Ointment as well as preparation method and application thereof

Abstract

The invention discloses ointment as well as a preparation method and application thereof, belongs to the technical field of external ointment, and solves the technical problems that an existing ointment for treating burns and scalds is relatively long in treatment course, relatively low in curative effect and poor in effect of remaining scars after healing on affected parts of large-area burns and scalds. The ointment is prepared from the following raw material medicines in parts by weight: 10-15 parts of a dried sea buckthorn fruit extract, 8-12 parts of a periplaneta americana extract, 0.5-1 part of erythromycin, 18-25 parts of a polygonum cuspidatum extract, 2-4 parts of borneol, 5-8 parts of a rheum officinale extract, 3-6 parts of a centella asiatica extract, 4-8 parts of aloe powder, 4-8 parts of green cucumber powder and 600-1000 parts of vaseline. Regeneration and repair of tissues are further promoted, and healing of wounds of patients is accelerated.

Description

Technical Field

[0001] The invention belongs to the technical field of external ointments, and in particular relates to an ointment and a preparation method and application thereof. Background Art

[0002] The main factors causing burns are steam, hot liquid, flame, high-temperature gas, hot metal, etc. that damage the skin and mucous membrane tissues. In medicine, skin damage caused by radioactive drugs, electricity, and chemistry is similar to burns and is also classified as burns. After a burn occurs, the most basic change is that the fluid that seeps out of the blood vessels enters the tissues, causing swelling. When the burn is severe, the fluid that seeps out of the blood vessels increases, which will lead to a decrease in total blood volume, thereby affecting organ blood flow, causing organ function damage or even failure. In my country, due to the number of patients with fire burns and the popularity of traditional Chinese medicine, traditional Chinese medicine ointments are generally used to treat scalds. The existing ointments for treating burns and scalds have a long course of treatment, low efficacy and poor scarring effect on large-area burns and scalds. Summary of the invention

[0003] The technical solution adopted by the present invention is as follows: An ointment is composed of the following raw materials by weight: 10-15 parts of seabuckthorn fruit dry extract, 8-12 parts of American cockroach extract, 0.5-1 part of erythromycin, 18-25 parts of knotweed extract, 2-4 parts of borneol, 5-8 parts of rhubarb extract, 3-6 parts of Centella asiatica extract, 4-8 parts of aloe powder, 4-8 parts of cucumber powder and 600-1000 parts of vaseline.

[0004] A method for preparing an ointment, comprising the following steps for preparing the ointment of claim 1: Step 1: heating a certain weight portion of vaseline to 35-40° C., adding a certain weight portion of seabuckthorn fruit extract, knotweed extract, rhubarb extract, centella asiatica extract, aloe powder and cucumber powder to the vaseline and mixing to obtain a mixture A; Step 2: Grind a determined amount of borneol by weight into powder, and add the powder to mixed material A to obtain mixed material B; Step 3: lowering the temperature of the mixture B to 25-35° C., adding determined weight portions of the American cockroach extract and erythromycin, and stirring to prepare an ointment.

[0005] An application of an ointment, based on the above ointment, in the treatment of burns, repair of scalds and repair of scars.

[0006] In summary, due to the adoption of the above technical solution, the beneficial effects of the present invention are: 1. Seabuckthorn can promote tissue regeneration and epithelial tissue healing, and can promote the synthesis of collagen, thereby promoting tissue regeneration and repair, and accelerating the healing of patients' wounds. The seabuckthorn seed oil formed inside the seabuckthorn can form a thin film on the wound surface, reduce wound exudation, and keep the wound surface dry to avoid bacterial growth and reproduction; 2. American cockroach extract can improve blood circulation in the ulcer area and reduce inflammation. By adding American cockroach extract, the healing ability of burns and scalds can be greatly improved, and the depth of scars can be greatly reduced; 3. Erythromycin has a strong inhibitory effect on Gram-positive bacteria such as Staphylococcus, Streptococcus pyogenes, and Streptococcus pneumoniae; 4. The combination of Polygonum cuspidatum and Rhubarb can clear away heat, reduce internal heat, detoxify, and treat carbuncle, swelling and poison. The combination of Polygonum cuspidatum and Rhubarb in the treatment of burns and scalds can enhance the heat-clearing, detoxification and repair effects on wound muscles; 5. Borneol can relieve pain, prevent corrosion, invigorate the mind, clear away heat and promote tissue regeneration; 6. Centella asiatica extract, aloe vera powder and cucumber powder work together to clear away heat, detoxify, reduce swelling and relieve pain, promote muscle growth and scar healing. DETAILED DESCRIPTION

[0007] In order to make the purpose, technical solution and advantages of the embodiments of the present application clearer, the technical solution of the present application will be clearly and completely described below in combination with the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments. Based on the embodiments of the present application, all other embodiments obtained by those skilled in the art without making creative work are within the scope of protection of the present application.

