Traditional Chinese medicine composition for treating chilblain and preparation method thereof

Abstract

The invention belongs to the technical field of chilblain medicines, and particularly relates to a traditional Chinese medicine composition for treating chilblain and a preparation method thereof.The traditional Chinese medicine composition for treating chilblain is prepared from 15-25 parts of a chilblain bag, 10-20 parts of a blood-activating and moisturizing bag, 8-13 parts of a whitening and itching-relieving bag, 3-7 parts of a pre-promoting bag and 1 part of triethanolamine; the pure coconut oil is rich in unsaturated fatty acid and can be used as a biological oleophylic surfactant, the pure coconut oil, the jojoba oil and the linseed oil are mutually combined to form an oil-based oil structure, rapid transfer of the pure coconut oil between skin layers is improved, and chilblain can be rapidly eradicated; the aloe and the horse oil can replenish water and preserve moisture, have a protection effect on the skin, accelerate the regeneration process of skin cells and repair damaged skin cells; the white mulberry root-bark, the willow bark, the bunge pricklyash leaves, the ginger slices and the pine needle oil can remove surface cutin, promote nutrient absorption, avoid bacterial reinfection, promote skin healing, repair scars after healing and avoid subsequent reattack.

Description

Technical Field

[0001] The invention belongs to the technical field of frostbite medicines, and specifically refers to a traditional Chinese medicine composition for treating frostbite and a preparation method thereof. Background Art

[0002] Frostbite, a "cold multiforme erythema", is a local blood circulation disorder disease of the skin caused by cold stimulation. In cold seasons, when the human body is exposed to low temperatures for a long time, especially in the extremities such as fingers, toes, auricles and other places with weak blood circulation, the skin blood vessels will contract to reduce heat loss. If the body cannot be effectively warmed for a long time, local tissues will suffer from hypoxia and ischemia, eventually forming erythema, edema, and even ulceration. Therefore, the selection of daily frostbite medicines is also a big problem.

[0003] There are many types of drugs for treating frostbite on the market. Although they can play a certain role, it is difficult to eradicate frostbite. The treatment is slow, the drug absorption is poor, and the epidermis becomes dark in color and scars and dry skin are left after treatment. There are also some special medicines that work quickly but are prone to relapse, causing many inconveniences to patients' lives. In addition, the unreasonable selection of materials will also cause certain harm to human health.

[0004] In addition, there is currently no drug on the market that takes into account multiple conditions to prepare an effective drug for treating frostbite to meet people's needs. Summary of the invention

[0005] In view of the defects of the prior art, the present invention discloses a Chinese medicine composition for treating frostbite and a preparation method thereof, which can achieve a thorough eradication effect by activating the epidermis, promoting blood circulation in the dermis, and further promoting the proliferation of adipose tissue cells in the subcutaneous layer; first, by removing surface grease, the epidermal structure is activated, itching and pain are relieved, and pores are opened; during the synthesis process, an oil-based oil structure is prepared to promote the penetration of pure coconut oil between skin layers, accelerate blood circulation in the skin, treat frostbite more quickly, and eradicate frostbite, reducing the trouble caused by the disease to the human body; at the same time, during the preparation, ingredients for preventing frostbite are added, which also ensures that the skin can play a self-protection role when cold conditions occur again; after the treatment, the mulberry bark whitens the skin and fades scars, making the skin more lustrous; during the preparation, moisturizing and hydrating ingredients are also added to ensure that symptoms such as dry skin and dehydration will not appear before and after the treatment, and the moisturizing function of the skin is enhanced. The scheme comprehensively prepares the Chinese medicine composition for treating frostbite from multiple aspects before, during and after the treatment.

[0006] To achieve the above object, the technical scheme adopted by the present invention is: a Chinese medicine composition for treating frostbite, prepared from the following raw materials in parts by weight: 15-25 parts of frostbite pack, 10-20 parts of blood circulation and water replenishing pack, 8-13 parts of whitening and itching relief pack, 3-7 parts of pre-promoting pack, and 1 part of triethanolamine;

[0007] Furthermore, the preparation method of the frostbite bag comprises the following steps:

[0008] A1: Weigh pure coconut oil, jojoba oil and linseed oil in a mass ratio of 3-6:2-4:0.5;

[0009] A2: symmetrically taken jojoba oil is heated and stirred in an oil bath at a heating temperature of 50-60° C. and a stirring speed of 120-150 r / min, linseed oil is added thereto, stirred and then shaken to obtain a mixture of jojoba oil and linseed oil;

[0010] A3: The symmetrically taken pure coconut oil is heated and stirred in an oil bath at a heating temperature of 60-70° C. and a stirring speed of 100-120 r / min. The mixture of jojoba oil and linseed oil obtained in step A2 is added dropwise to the pure coconut oil at a dropping rate of 1-3 dps. After stirring, the mixture is shaken and cooled naturally to room temperature to obtain a frostbite bag.

