Membrane type oxygenator and winding method of integrated oxygenation chamber, oxygen pressure membrane and filter screen

Abstract

The invention belongs to the technical field of membrane type oxygenators, and particularly relates to a membrane type oxygenator and a winding method of an integrated oxygenation chamber, an oxygen pressure membrane and a filter screen, the membrane type oxygenator comprises an oxygenation chamber outer shell, an oxygenation chamber inner shell and a variable-temperature chamber shell, the variable-temperature chamber shell is located in the oxygenation chamber inner shell, and an occupation core is installed in the variable-temperature chamber shell; the specific surface area of the threaded temperature change pipe is increased by means of the spiral groove of the threaded temperature change pipe in the temperature change chamber shell, the contact area of blood and the heat exchanger is large, the heat conduction efficiency is high, meanwhile, the heat exchange efficiency is improved, and meanwhile the heat exchange efficiency is improved. The blood channel is divided into a large number of narrow and small channels by the spiral grooves and is of a net-shaped structure similar to a woven film roll, blood is divided and converged repeatedly, turbulent flow is generated, heat can be fully diffused and conducted in blood flow, and then under the same heat exchange area, the inner structure of the variable-temperature chamber shell is more compact, and the blood volume is smaller.

Description

Technical Field

[0001] The invention belongs to the technical field of membrane oxygenators, and in particular relates to a membrane oxygenator and a winding method of an integrated oxygenation chamber, an oxygen pressure membrane and a filter screen. Background Art

[0002] Membrane oxygenator, commonly known as artificial lung, is a disposable Class III medical device used to replace human lung function for a short period of time and perform gas exchange in blood during extracorporeal circulation during open heart surgery. The device mainly consists of two parts: an oxygenation chamber for gas exchange and a temperature-changing chamber for heat exchange. The blood channel of the oxygenation chamber and the temperature-changing chamber is connected to form a pathway. The blood first changes its temperature through the temperature-changing chamber, then combines with oxygen and discharges carbon dioxide through the oxygenation chamber, and finally enters the patient's blood vessels, achieving the purpose of maintaining the body's vital activities and raising and lowering body temperature at the appropriate stage of the operation.

[0003] At present, the combination of oxygenation chamber and temperature-changing chamber mainly includes the series mode of independent shells and the integrated mode of double-chamber nesting. In the prior art, if the temperature-changing chamber uses a tube-in-tube metal heat exchanger, it usually adopts the form of blood running inside the tube and water running outside the tube. The blood is easy to form laminar flow in the metal tube with a relatively large length-to-diameter ratio. The heat exchange effect of the blood in contact with the tube wall is good but the flow rate is low. The blood flow rate in the center of the pipe is high, but the heat exchange effect is poor, which affects the overall heat exchange efficiency. In addition, the blood flow in this heat exchanger directly impacts the end face of the temperature-changing tube array, which causes great damage to blood cells. If the temperature-changing chamber uses a corrugated tube or folded plate metal heat exchanger, because the processing technology determines that the blood channel gap cannot be very low, the heat exchange effect is also significantly lower than the hollow fiber microtube braided membrane roll, and the blood path volume is relatively high under the same heat exchange area. Therefore, the ideal heat exchanger should preferably combine the advantages of fast thermal conductivity of metal materials and small gaps and no laminar flow of hollow fiber tubes, taking into account heat exchange efficiency, blood path volume and resistance. Summary of the invention

[0004] The object of the present invention is to provide a membrane oxygenator, aiming to solve the problems of poor heat exchange efficiency, large blood path volume and resistance existing in the membrane oxygenator in the above technology.

[0005] To achieve the above-mentioned purpose, the present invention provides the following technical solutions: a membrane oxygenator, comprising: an oxygenation chamber shell, an oxygenation chamber outer shell and a variable temperature shell, the variable temperature shell is located inside the oxygenation chamber inner shell, a placeholder core is installed inside the variable temperature shell, a diverter cone is connected to the top of the placeholder core, a diverter is also supported and connected to the top of the placeholder core, a threaded variable temperature tube is installed between the outer wall of the placeholder core and the variable temperature shell, an oxygen pressure membrane is filled between the oxygenation chamber shell and the oxygenation chamber inner shell, and a filter is arranged inside the oxygen pressure membrane.

[0006] As a preferred membrane oxygenator of the present invention, the threaded temperature-variable tubes are closely arranged in parallel between the outer wall of the space-occupying core and the temperature-variable chamber shell, the surface of the threaded temperature-variable tubes is provided with spiral grooves and the interior of the threaded temperature-variable tubes is hollow.

