Spliced sleep deprivation mouse cage

Abstract

The spliced sleep deprivation mouse cage comprises a plurality of square cage bodies, a tray and a food box, the square cage bodies are transparent structural members, the top of each square cage body is provided with an organism inlet and at least one square notch, and the square notches are formed in the side edges of the square cage bodies. A plurality of water leakage holes are evenly formed in the bottoms of the square cage bodies at intervals, clamping grooves are formed in the tray, the square cage bodies can be spliced and embedded into the clamping grooves, circulation gaps are formed between the bottom walls of the square cage bodies and the inner bottom wall of the tray, and a water injection opening is formed in the side wall of the tray. When the sides, provided with the square notches, of any four square cage bodies are spliced, a containing groove communicated with the four square cage bodies is formed, and the food box is arranged in the containing groove. The spliced sleep deprivation mouse cage can effectively deprive the sleep of the mouse, the problems of poor sleep deprivation and wire entanglement caused by mixed feeding of the mouse are avoided, the water level height in each mouse cage is ensured to be consistent, and meanwhile, the water quality is convenient to replace.

Description

Technical Field

[0001] The invention relates to a spliced ​​sleep deprivation mouse cage and belongs to the technical field of animal experimental equipment. Background Art

[0002] Sleep deprivation is a commonly used experimental method, generally used to study the effects of sleep on organisms. This method limits or deprives animals of their sleep time to observe the effects of sleep on animal behavior, physiology, and cognitive function.

[0003] In experiments, researchers use specific devices or methods to deprive animals of sleep. For example, they can force animals to stay awake by placing them on a rotating platform or installing a horizontally moving lever in their cages. Researchers can also use other methods, such as Curling Prevention by Water (CPW), electrical stimulation, noise, or drug intervention, to deprive animals of sleep.

[0004] Traditional sleep deprivation cages have the following disadvantages:

[0005] 1. Poor sleep deprivation: Traditional mechanical interference mouse cages may cause mice to ignore mechanical interference and enter a sleep state when they are extremely sleepy. Ordinary water-prevented curling mouse cages can effectively deprive mice of sleep if multiple mice are kept in one cage at the same time. The mice may cuddle with each other and enter a sleep state.

[0006] 2. Difficulty in distinguishing wires: Sleep deprivation experiments often require detecting the sleep status of mice by connecting them with wires in order to measure EEG and EMG. Traditional mechanical interference with mouse cages may cause wire entanglement, making it difficult to distinguish and separate them.

[0007] Existing water-blocking curl-up sleep deprivation cages have the following deficiencies:

[0008] 1. Difficulty in controlling the water level: Ordinary water prevents the bottom of the curled squirrel cage from being sealed. It is difficult to accurately control the water level when injecting water, and it is impossible to control the water level conditions of each squirrel cage to be consistent and scientifically control the variables;

[0009] 2. Inconvenient cage cleaning: The existing cage device is fixed on a fixed plate, so that when the excrement of rats and mice inside the cage needs to be cleaned, additional tools are needed for auxiliary operation, and the rats and mice need to be taken out, which makes the cleaning operation inconvenient.

[0010] Therefore, there is an urgent need in the art for a device that can solve the shortcomings of poor sleep deprivation and difficulty in distinguishing wires in existing sleep deprivation cages, as well as difficulty in controlling the water level and inconvenience in cleaning the cages of existing water-blocked curled sleep deprivation cages, so as to provide a more scientific, hygienic and convenient mouse breeding device for sleep deprivation related experiments. Summary of the invention

[0011] In order to solve the above technical problems, the present invention provides a spliced ​​sleep deprivation mouse cage, which can effectively deprive mice of sleep, avoid the problems of poor sleep deprivation and wire entanglement caused by mixed breeding of mice, ensure that the water level in each mouse cage is consistent and the water quality is easy to change.

