Health-care food with auxiliary protection effect on chemical liver injury and preparation method of health-care food

Abstract

The invention relates to the technical field of health-care foods, in particular to a health-care food with an auxiliary protection effect on chemical liver injury and a preparation method of the health-care food. The silymarin chewing gum is prepared from the following raw materials in parts by weight: 80 to 180 parts of silymarin, 50 to 120 parts of lipoic acid, 60 to 100 parts of curcumin, 50 to 80 parts of vitamin E, 20 to 60 parts of coenzyme Q10 and 10 to 30 parts of other auxiliary agents, and the other auxiliary agents comprise a stabilizer, a filling agent, a sweetening agent, a lubricating agent and perfume. The invention provides a health-care food with an auxiliary protection effect on chemical liver injury and a preparation method thereof, and provides a health-care food which can effectively protect the liver in an auxiliary manner and relieve the chemical liver injury through a specific raw material ratio and a preparation process.

Description

Technical Field

[0001] The present invention relates to the technical field of health food, and in particular to a health food having an auxiliary protective effect on chemical liver damage and a preparation method thereof. Background Art

[0002] Liver damage is a lesion that occurs when the liver is affected by various harmful factors, including but not limited to viruses, drugs, alcohol, chemicals, etc. The liver is the largest solid organ in the human body and is responsible for many important functions such as detoxification, metabolism, bile secretion, protein synthesis, etc. Chemical liver damage usually refers to liver damage caused by contact with or ingestion of certain chemicals. This type of damage may cause liver cell necrosis, inflammatory response, and even liver fibrosis and cirrhosis.

[0003] Currently, the main methods for treating liver damage include drug therapy, lifestyle adjustment and liver transplantation. However, these methods have certain limitations. Drug therapy may be accompanied by side effects, lifestyle adjustment requires long-term adherence by patients, and liver transplantation faces problems such as donor shortage and surgical risks.

[0004] Existing health foods have some deficiencies in assisting the protection of liver function. For example, some products may lack specificity and fail to effectively protect against chemical liver damage; or the selection and proportion of ingredients are not scientific enough, resulting in poor health effects. In addition, imperfect preparation processes may also affect the stability and absorption rate of the product. Summary of the invention

[0005] The present invention provides a health food having an auxiliary protective effect on chemical liver damage and a preparation method thereof. Through a specific raw material ratio and a preparation process, a health food capable of effectively auxiliary protecting the liver and alleviating chemical liver damage is provided.

[0006] The technical solution adopted by the present invention is: a health food with auxiliary protective effect on chemical liver damage, which includes the following raw materials by weight: 80-180 parts of silymarin, 50-120 parts of lipoic acid, 60-100 parts of curcumin, 50-80 parts of vitamin E, 20-60 parts of coenzyme Q10, and 10-30 parts of other auxiliary agents, wherein the other auxiliary agents include stabilizers, fillers, sweeteners, lubricants, and spices.

[0007] As a further improvement of the present invention, the stabilizer is one or more of povidone, gelatin, sodium alginate, and sodium carboxymethyl cellulose.

[0008] As a further improvement of the present invention, the filler is one or more of lactose, microcrystalline cellulose, mannitol, and starch.

[0009] As a further improvement of the present invention, the sweetener is one or more of sucrose, aspartame, acesulfame potassium, and stevioside.

[0010] As a further improvement of the present invention, the lubricant is one or more of magnesium stearate, talc, silicon dioxide, and polyethylene glycol.

[0011] As a further improvement of the present invention, the flavor is one or more of natural vanilla, mint flavor, lemon flavor, and orange flavor.

[0012] A method for preparing a health food having an auxiliary protective effect on chemical liver damage comprises the following steps:

[0013] Step 1: Weigh silymarin, lipoic acid, curcumin, vitamin E, coenzyme Q10, stabilizer, filler, sweetener, lubricant, and flavor according to the above weight proportions;

[0014] Step 2: Put silymarin, lipoic acid, curcumin, vitamin E and coenzyme Q10 into a mixer for preliminary mixing, add stabilizer, filler, sweetener, lubricant and flavor during the mixing process, and continue to mix evenly;

[0015] Step 3: wet granulating the uniformly mixed powder using an extrusion wet granulator, adding a binder, and preparing granules;

[0016] Step 4: Drying the obtained particles to reduce the moisture content to less than 3%;

[0017] Step 5: The dried granules are compressed into tablets by a tablet press and quality tested.