[0011] Furthermore, the preparation method of the blood-activating and water-replenishing bag comprises the following steps:

[0012] B1: Weigh out Polygonum cuspidatum, Rhubarb, Lithospermum officinale and water in a mass ratio of 1-2:0.5-1.5:0.5-1:5, wash and dry Polygonum cuspidatum, Rhubarb and Lithospermum officinale;

[0013] B2: Grind the polygonum cuspidatum, rhubarb and lithospermum officinale weighed in step B1 to obtain polygonum cuspidatum powder, rhubarb powder and lithospermum officinale powder;

[0014] B3: adding the polygonum cuspidatum powder, rhubarb powder and lithospermum powder obtained in step B2 into water, stirring and heating with ultrasonic wave for 20-40 min, heating at 80-90° C. for 6-8 h, cooling naturally to room temperature, removing residues by centrifugation to obtain a mixed aqueous solution, placing the mixed aqueous solution into a blast drying oven for drying at 55-65° C. for 12-15 h, collecting and grinding the dry powder material to obtain a mixed material I;

[0015] B4: Weigh aloe vera and horse oil, heat and stir in an oil bath to obtain a mixture of aloe vera and horse oil, the heating temperature is 50-70°C, the stirring time is 20-30 min, and the mixed material I obtained in step B3 is added to the mixture of aloe vera and horse oil, the mass ratio of aloe vera, horse oil and mixed material I is 1-2:1-2:4, heat twice, and cool naturally to room temperature to obtain a blood circulation and water replenishing package.

[0016] Furthermore, the preparation method of the whitening and itching-relieving pain pack comprises the following steps:

[0017] C1: Weigh mulberry bark, willow bark, prickly ash leaves, peach blossom, impatiens, azalea and honey in a mass ratio of 3-4:2-3:1-3:3:0.5-1.5:2-4, wash, dry, crush and mix the mulberry bark, willow bark, prickly ash leaves, peach blossom, impatiens and azalea to obtain a mixed material II;

[0018] C2: mixing water and honey in a mass ratio of 5:2-4 to obtain honey hydrate;

[0019] C3: adding the mixed material II obtained in step C1 to the honey hydrate obtained in step C2, heating and stirring, the heating temperature is 60-80° C., the stirring time is 1-2 h, naturally cooling to room temperature, and filtering to obtain the hydrate;

[0020] C4: The hydrate obtained in step C3 is placed in a forced air drying oven for drying and dehydration treatment at a drying temperature of 50-70°C for 18-24 hours to obtain a viscous whitening and itching-relieving bag.

[0021] Furthermore, the preparation method of the pre-promotion package comprises the following steps:

[0022] D1: Weigh ginger slices, wormwood and pine needle oil in a mass ratio of 0.5:1-2:0.5-1.5, wash, dry and crush the ginger slices and wormwood to obtain a mixed powder of ginger and wormwood;

[0023] D2: The symmetrically taken pine needle oil is heated to 60-80° C., the ginger and wormwood mixed powder obtained in step D1 is added to the pine needle oil, and the mixture is further boiled for 20-40 minutes, and naturally cooled to room temperature, and the residue is filtered to obtain a pine needle oil mixture;

[0024] D3: The pine needle oil mixture obtained in step D2 is further dried and concentrated to obtain a pre-promoting package.

[0025] The present invention also provides a method for preparing a Chinese medicine composition for treating frostbite, comprising the following steps:

[0026] Step 1, weigh 15-25 parts of frostbite pack, 10-20 parts of blood circulation and water replenishing pack, 8-13 parts of whitening and itching relief pack, 3-7 parts of pre-promoting pack, and 1 part of triethanolamine;

[0027] Step 2, measure water and triethanolamine in a mass ratio of 10:1, disperse by stirring at room temperature, heat in an oil bath at a temperature of 50-70° C., obtain a triethanolamine aqueous solution, add a whitening and itching-relieving bag to the triethanolamine aqueous solution, stir and perform ultrasonication, and then remove water to obtain a mixed material III;

[0028] Step 3, the chilblain pack, the blood circulation and water replenishing pack and the pre-promotion pack weighed in step 1 are mixed and stirred to obtain an oil condensate precursor, and heated under an argon atmosphere with a flow rate of 100-150 mL / min and a heating temperature of 50-60° C., and the mixed material III obtained in step 2 is further added to the oil condensate precursor and stirred to obtain an oil condensate;

[0029] Step 4: The oil condensate obtained in step 3 is sealed and packaged to obtain a Chinese medicinal composition for treating frostbite.

[0030] The beneficial effects achieved by the present invention are as follows:

[0031] The Chinese medicine composition for treating frostbite prepared by the present invention introduces pure coconut oil, linseed oil and jojoba oil for the first time, wherein the pure coconut oil is rich in unsaturated fatty acids, linolenic acid and linoleic acid, and can cure frostbite, but has low skin permeability, while jojoba oil is a liquid wax, which is very close to our sebum, so it has very good permeability and does not feel greasy; in order to improve the permeability of the pure coconut oil, the pure coconut oil is used as a base, and the unsaturated fatty acids are used as a biological lipophilic surfactant as a bridge, and the pure coconut oil and the jojoba oil are connected to form an oil-based oil structure, so as to promote the rapid transfer of the pure coconut oil between the epidermis, dermis and subcutaneous layer of the skin, so as to achieve the effect of quickly curing frostbite and eradicate frostbite, and at the same time, the linseed oil can form a breathable and water-retaining film on the skin surface, reduce the water loss in the deep layer of the skin, and keep the skin moist, smooth and elastic.