[0007] As a preferred membrane oxygenator of the present invention, the cross-section of the place-occupying core is a regular hexagonal structure, the bottom end of the place-occupying core is open, and the top end of the place-occupying core is closed.

[0008] As a preferred membrane oxygenator of the present invention, the oxygen pressure membrane is wound by a double-layer woven hollow fiber oxygen pressure membrane pad, the membrane pad is composed of equal-length hollow fiber microtubes arranged equidistantly, the two layers are slightly inclined to both sides, and are woven into a door curtain shape by warp threads, and diamond-shaped pores are formed between the two layers of fibers after the inclination. After the oxygen pressure membrane is wound to a certain diameter, two to three filter screens are sandwiched in the membrane roll.

[0009] As a preferred membrane oxygenator of the present invention, the top and bottom ends of the temperature-changing chamber shell are respectively sealed with a first polyurethane glue and a second polyurethane glue, and the top and bottom ends between the oxygenation chamber outer shell and the oxygenation chamber inner shell are also respectively sealed with a third polyurethane glue and a fourth polyurethane glue.

[0010] As a preferred membrane oxygenator of the present invention, the temperature changing chamber shell is sealed by a first polyurethane glue and a second polyurethane glue, and the oxygenation chamber outer shell and the oxygenation chamber inner shell are sealed by a third polyurethane glue and a fourth polyurethane glue.

[0011] As a preferred membrane oxygenator of the present invention, two baffles are connected to the bottom end of the variable temperature chamber shell, a sealing strip is sandwiched between the two baffles and the lower end surface of the second polyurethane glue, a connecting ring is sandwiched between the variable temperature chamber shell and the top of the inner shell of the oxygenation chamber, the outer side of the connecting ring is bonded to the inner side of the upper end of the inner shell of the oxygenation chamber, the inner side hole of the connecting ring is hung with the hanging point of the variable temperature chamber shell, a sealing ring is connected between the bottom ends of the variable temperature chamber shell and the inner shell of the oxygenation chamber, and a sealing connection is formed between the variable temperature chamber shell and the bottom ends of the inner shell of the oxygenation chamber through the sealing ring.

[0012] As a preferred membrane oxygenator of the present invention, the top and bottom ends of the oxygenation chamber shell, the oxygenation chamber inner shell and the variable temperature chamber shell are provided with an upper end cover and a lower end cover, and the upper end cover and the lower end cover are connected with the oxygenation chamber shell, the oxygenation chamber inner shell and the variable temperature chamber shell, the placeholder core and the end face of the diverter to form an inner ring water channel and an outer ring gas channel, the top of the upper end cover is provided with a blood inlet and exhaust port, the side of the upper end cover is connected with a blood inlet nozzle, and the inside of the blood inlet nozzle is connected with the central area of ​​the upper end cover to form a blood inlet passage The surface of the upper end cover is connected with an air inlet nozzle, and the inner opening of the air inlet nozzle is in the gas channel of the upper end cover; the surface of the lower end cover is symmetrically connected with a water inlet nozzle and a water outlet nozzle, and the inner openings of the water inlet nozzle and the water outlet nozzle are in the water channel of the lower end cover, and the two are separated by a water baffle with a sealing strip; the surface of the lower end cover is connected with an exhaust nozzle, and the inner opening of the exhaust nozzle is in the gas channel of the lower end cover; a blood collection groove is provided inside the shell of the oxygenation chamber shell.

[0013] As a preferred membrane oxygenator of the present invention, a recirculation nozzle is provided on the right side of the oxygenation chamber shell, and a cold perfusion interface and a bleeding nozzle are provided on the left side of the oxygenation chamber shell in sequence from top to bottom, a temperature measuring probe is provided at the bottom end of the bleeding nozzle, and a blood collection port is provided on the side wall of the bleeding nozzle.

[0014] A membrane oxygenator and an integrated oxygenation chamber with an oxygen pressure membrane and a winding method for a filter screen, wherein the oxygen pressure membrane is wound on the outer wall of the inner shell of the oxygenation chamber, the oxygen pressure membrane is wound by a double-layer woven hollow fiber oxygen pressure membrane pad, the membrane pad is formed by equidistantly arranged hollow fiber microtubes of equal length, the two layers are slightly inclined to both sides, and are woven into a door curtain shape by warp threads, and diamond-shaped pores are formed between the two layers of fibers after the inclination, which is a blood channel. After the oxygen pressure membrane is wound to a certain diameter, the filter screen is clamped into the membrane roll of the oxygen pressure membrane, and then this is sequentially repeated until two to three filter screens are clamped and stopped, and then the oxygen pressure membrane is wound to the inner wall of the outer shell of the oxygenation chamber.