[0018] As a further improvement of the present invention, the rotation speed of the mixer is controlled at 100-200 rpm, and the time is controlled at 20-40 minutes.

[0019] As a further improvement of the present invention, the binder is one of ethanol, purified water and povidone solution, and the added amount is 5-15% of the total amount of raw materials.

[0020] As a further improvement of the present invention, the drying treatment is a hot air drying method, and the temperature is controlled at 40-60°C.

[0021] The beneficial effects of the present invention are as follows: (1) Strong targeting and significant effect: The present invention can provide effective auxiliary protection against chemical liver damage, reduce the burden on the liver, and promote liver recovery through careful selection and proportioning of raw materials.

[0022] (2) Advanced preparation technology to ensure quality: The present invention adopts advanced preparation technology, including wet granulation and hot air drying, to ensure the stability and absorption rate of the product, thereby improving the overall quality and effect of the health food.

[0023] (3) Safe and reliable, suitable for long-term use: The present invention does not contain any known harmful substances, and the quality is strictly controlled during the preparation process, which ensures the safety and reliability of the product. It is suitable for long-term use and provides continuous protection for liver health. DETAILED DESCRIPTION

[0024] In order to make the technical problems, technical solutions and beneficial effects to be solved by the present application more clearly understood, the present application is further described in detail below in conjunction with the embodiments. It should be understood that the embodiments described herein are only used to explain the present application and are not used to limit the present application.

[0025] The invention provides a health food with auxiliary protective effect on chemical liver damage, which comprises the following raw materials by weight: 80-180 parts of silymarin, 50-120 parts of lipoic acid, 60-100 parts of curcumin, 50-80 parts of vitamin E, 20-60 parts of coenzyme Q10, and 10-30 parts of other auxiliary agents, wherein the other auxiliary agents include stabilizers, fillers, sweeteners, lubricants, and spices.

[0026] The stabilizer is one or more of povidone, gelatin, sodium alginate, and sodium carboxymethyl cellulose; the filler is one or more of lactose, microcrystalline cellulose, mannitol, and starch; the sweetener is one or more of sucrose, aspartame, acesulfame potassium, and stevia; the lubricant is one or more of magnesium stearate, talc, silicon dioxide, and polyethylene glycol; the flavor is one or more of natural vanilla, mint flavor, lemon flavor, and orange flavor.

[0027] A method for preparing a health food having an auxiliary protective effect on chemical liver damage comprises the following steps:

[0028] Step 1: Weigh silymarin, lipoic acid, curcumin, vitamin E, coenzyme Q10, stabilizer, filler, sweetener, lubricant, and flavor according to the above weight proportions;

[0029] Step 2: putting silymarin, lipoic acid, curcumin, vitamin E and coenzyme Q10 into a mixer for preliminary mixing, adding stabilizer, filler, sweetener, lubricant and flavor during the mixing process, and continuing to mix evenly, wherein the speed of the mixer is controlled at 100-200 rpm and the mixing time is controlled at 20-40 minutes;

[0030] Step 3: wet granulating the uniformly mixed powder using an extrusion wet granulator, adding a binder to prepare granules, wherein the binder is one of ethanol, purified water, and povidone solution, and the amount added is 5-15% of the total amount of the raw materials;

[0031] Step 4: drying the obtained particles to reduce the moisture content to less than 3%, wherein the drying is carried out by hot air drying at a temperature of 40-60°C;

[0032] Step 5: The dried granules are compressed into tablets by a tablet press and quality tested.

[0033] Embodiment 1:

[0034] This embodiment provides a method for preparing a health food having an auxiliary protective effect on chemical liver damage, and the specific steps are as follows.

[0035] Weigh the following raw materials: 120 parts of silymarin, 80 parts of lipoic acid, 80 parts of curcumin, 70 parts of vitamin E, 40 parts of coenzyme Q10, 5 parts of povidone, 6 parts of lactose, 3 parts of sucrose, 5 parts of magnesium stearate, 3 parts of natural vanilla flavor, and 40 parts of ethanol.