[0032] The Chinese medicinal composition for treating frostbite prepared by the present invention introduces mulberry bark and willow bark for the first time, and can repair subsequent scars, eliminate accumulation and dark spots, and prevent wrinkles and remove scars. The salicylic acid in the willow bark can activate the stratum corneum, unclog the pores, make the skin more permeable, promote the penetration of pure coconut oil, accelerate the recovery of frostbite, and make the skin white. In addition, during the treatment process, the prickly ash leaves are rich in citral and prickly ash acid, which can inhibit the growth of fungi and bacteria in the frostbite area; horse oil and pine needle oil can promote and accelerate the regeneration process of skin cells, repair damaged skin cells, and promote skin healing; ginger slices can prevent the recurrence of frostbite, thereby ensuring that the frostbite can be prevented from further attack during the healing process, and the recovery of frostbite can be accelerated.

[0033] The Chinese medicinal composition for treating frostbite prepared by the present invention activates the structure of the epidermis layer, removes oil stains and impurities on the surface, further reduces inflammation, relieves pain and itching, has antibacterial and antioxidant effects, promotes wound healing, and promotes blood circulation; rhubarb and aloe are rich in anthraquinone compounds, can promote blood circulation and remove blood stasis, clear away heat and detoxify, and have a good healing effect on the skin; in addition, aloe is a moisturizing component, and horse oil is a water-locking component. The combination of the two can avoid the loss of replenished water, prevent skin dryness, form a protective layer, and play a protective role on the skin.

[0034] The traditional Chinese medicine composition for treating frostbite prepared by the invention uses green, safe, non-toxic raw materials with no side effects on human health. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] Figure 1 A diagram showing a preparation method according to an embodiment of the present invention;

[0036] Figure 2 This is a graph showing the time of curing frostbite in a clinical trial of a comparative example of the present invention;

[0037] The accompanying drawings are used to provide further understanding of the present invention and constitute a part of the specification. They are used to explain the present invention together with the embodiments of the present invention and do not constitute a limitation of the present invention. DETAILED DESCRIPTION

[0038] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments; based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0039] Unless otherwise defined, all professional and scientific terms used herein have the same meanings as those familiar to those skilled in the art. In addition, any methods and materials similar or equivalent to those described herein may be applied to the present invention. The preferred implementation methods and materials described herein are for demonstration purposes only and are not intended to limit the content of this application.

[0040] The preparation methods in the following examples are referred to Figure 1 Unless otherwise specified, all methods are conventional; the materials used in the following embodiments, unless otherwise specified, are new materials purchased from the market.

[0041] Example 1: A Chinese medicine composition for treating frostbite, comprising the following components by weight: 15 parts of frostbite pack, 10 parts of blood circulation and water replenishing pack, 8 parts of whitening and itching relief pack, 3 parts of pre-promoting pack, and 1 part of triethanolamine;

[0042] The preparation steps of the frostbite bag are as follows:

[0043] A1: Weigh pure coconut oil, jojoba oil and linseed oil in a mass ratio of 3:2:0.5;

[0044] A2: Pour the weighed jojoba oil into tank I, heat the oil bath to 50° C., keep the temperature stable, then start the stirrer for stirring at a speed of 120 r / min, then add linseed oil thereto, continue shaking after stirring, the stirring time is 1 h, and the shaking time is 1 h, to obtain a mixture of jojoba oil and linseed oil;

[0045] A3: Weigh pure coconut oil and pour it into tank II. Heat the oil bath to 60°C and keep the temperature stable. Then turn on the stirrer for stirring at a speed of 100 r / min. Add the mixture of jojoba oil and linseed oil obtained in step A2 dropwise into tank II at a rate of 1 dps using a dropper. After stirring, continue to oscillate for 0.5 h and 1 h. Then naturally cool to room temperature to obtain a frostbite bag.

[0046] The preparation steps of the blood circulation and water replenishing bag are as follows:

[0047] B1: Weigh out Polygonum cuspidatum, Rhubarb and Lithospermum officinale, wash and dry;

[0048] B2: Put the polygonum cuspidatum, rhubarb and lithospermum officinale weighed in step B1 into a mortar and grind them respectively to obtain polygonum cuspidatum powder, rhubarb powder and lithospermum officinale powder;

[0049] B3: Pour water into an electric heating reactor, add the polygonum cuspidatum powder, rhubarb powder and lithospermum powder obtained in step B2, the mass ratio of polygonum cuspidatum powder, rhubarb powder, lithospermum powder and water is 1:0.5:0.5:5, ultrasonic power is 500HZ, ultrasonic time is 10min, mixing and stirring for 20min, heating to 80°C for 6h, then naturally cooling to room temperature, removing residues by centrifugation to obtain a mixed aqueous solution, the centrifugation time is 10min, the centrifugal speed is 3000r / min, the mixed aqueous solution is placed in a blast drying oven for drying, the drying temperature is 55°C, and the drying time is 12h, the dry powder material is collected and ground to obtain a mixed material I;

[0050] B4: Weigh aloe vera and horse oil, pour the aloe vera and horse oil into an oil bath, heat to 50°C and stir for 20 minutes to obtain a mixture of aloe vera and horse oil, then add the mixed material I obtained in step B3 to the mixture of aloe vera and horse oil, the mass ratio of aloe vera, horse oil and mixed material I is 1:1:4, continue to maintain this temperature, heat again for 1 hour, and then naturally cool to room temperature to obtain a blood circulation and water replenishing package.

