Purification equipment for active folic acid

Abstract

The invention discloses purification equipment for active folic acid, and relates to the technical field of active folic acid production. The device comprises a stirring and dissolving tank and a crystal precipitation tank communicated with the stirring and dissolving tank, the stirring and dissolving tank is used for mixing 5-methyltetrahydrofolic acid, organic alkali and a solvent into salt; the crystal precipitation tank is used for cooling the mixture obtained in the stirring and dissolving tank, so that salt crystals are precipitated; the constant-temperature storage tank A is used for storing high-temperature water, the constant-temperature storage tank B is used for storing low-temperature water, and the storage tank is used for storing medium-temperature water. The whole set of equipment comprising a stirring and dissolving tank and a crystallization and separation tank communicated with the stirring and dissolving tank is used for purifying the 5-methyltetrahydrofolic acid; meanwhile, liquid used for cooling and heating is controlled to flow in a closed-loop system composed of the constant-temperature storage tank A, the storage tank, the constant-temperature storage tank B, the transfer storage tank, the constant-temperature transfer tank and the cooling box during use, pollution is reduced, and meanwhile energy consumption for heating and cooling water is saved.

Description

Technical Field

[0001] The invention belongs to the technical field of active folic acid production, and particularly relates to active folic acid purification equipment. Background Art

[0002] Active folic acid is also called 5-methyltetrahydrofolate. The chemical name of 5-methyltetrahydrofolate is N-(5-methyl)-6(S)-5,6,7,8,-tetrahydropteroyl-L-glutamic acid, referred to as (6S)-5-MTHF. 5-methyltetrahydrofolate is the most biologically active and functional form of folic acid. It is the only way for folic acid to participate in physiological metabolism and the only form of free folic acid in animal plasma and cells. It is mainly used as an active ingredient in drugs and a food additive to prevent fetal neural tube defects and arteriosclerosis, treat megaloblastic anemia, enhance the therapeutic effect of fluorinated pyrimidines, and treat autoimmune diseases such as psoriasis and rheumatoid arthritis. The combined use of progesterone and 5-methyltetrahydrofolate is used in the treatment of endometriosis while reducing the side effects of treatment and reducing the risk of congenital malformations during pregnancy.

[0003] When preparing folic acid, the crude acid needs to be purified. For example, CN218307501 U discloses a purification device for nano-level folic acid, comprising a device box, a support frame, a stirring shaft and a device box, wherein a support frame is installed on the side of the device box, a discharge port is opened in the middle of the bottom of the device box, a feed port is opened on one side of the top of the device box, a device box is installed in the middle of the top of the device box, a first motor is installed on one side of the bottom of the inner cavity of the device box, a rotating shaft is connected to the top of the inner cavity of the device box through a bearing, a crank wheel is installed on the rotating shaft, a connecting piece is installed in the crank wheel, a linkage rod is connected to the bottom of the connecting piece through a rotating shaft, a mounting block is connected to the bottom of the linkage rod inside the device box, a second motor is connected to both sides of the mounting block, a stirring shaft is connected to the output shaft at the bottom of the second motor, a fixing rod is connected to the bottom of the mounting block, a connecting frame is installed on the surface of the linkage rod above the mounting block, and a scraper is connected to the side of the connecting frame; the device solves the problem of insufficient stirring during the stirring of crude acid in the existing purification device; the device does not actually provide a complete set of devices for purifying crude acid. Summary of the invention

[0004] The object of the present invention is to provide an active folic acid purification device, which solves the problems raised by the existing background technology by providing a complete set of equipment consisting of a stirring and dissolving tank and a crystallization and precipitation tank connected to the stirring and dissolving tank for purifying 5-methyltetrahydrofolate.

[0005] In order to solve the above technical problems, the present invention is achieved through the following technical solutions:

[0006] The present invention discloses an active folic acid purification device, comprising a stirring and dissolving tank, and a crystallization and precipitation tank connected to the stirring and dissolving tank; the stirring and dissolving tank is used to mix 5-methyltetrahydrofolate, an organic base and a solvent into salt; the crystallization and precipitation tank is used to cool the mixture obtained in the stirring and dissolving tank to crystallize the salt; a jacket heating layer A is arranged on the outside of the stirring and dissolving tank, a heating pipe wound around the outer wall of the tank body is arranged inside the jacket heating layer A, and two ends of the heating pipe are respectively arranged as a water inlet joint A and a water outlet joint A; a jacket heating layer B is arranged on the outside of the crystallization and precipitation tank, a cooling pipe wound around the outer wall of the tank body is arranged inside the jacket heating layer B, and two ends of the cooling pipe are respectively arranged as a water inlet joint B and a water outlet joint B; the device also comprises a constant temperature storage tank A storing high temperature water, a constant temperature storage tank B storing low temperature water, and a storage tank storing medium temperature water;

[0007] Wherein, the water outlet of the constant temperature storage tank B is connected to the water inlet joint B;

[0008] The water outlet end of the constant temperature storage tank A is connected to the water inlet joint A, and the water outlet joint A is connected to a constant temperature transfer tank. A water pump A is arranged in the constant temperature transfer tank. The water outlet end of the water pump A is connected to a one-inlet and two-outlet valve through a pipeline A. The two outlets of the one-inlet and two-outlet valve are connected to the top of the storage tank and the constant temperature storage tank A through a pipeline B respectively; the water outlet end of the storage tank is connected to the water inlet joint B, and the water outlet joint B is connected to a transfer tank. The transfer tank is connected through a constant temperature transfer tank provided with a valve; a water pump B is arranged in the transfer tank, and the water outlet end of the water pump B is connected to the top of the storage tank through a pipeline C.

