claim 2, characterized in that: The adjusting plate (6) is arranged horizontally and is slidably connected to the placing frame (2); the slideway is a space formed by the placing frame (2) and the positioning plate (7); the positioning plate (7) is fixedly connected to the placing frame (2); and bolts are arranged on the positioning plate (7) for fixing the adjusting plate (6).

4. The test device for a controlled impact brain injury animal model according to claim 3, characterized in that: The positioning assembly comprises an adjusting bolt A (23) arranged on an elastic sheet (21), the adjusting bolt A (23) being threadedly connected to the elastic sheet (21), the lower end of the adjusting bolt A (23) being connected to a clamping frame (22), the clamping frame (22) being arc-shaped and used for fixing the head of the animal model.

5. The test device for a controlled impact brain injury animal model according to claim 4, characterized in that: The locking block (10) is provided with bolts and is fixed to the vertical rod (9) by bolts. The cross bar (11) and the locking block (10) are connected by a shaft sleeve, and a groove is provided to prevent the cross bar (11) from rotating.

6. The test device for a controlled impact brain injury animal model according to claim 5, characterized in that: The adjusting block (12) and the cross bar (11) are connected by a shaft sleeve, and the groove prevents the cross bar (11) from rotating. The adjusting block (12) and the sliding rod (13) are connected by a shaft sleeve, and there is a clearance fit between the sliding rod (13) and the adjusting block (12). The sliding rod (13) is lifted upward under the action of the pull rope (16).

7. The test device for a controlled impact brain injury animal model according to claim 6, characterized in that: A brake block (25) is arranged inside the brake (15), a wing plate (26) is installed on the side of the brake block (25), a threaded hole is arranged on the wing plate (26), a screw rod (27) is connected to the threaded hole, and the screw rod (27) is connected to a motor, and the motor is fixed on the outer shell of the brake (15), and the pull rope (16) is arranged in the middle space between the two brake blocks (25) and vertically passes through the space.

8. The test device for a controlled impact brain injury animal model according to claim 7, characterized in that: A frosted surface (29) is provided on the inner side surface of the brake block (25); the frosted surface (29) is arc-shaped and inwardly concave; the pull rope (16) is arranged between the frosted surfaces (29).

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