[0051] The preparation steps of the whitening and itching relief pack are as follows:

[0052] C1: Weigh mulberry bark, willow bark, prickly ash leaves, peach blossom, impatiens, azalea and honey in a mass ratio of 3:2:1:3:0.5:2, wash, dry, crush and mix the mulberry bark, willow bark, prickly ash leaves, peach blossom, impatiens and azalea to obtain a mixed material II;

[0053] C2: Weigh water and honey and heat them to make them hydrated, wherein the mass ratio of water to honey is 5:2, to obtain honey hydrate;

[0054] C3: The honey hydrate obtained in step C2 is further heated to 60° C., and then the mixed material II is added thereto, and stirred continuously for 1 hour, and then naturally cooled to room temperature, and filtered to obtain the hydrate;

[0055] C4: The hydrate obtained in step C3 is placed in a forced air drying oven for drying and dehydration treatment at a drying temperature of 50° C. for 18 h to obtain a viscous whitening and antipruritic bag.

[0056] The preparation steps of the pre-promotion package are as follows:

[0057] D1: Weigh ginger slices, wormwood and pine needle oil, wherein the mass ratio of ginger slices, wormwood and pine needle oil is 0.5:1:0.5, wash, dry and crush the ginger slices and wormwood to obtain a mixed powder of ginger and wormwood;

[0058] D2: The symmetrically taken pine needle oil is heated to 60°C. After the temperature stabilizes, the ginger and wormwood mixed powder is added thereto, and the mixture is further boiled for 20 minutes. The mixture is then naturally cooled to room temperature, and the residue is filtered to obtain a pine needle oil mixture;

[0059] D3: The pine needle oil mixture obtained in step D2 is further placed in a drying device for drying and concentration at a drying temperature of 55° C. for 6 hours to obtain a pre-promoted package.

[0060] The preparation method of the Chinese medicine composition for treating frostbite comprises the following steps:

[0061] Step 1, weigh 15 parts of frostbite pack, 10 parts of blood circulation and water replenishing pack, 8 parts of whitening and itching relief pack, 3 parts of pre-promoting pack, and 1 part of triethanolamine;

[0062] Step 2, measure water and triethanolamine in a mass ratio of 10:1, stir and disperse at room temperature, then put into an oil bath and heat to 50°C, keep this temperature stable, add the whitening and itching pain relief bag thereto, stir and ultrasonicate, stir for 1 hour, the ultrasonic power is 800HZ, then dry to remove moisture, the drying temperature is 65°C, and obtain mixed material III;

[0063] Step 3, adding the frostbite pack, blood circulation and water replenishing pack and pre-promoting pack weighed in step 1 into the reaction tank in sequence for mixing and stirring, under argon atmosphere conditions, the gas flow rate is 100 mL / min, and the mixture is heated to 50° C., and the mixed material III obtained in step 2 is further added thereto, and the mixing and stirring is continued for 30 minutes to obtain an oil condensate;

[0064] Step 4: The oil condensate obtained in step 3 is sealed and packaged to obtain a Chinese medicinal composition for treating frostbite.

[0065] Example 2: A Chinese medicine composition for treating frostbite, comprising the following components by weight: 20 parts of frostbite pack, 15 parts of blood circulation and water replenishing pack, 11 parts of whitening and itching relief pack, 5 parts of pre-promoting pack, and 1 part of triethanolamine;

[0066] The preparation steps of the frostbite bag are as follows:

[0067] A1: Weigh pure coconut oil, jojoba oil and linseed oil in a mass ratio of 4.5:3:0.5;

[0068] A2: Pour the jojoba oil weighed above into tank I, heat the oil bath to 55° C., keep the temperature stable, then turn on the stirrer for stirring at a speed of 140 r / min, then add linseed oil thereto, continue shaking after stirring, the stirring time is 1 hour, and the shaking time is 1 hour, to obtain a mixture of jojoba oil and linseed oil;

[0069] A3: Weigh pure coconut oil and pour it into tank II. Heat the oil bath to 65°C and keep the temperature stable. Then turn on the stirrer for stirring at a speed of 110 r / min. Add the mixture of jojoba oil and linseed oil obtained in step A2 dropwise into tank II at a rate of 2 dps using a dropper. After stirring, continue to oscillate for 0.5 h and 1 h. Then naturally cool to room temperature to obtain a frostbite bag.

[0070] The preparation steps of the blood circulation and water replenishing bag are as follows:

[0071] B1: Weigh out Polygonum cuspidatum, Rhubarb and Lithospermum officinale, wash and dry;

[0072] B2: Put the polygonum cuspidatum, rhubarb and lithospermum officinale weighed in step B1 into a mortar and grind them respectively to obtain polygonum cuspidatum powder, rhubarb powder and lithospermum officinale powder;

[0073] B3: Pour water into an electric heating reactor, add the polygonum cuspidatum powder, rhubarb powder and lithospermum powder obtained in step B2, the mass ratio of polygonum cuspidatum powder, rhubarb powder, lithospermum powder and water is 1.5:1:0.8:5, ultrasonic power is 500HZ, ultrasonic time is 10min, mixing and stirring for 30min, heating to 85°C for 7h, then naturally cooling to room temperature, removing residues by centrifugation to obtain a mixed aqueous solution, the centrifugation time is 10min, the centrifugal speed is 3000r / min, the mixed aqueous solution is placed in a blast drying oven for drying, the drying temperature is 60°C, and the drying time is 14h, the dry powder material is collected and ground to obtain a mixed material I;

[0074] B4: Weigh aloe vera and horse oil, pour the aloe vera and horse oil into an oil bath, heat to 60°C and stir for 25 minutes to obtain a mixture of aloe vera and horse oil, then add the mixed material I obtained in step B3 to the mixture of aloe vera and horse oil, the mass ratio of aloe vera, horse oil and mixed material I is 1.5:1.5:4, continue to maintain this temperature, heat again for 1 hour, and then naturally cool to room temperature to obtain a blood circulation and water replenishing package.