[0009] Furthermore, temperature sensors A and B are respectively provided in the constant temperature transfer tank and the transfer storage tank; control valves A, B and C are respectively provided at the water outlets of the constant temperature storage tank A, the constant temperature storage tank B and the storage tank; the temperature sensor A, the temperature sensor B, the one-inlet and two-outlet valve, the valve, the control valve A, the control valve B and the control valve C are all connected to a controller.

[0010] Furthermore, a temperature sensor C and a heating module are provided in the constant temperature storage tank A, and a temperature sensor D and a semiconductor refrigeration module are provided in the constant temperature storage tank B; and the temperature sensor C, the heating module, the temperature sensor D and the semiconductor refrigeration module are all connected to the controller.

[0011] Furthermore, a drain pipe A and a drain pipe B are respectively provided at the bottom ends of the constant temperature transfer tank and the transfer storage tank, and the drain pipe A and the drain pipe are respectively equipped with control valve 1 and control valve 2; the drain pipe A and the drain pipe are connected to a cooling box, a water pump C is provided in the cooling box, and the water outlet end of the water pump C is connected to the top of the constant temperature storage tank B through a pipeline D; and a liquid level sensor A and a liquid level sensor B are respectively provided in the constant temperature storage tank A and the storage tank.

[0012] Furthermore, a driving structure A including a stirring motor A and a reducer A is provided on the top of the stirring and dissolving tank, and an output end of the driving structure A is connected to the stirring structure A located inside the stirring and dissolving tank; a driving structure B including a stirring motor B and a reducer B is provided on the top of the crystallization and precipitation tank, and an output end of the driving structure B is connected to the stirring structure B located inside the crystallization and precipitation tank.

[0013] Furthermore, a feeding port and at least two liquid inlet pipes A are provided at the top of the stirring and dissolving tank, and at least two liquid inlet pipes B are provided at the top of the crystallization and precipitation tank; the bottom of the stirring and dissolving tank is connected to a discharge pipe A provided with a discharge valve A, one end of the discharge pipe A is connected to a feed pipe at the top of a filtering device, the bottom end of the filtering device is connected to a discharge pipe, and one end of the discharge pipe is connected to a liquid inlet pipe B; the bottom of the crystallization and precipitation tank is connected to a discharge pipe B provided with a discharge valve B, and is provided with a discharge pipe C.

[0014] Furthermore, the top of the discharge pipe B slightly protrudes from the inner bottom side of the crystallization precipitation tank, and a filtering structure is detachably installed on the top of the discharge pipe B; the filtering structure includes an annular porous plate A, and the inner and outer peripheral sides of the upper surface of the porous plate A are both provided with convex rings, the inner ring of the convex ring is provided with a sealing ring, and the outer ring is provided with bolt holes; a cover plate that is sealed and matched with the porous plate A is provided directly above the porous plate A, and the cover plate is an annular structure, and the peripheral side of the cover plate is provided with bolts that match the bolt holes, and a sealing groove that matches the sealing ring;

[0015] Filter paper A is arranged on the upper surface of the porous plate A, and the bottom side surface of the cover plate is connected to the porous plate B against the filter paper A through a connecting column, and the porous plate B is an annular structure; it also includes a connecting pipe that passes through the center of the porous plate A, and the bottom end of the connecting pipe is threadedly connected to the discharge pipe B; a connecting rod is welded to the upper surface of the cover plate, one end of the connecting rod is welded to the outer side wall of the connecting pipe, and the upper surface of the cover plate is connected to an L-shaped pipe, and one end of the L-shaped pipe is connected to one side of the connecting pipe.

[0016] Furthermore, the discharge pipe C includes a tube body A connected to the bottom of the crystallization precipitation tank, the bottom end of the tube body A is connected to the tube body C through a tube body B with a gradually increasing diameter, a rotating sleeve is connected to the tube body C through a bracket, a rotating rod is arranged in the rotating sleeve, the top of the rotating rod is connected to a sealing plate, the upper surface of the sealing plate is connected to a scraper through a column, the bottom end of the rotating rod is connected to a hexagonal operating column, and the bottom end of the tube body C is threadedly connected to an end cover, and a limiting ring located above the rotating sleeve is arranged on the rotating rod.

[0017] Furthermore, the filtering device includes a box body, a porous partition is arranged inside the box body, and the boxes located on the upper and lower sides of the porous partition are respectively connected to the feed pipe and the discharge pipe; the upper surface of the porous partition is covered with filter paper B, and a porous pressure plate A is arranged above the porous partition, and the bottom side surface of the porous pressure plate A is connected to the porous pressure plate B through a number of springs, and the porous pressure plate B is against the filter paper B.