[0008] Examples 1 to 19 and Comparative Examples 1 to 9 all adopt the following steps to prepare ointments: Step 1: Heat the vaseline in corresponding weight portions in Table 1 to 35-40° C., add the dried seabuckthorn fruit extract, knotweed extract, rhubarb extract, Centella asiatica extract, aloe powder and cucumber powder in corresponding weight portions in Table 1 to the vaseline and mix to obtain a mixture A; Step 2: Grind the borneol in corresponding weight parts in Table 1 into powder, and add it to mixed material A to obtain mixed material B; Step 3: Lower the temperature of mixed material B to 25-35° C., add the American cockroach extract and erythromycin in corresponding weight parts as shown in Table 1, and stir to prepare an ointment.

[0009] Table 1 is a record of the weight of each added material in Examples 1 to 19 and Comparative Examples 1 to 9

[0010] Conducting a test to verify the effectiveness of the ointment: (1) 280 normal-weight rats were divided into 28 groups, with 10 rats in each group; (2) The legs of rats in each group were burned to the same extent to construct a burn model; (3) Each group of rats was treated with the ointments of Examples 1 to 19 and Comparative Examples 1 to 9, with the same dosage and thickness applied at the same time every day, and the ointment was applied once, and then the administration was suspended; (4) Observe the burn wound every day to observe the healing of the wound; (5) The Bates-Jensen wound assessment tool (BWAT) was used to evaluate the degree of burn healing in rats. The specific results are shown in Table 2 below; The degree of burn healing improvement of a single rat = (the degree of burns detected on the first day - the degree of burns detected on the day of detection) / the degree of burns detected on the first day; the degree of burn healing = the sum of the degrees of burn healing improvement of all rats in the same group / 10.

[0011] Table 2 Burn healing test table

[0012] From the data in Table 2, we can see that Seabuckthorn can promote tissue regeneration and epithelial tissue healing, and can promote collagen synthesis, thereby promoting tissue regeneration and repair, and accelerating the healing of patients' wounds. The seabuckthorn seed oil formed inside seabuckthorn can form a thin film on the wound surface, reduce wound exudation, and keep the wound surface dry to avoid bacterial growth and reproduction; American cockroach extract can improve blood circulation in the ulcer area and can alleviate verification. By adding American cockroach extract, the healing ability of burns and scalds can be greatly improved, and the depth of scars can be greatly reduced. Erythromycin has a strong inhibitory effect on Gram-positive bacteria such as Staphylococcus, Streptococcus pyogenes and Streptococcus pneumoniae; Polygonum cuspidatum and rhubarb can work together to clear away heat, reduce internal heat, detoxify, and treat carbuncles and swellings. Using Polygonum cuspidatum and rhubarb together to treat burns and scalds can improve the heat-clearing, detoxifying and repairing effects on wound muscles; Borneol can relieve pain, preserve, invigorate the mind, clear away heat and regenerate tissue; Centella asiatica extract, aloe powder and cucumber powder work together to clear away heat, detoxify, reduce swelling and relieve pain, and promote muscle growth and scar healing.

[0013] It should be noted that: The above-mentioned embodiments only express the specific implementation methods of the present application, and the descriptions thereof are relatively specific and detailed, but they cannot be understood as limiting the protection scope of the present application. It should be pointed out that, for ordinary technicians in this field, several variations and improvements can be made without departing from the technical solution concept of the present application, and these all belong to the protection scope of the present application.

Claims

1. An ointment, characterized in that The composition is composed of the following raw materials by weight: 10-15 parts of seabuckthorn dry fruit extract, 8-12 parts of American cockroach extract, 0.5-1 part of erythromycin, 18-25 parts of knotweed extract, 2-4 parts of borneol, 5-8 parts of rhubarb extract, 3-6 parts of Centella asiatica extract, 4-8 parts of aloe powder, 4-8 parts of cucumber powder and 600-1000 parts of vaseline.

2. A method for preparing an ointment, characterized in that: The steps for preparing the method according to claim 1 include: Step 1: heating a certain weight portion of vaseline to 35-40° C., adding a certain weight portion of seabuckthorn fruit extract, knotweed extract, rhubarb extract, centella asiatica extract, aloe powder and cucumber powder to the vaseline and mixing to obtain a mixture A; Step 2: Grind a determined amount of borneol by weight into powder, and add the powder to mixed material A to obtain mixed material B; Step 3: lowering the temperature of the mixture B to 25-35° C., adding determined weight portions of the American cockroach extract and erythromycin, and stirring to prepare an ointment.

3. An application of an ointment, characterized in that: Use of the ointment according to claim 1 in the treatment of burns, repair of scalds and repair of scars.

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