[0036] Step 1: Place silymarin, lipoic acid, curcumin, vitamin E, and coenzyme Q10 into a blender;

[0037] Step 2: Start the mixer, set the speed to 150 rpm, set the mixing time to 30 minutes, and add povidone, lactose, sucrose, magnesium stearate, and natural vanilla flavor during the mixing process;

[0038] Step 3: After uniform mixing, the mixture is put into an extrusion wet granulator, and ethanol is added to prepare granules;

[0039] Step 4: The obtained wet granules are then dried using a hot air drying method, with the temperature set at 50° C., and the granules are dried until the moisture content is less than 3%.

[0040] Step 5: The dried granules are compressed into tablets by a tablet press.

[0041] Through the above steps, this embodiment successfully prepared a health food that has an auxiliary protective effect on chemical liver damage, has good stability and absorption rate, does not contain any known harmful substances, is suitable for long-term use, and provides continuous protection for liver health.

[0042] Embodiment 2:

[0043] This embodiment provides a method for preparing a health food having an auxiliary protective effect on chemical liver damage, and the specific steps are as follows.

[0044] Weigh the following raw materials: 150 parts of silymarin, 100 parts of lipoic acid, 70 parts of curcumin, 60 parts of vitamin E, 30 parts of coenzyme Q10, 8 parts of gelatin, 5 parts of microcrystalline cellulose, 4 parts of aspartame, 6 parts of talc, 2 parts of mint essence, and 45 parts of purified water.

[0045] Step 1: Place silymarin, lipoic acid, curcumin, vitamin E, and coenzyme Q10 into a blender;

[0046] Step 2: Start the mixer, set the speed to 180 rpm, set the mixing time to 25 minutes, and add gelatin, microcrystalline cellulose, aspartame, talcum powder, and mint flavor during the mixing process;

[0047] Step 3: After mixing evenly, the mixture is put into an extrusion wet granulator, and purified water is added to prepare granules;

[0048] Step 4: The obtained wet granules are then dried using a hot air drying method, with the temperature set at 45° C., and the granules are dried until the moisture content is less than 3%.

[0049] Step 5: The dried granules are compressed into tablets by a tablet press.

[0050] Through the above steps, this embodiment successfully prepared a health food that has an auxiliary protective effect on chemical liver damage, has good stability and absorption rate, does not contain any known harmful substances, is suitable for long-term use, and provides continuous protection for liver health.

[0051] Embodiment 3:

[0052] This embodiment provides a method for preparing a health food having an auxiliary protective effect on chemical liver damage, and the specific steps are as follows.

[0053] Weigh the raw materials: 100 parts of silymarin, 60 parts of lipoic acid, 70 parts of curcumin, 60 parts of vitamin E, 30 parts of coenzyme Q10, 5 parts of sodium alginate, 2 parts of mannitol, 2 parts of acesulfame potassium, 3 parts of silicon dioxide, 4 parts of lemon essence, and 30 parts of povidone solution.

[0054] Step 1: Add silymarin, lipoic acid, curcumin, vitamin E and coenzyme Q10 into a mixer;

[0055] Step 2: Start the mixer, set the speed to 160 rpm, set the mixing time to 35 minutes, and add sodium alginate, mannitol, acesulfame potassium, silicon dioxide and lemon essence during the mixing process;

[0056] Step 3: After uniform mixing, the mixture is put into an extrusion wet granulator, and the povidone solution is added to prepare granules;

[0057] Step 4: The obtained wet granules are then dried using a hot air drying method, with the temperature set at 55° C., and the granules are dried until the moisture content is less than 3%.

[0058] Step 5: The dried granules are compressed into tablets by a tablet press.

[0059] Through the above steps, this embodiment successfully prepared a health food that has an auxiliary protective effect on chemical liver damage, has good stability and absorption rate, does not contain any known harmful substances, is suitable for long-term use, and provides continuous protection for liver health.

[0060] Performance Testing

[0061] The health food obtained in Example 1 was ground into powder and then subjected to experimental testing.

[0062] Experimental animals: 50 male mice weighing 18.0-22.0 g were selected.

[0063] Experimental groups: The mice were randomly divided into 5 groups, with 10 mice in each group, namely blank control group, model control group, low-dose group, medium-dose group, and high-dose group.

[0064] The blank control group was given ordinary feed, and the model control group and the low-dose group, medium-dose group, and high-dose group were given feed containing carbon tetrachloride to induce chemical liver damage. The low-dose group, medium-dose group, and high-dose group were given different doses of health food for 4 consecutive weeks.