[0075] The preparation steps of the whitening and itching relief pack are as follows:

[0076] C1: Weigh mulberry bark, willow bark, prickly ash leaves, peach blossom, impatiens, azalea and honey in a mass ratio of 3.5:2.5:2:3:1:3, wash, dry, crush and mix the mulberry bark, willow bark, prickly ash leaves, peach blossom, impatiens and azalea to obtain a mixed material II;

[0077] C2: Weigh water and honey and heat them to make them hydrate, wherein the mass ratio of water to honey is 5:3, to obtain honey hydrate;

[0078] C3: The honey hydrate obtained in step C2 is further heated to 70° C., and then the mixed material II is added thereto, and stirred continuously for 1.5 h, and then naturally cooled to room temperature, and filtered to obtain the hydrate;

[0079] C4: The hydrate obtained in step C3 is placed in a forced air drying oven for drying and dehydration treatment at a drying temperature of 60° C. for 21 h to obtain a viscous whitening and itching-relieving bag.

[0080] The preparation steps of the pre-promotion package are as follows:

[0081] D1: Weigh ginger slices, wormwood and pine needle oil, wherein the mass ratio of ginger slices, wormwood and pine needle oil is 0.5:1.5:1, wash, dry and crush the ginger slices and wormwood to obtain a mixed powder of ginger and wormwood;

[0082] D2: The symmetrically taken pine needle oil is heated to 70°C. After the temperature stabilizes, the ginger and wormwood mixed powder is added thereto and further boiled for 30 minutes. After that, the mixture is naturally cooled to room temperature and the residue is filtered to obtain the pine needle oil mixture.

[0083] D3: The pine needle oil mixture obtained in step D2 is further placed in a drying device for drying and concentration at a drying temperature of 55° C. for 6 hours to obtain a pre-promoted package.

[0084] The preparation method of the Chinese medicine composition for treating frostbite comprises the following steps:

[0085] Step 1, weigh 20 parts of frostbite pack, 15 parts of blood circulation and water replenishing pack, 11 parts of whitening and itching relief pack, 5 parts of pre-promoting pack, and 1 part of triethanolamine;

[0086] Step 2, measure water and triethanolamine in a mass ratio of 10:1, stir and disperse at room temperature, then put into an oil bath and heat to 50°C, keep this temperature stable, add the whitening and itching pain relief bag thereto, stir and ultrasonicate, stir for 1 hour, the ultrasonic power is 800HZ, then dry to remove moisture, the drying temperature is 65°C, and obtain mixed material III;

[0087] Step 3, adding the frostbite pack, blood circulation and water replenishing pack and pre-promoting pack weighed in step 1 into the reaction tank in sequence for mixing and stirring, under argon atmosphere conditions, the gas flow rate is 100 mL / min, and the mixture is heated to 50° C., and the mixed material III obtained in step 2 is further added thereto, and the mixing and stirring is continued for 30 minutes to obtain an oil condensate;

[0088] Step 4: The oil condensate obtained in step 3 is sealed and packaged to obtain a Chinese medicinal composition for treating frostbite.

[0089] Example 3: A Chinese medicine composition for treating frostbite, comprising the following components by weight: 25 parts of frostbite pack, 20 parts of blood circulation and water replenishing pack, 13 parts of whitening and itching relief pack, 7 parts of pre-promoting pack, and 1 part of triethanolamine;

[0090] The preparation steps of the frostbite bag are as follows:

[0091] A1: Weigh pure coconut oil, jojoba oil and linseed oil in a mass ratio of 6:4:0.5;

[0092] A2: Pour the jojoba oil weighed above into tank I, heat the oil bath to 70°C, keep the temperature stable, then turn on the stirrer for stirring at a speed of 150 r / min, then add linseed oil thereto, continue shaking after stirring, the stirring time is 1 hour, and the shaking time is 1 hour to obtain a mixture of jojoba oil and linseed oil;

[0093] A3: Weigh pure coconut oil and pour it into tank II. Heat the oil bath to 60°C and keep the temperature stable. Then turn on the stirrer for stirring at a speed of 120 r / min. Add the mixture of jojoba oil and linseed oil obtained in step A2 dropwise into tank II at 3 dps using a dropper. After stirring, continue to oscillate for 0.5 h and 1 h. Then naturally cool to room temperature to obtain a frostbite bag.