[0018] Furthermore, the feeding port includes a convex tube protruding from the top surface of the stirring and dissolving tank, and a hinge seat A and a hinge seat B are respectively provided on both sides of the convex tube. The hinge seat A is rotatably connected to an arc-shaped movable arm through a hinge shaft A, and the middle part of the arc-shaped movable arm is rotatably connected to a connecting seat, and the connecting seat is connected to a sealing cover, and the sealing cover is installed at the end of the convex tube in a sealing manner; one end of the arc-shaped movable arm is connected to a U-shaped block, and the hinge seat B is rotatably connected to a stud through a hinge shaft B, and the stud is stuck in the U-shaped block, and a hand-tightening nut is threaded on the stud, and the hand-tightening nut is against the U-shaped block.

[0019] The present invention has the following beneficial effects:

[0020] The present invention provides a complete set of equipment consisting of a stirring and dissolving tank and a crystallization and precipitation tank connected with the stirring and dissolving tank for purifying 5-methyltetrahydrofolate. When in use, when the stirring and dissolving tank needs to be heated, high-temperature water stored in a constant temperature storage tank A is controlled to be sent into a heating pipe, and then the solution in the stirring and dissolving tank is heated to 60°C. When the crystallization and precipitation tank needs to be cooled, the medium-temperature water stored in the storage tank is first sent into the cooling pipe for preliminary cooling, and then the low-temperature water stored in the constant temperature storage tank B is sent into the cooling pipe for final cooling, so that the solution in the crystallization and precipitation tank is cooled to between 5°C and 20°C.

[0021] Of course, any product implementing the present invention does not necessarily need to achieve all of the advantages described above at the same time. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings required for describing the embodiments will be briefly introduced below. Obviously, the accompanying drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other accompanying drawings can be obtained based on these accompanying drawings without paying creative work.

[0023] Figure 1 It is a schematic diagram of the structure of the purification equipment of the present invention;

[0024] Figure 2 This is a schematic diagram of cooling water and heating water circulation of the present invention;

[0025] Figure 3 It is a schematic diagram of the structure of the filtering device of the present invention;

[0026] Figure 4 It is a schematic diagram of the filtering structure of the present invention;

[0027] Figure 5 for Figure 4 A partial enlarged view of the middle part;

[0028] Figure 6 This is a schematic diagram of the feeding port structure of the present invention;

[0029] Figure 7 It is a schematic diagram of the structure of the discharge pipe C of the present invention. DETAILED DESCRIPTION

[0030] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0031] In the description of the present invention, it should be understood that the terms "opening", "upper", "lower", "thickness", "top", "middle", "length", "inside", "all around" and the like indicating orientation or positional relationship are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the components or elements referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as limiting the present invention.

[0032] Example 1, please refer to Figure 1-2As shown, the present invention is a purification device for active folic acid, comprising a stirring and dissolving tank 1, a filtering device 3 connected to the bottom of the stirring and dissolving tank 1, and a crystallization and precipitation tank 2 connected to the bottom of the filtering device 3; and in the present invention, a jacket heating layer A is arranged on the outside of the stirring and dissolving tank 1, a heating pipe wound around the outer wall of the tank body is arranged in the jacket heating layer A, and two ends of the heating pipe are respectively arranged as a water inlet joint A101 and a water outlet joint A102; a jacket heating layer B is arranged on the outside of the crystallization and precipitation tank 2, a cooling pipe wound around the outer wall of the tank body is arranged in the jacket heating layer B, and two ends of the cooling pipe are respectively arranged as a water inlet joint B201 and a water outlet joint B202.

[0033] The bottom of the stirring and dissolving tank 1 is connected to a discharge pipe A103 provided with a discharge valve A104; the bottom of the crystallization and precipitation tank 2 is connected to a discharge pipe B22 provided with a discharge valve B27, and a discharge pipe C21.

[0034] Based on the above, when in use, 5-methyltetrahydrofolate, an organic base and a solvent are put into a stirring and dissolving tank 1 for uniform stirring, and during the stirring process, high-temperature water is introduced into a heating tube to heat the solution stored in the stirring and dissolving tank 1; after uniform stirring, the solution stored in the stirring and dissolving tank 1 is discharged into a filtering device 3, filtered by the filtering device 3 to remove impurities, and then the mixed solution is sent to a crystallization tank 2, and the solution in the crystallization tank 2 is cooled by injecting cold water into a cooling tube, so that the salt is crystallized and precipitated, and a discharge valve B27 arranged on a discharge pipe B22 is opened to discharge the solution in the crystallization tank 2; then, after closing the discharge valve B27, an aqueous solution of alkali is put into the crystallization tank 2 for uniform stirring, and then an appropriate amount of acid is added to free and precipitate the 5-methyltetrahydrofolate; then, the discharge valve B27 on the discharge pipe B22 is opened again to discharge the solution in the crystallization tank 2, and finally, the discharge pipe C21 is opened to discharge the 5-methyltetrahydrofolate obtained with high purity.