[0012] In order to achieve the above technical objectives and the above technical effects, the present invention is implemented through the following technical solutions:

[0013] The invention provides a spliced ​​sleep deprivation mouse cage, comprising a square cage body, a tray and a food box, wherein the square cage body is provided with a plurality of transparent structural parts, the top of the square cage body is provided with a biological body placement entrance and at least one square notch, the square notch is arranged at the side edge of the square cage body, a plurality of water leakage holes are evenly arranged at the bottom of the square cage body, a card slot is provided on the tray, a plurality of square cage bodies can be spliced ​​and embedded in the card slot, a flow gap is formed between the bottom wall of the square cage body and the inner bottom wall of the tray, a water injection port is provided on the side wall of the tray, and a placement slot communicating with the four square cage bodies is formed when one side of any four square cage bodies provided with the square notch is spliced, and the food box is placed in the placement slot.

[0014] Preferably, the square cage body comprises a cage body 1, the cage body 1 is provided with a square notch, and the slot is a notch for embedding four cage bodies 1.

[0015] Preferably, the square cage body comprises cage body 1 and cage body 2, cage body 1 is provided with a square notch, two side edges on the same side of cage body 2 are provided with a square notch respectively, and the slot is a notch for accommodating four cage bodies 1 and two cage bodies 2.

[0016] Preferably, the square cage body includes cage body one, cage body two and cage body three, the cage body one is provided with a square notch, the two side edges on the same side of the cage body two are each provided with a square notch, the four side edges of the cage body three are each provided with a square notch, and the card slot is a notch for accommodating four cage bodies one, four cage bodies two and one cage body three.

[0017] Preferably, the food box is a mesh structure box with an open top.

[0018] Furthermore, the food box is made of stainless steel wires, including transverse wires and vertical wires, the diameters of the transverse wires and the vertical wires are both 2 mm, and the intervals between two adjacent transverse wires and two adjacent vertical wires are both 6 mm.

[0019] Preferably, gaskets are provided on the inner bottom wall of the slot at four corners corresponding to the spliced ​​multiple square cage bodies, and the square cage bodies are mounted on the gaskets.

[0020] Preferably, a water level scale is provided on an outer wall of the tray on one side of the water inlet, and the "0" mark of the water level scale corresponds to the position of the inner bottom wall of the square cage body.

[0021] Preferably, a drain outlet communicating with the flow gap is provided on an outer wall of the tray on a side away from the water inlet, and a control valve is provided on the drain outlet.

[0022] Preferably, the water leakage hole is a waist-shaped hole.

[0023] The spliced ​​sleep deprivation mouse cage provided by the present invention has the following advantages:

[0024] 1. Sleep deprivation is stable, and the water-prevented curling test method can effectively deprive mice of sleep.

[0025] 2. Raise mice independently and set up multiple square cages to avoid problems such as poor sleep deprivation and wire entanglement caused by mixed housing of mice.

[0026] 3. The water level is precisely controlled. The water level is precisely controlled with the help of the water level scale line on the inside of the tray, and the water level in each cage can be kept consistent.

[0027] 4. The water quality can be changed conveniently. For daily water changes, after discharging the sewage from the drain outlet, do not close the drain outlet, add water to the water inlet side for flushing. After flushing, close the drain outlet and add clean water from the water inlet to the required liquid level height, which simplifies the water quality change process and reduces the risk of pollution. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] Figure 1 A schematic diagram of the structure of a spliced ​​sleep deprivation mouse cage provided in Example 1 of the present invention;

[0029] Figure 2 This is an exploded schematic diagram of the structure of the placement slot mainly embodied in the first embodiment of the present invention;

[0030] Figure 3 This is a schematic cross-sectional structure diagram of the first embodiment of the present invention, which mainly reflects the positional relationship between the tray and the square cage body;

[0031] Figure 4 A schematic diagram of the structure of a spliced ​​sleep deprivation mouse cage provided in the second embodiment of the present invention;

