Sesquiterpene alcohol caffeic acid ester compound as well as preparation method and application thereof

The sesquiterol caffeate compounds bausesquitate A and bausesquitate B isolated from the stems and leaves of the saddle leaf ash, significantly inhibited α-glucosidase, solved the side effects and toxicity problems of existing drugs, and provided more effective reduction Blood sugar and medication options for treating diabetes.

CN119219499AActive Publication Date: 2024-12-31KUNMING MEDICAL UNIVERSITY
View PDF 4 Cites 0 Cited by

Patent Information

Application Number
CN202411217601.8
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-09-02
Publication Date
2024-12-31
Estimated Expiration
2044-09-02

AI Technical Summary

Technical Problem

The existing α-glucosidase inhibitors have side effects and are highly toxic, making it difficult to meet the demand for higher activity and lower toxicity, especially when treating type 2 diabetes, a more effective hypoglycemia drug is needed.

Method used

Two new sesquiterpene alcohol caffeate compounds bausesquitate A and bausesquitate B were isolated from the stems and leaves of the saddle leaf goat argas and identified, and were coagulated by organic solvent leaching, normal phase silica gel column, MCI chromatography column, Sephadex LH-20 Purification was performed by a combined separation method of gel column and HPLC to prepare compounds with significant α-glucosidase inhibitory activity.

Benefits of technology

The inhibitory activity of bausesquitate A and bausesquitate B on α-glucosidase far exceeds that of the existing clinical drug acarbose, has potential effects on lowering blood sugar and treating diabetes, and provides easy-to-get extraction methods suitable for industrial operations.

✦ Generated by Eureka AI based on patent content.

Smart Images

  • Figure CN119219499A_ABST
    Figure CN119219499A_ABST
Patent Text Reader

Abstract

The invention discloses a sesquiterpene alcohol caffeate compound and a preparation method and application thereof, two sesquiterpene alcohol caffeate novel compounds are found from leaves of Bauhinia championii of a leguminous plant, and the alpha-glucosidase inhibitory activity IC50 of the sesquiterpene alcohol caffeate novel compounds is 1.81 + / -0.12 and 3.79 + / -0.27 respectively, which is significantly stronger than that of a clinical drug acarbose. The sesquiterpenol caffeic acid ester compound provided by the invention can form a pharmaceutical composition with a pharmaceutically acceptable carrier, is used for treating diseases related to diabetes mellitus, and can also be used for preparing healthy products for reducing blood sugar. The preparation method is simple, convenient, easy to operate and suitable for industrial production.
Need to check novelty before this filing date? Find Prior Art

Citation Information

Patent Citations

  • 1-tanshinone acid ester derivatives with cardioprotective effect and application of 1-tanshinone acid ester derivatives

    CN106800582A

  • Application of caffeic acid glyceride compound in preparation of medicine or functional food

    CN116473953A

  • Diterpene component with hypoglycemic activity in coffee pericarp as well as preparation method and application of diterpene component

    CN116768706A

  • Method for the treatment of hyperproliferative epithelial skin diseases by topical application of hydroxylated aromatic protein cross-linking compounds

    US5610185A