[0035] In the present invention, the organic base is selected from one of benzylamine, α-phenylethylamine, L-phenylethylamine, D-phenylethylamine, L-phenylglycinol, D-phenylglycinol, L-phenylalaninol, D-phenylalaninol, 1-naphthylethylamine, R-1-naphthylethylamine, S-1-naphthylethylamine and diethylamine.

[0036] In the present invention, the solvent is selected from water, organic solvents miscible with water and mixtures thereof; the base is selected from sodium hydroxide, potassium hydroxide, sodium carbonate, potassium carbonate and lithium hydroxide; and the acid is a protonic acid.

[0037] Based on the requirements of the present invention for heating the stirring and dissolving tank 1 and cooling the crystallization and precipitation tank 2, the present invention also provides a constant temperature storage tank A100 for storing high temperature water, a constant temperature storage tank B300 for storing low temperature water, and a storage tank 200 for storing medium temperature water.

[0038] Then, the above convenient control controls the heating water and the low-temperature water to flow into the corresponding heating pipes and cooling pipes for heating and cooling respectively. The water outlet end of the constant temperature storage tank A100 provided by the present invention is connected to the water inlet joint A101, and the water outlet joint A102 is connected to the constant temperature transfer tank 500. The water outlet end of the storage tank 200 is connected to the water inlet joint B201, and the water outlet joint B202 is connected to the transfer tank 400. The transfer tank 400 is connected through the constant temperature transfer tank 500 provided with a valve 600, and the water outlet end of the constant temperature storage tank B300 is connected to On the water inlet joint B201; when the stirring and dissolving tank 1 needs to be heated during use, the high-temperature water stored in the constant temperature storage tank A100 is controlled to be sent into the heating pipe, and then the solution in the stirring and dissolving tank 1 is heated to 60°C; when the crystallization tank 2 needs to be cooled, the medium-temperature water stored in the storage tank 200 is first sent into the cooling pipe for preliminary cooling, and then the low-temperature water stored in the constant temperature storage tank B300 is sent into the cooling pipe for final cooling, so as to cool the solution in the crystallization tank 2 to between 5°C and 20°C.

[0039] Based on the above, a water pump A is arranged in the constant temperature transfer tank 500, and the water outlet of the water pump A is connected to a one-inlet and two-outlet valve 502 through a pipeline A, and the two outlets of the one-inlet and two-outlet valve 502 are connected to the top of the storage tank 200 and the constant temperature storage tank A100 through a pipeline B respectively; a water pump B is arranged in the transfer tank 400, and the water outlet of the water pump B is connected to the top of the storage tank 200 through a pipeline C, and at the same time, a temperature sensor A and a temperature sensor B are respectively arranged in the constant temperature transfer tank 500 and the transfer tank 400; a control valve A, a control valve B and a control valve C are respectively arranged at the water outlet of the constant temperature storage tank A100, the constant temperature storage tank B300, and the storage tank 200; the temperature sensor A, the temperature sensor B, the one-inlet and two-outlet valve 502, the valve 600, the control valve A, the control valve B and the control valve C are all connected to a controller.

[0040] Then, when in use, the high-temperature water stored in the constant temperature storage tank A100 is controlled to be sent into the heating pipe and discharged from the water outlet joint A102 of the heating pipe to the constant temperature transfer tank 500. When the temperature is detected to be lower than 35°C, the water in the constant temperature transfer tank 500 is sent into the storage tank 200, and the water with a temperature higher than 35°C is returned to the constant temperature storage tank A100. At the same time, the water with a temperature lower than 35°C is sent to the cooling pipe in the storage tank 200, and the crystallization tank 2 is preliminarily cooled by the water with a temperature lower than 35°C. At this time, the water discharged from the water outlet joint B202 of the cooling pipe is sent to the transfer tank 400. When the water temperature is detected to be higher than 35°C, the valve 600 is opened to send the water stored in the transfer tank 400 into the constant temperature transfer tank 500, and the warm water set in the constant temperature transfer tank 500 is used to send the constant temperature When the detected temperature is lower than 35°C, the valve 600 is closed at this time, and the water pump B is started to send the water in the transfer tank 400 into the storage tank 200; at the same time, when the detected water temperature is lower than 30°C, the water stored in the storage tank 200 is stopped from being sent into the cooling pipe, and the low-temperature water stored in the constant temperature storage tank B300 is sent into the cooling pipe, and the crystallization precipitation tank 2 is cooled by low-temperature water. After cooling, the water in the cooling pipe is sent to the transfer tank 400. When the temperature detected in the transfer tank 400 is higher than 25°C, the water in the transfer tank 400 is sent into the storage tank 200 by the water pump. On the contrary, when the temperature detected in the transfer tank 400 is lower than 25°C, the water in the transfer tank 400 is returned to the constant temperature storage tank B300 by the water pump.