[0094] The preparation steps of the blood circulation and water replenishing bag are as follows:

[0095] B1: Weigh out Polygonum cuspidatum, Rhubarb and Lithospermum officinale, wash and dry;

[0096] B2: Put the polygonum cuspidatum, rhubarb and lithospermum officinale weighed in step B1 into a mortar and grind them respectively to obtain polygonum cuspidatum powder, rhubarb powder and lithospermum officinale powder;

[0097] B3: Pour water into an electric heating reactor, add the polygonum cuspidatum powder, rhubarb powder and lithospermum powder obtained in step B2, the mass ratio of polygonum cuspidatum powder, rhubarb powder, lithospermum powder and water is 2:1.5:1:5, ultrasonic power is 500HZ, ultrasonic time is 10min, mixing and stirring for 40min, heating to 90°C for 8h, then naturally cooling to room temperature, removing residues by centrifugation to obtain a mixed aqueous solution, the centrifugation time is 10min, the centrifugal speed is 3000r / min, the mixed aqueous solution is placed in a blast drying oven for drying, the drying temperature is 65°C, and the drying time is 15h, the dry powder material is collected and ground to obtain a mixed material I;

[0098] B4: Weigh aloe vera and horse oil, pour the aloe vera and horse oil into an oil bath, heat to 70°C and stir for 30 minutes to obtain a mixture of aloe vera and horse oil, then add the mixed material I obtained in step B3 to the mixture of aloe vera and horse oil, the mass ratio of aloe vera, horse oil and mixed material I is 2:2:4, continue to maintain this temperature, heat again for 1 hour, and then naturally cool to room temperature to obtain a blood circulation and water replenishing package.

[0099] The preparation steps of the whitening and itching relief pack are as follows:

[0100] C1: Weigh mulberry bark, willow bark, prickly ash leaves, peach blossom, impatiens, azalea and honey in a mass ratio of 4:3:3:3:1.5:4, wash, dry, crush and mix the mulberry bark, willow bark, prickly ash leaves, peach blossom, impatiens and azalea to obtain a mixed material II;

[0101] C2: Weigh water and honey and heat them to make them hydrated, wherein the mass ratio of water to honey is 5:4, to obtain honey hydrate;

[0102] C3: The honey hydrate obtained in step C2 is further heated to 80° C., and then the mixed material II is added thereto, and stirred continuously for 2 hours, and then naturally cooled to room temperature, and filtered to obtain the hydrate;

[0103] C4: The hydrate obtained in step C3 is placed in a forced air drying oven for drying and dehydration treatment at a drying temperature of 70° C. for 24 hours to obtain a viscous whitening and itching-relieving bag.

[0104] The preparation steps of the pre-promotion package are as follows:

[0105] D1: Weigh ginger slices, wormwood and pine needle oil, wherein the mass ratio of ginger slices, wormwood and pine needle oil is 0.5:2:1.5, wash, dry and crush the ginger slices and wormwood to obtain a mixed powder of ginger and wormwood;

[0106] D2: The symmetrically taken pine needle oil is heated to 80°C. After the temperature stabilizes, the ginger and wormwood mixed powder is added thereto and further boiled for 40 minutes. After that, the mixture is naturally cooled to room temperature and the residue is filtered to obtain the pine needle oil mixture.

[0107] D3: The pine needle oil mixture obtained in step D2 is further placed in a drying device for drying and concentration at a drying temperature of 55° C. for 6 hours to obtain a pre-promoted package.

[0108] The preparation method of the Chinese medicine composition for treating frostbite comprises the following steps:

[0109] Step 1, weigh 25 parts of frostbite pack, 20 parts of blood circulation and water replenishing pack, 13 parts of whitening and itching relief pack, 7 parts of pre-promoting pack, and 1 part of triethanolamine;

[0110] Step 2, measure water and triethanolamine in a mass ratio of 10:1, stir and disperse at room temperature, then put into an oil bath and heat to 70°C, keep this temperature stable, add a whitening and itching pain relief bag thereto, stir and ultrasonicate, stir for 1 hour, the ultrasonic power is 800HZ, then dry to remove moisture, the drying temperature is 65°C, and obtain a mixed material III;

[0111] Step 3, the chilblain pack, blood circulation and water replenishing pack and pre-promoting pack weighed in step 1 are sequentially added into the reaction tank for mixing and stirring, under argon atmosphere conditions, the gas flow rate is 150 mL / min, and the mixture is heated to 60° C., and the mixed material III obtained in step 2 is further added thereto, and the mixing and stirring is continued for 30 minutes to obtain an oil condensate;

[0112] Step 4: The oil condensate obtained in step 3 is sealed and packaged to obtain a Chinese medicinal composition for treating frostbite.

[0113] The difference between Comparative Example 1 and Example 2 is that no frostbite bag is added, and the rest is the same as Example 2;

[0114] The difference between Comparative Example 2 and Example 2 is that the blood-activating and water-replenishing bag is not added, and the rest is the same as Example 2;

[0115] The difference between Comparative Example 3 and Example 2 is that the whitening and itching-relieving package is not added, and the rest is the same as Example 2;

[0116] The difference between Comparative Example 4 and Example 2 is that no pre-promotion package is added, and the rest is the same as Example 2;

[0117] The difference between Comparative Example 5 and Example 2 is that the whitening and antipruritic package and the pre-promoting package are not added, and the rest of the parts are the same as Example 2;

[0118] The difference between Comparative Example 6 and Example 2 is that the blood circulation and water replenishing package and the pre-promoting package are not added, and the rest is the same as Example 2;