[0015] Compared with the prior art, the present invention has the following beneficial effects:

[0016] The spiral groove of the threaded temperature-changing tube in the temperature-changing chamber shell of the present invention is used to increase the specific surface area of ​​the threaded temperature-changing tube, so that the contact area between the blood and the heat exchanger is large and the heat conduction efficiency is high. At the same time, the blood channel is divided into a large number of narrow channels by the spiral groove, which is similar to the mesh structure of a woven membrane roll. The blood is repeatedly diverted and merged to generate turbulence, so that heat can be fully diffused and conducted in the blood flow. Subsequently, under the same heat exchange area, the structure inside the temperature-changing chamber shell is more compact and the blood volume is smaller. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] The accompanying drawings are used to provide a further understanding of the present invention and constitute a part of the specification. Together with the embodiments of the present invention, they are used to explain the present invention and do not constitute a limitation of the present invention. In the accompanying drawings:

[0018] Figure 1 It is a schematic diagram of the main cross-sectional structure of the present invention;

[0019] Figure 2 It is a schematic diagram of the main structure of the present invention;

[0020] Figure 3 It is a schematic diagram of the cross-sectional structure of the variable temperature chamber shell of the present invention;

[0021] Figure 4 It is a schematic diagram of the structure of the threaded temperature-variable tube of the present invention;

[0022] Figure 5 It is a schematic diagram of the main cross-section temperature-changing chamber structure of the present invention;

[0023] Figure 6 It is a schematic diagram of the oxygen pressure membrane connection structure in the oxygenation chamber of the present invention;

[0024] Figure 7 For the present invention Figure 6 The enlarged connection structure diagram at A in the figure.

[0025] In the figure: 1. oxygenation chamber shell; 2. oxygenation chamber inner shell; 3. variable temperature chamber shell; 4. diverter cone; 5. placeholder core; 6. threaded variable temperature tube; 7. oxygen pressure membrane; 8. filter; 9. first polyurethane glue; 10. second polyurethane glue; 11. third polyurethane glue; 12. fourth polyurethane glue; 13. sealing strip; 14. upper end cover; 15. lower end cover; 16. blood inlet and exhaust port; 17. blood inlet nozzle; 18. air inlet nozzle; 19. cold perfusion interface; 20. bleeding nozzle; 21. blood collection port; 22. temperature measuring probe; 23. exhaust nozzle; 24. recirculation nozzle; 25. baffle; 26. water inlet nozzle; 27. water outlet nozzle; 28. sealing ring; 29. ​​blood collection trough; 30. connecting ring; 31. diverter. DETAILED DESCRIPTION

[0026] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0027] Embodiment 1

[0028] See also Figure 1-7The present invention provides the following technical solutions: a membrane oxygenator, comprising: an oxygenation chamber shell 1, an oxygenation chamber inner shell 2 and a variable temperature shell 3, the variable temperature shell 3 is located inside the oxygenation chamber inner shell 2, a placeholder core 5 is installed inside the variable temperature shell 3, a diverter cone 4 is connected to the top of the placeholder core 5, a diverter 31 is also supported and connected to the top of the placeholder core 5, a threaded variable temperature tube 6 is installed between the outer wall of the placeholder core 5 and the variable temperature shell 3, an oxygen pressure membrane 7 is filled between the oxygenation chamber shell 1 and the oxygenation chamber inner shell 2, and a filter screen 8 is arranged inside the oxygen pressure membrane 7.

[0029] Preferably, the threaded temperature-variable tubes 6 are closely arranged in parallel between the outer wall of the space-occupying core 5 and the temperature-variable chamber shell 3 , the surface of the threaded temperature-variable tubes 6 is provided with spiral grooves and the interior of the threaded temperature-variable tubes 6 is hollow.

[0030] Preferably, the cross section of the placeholder core 5 is a regular hexagonal structure, the bottom end of the placeholder core 5 is open, and the top end of the placeholder core 5 is closed.

[0031] Preferably: the oxygen pressure membrane 7 is wound by a double-layer woven hollow fiber oxygen pressure membrane pad, the membrane pad is composed of equal-length hollow fiber microtubes arranged equidistantly, the two layers are slightly inclined to both sides, and are woven into a door curtain shape by warp threads. After the inclination, diamond-shaped pores are formed between the two layers of fibers. After the oxygen pressure membrane 7 is wound to a certain diameter, two to three filter screens 8 are sandwiched in the membrane roll.

[0032] Preferably, the top and bottom of the variable temperature chamber shell 3 are respectively filled with the first polyurethane glue 9 and the second polyurethane glue 10, and the top and bottom between the oxygenation chamber outer shell 1 and the oxygenation chamber inner shell 2 are also respectively filled with the third polyurethane glue 11 and the fourth polyurethane glue 12.