[0041] In the present invention, the temperature of the high-temperature water stored in the constant temperature storage tank A100 is 85°C-95°C, the temperature of the medium-temperature water stored in the storage tank 200 is 20°C-35°C, and the temperature of the low-temperature water stored in the constant temperature storage tank B300 is 1°C-15°C; to achieve the above purpose, it is necessary to set a temperature sensor C and a heating module in the constant temperature storage tank A100, and set a temperature sensor D and a semiconductor refrigeration module in the constant temperature storage tank B300; and the temperature sensor C, the heating module, the temperature sensor D and the semiconductor refrigeration module They are all connected to the controller; and when in use, the heating module is used to heat the high-temperature water stored in the constant temperature storage tank A100, so that the stored water temperature is higher than the preset lower limit of 85°C; at the same time, the semiconductor refrigeration module is used to adjust the low-temperature water stored in the constant temperature storage tank B300, so that the low-temperature water is lower than the preset upper limit of 15°C; similarly, the storage tank 200 in the present invention is an ordinary steel tank or a water pool, which can achieve natural cooling, so that the water temperature is cooled to room temperature under natural conditions.

[0042] Similarly, a drain pipe A501 and a drain pipe B401 are respectively provided at the bottom ends of the constant temperature transfer tank 500 and the transfer storage tank 400, and the drain pipe A501 and the drain pipe 401 are respectively equipped with a control valve 1 and a control valve 2; the drain pipe A501 and the drain pipe 401 are connected to a cooling box 700, a water pump C is provided in the cooling box 700, and the water outlet end of the water pump C is connected to the top of the constant temperature storage tank B300 through a pipeline D; and a liquid level sensor A and a liquid level sensor B are respectively provided in the temperature storage tank A100 and the storage tank 200; based on this setting, when the liquid level in the constant temperature storage tank A100 reaches the upper limit value during use, no matter what the water temperature in the constant temperature transfer tank 500 is, the water stored in the constant temperature transfer tank 500 at this time will be discharged into the cooling box 70 0; and when the liquid level in the storage tank 200 reaches the upper limit, at this time, when the temperature in the transfer tank 400 is between 30℃-35℃, the water in the transfer tank 400 is sent to the constant temperature transfer tank 500, and the water in the constant temperature transfer tank 500 is controlled to be sent to the constant temperature storage tank A100; of course, when the liquid level in the storage tank 200 reaches the upper limit, and the liquid level in the constant temperature storage tank A100 also reaches the upper limit, at this time, when in use, the water discharged into the transfer tank 400 is directly discharged into the cooling box 700; the water in the cooling box 700 is cooled under natural conditions, and when the internal liquid level is detected to be lower than the set value by the liquid level sensor C arranged in the constant temperature storage tank B300, the water in the cooling box 700 is sent to the constant temperature storage tank B300.

[0043] Based on the above-mentioned arrangement in the present invention, the present invention, when in use, controls the flow of liquid used for cooling and heating in a closed-loop system composed of the constant temperature storage tank A100, the storage tank 200, the constant temperature storage tank B300, the transfer tank 400, the constant temperature transfer tank 500 and the cooling box 700 through the coordinated arrangement of the cooling box 700, the constant temperature transfer tank 500 and the transfer storage tank 400, thereby reducing pollution and saving energy consumption for water heating and cooling.

[0044] In the present invention, a driving structure A including a stirring motor A12 and a reducer A is provided on the top of the stirring and dissolving tank 1, and the output end of the driving structure A is connected to the stirring structure A located in the stirring and dissolving tank 1; a driving structure B including a stirring motor B26 and a reducer B is provided on the top of the crystallization tank 2, and the output end of the driving structure B is connected to the stirring structure B located in the crystallization tank 2; and thus, the use of the stirring structure A and the stirring structure B facilitates stirring during the above-mentioned use.

[0045] At the same time, in order to facilitate the addition of relevant materials during use, a feeding port 10 and two liquid inlet pipes A11 are provided at the top of the stirring and dissolving tank 1, and two liquid inlet pipes B25 are provided at the top of the crystallization and precipitation tank 2; one end of the discharge pipe A103 is connected to a feed pipe 31 at the top of a filter device 3, and the bottom end of the filter device 3 is connected to a discharge pipe 32, and one end of the discharge pipe 32 is connected to a liquid inlet pipe B25; and then when in use, the solution dissolved in the stirring and dissolving tank 1 is sent to the filter device 3 for filtration and then sent to the crystallization and precipitation tank 2.

[0046] Embodiment 2, as Figure 3 On the basis of Example 1, the filtering device 3 provided by the present invention includes a box body 30, a porous partition 301 is arranged in the box body 30, and the box bodies 30 located on the upper and lower sides of the porous partition 301 are respectively connected to the feed pipe 31 and the discharge pipe 32; the upper surface of the porous partition 301 is paved with filter paper B302, and a porous pressing plate A303 is arranged above the porous partition 301, and the bottom side of the porous pressing plate A303 is connected to the porous pressing plate B305 through a plurality of springs 304, and the porous pressing plate B305 is against the filter paper B302. The above-mentioned coordinated arrangement of the porous pressing plate A303 and the porous pressing plate B305 is used to realize that the filter paper B302 is tightly attached to the porous partition 301 by using the mechanism composed of the two when in use, and avoid the situation in which the filter paper B302 is separated from the porous partition 301 due to the impact of the solution during use.