[0119] The difference between Comparative Example 7 and Example 2 is that the whitening and itching-relieving package and the blood circulation and water replenishing package are not added, and the rest of the parts are the same as Example 2;

[0120] The difference between Comparative Example 8 and Example 2 is that no frostbite pack and pre-promoting pack are added, and the rest is the same as Example 2;

[0121] The difference between Comparative Example 9 and Example 2 is that no frostbite pack and whitening and itching pain relief pack are added, and the rest is the same as Example 2;

[0122] The difference between Comparative Example 10 and Example 2 is that the blood circulation and water replenishing bag and the frostbite bag are not added, and the rest of the parts are the same as Example 2;

[0123] The difference between Comparative Example 11 and Example 2 is that the blood circulation and water replenishing package, the whitening and itching relief package and the pre-promoting package are not added, and the rest of the parts are the same as Example 2;

[0124] The difference between Comparative Example 12 and Example 2 is that no frostbite pack, whitening and itching relief pack and pre-promoting pack are added, and the rest is the same as Example 2;

[0125] The difference between Comparative Example 13 and Example 2 is that no frostbite pack, blood circulation and water replenishing pack and pre-promoting pack are added, and the rest is the same as Example 2;

[0126] The difference between Comparative Example 14 and Example 2 is that no frostbite pack, blood circulation and water replenishing pack and whitening and itching pain relief pack are added, and the rest is the same as Example 2;

[0127] Obviously, the above comparative examples and embodiments are only a part of comparative examples and embodiments of the present invention, and they and the comparative examples and embodiments based on such references are all within the scope of protection of the present invention.

[0128] Six patients with II degree frostbite were selected, and two people were assigned to each group of Examples 1, 2 and 3 to conduct clinical trials to test the medicinal effects of the Chinese medicine composition for treating frostbite prepared. An appropriate amount of the Chinese medicine composition was applied to the frostbite position of the patient's hand, once in the morning and evening every day, and the healing time was observed. The criterion for healing was compared with normal skin, and the number of days of healing was averaged, and the healing and subsequent recurrence of frostbite were followed up. Recurrence at the same site refers to the recurrence in the subsequent years without any protective measures:

[0129] Table 1 is the clinical trial results of the Chinese medicine composition for treating frostbite obtained in the examples:

[0130]

[0131] It can be seen from the results in Table 1 above that Example 2 has the best effect.

[0132] In order to further verify the healing effect of the control group, two patients with II degree frostbite were selected from each group for clinical trials. An appropriate amount of the Chinese medicine composition was applied to the frostbite positions on the patients' hands, once in the morning and once in the evening every day, and the healing time, whether dryness and dehydration occurred, and whether scars were left after healing were observed. The healing standard was consistent with normal skin, and the number of days to healing was averaged.

[0133] The number of days to cure is Figure 2 As shown, when no frostbite pack was added, the frostbite was not healed, while the healing time of other corresponding comparative examples was significantly longer than that of Example 2.

[0134] Table 2 is the clinical trial results of the Chinese medicine composition for treating frostbite obtained in the comparative example:

[0135]

[0136] From the results in Table 2 above, it can be seen that the clinical trials of chilblains in the comparative examples all had poor results.

[0137] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

[0138] The present invention and its implementation methods are described above, which is not restrictive. The drawings are only one of the implementation methods of the present invention, and the actual application is not limited thereto. In short, if ordinary technicians in the field are inspired by it and design methods and embodiments similar to the technical solution without creativity without departing from the purpose of the invention, they should all fall within the protection scope of the present invention.

Claims

1. A Chinese medicine composition for treating frostbite, characterized in that: The invention is prepared from the following raw materials in parts by weight: 15-25 parts of frostbite pack, 10-20 parts of blood circulation and water replenishing pack, 8-13 parts of whitening and itching relief pack, 3-7 parts of pre-promoting pack, and 1 part of triethanolamine; The raw materials for preparing the frostbite bag include pure coconut oil, jojoba oil and linseed oil, and the mass ratio of pure coconut oil, jojoba oil and linseed oil is 3-6:2-4:0.5; The raw materials for preparing the blood circulation and water replenishing bag include knotweed, rhubarb, lithospermum officinale, aloe vera and horse oil; The raw materials for preparing the whitening and itching-relieving pain package include mulberry bark, willow bark, prickly ash leaves, peach blossom, impatiens, azalea and honey, and the mass ratio of mulberry bark, willow bark, prickly ash leaves, peach blossom, impatiens, azalea and honey is 3-4:2-3:1-3:3:0.5-1.5:2-4; The raw materials for preparing the pre-promotion package include ginger slices, wormwood and pine needle oil, and the mass ratio of the ginger slices, wormwood and pine needle oil is 0.5:1-2:0.5-1.

5.

2. A Chinese medicine composition for treating frostbite according to claim 1, characterized in that: The preparation method of the frostbite bag comprises the following steps: A1: Weigh pure coconut oil, jojoba oil and linseed oil; A2: symmetrically taken jojoba oil is heated and stirred in an oil bath, linseed oil is added thereto, and the mixture is stirred and shaken to obtain a mixture of jojoba oil and linseed oil; A3: The pure coconut oil taken symmetrically is heated in an oil bath with stirring, and the mixture of jojoba oil and linseed oil obtained in step A2 is added dropwise to the pure coconut oil, after stirring, it is shaken, and naturally cooled to room temperature to obtain a frostbite bag.