[0032] Figure 5 A schematic diagram of the structure of a spliced ​​sleep deprivation mouse cage provided in Embodiment 3 of the present invention;

[0033] In the figure:

[0034] 1-square cage; 11-cage one; 12-cage two; 13-cage three; 14-entrance for placing organism; 15-square notch; 16-leakage hole; 2-placing slot; 3-tray; 31-card slot; 32-water inlet; 33-drainage outlet; 4-food box; 41-horizontal wire; 42-vertical wire; 5-circulation gap; 6-gasket; 7-water level mark; 8-control valve. DETAILED DESCRIPTION

[0035] The following will be combined with the drawings in the embodiments of the present application to clearly and completely describe the technical solutions in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technical personnel in this field without making creative work are within the scope of protection of the present invention.

[0036] Embodiment 1:

[0037] Reference Figure 1-Figure 3 , a spliced ​​sleep deprivation mouse cage, comprising a square cage body 1, the square cage body 1 is provided with a plurality of cage structures made of transparent material, which is convenient for observing mouse activities and controlling light brightness, a biological body placement entrance 14 and at least one square notch 15 are provided on the top of the square cage body 1, the biological body placement entrance 14 can be an opening of any shape, the square notch 15 is provided at the side edge of the square cage body 1 and the height is less than the height of the square cage body 1, and a plurality of leakage holes 16 are evenly spaced at the bottom of the square cage body 1. In this embodiment, the biological body placement entrance 14 is preferably a circular notch provided in the middle of the square cage body 1 for placing mice and accommodating wires, taking the square cage body 1 with a length×width×height size of 100mm×100mm×120mm as an example, the square notch 15 is preferably a notch with a length×width×height size of 25mm×25mm×50mm, and when one side of any four square cage bodies 1 with square notches 15 is spliced ​​together, a placement groove 2 connecting the inner cavities of the four square cage bodies 1 is formed, and the diameter of the circular notch is preferably 60mm.

[0038] Furthermore, the square cage body 1 includes a cage body 11, and a square notch 15 is opened on the cage body 11, that is, when four cage bodies 11 are assembled, any four square cage bodies 1 can be assembled to form a placement slot 2 to achieve the purpose of communication.

[0039] Reference Figure 1-Figure 3The spliced ​​sleep deprivation mouse cage also includes a tray 3 and a food box 4. The tray 3 is integrally injection-molded with a card slot 31. In this embodiment, the card slot 31 is set to be a notch that just fits four cage bodies 11. Multiple square cage bodies 1 can be spliced ​​and embedded in the card slot 31, and a flow gap 5 is formed between the bottom wall of the square cage body 1 and the inner bottom wall of the tray 3. A water injection port 32 is integrally formed on the side wall of the tray 3. When conducting an experiment, the experimenter pours clean water into the tray 3 through the water injection port 32. The clean water flows in the tray 3 through the flow gap 5 and simultaneously seeps into the square cage body 1 through the water leakage hole 16 at the bottom of the square cage body 1 until the required scale is required, generally covering the ankles of the mice, so as to achieve the purpose of water preventing curling (CPW). Such a setting can keep the liquid level in each square cage body 1 consistent during the experiment, so that the experimental data is more accurate; the food box 4 is set up and placed in the placement slot 2 so that the mice in any four square cage bodies 1 can be fed through one food box 4 at the same time.

[0040] Furthermore, the water leakage hole 16 is a waist-shaped hole, the size of which is preferably 3 mm×20 mm, and five water leakage holes 16 are preferably arranged.

[0041] Reference Figure 1-Figure 3 The food box 4 is a mesh structure box with an open top. Specifically, the food box 4 is made of stainless steel wire, including a horizontal wire 41 and a vertical wire 42. The horizontal wire 41 and the vertical wire 42 are both round wires with a diameter of 2 mm. The intervals between two adjacent horizontal wires 41 and two adjacent vertical wires 42 are both 6 mm. The length × width × height dimensions of the food box 4 correspond to the dimensions of the placement slot 2, which are 50 mm × 50 mm × 50 mm.