[0047] Embodiment 3, on the basis of embodiment 1, as Figure 6 The feeding port 10 is used to conveniently feed solid folic acid during use. That is, the feeding port 10 includes a convex tube 1001 protruding from the top surface of the stirring and dissolving tank 1. A hinge seat A1002 and a hinge seat B1003 are respectively provided on both sides of the convex tube 1001. The hinge seat A1002 is rotatably connected to an arc-shaped movable arm 1004 through a hinge shaft A. The middle part of the arc-shaped movable arm 1004 is rotatably connected to a connecting seat 1005. The connecting seat 1005 A sealing cover 1006 is connected, and the sealing cover 1006 is installed at the end of the convex tube 1001 in cooperation with the seal; one end of the arc-shaped movable arm 1004 is connected to a U-shaped block 1007, and a stud 1008 is rotatably connected to the hinge seat B1003 through a hinge shaft B, and the stud 1008 is stuck in the U-shaped block 1007, and a hand-tightening nut 1009 is threadedly connected to the stud 1008, and the hand-tightening nut 1009 rests on the U-shaped block 1007; through the above arrangement, the installation of the sealing cover 1006 can be conveniently controlled.

[0048] Embodiment 4, on the basis of embodiment 1, as Figure 4-5In order to facilitate unloading, the top of the unloading pipe B22 provided by the present invention slightly protrudes from the inner bottom side of the crystallization precipitation tank 2, and the top of the unloading pipe B22 is detachably installed with a filtering structure 28; the filtering structure 28 includes an annular porous plate A281, and the inner and outer peripheral sides of the upper surface of the porous plate A281 are both provided with convex rings 282, the inner ring of the convex ring 282 is provided with a sealing ring 283, and the outer ring is provided with bolt holes; a cover plate 280 is provided above the porous plate A281 to seal with it, and the cover plate 280 is a circular ring structure, and the peripheral side of the cover plate 280 is provided with bolts 284 that cooperate with the bolt holes, and a sealing groove 285 that cooperates with the sealing ring 283; a filter paper A286 is provided on the upper surface of the porous plate A281, and the bottom side of the cover plate 280 is connected to a porous plate B288 that rests on the filter paper A286 through a connecting column 287, and the porous plate B288 is annular in structure; it also includes A connecting pipe 29 that runs through the center of the porous plate A281 is included, and the bottom end of the connecting pipe 29 is threadedly connected to the discharge pipe B22; a connecting rod 289 is welded on the upper surface of the cover plate 280, and one end of the connecting rod 289 is welded to the outer wall of the connecting pipe 29, and an L-shaped pipe 291 is connected to the upper surface of the cover plate 280, and one end of the L-shaped pipe 291 is connected to one side of the connecting pipe 29; thereby, when the discharge pipe B22 is opened, the liquid is filtered by the filter paper A286 and then discharged into the connecting pipe 29 through the L-shaped pipe 291 and then discharged from the discharge pipe B22. In combination with the present invention, in order to facilitate the control of filtering during use, the filter paper A286 is located at the bottom, and the liquid passes through the filter paper A286 from bottom to top; at the same time, in order to accelerate the liquid passing through the filter paper A286 during use, nitrogen can be injected into the crystallization precipitation tank 2 or a vacuum pump can be connected at the discharge pipe B22 to form a pressure difference and thus complete the accelerated filtration.

[0049] Embodiment 5, on the basis of embodiment 1, as Figure 7The discharge pipe C21 includes a pipe body A210 connected to the bottom of the crystallization precipitation tank 2, the bottom end of the pipe body A210 is connected to the pipe body C212 through the pipe body B211 with a gradually increasing diameter, the pipe body C212 is connected to a rotating sleeve 214 through a bracket 213, and a rotating rod 215 is arranged in the rotating sleeve 214, the top of the rotating rod 215 is connected to a blocking plate 216, and the upper surface of the blocking plate 216 is connected to a scraper 218 through a column 217, the bottom end of the rotating rod 215 is connected to a hexagonal operating column 219, and the bottom end of the pipe body C212 is threadedly connected to an end cap 2110, and the rotating rod 215 is provided with a screw thread located on the rotating sleeve 214. Then, after completing the folic acid purification, open the end cover 2110, control the rotating rod 215 to move downward until the bottom end of the blocking plate 216 is lower than the bottom end of the tube body A210, and at the same time, the scraper 218 is against the bottom of the crystallization tank 2, and then the scraper 218 is controlled to rotate to control the material accumulated at the bottom of the crystallization tank 2 to be discharged through the discharge pipe C21. At the same time, when in use, a vibration device can be set on one side of the outer wall of the crystallization tank 2, and the setting of the vibration device can be used to drive the crystallization tank 2 to vibrate, thereby prompting the material that was originally far away from the discharge pipe C21 and accumulated at the bottom of the crystallization tank 2 to slowly move to the position of the discharge pipe C21.