[0033] Preferably, the temperature-changing chamber shell 3 is sealed by the first polyurethane glue 9 and the second polyurethane glue 10 , and the oxygenation chamber outer shell 1 and the oxygenation chamber inner shell 2 are sealed by the third polyurethane glue 11 and the fourth polyurethane glue 12 .

[0034] Preferably: two baffles 25 are connected to the bottom end of the variable temperature chamber shell 3, a sealing strip 13 is sandwiched between the two baffles 25 and the lower end surface of the second polyurethane glue 10, a connecting ring 30 is sandwiched between the variable temperature chamber shell 3 and the top of the oxygenation chamber inner shell 2, the outer side of the connecting ring 30 is bonded to the inner side of the upper end of the oxygenation chamber inner shell 2, the inner side hole of the connecting ring 30 is hung with the hanging point of the variable temperature chamber shell 3, a sealing ring 28 is connected between the variable temperature chamber shell 3 and the bottom end of the oxygenation chamber inner shell 2, and a sealing connection is formed between the variable temperature chamber shell 3 and the bottom end of the oxygenation chamber inner shell 2 through the sealing ring 28.

[0035] Preferably: the top and bottom ends of the oxygenation chamber shell 1, the oxygenation chamber inner shell 2 and the variable temperature chamber shell 3 are provided with an upper end cover 14 and a lower end cover 15, and the upper end cover 14 and the lower end cover 15 are connected to the oxygenation chamber shell 1, the oxygenation chamber inner shell 2 and the variable temperature chamber shell 3, the placeholder core 5 and the diverter 31 end surface to form an inner ring water channel and an outer ring gas channel, the top of the upper end cover 14 is provided with a blood inlet and exhaust port 16, the side of the upper end cover 14 is connected to a blood inlet nozzle 17, the inside of the blood inlet nozzle 17 is connected to the central area of ​​the upper end cover 14 to form a blood inlet channel, and the upper end cover 1 4 is connected to an air inlet nozzle 18, and the inner opening of the air inlet nozzle 18 is in the gas channel of the upper end cover 14, the surface of the lower end cover 15 is symmetrically connected to a water inlet nozzle 26 and a water outlet nozzle 27, and the inner openings of the water inlet nozzle 26 and the water outlet nozzle 27 are in the water channel of the lower end cover 15, and the two are separated by a water baffle 25 with a sealing strip 13, the surface of the lower end cover 15 is connected to an exhaust nozzle 23, and the inner opening of the exhaust nozzle 23 is in the gas channel of the lower end cover 15, and a blood collection groove 29 is opened inside the shell of the oxygenation chamber shell 1.

[0036] Preferably: a recirculation nozzle 24 is provided on the right side of the oxygenation chamber shell 1, a cold perfusion interface 19 and a bleeding nozzle 20 are provided on the left side of the oxygenation chamber shell 1 from top to bottom, a temperature measuring probe 22 is provided at the bottom end of the bleeding nozzle 20, and a blood collection port 21 is provided on the side wall of the bleeding nozzle 20.

[0037] A membrane oxygenator and an integrated oxygenation chamber with an oxygen pressure membrane and a winding method for a filter screen, wherein an oxygen pressure membrane 7 is wound around the outer wall of an inner shell 2 of the oxygenation chamber, the oxygen pressure membrane 7 is wound by a double-layer woven hollow fiber oxygen pressure membrane pad, the membrane pad is formed by equally arranged hollow fiber microtubes of equal length, the two layers are slightly inclined to both sides, and are woven into a door curtain shape by warp threads, and diamond-shaped pores are formed between the two layers of fibers after the inclination, which is a blood channel. After the oxygen pressure membrane 7 is wound to a certain diameter, a filter screen 8 is sandwiched into the membrane roll of the oxygen pressure membrane 7, and then this is sequentially repeated until two to three filter screens 8 are sandwiched and stopped, and then the oxygen pressure membrane 7 is wound around the inner wall of the outer shell 1 of the oxygenation chamber.