[0042] Gaskets 6 are bonded and fixed on the four corners of the inner bottom wall of the slot 31 corresponding to the multiple square cage bodies 1 spliced ​​together. The length×width×height dimensions of the gasket 6 are preferably 5mm×5mm×5mm. The square cage body 1 is mounted in the tray 3 through the gasket 6 and forms a flow gap 5 with the inner bottom wall of the slot 31.

[0043] A water level mark 7 is provided on the outer wall of the tray 3 on one side of the water inlet 32. The "0" mark of the water level mark 7 corresponds to the position of the inner bottom wall of the square cage 1, so that the test personnel can fill the square cage 1 with clean water of the required water level more quickly. The tray 3 can be a stainless steel tray or a transparent material, such as a transparent acrylic plate. In this embodiment, the tray 3 is preferably a transparent material tray, so that the operator can better compare the liquid level in the square cage 1 through the water level mark 7.

[0044] Reference Figure 2In a further embodiment, a drain port 33 connected to the circulation gap 5 is integrally formed on the outer wall of the tray 3 on the side away from the water inlet 32. The drain port 33 is arranged to be inclined downward, and a control valve 8 is installed on the drain port 33 to facilitate daily water changing operations of the tray 3.

[0045] The working principle of the spliced ​​sleep deprivation mouse cage of the present invention is as follows:

[0046] 1. Assemble the square cage 1, tray 3 and food box 4;

[0047] 2. Put the mouse in: Put the mouse in through the circular entrance on the top, which can accommodate the wire;

[0048] 3. Add clean water: Add clean water to tray 3 to a specific scale, generally covering the ankles of the mouse, to achieve the purpose of water-prevented curling (CPW);

[0049] 4. Put food in: put food into the food box 4;

[0050] 5. Change the water quality: open the control valve 8, the sewage flows out from the drain port 33, and in daily operation, you can also use the liquid pump to remove the liquid in the tray 3. When discharging sewage, add water to the water inlet 32 ​​for flushing. After flushing, close the drain port 33 through the control valve 8, and add clean water from the water inlet 32 ​​to the required liquid level.

[0051] Embodiment 2:

[0052] Reference Figure 4 The difference between this embodiment and the first embodiment is that the square cage body 1 includes a cage body 11 and a cage body 12, a square notch 15 is opened on the cage body 11, and a square notch 15 is opened on the two side edges on the same side of the cage body 12, that is, when four cage bodies 11 and two cage bodies 12 are assembled, any four square cage bodies 1 can be assembled to form a placement slot 2 to achieve the purpose of connection. In this embodiment, the card slot 31 is set to be a notch that just fits the four cage bodies 11 and the two cage bodies 12.

[0053] Embodiment three:

[0054] Reference Figure 5The difference between this embodiment and the first embodiment is that the square cage body 1 includes a cage body 11, a cage body 2 12 and a cage body 3 13. A square notch 15 is opened on the cage body 11, and a square notch 15 is opened on the two side edges on the same side of the cage body 2 12. A square notch 15 is opened on the four side edges of the cage body 3 13, that is, when four cage bodies 11, four cage bodies 2 12 and one cage body 3 13 are assembled, any four square cage bodies 1 can be assembled to form a placement slot 2 to achieve the purpose of connection. In this embodiment, the card slot 31 is set to be a notch that just fits four cage bodies 11, four cage bodies 2 12 and one cage body 3 13.