[0050] It should be noted that, in the present invention, Figure 1 The jacket heating layer A and the jacket heating layer B are both sealed spaces, and are respectively provided with an inlet and outlet air pipe A13 and an inlet and outlet air pipe B23 connecting the jacket heating layer A and the jacket heating layer B. A stop valve A14 and a stop valve B24 connected to the controller are respectively provided on the inlet and outlet air pipe A13 and the inlet and outlet air pipe B23. At the same time, an air pressure detection sensor A and an air pressure detection sensor B connected to the controller are respectively provided in the jacket heating layer A and the jacket heating layer B. Furthermore, when in use, whether to open the stop valve A14 and the stop valve B24 is determined by the internal air pressure conditions of the air pressure detection sensor A and the air pressure detection sensor B. By adopting this arrangement, the flow of gas inside and outside the jacket heating layer A and the jacket heating layer B under unnecessary conditions is reduced.

[0051] In the description of this specification, the description with reference to the terms "one embodiment", "example", "specific example", etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.

[0052] The preferred embodiments of the present invention disclosed above are only used to help illustrate the present invention. The preferred embodiments do not describe all the details in detail, nor do they limit the invention to the specific implementation methods described. Obviously, many modifications and changes can be made according to the content of this specification. This specification selects and specifically describes these embodiments in order to better explain the principles and practical applications of the present invention, so that those skilled in the art can understand and use the present invention well. The present invention is limited only by the claims and their full scope and equivalents.

Claims

1. An active folic acid purification device, characterized in that: It comprises a stirring and dissolving tank (1) and a crystallization and precipitation tank (2) connected to the stirring and dissolving tank (1); The stirring and dissolving tank (1) is used to mix 5-methyltetrahydrofolate, an organic base and a solvent into a salt; The crystallization tank (2) is used to cool the mixture obtained in the stirring and dissolving tank (1) to allow salt crystals to precipitate; The outer side of the stirring and dissolving tank (1) is provided with a jacket heating layer A, the jacket heating layer A is provided with a heating pipe wound around the outer side wall of the tank body, and the two ends of the heating pipe are respectively provided with a water inlet joint A (101) and a water outlet joint A (102); The outer side of the crystallization tank (2) is provided with a jacket heating layer B, the jacket heating layer B is provided with a cooling pipe wound around the outer side wall of the tank body, and the two ends of the cooling pipe are respectively provided with a water inlet joint B (201) and a water outlet joint B (202); It also includes a constant temperature storage tank A (100) storing high temperature water, a constant temperature storage tank B (300) storing low temperature water, and a storage tank (200) storing medium temperature water; The water outlet of the constant temperature storage tank A (100) is connected to the water inlet joint A (101), the water outlet joint A (102) is connected to the constant temperature transfer tank (500), a water pump A is arranged in the constant temperature transfer tank (500), the water outlet of the water pump A is connected to a one-inlet and two-outlet valve (502) through a pipeline A, and the two outlets of the one-inlet and two-outlet valve (502) are respectively connected to the top of the storage tank (200) and the constant temperature storage tank A (100) through a pipeline B; Wherein, the water outlet end of the constant temperature storage tank B (300) is connected to the water inlet joint B (201); The water outlet of the storage tank (200) is connected to the water inlet joint B (201), the water outlet joint B (202) is connected to the transfer tank (400), and the transfer tank (400) is connected via a constant temperature transfer tank (500) provided with a valve (600); a water pump B is provided in the transfer tank (400), and the water outlet of the water pump B is connected to the top of the storage tank (200) via a pipeline C.

2. The active folic acid purification device according to claim 1, characterized in that: A temperature sensor A and a temperature sensor B are respectively arranged in the constant temperature transfer tank (500) and the transfer storage tank (400); The water outlets of the constant temperature storage tank A (100), the constant temperature storage tank B (300), and the storage tank (200) are respectively provided with a control valve A, a control valve B, and a control valve C; The temperature sensor A, the temperature sensor B, the one-inlet-two-outlet valve (502), the valve (600), the control valve A, the control valve B and the control valve C are all connected to a controller.

3. The active folic acid purification device according to claim 2, characterized in that: The constant temperature storage tank A (100) is provided with a temperature sensor C and a heating module, and the constant temperature storage tank B (300) is provided with a temperature sensor D and a semiconductor refrigeration module; The temperature sensor C, the heating module, the temperature sensor D and the semiconductor refrigeration module are all connected to the controller.

4. The active folic acid purification device according to claim 2 or 3, characterized in that: A drain pipe A (501) and a drain pipe B (401) are respectively provided at the bottom ends of the constant temperature transfer tank (500) and the transfer storage tank (400), and a control valve 1 and a control valve 2 are respectively installed on the drain pipe A (501) and the drain pipe (401); the drain pipe A (501) and the drain pipe (401) are connected to a cooling box (700), a water pump C is provided in the cooling box (700), and the water outlet end of the water pump C is connected to the top of the constant temperature storage tank B (300) through a pipeline D; The constant temperature storage tank A (100) and the storage tank (200) are respectively provided with a liquid level sensor A and a liquid level sensor B.