[0038] In the embodiment, the membrane oxygenator is a cylindrical double-layer nested structure, the outer layer is an oxygenation chamber outer shell 1, an oxygenation chamber inner shell 2, the inner layer is a variable temperature shell 3, the double chambers share an upper end cover 14 and a lower end cover 15, the center of the variable temperature shell 3 is a placeholder core 5, the cross section of the placeholder core 5 is a hollow regular hexagonal structure, the bottom is open, the top is closed, and it is gathered into an arc-shaped diverter cone 4, the outer side of the diverter cone 4 is a cage-shaped diverter 31, the top of the diverter 31 is annular, and is sealed and connected to the inner ring of the upper end cover 14. The outer side of the placeholder core 5 is Figure 5An array of threaded temperature-variable tubes 6 of equal size are neatly arranged in the form of a tube. The threaded temperature-variable tubes 6 are formed by spinning of a thin-walled metal tube, and a plurality of thread grooves of equal depth and pitch are evenly distributed on the surface. The cross-section of the thread groove is arc-shaped, and there is a tiny arc at the transition to the tube wall without indentation to reduce the damage of the sharp corners to the blood cells. The threaded temperature-variable tubes 6 are arranged in parallel and closely, and a herringbone layout is formed between every three threaded temperature-variable tubes 6. The inner layer of the threaded temperature-variable tube 6 is in close contact with the outer wall of the space-occupying core 5. A temperature-variable temperature shell 3 is sheathed outside the space-occupying core 5 array, and the inner surface of the temperature-variable temperature shell 3 forms depressions and protrusions according to the arrangement of the temperature-variable tubes to ensure that the temperature-variable temperature shell 3 is in close contact with the outermost layer of the threaded temperature-variable tube 6, and the inner surface of the temperature-variable temperature shell 3 is fitted The threaded temperature-variable tube 6 forms a blood channel with a very small gap. The inner wall of the inner surface of the temperature-variable room shell 3 becomes a special-shaped curved surface, and there are multiple flat holes on the side of the lower section. The outer surface of the temperature-variable room shell 3 is cylindrical, and there are two water-blocking plates 25 above the flat holes. A sealing strip 13 is sandwiched between the two water-blocking plates 25 and the lower end surface of the second polyurethane glue 10. The upper and lower ends of the annular channel between the temperature-variable room shell 3 and the occupying core 5 are sealed with the first polyurethane glue 9 and the second polyurethane glue 10. The first polyurethane glue 9 and the second polyurethane glue 10 wrap both ends of all the threaded temperature-variable tubes 6. The end faces of the first polyurethane glue 9 and the second polyurethane glue 10 are flush with the threaded temperature-variable tube 6, forming two upper and lower planes slightly lower than the end faces of the temperature-variable room shell 3.

[0039] In another embodiment, the oxygenation chamber shell 2 is sleeved outside the variable temperature chamber, and a plurality of oblate holes are opened on the side wall of the lower section thereof, which are aligned with and closely fitted to the openings on the side of the lower section of the variable temperature chamber shell 3, and the upper part of the fitting surface is sealed with a sealing ring 28, and the lower part is sealed with a third polyurethane glue 11 and a fourth polyurethane glue 12. The oxygenation chamber shell 2 is wrapped with an oxygen pressure membrane 7, and the oxygen pressure membrane 7 is wound with a double-layer braided hollow fiber oxygen pressure membrane pad. The membrane pad is formed by equidistantly arranged hollow fiber microtubes of equal length, and the two layers are slightly inclined to both sides, and are woven into a door curtain shape by warp threads. After the inclination, diamond-shaped pores are formed between the two layers of fibers, and the oxygen pressure membrane 7 is wound to one side. After the diameter is determined, two to three filters 8 are sandwiched in the membrane roll, and the oxygen pressure membrane 7 is covered with the oxygenation chamber shell 1. The upper section of the oxygenation chamber shell 1 is a double-layer structure, and there is a blood collection groove 29 between the two layers. The bottom of the blood collection groove 29 is an inclined surface or an arc surface, and a bleeding nozzle 20 is arranged on the outer wall of the lowest point. A temperature measuring probe 22 and a blood sampling port 21 are arranged on the side or below the bleeding nozzle 20. The temperature measuring interface of the temperature measuring probe 22 is a built-in stainless steel probe with a closed tip. The outlet end of the temperature measuring probe 22 is provided with a hanging point for the temperature sensor probe to be inserted and locked, so as to measure the blood temperature at the oxygenator outlet without contacting the blood. The blood sampling port 21 is a Luer internal conical connector with a size that conforms to GB / T1962.2 and has an external thread lock. A cold perfusion interface 19 is arranged above the bleeding nozzle 20, and a recirculation nozzle 24 is arranged on the opposite side of the shell. Both the cold perfusion interface 19 and the recirculation nozzle 24 are conical interfaces with a hanging platform. The position of the recirculation nozzle 24 is slightly higher than the cold perfusion interface 19, and the inner hole is flush with the lower surface of the third polyurethane glue 11 potting layer at the upper end of the oxygenation chamber shell 1. The upper and lower ends of the annular channel between the oxygenation chamber shell 1 and the oxygenation chamber inner shell 2 are potted by the third polyurethane glue 11 and the fourth polyurethane glue 12. The third polyurethane glue 11 and the fourth polyurethane glue 12 wrap all the oxygen pressure membranes 7, and the end faces of the third polyurethane glue 11 and the fourth polyurethane glue 12 form two upper and lower planes that are slightly higher than the end face of the oxygenation chamber shell 1.