[0055] The above is only a preferred embodiment of the present invention, and is not any formal or substantial limitation of the present invention. It should be pointed out that ordinary technicians in this technical field can make several improvements and supplements without departing from the present invention, and these improvements and supplements should also be regarded as the protection scope of the present invention. Any technician familiar with this profession, without departing from the spirit and scope of the present invention, can make some changes, modifications and equivalent changes made by using the technical content disclosed above, which are equivalent embodiments of the present invention; at the same time, any changes, modifications and evolutions of any equivalent changes made to the above embodiments based on the essential technology of the present invention are still within the scope of the technical solution of the present invention.

Claims

1. A spliced ​​sleep deprivation mouse cage, characterized in that: The invention comprises a square cage body (1), a tray (3) and a food box (4); the square cage body (1) is provided with a plurality of transparent structural parts; the top of the square cage body (1) is provided with a biological body placement entrance (14) and at least one square notch (15); the square notch (15) is arranged at the side edge of the square cage body (1); the bottom of the square cage body (1) is evenly spaced with a plurality of water leakage holes (16); the tray (3) is provided with a card slot (31); a plurality of square cage bodies (1) can be assembled and embedded in the card slot (31); a flow gap (5) is formed between the bottom wall of the square cage body (1) and the inner bottom wall of the tray (3); a water injection port (32) is provided on the side wall of the tray (3); when one side of any four square cage bodies (1) provided with the square notches (15) is assembled, a placement slot (2) connecting the four square cage bodies (1) is formed; and the food box (4) is placed in the placement slot (2).

2. The spliced ​​sleep deprivation mouse cage according to claim 1, characterized in that: The square cage body (1) comprises a cage body one (11), the cage body one (11) is provided with a square notch (15), and the slot (31) is a slot for embedding four cage bodies one (11).

3. The spliced ​​sleep deprivation mouse cage according to claim 1, characterized in that: The square cage body (1) comprises a cage body 1 (11) and a cage body 2 (12); the cage body 1 (11) is provided with a square notch (15); two side edges on the same side of the cage body 2 (12) are provided with a square notch (15); the slot (31) is a slot for accommodating four cage bodies 1 (11) and two cage bodies 2 (12).

4. The spliced ​​sleep deprivation mouse cage according to claim 1, characterized in that: The square cage body (1) comprises a cage body one (11), a cage body two (12) and a cage body three (13); the cage body one (11) is provided with a square notch (15); the two side edges on the same side of the cage body two (12) are each provided with a square notch (15); the four side edges of the cage body three (13) are each provided with a square notch (15); the slot (31) is a slot for accommodating four cage bodies one (11), four cage bodies two (12) and one cage body three (13).

5. The spliced ​​sleep deprivation mouse cage according to claim 1, characterized in that: The food box (4) is a box body with a mesh structure and an opening at the top.

6. The spliced ​​sleep deprivation mouse cage according to claim 5, characterized in that: The food box (4) is made of stainless steel wires, including transverse wires (41) and vertical wires (42). The diameters of the transverse wires (41) and vertical wires (42) are both 2 mm, and the intervals between two adjacent transverse wires (41) and two adjacent vertical wires (42) are both 6 mm.

7. The spliced ​​sleep deprivation mouse cage according to claim 1, characterized in that: Gaskets (6) are provided on the inner bottom wall of the slot (31) at the four corners corresponding to the spliced ​​plurality of square cage bodies (1), and the square cage bodies (1) are mounted on the gaskets (6).

8. The spliced ​​sleep deprivation mouse cage according to claim 1, characterized in that: A water level scale line (7) is provided on the outer wall of one side of the tray (3) located at the water injection port (32), and the "0" scale line (7) corresponds to the position of the inner bottom wall of the square cage body (1).

9. The spliced ​​sleep deprivation mouse cage according to claim 1, characterized in that: A drainage port (33) communicating with the circulation gap (5) is provided on the outer wall of the tray (3) on the side facing away from the water injection port (32), and a control valve (8) is provided on the drainage port (33).

10. The spliced ​​sleep deprivation mouse cage according to claim 1, characterized in that: The water leakage hole (16) is a waist-shaped hole.

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