5. The active folic acid purification device according to claim 4, characterized in that: A driving structure A including a stirring motor A (12) and a reducer A is arranged on the top of the stirring and dissolving tank (1), and an output end of the driving structure A is connected to the stirring structure A located inside the stirring and dissolving tank (1); A driving structure B including a stirring motor B (26) and a reducer B is arranged on the top of the crystallization tank (2), and an output end of the driving structure B is connected to the stirring structure B located in the crystallization tank (2).

6. The active folic acid purification device according to claim 5, characterized in that: The top of the stirring and dissolving tank (1) is provided with a feeding port (10) and at least two liquid inlet pipes A (11), and the top of the crystallization and precipitation tank (2) is provided with at least two liquid inlet pipes B (25); The bottom of the stirring and dissolving tank (1) is connected to a discharge pipe A (103) provided with a discharge valve A (104), one end of the discharge pipe A (103) is connected to a feed pipe (31) at the top of a filter device (3), the bottom end of the filter device (3) is connected to a discharge pipe (32), one end of the discharge pipe (32) is connected to a liquid inlet pipe B (25); The bottom of the crystallization precipitation tank (2) is connected to a discharge pipe B (22) provided with a discharge valve B (27) and a discharge pipe C (21).

7. The active folic acid purification device according to claim 6, characterized in that: The top end of the discharge pipe B (22) slightly protrudes from the inner bottom side of the crystallization precipitation tank (2), and the top end of the discharge pipe B (22) is detachably mounted with a filtering structure (28); The filtering structure (28) comprises an annular porous plate A (281), wherein the inner circumference and the outer circumference of the upper surface of the porous plate A (281) are both provided with convex rings (282), the inner ring of the convex ring (282) is provided with a sealing ring (283), and the outer ring is provided with bolt holes; a cover plate (280) is provided directly above the porous plate A (281) to seal with it, the cover plate (280) is in an annular structure, and the circumference of the cover plate (280) is provided with bolts (284) to cooperate with the bolt holes, and a sealing groove (285) to cooperate with the sealing ring (283); The upper surface of the porous plate A (281) is provided with filter paper A (286), and the bottom side of the cover plate (280) is connected to a porous plate B (288) resting on the filter paper A (286) through a connecting column (287), and the porous plate B (288) is in an annular structure; It also includes a connecting pipe (29) that passes through the center of the porous plate A (281), and the bottom end of the connecting pipe (29) is threadedly connected to the discharge pipe B (22); A connecting rod (289) is welded on the upper surface of the cover plate (280), one end of the connecting rod (289) is welded to the outer wall of the connecting pipe (29), and an L-shaped pipe (291) is connected to the upper surface of the cover plate (280), one end of the L-shaped pipe (291) is connected to one side of the connecting pipe (29).

8. The active folic acid purification device according to claim 6, characterized in that: The discharge pipe C (21) comprises a pipe body A (210) connected to the bottom of the crystallization precipitation tank (2); the bottom end of the pipe body A (210) is connected to the pipe body C (212) via a pipe body B (211) with a gradually increasing diameter; the pipe body C (212) is connected to a rotating sleeve (214) via a bracket (213); a rotating rod (215) is arranged in the rotating sleeve (214); the top of the rotating rod (215) is connected to a sealing plate (216); the upper surface of the sealing plate (216) is connected to a scraper (218) via a column (217); the bottom end of the rotating rod (215) is connected to a hexagonal operating column (219); the bottom end of the pipe body C (212) is threadedly connected to an end cover (2110); and the rotating rod (215) is provided with a limiting ring (2111) located above the rotating sleeve (214).

9. The active folic acid purification device according to claim 6, characterized in that: The filtering device (3) comprises a box (30), a porous partition (301) is arranged inside the box (30), and the boxes (30) located on the upper and lower sides of the porous partition (301) are respectively connected to a feed pipe (31) and a discharge pipe (32); The upper surface of the porous partition (301) is paved with filter paper B (302), and a porous pressure plate A (303) is arranged above the porous partition (301). The bottom side of the porous pressure plate A (303) is connected to a porous pressure plate B (305) via a plurality of springs (304), and the porous pressure plate B (305) is pressed against the filter paper B (302).

10. The active folic acid purification device according to claim 1, characterized in that: The feeding port (10) comprises a convex tube (1001) protruding from the top surface of the stirring and dissolving tank (1), and hinge seats A (1002) and hinge seats B (1003) are respectively arranged on both sides of the convex tube (1001), and an arc-shaped movable arm (1004) is rotatably connected to the hinge seat A (1002) via a hinge shaft A, and a connecting seat (1005) is rotatably connected to the middle part of the arc-shaped movable arm (1004), and the connecting seat (1005) is connected to a sealing cover (1006), and the sealing cover (1006) is installed at the end of the convex tube (1001) in a sealing manner; One end of the arc-shaped movable arm (1004) is connected to a U-shaped clamping block (1007); a stud (1008) is rotatably connected to the hinge seat B (1003) via a hinge shaft B, and the stud (1008) is clamped in the U-shaped clamping block (1007); a hand-tightening nut (1009) is threadedly connected to the stud (1008), and the hand-tightening nut (1009) is pressed against the U-shaped clamping block (1007).

Images