[0040] A connecting ring 30 is sandwiched between the oxygenation chamber shell 2 and the variable temperature shell 3. The outer side of the connecting ring 30 is bonded to the inner side of the upper end of the oxygenation chamber shell 2. The inner side hole of the connecting ring 30 is hung with the hanging point of the variable temperature shell 3, so that the oxygenation chamber shell 2 and the variable temperature shell 3 are in an integral shape. The oxygenation chamber shell 1, the oxygenation chamber shell 2 and the variable temperature shell 3 are equipped with an upper end cover 14 on the top. The bottom of the upper end cover 14 is a three-ring structure. The three-layer annular side wall is respectively connected to the top of the diverter 31, the top of the variable temperature shell 3 and the top of the oxygenation chamber shell 1 from the inside to the outside. Sealed and bonded, the center of the upper end cover 14 is a conical structure that is conducive to gas gathering and exhaust. A blood inlet and exhaust port 16 is arranged on the top. The blood inlet nozzle 17 is a circular tube structure. The inlet is conical and has a hanging platform for pipe sliding. The blood inlet nozzle 17 is a circular tube structure connected to the blood inlet channel. The blood inlet channel passes through the three-layer annular side wall of the upper end cover 14 to reach the space below the exhaust cone. The inner cavity of the blood inlet nozzle 17 is tangent to the side wall of the cylindrical space. The air inlet nozzle 18 is arranged on the side of the upper cover, and the inner hole is connected to the space above the upper end surface of the oxygenation chamber. The blood inlet nozzle 17 and the air inlet nozzle 18 are integrated with the upper end cover 14, and the lower end cover 15 is installed at the bottom of the oxygenation chamber shell 1, the oxygenation chamber shell 2 and the variable temperature chamber shell 3. The bottom of the lower end cover 15 is a three-ring structure, and the three-layer annular side wall is sealed and bonded to the bottom of the space-occupying core 5, the bottom of the variable temperature chamber shell 3 and the bottom of the oxygenation chamber shell 1 from the inside to the outside. The water inlet nozzle 26 and the water outlet nozzle 27 are standard Hansen interfaces and can be connected with quick-plug connectors. The water inlet nozzle 26 and the water outlet nozzle 27 are connected to the water inlet and outlet channels, and the water inlet and outlet channels pass through the middle and outer layers The annular side wall reaches the space below the lower end surface of the variable temperature chamber shell 3. There is a water-blocking plate 25 between the inner and middle annular side walls of the lower end cover 15. A silicone rubber sealing strip is installed on the top of the water-blocking plate 25, which abuts against the lower end surface of the variable temperature chamber shell 3 to separate the openings of the water inlet and outlet channels on the inner side of the middle annular side wall. An exhaust nozzle 23 is arranged on the back side between the outer ring and the middle ring of the lower end cover 15. The exhaust nozzle 23 is a conical tube style, and a longitudinal groove is opened on the side wall. The lower end cover 15 has a circular air supplement hole at a 90° position of the exhaust nozzle 23.