3. A Chinese medicine composition for treating frostbite according to claim 2, characterized in that: The oil bath heating temperature in step A2 is 50-60°C, the stirring speed is 120-150r / min, the oil bath heating temperature in step A3 is 60-70°C, the stirring speed is 100-120r / min, and the dripping acceleration rate is 1-3dps.

4. A Chinese medicine composition for treating frostbite according to claim 1, characterized in that: The preparation method of the blood-activating and water-replenishing bag comprises the following steps: B1: Weigh out Polygonum cuspidatum, Rhubarb and Lithospermum officinale, wash and dry; B2: Grinding the dried polygonum cuspidatum, rhubarb and lithospermum officinale in step B1 respectively to obtain polygonum cuspidatum powder, rhubarb powder and lithospermum officinale powder; B3: adding the polygonum cuspidatum powder, rhubarb powder and lithospermum powder obtained in step B2 into water, stirring and heating with ultrasonic wave, cooling naturally to room temperature, removing residues by centrifugation to obtain a mixed aqueous solution, drying the mixed aqueous solution, collecting and grinding the dry powder material to obtain a mixed material I; B4: Weigh aloe vera and horse oil, heat and stir in an oil bath to obtain a mixture of aloe vera and horse oil, add the mixed material I obtained in step B3 to the mixture of aloe vera and horse oil, heat again, and naturally cool to room temperature to obtain a blood circulation and water replenishing package.

5. A Chinese medicine composition for treating frostbite according to claim 4, characterized in that: In step B3, the mass ratio of knotweed powder, rhubarb powder, lithospermum powder and water is 1-2:0.5-1.5:0.5-1:5, the stirring time is 20-40min, the heating temperature is 80-90°C, the heating time is 6-8h, and the drying is carried out in a blast drying oven, the drying temperature is 55-65°C, and the drying time is 12-15h. In step B4, the mass ratio of aloe vera, horse oil and mixed material I is 1-2:1-2:4, the heating temperature is 50-70°C, and the stirring time is 20-30min.

6. A Chinese medicine composition for treating frostbite according to claim 1, characterized in that: The preparation method of the whitening and itching-relieving pain pack comprises the following steps: C1: Weigh mulberry bark, willow bark, prickly ash leaves, peach blossom, impatiens, azalea and honey, wash, dry, crush and mix the mulberry bark, willow bark, prickly ash leaves, peach blossom, impatiens and azalea to obtain mixed material II; C2: Weigh water and honey and mix them to obtain honey hydrate; C3: adding the mixed material II obtained in step C1 to the honey hydrate obtained in step C2, heating and stirring, naturally cooling to room temperature, and filtering to obtain a hydrate; C4: Dry and remove water from the hydrate obtained in step C3 to obtain a viscous whitening and itching-relieving bag.

7. A Chinese medicinal composition for treating frostbite according to claim 6, characterized in that: The mass ratio of water to honey in step C2 is 5:2-4, the heating temperature in step C3 is 60-80°C, the stirring time is 1-2h, and step C4 uses a blast drying oven for drying and dehydration treatment, the drying temperature is 50-70°C, and the drying time is 18-24h.

8. A Chinese medicine composition for treating frostbite according to claim 1, characterized in that: The preparation method of the pre-promotion package comprises the following steps: D1: Weigh ginger slices, wormwood and pine needle oil, wash, dry and crush the ginger slices and wormwood to obtain a mixed powder of ginger and wormwood; D2: symmetrically taking pine needle oil and heating it to 60-80° C., adding the ginger and wormwood powder mixture obtained in step D1 to the pine needle oil, boiling for 20-40 minutes, cooling naturally to room temperature, and filtering the residue to obtain a pine needle oil mixture; D3: Dry and concentrate the pine needle oil mixture obtained in step D2 to obtain a pre-promotion package.

9. A method for preparing a traditional Chinese medicine composition for treating frostbite according to any one of claims 1 to 8, characterized in that: The steps include: Step 1, weigh 15-25 parts of frostbite pack, 10-20 parts of blood circulation and water replenishing pack, 8-13 parts of whitening and itching relief pack, 3-7 parts of pre-promoting pack, and 1 part of triethanolamine; Step 2, measuring water and triethanolamine, stirring and dispersing at room temperature, heating in an oil bath to obtain a triethanolamine aqueous solution, adding a whitening and itching-relieving bag to the triethanolamine aqueous solution, stirring and ultrasonicating, and then removing water to obtain a mixed material III; Step 3, mixing and stirring the chilblain pack, the blood circulation and water replenishing pack and the pre-promotion pack weighed in step 1 to obtain an oil condensate precursor, heating under argon atmosphere, adding the mixed material III obtained in step 2 to the oil condensate precursor and stirring to obtain an oil condensate; Step 4: sealing and packaging the oil condensate obtained in step 3 to obtain a Chinese medicine composition for treating frostbite.

10. The method for preparing a traditional Chinese medicine composition for treating frostbite according to claim 9, characterized in that: The mass ratio of water to triethanolamine in step 2 is 10:1, the oil bath heating temperature is 50-70°C, the heating temperature in step 3 is 50-60°C, and the flow rate of argon is 100-150mL / min.

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