[0041] The specific working principle is that before using this product, all interfaces are connected with corresponding functional pipelines, and the whole blood channel is perfused with pre-filled liquid to discharge the gas in the channel and wet the channel surface at the same time to prevent the blood from contacting with the surface of dry foreign materials to produce coagulation, and check the sealing of the channel. The air in the variable temperature room and oxygenation room is discharged into the venous blood reservoir through the blood inlet and exhaust port 16 and the recirculation nozzle 24 located at the highest point of the chamber, respectively. After exhausting, the pipes connected to the interface are clamped. When it is officially used, venous blood enters the blood inlet channel from the blood inlet nozzle 17, rotates downward along the tangent and flows into the diverter 31, disperses around the diverter cone 4, and is evenly divided into multiple branches in the cage structure of the diverter 31, and enters the variable temperature shell 3. The blood flows downward through the outer surface threads of the densely packed threaded variable temperature tube 6. At the same time, the variable temperature water (cold water in the initial cooling stage of the operation and warm water in the heating stage after the operation) enters the lower end cover 15, the second polyurethane glue 10 at the lower end of the variable temperature shell 3, and the semi-circular area on one side formed by the water inlet nozzle 26, and then enters The upper half of the threaded temperature-changing tube 6 flows upward, flows from the top opening of the threaded temperature-changing tube 6 into the annular space formed by the first polyurethane glue 9 at the upper end of the temperature-changing chamber shell 3 and the upper end cover 14, and then flows downward through the other half of the threaded temperature-changing tube 6, enters the other side semi-annular area formed by the lower end cover 15, the second polyurethane glue 10 at the lower end of the temperature-changing chamber shell 3 and the water-blocking plate 25, and finally flows out from the water outlet 27. The blood flow and the water flow exchange blood heat on the surface of the temperature-changing tube to adjust the blood temperature, thereby gradually changing the patient's body temperature and tissue oxygen consumption. The temperature-changed venous blood is evenly dispersed from the side holes around the lower end of the temperature-changing chamber shell 3 into the oxygenation chamber shell 1 and the oxygenation chamber shell 2, filling the outer space of the oxygen pressure membrane 7 fiber, and flowing upward between the fiber microtubes. At the same time, oxygen or air-oxygen mixed gas enters the annular space formed by the upper end cover 14 and the third polyurethane glue 11 at the upper end of the oxygenation chamber through the air inlet nozzle 18, and flows downward from the inside of the oxygen pressure membrane 7 fiber microtube. The surface of the oxygen pressure membrane 7 fiber is densely covered with microscopic pores. The gas and blood exchange oxygen and carbon dioxide on the surface of the fiber microtube. After oxygen enters the blood, it is oxygenated with the hemoglobin in the red blood cells to form oxygenated hemoglobin, which converts venous blood into arterial blood. The blood is oxygenated in the upward flow of the oxygenation chamber. At the same time, the entrained tiny solids and gas emboli are intercepted when passing through the filter screen 8 sandwiched in the oxygen pressure membrane 7, and finally converge in the upper blood collection groove 29 of the oxygenation chamber, and then enter the patient's circulatory system through the bleeding nozzle 20 through the arterial pipeline to maintain the patient's life activities during the operation.

[0042] In summary, the spiral groove of the threaded temperature-variable tube 6 is used in the temperature-variable housing 3 of the present invention to increase the specific surface area of ​​the threaded temperature-variable tube 6, so that the contact area between the blood and the heat exchanger is large and the heat conduction efficiency is high. At the same time, the blood channel is divided into a large number of narrow channels by the spiral groove, similar to the mesh structure of a woven membrane roll. The blood is repeatedly diverted and merged to generate turbulence, so that the heat can be fully diffused and conducted in the blood flow. Subsequently, under the same heat exchange area, the structure inside the temperature-variable housing 3 is more compact and the blood volume is smaller.

[0043] Finally, it should be noted that the above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art can still modify the technical solutions described in the aforementioned embodiments or replace some of the technical features therein by equivalents. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A membrane oxygenator, characterized in that: include: An oxygenation chamber shell (1), an oxygenation chamber inner shell (2) and a temperature-changing chamber shell (3), wherein the temperature-changing chamber shell (3) is located inside the oxygenation chamber outer shell (2), a placeholder core (5) is installed inside the temperature-changing chamber shell (3), a top end of the placeholder core (5) is connected to a flow diverter cone (4), a top end of the placeholder core (5) is also supported and connected to a flow diverter (31), and a threaded temperature-changing tube (6) is installed between the outer wall of the placeholder core (5) and the temperature-changing chamber shell (3); An oxygen pressure membrane (7) is installed between the oxygenation chamber outer shell (1) and the oxygenation chamber inner shell (2), and a filter screen (8) is arranged inside the oxygen pressure membrane (7).

2. A membrane oxygenator according to claim 1, characterized in that: The threaded temperature-changing tubes (6) are arranged in parallel and closely between the outer wall of the space-occupying core (5) and the temperature-changing chamber shell (3); a spiral groove is provided on the surface of the threaded temperature-changing tubes (6) and the interior of the threaded temperature-changing tubes (6) is hollow.

3. A membrane oxygenator according to claim 1, characterized in that: The cross section of the place-occupying core (5) is in a regular hexagonal structure, the bottom end of the place-occupying core (5) is in an open shape, and the top end of the place-occupying core (5) is in a closed shape.

4. A membrane oxygenator according to claim 1, characterized in that: The oxygen pressure membrane (7) is wound by a double-layer woven hollow fiber oxygen pressure membrane pad, and the membrane pad is formed by equidistantly arranged hollow fiber microtubes of equal length, and the two layers are slightly inclined to both sides and woven into a door curtain shape by warp threads. After the inclination, diamond-shaped pores are formed between the two layers of fibers. After the oxygen pressure membrane (7) is wound to a certain diameter, two to three filter screens (8) are sandwiched in the membrane roll.

5. A membrane oxygenator according to claim 1, characterized in that: The top and bottom ends of the temperature-changing chamber shell (3) are respectively filled with a first polyurethane glue (9) and a second polyurethane glue (10), and the top and bottom ends between the oxygenation chamber outer shell (1) and the oxygenation chamber inner shell (2) are also respectively filled with a third polyurethane glue (11) and a fourth polyurethane glue (12).

6. A membrane oxygenator according to claim 5, characterized in that: The temperature-changing chamber shell (3) is sealed by a first polyurethane glue (9) and a second polyurethane glue (10), and the oxygenation chamber outer shell (1) and the oxygenation chamber inner shell (2) are sealed by a third polyurethane glue (11) and a fourth polyurethane glue (12).

7. A membrane oxygenator according to claim 1, characterized in that: The bottom end of the variable temperature housing (3) is connected to two water-blocking plates (25), and a sealing strip (13) is sandwiched between the two water-blocking plates (25) and the lower end surface of the second polyurethane glue (10). A connecting ring (30) is sandwiched between the top of the variable temperature housing (3) and the inner shell of the oxygenation chamber (2). The outer side of the connecting ring (30) is bonded to the inner side of the upper end of the oxygenation chamber inner shell (2), and the inner side hole of the connecting ring (30) is hung with the hanging point of the variable temperature housing (3). A sealing ring (28) is connected between the bottom ends of the variable temperature housing (3) and the inner shell of the oxygenation chamber (2), and a sealing connection is formed between the bottom ends of the variable temperature housing (3) and the inner shell of the oxygenation chamber (2) through the sealing ring (28).

8. The membrane oxygenator according to claim 1, characterized in that: The top and bottom ends of the oxygenation chamber shell (1), the oxygenation chamber inner shell (2) and the variable temperature chamber shell (3) are provided with an upper end cover (14) and a lower end cover (15), and the upper end cover (14) and the lower end cover (15) are connected to the end faces of the oxygenation chamber shell (1), the oxygenation chamber inner shell (2) and the variable temperature chamber shell (3), the spacer core (5) and the diverter (31) to form an inner ring water channel and an outer ring gas channel. The top of the upper end cover (14) is provided with a blood inlet and exhaust port (16). The side of the upper end cover (14) is connected with a blood inlet nozzle (17). The inside of the blood inlet nozzle (17) is connected to the central area of ​​the upper end cover (14) to form a blood inlet channel. The upper end cover (14) The surface of the upper end cover (14) is connected to an air inlet nozzle (18), and the inner opening of the air inlet nozzle (18) is located in the gas passage of the upper end cover (14); the surface of the lower end cover (15) is symmetrically connected to a water inlet nozzle (26) and a water outlet nozzle (27), and the inner openings of the water inlet nozzle (26) and the water outlet nozzle (27) are located in the water passage of the lower end cover (15), and the two are separated by a water baffle (25) with a sealing strip (13); the surface of the lower end cover (15) is connected to an exhaust nozzle (23), and the inner opening of the exhaust nozzle (23) is located in the gas passage of the lower end cover (15); and a blood collection groove (29) is provided inside the shell of the oxygenation chamber shell (1).

9. The membrane oxygenator according to claim 1, characterized in that: A recirculation nozzle (24) is provided on the right side of the oxygenation chamber shell (1), and a cold perfusion interface (19) and a bleeding nozzle (20) are provided on the left side of the oxygenation chamber shell (1) in order from top to bottom. A temperature measuring probe (22) is provided at the bottom end of the bleeding nozzle (20), and a blood collection port (21) is provided on the side wall of the bleeding nozzle (20).

10. A membrane oxygenator and an integrated oxygenation chamber with an oxygen pressure membrane and a filter winding method, characterized in that: The oxygen pressure membrane (7) is wound around the outer wall of the inner shell (2) of the oxygenation chamber. The oxygen pressure membrane (7) is wound by a double-layer woven hollow fiber oxygen pressure membrane pad. The membrane pad is formed by equidistantly arranged hollow fiber microtubes of equal length. The two layers are slightly inclined to both sides and are woven into a door curtain shape by warp threads. After the inclination, diamond-shaped pores are formed between the two layers of fibers, which are blood channels. After the oxygen pressure membrane (7) is wound to a certain diameter, the filter screen (8) is clamped into the membrane roll of the oxygen pressure membrane (7), and then it is stopped after two or three filter screens (8) are clamped. Then the oxygen pressure membrane (7) is wound to the inner wall of the outer shell (1) of the oxygenation chamber.

Images