[0065] Among them, the low-dose group: take 6.3g of health food powder, add pure water to 50ml; the medium-dose group: take 12.6g of health food powder, add pure water to 50ml; the high-dose group: take 25.2g of health food powder, add pure water to 50ml. The dosage is as follows:

[0066]

[0067]

[0068] Dosage cycle: Administer twice a day (once in the morning and once in the afternoon) for 4 consecutive weeks.

[0069] After the experiment, the biochemical indexes of blood and liver tissue of each group of mice were tested, including ALT, AST, ALP, total protein, albumin, globulin and other indicators, and the pathological sections of liver tissue were observed. The specific data are as follows:

[0070]

[0071] As can be seen from the above table, all indicators of the blank control group were normal, and pathological sections showed normal liver tissue; the model control group was given carbon tetrachloride to induce liver damage, ALT, AST, ALP increased significantly, total protein, albumin, globulin decreased, and pathological sections showed severe liver damage; compared with the model control group, the low-dose group showed improvement in all indicators, but still deviated from the normal range, and pathological sections showed moderate liver damage; the medium-dose group further improved all indicators and approached the normal range, and pathological sections showed mild liver damage; the high-dose group basically returned to normal, and pathological sections showed that the liver tissue was close to normal.

[0072] In summary, the health food of the present invention that has an auxiliary protective effect on chemical liver damage and its preparation method have significant liver protection function, can effectively reduce the abnormal biochemical indicators caused by chemical liver damage, and improve the pathological state of liver tissue. The experimental results show that the health food of the present invention can provide different degrees of protection to the liver at different doses, among which the effect of the high-dose group is the most significant, close to the normal liver state. Therefore, the health food of the present invention has potential application value in the prevention and auxiliary treatment of chemical liver damage, and is suitable for further promotion in preclinical research and practical applications.

[0073] The above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit the same. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that the technical solutions described in the aforementioned embodiments may still be modified, or some of the technical features thereof may be replaced by equivalents. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A health food having an auxiliary protective effect on chemical liver damage, characterized in that: The raw materials are counted in parts by weight: 80-180 parts of silymarin, 50-120 parts of lipoic acid, 60-100 parts of curcumin, 50-80 parts of vitamin E, 20-60 parts of coenzyme Q10, and 10-30 parts of other auxiliary agents, wherein the other auxiliary agents include stabilizers, fillers, sweeteners, lubricants, and flavors.

2. The health food having auxiliary protective effect on chemical liver damage according to claim 1, characterized in that: The stabilizer is one or more of povidone, gelatin, sodium alginate and sodium carboxymethyl cellulose.

3. The health food having auxiliary protective effect on chemical liver damage according to claim 1, characterized in that: The filler is one or more of lactose, microcrystalline cellulose, mannitol and starch.

4. The health food having auxiliary protective effect on chemical liver damage according to claim 1, characterized in that: The sweetener is one or more of sucrose, aspartame, acesulfame potassium and stevioside.

5. The health food having auxiliary protective effect on chemical liver damage according to claim 1, characterized in that: The lubricant is one or more of magnesium stearate, talc, silicon dioxide and polyethylene glycol.

6. The health food having auxiliary protective effect on chemical liver damage according to claim 1, characterized in that: The flavor is one or more of natural vanilla, mint flavor, lemon flavor, and orange flavor.

7. A method for preparing a health food having an auxiliary protective effect on chemical liver damage, characterized in that: The following steps are involved: Step 1: Weigh silymarin, lipoic acid, curcumin, vitamin E, coenzyme Q10, stabilizer, filler, sweetener, lubricant, and flavor according to the above weight proportions; Step 2: Put silymarin, lipoic acid, curcumin, vitamin E and coenzyme Q10 into a mixer for preliminary mixing, add stabilizer, filler, sweetener, lubricant and flavor during the mixing process, and continue to mix evenly; Step 3: wet granulating the uniformly mixed powder using an extrusion wet granulator, adding a binder, and preparing granules; Step 4: Drying the obtained particles to reduce the moisture content to less than 3%; Step 5: The dried granules are compressed into tablets by a tablet press and quality tested.

8. The method for preparing a health food having an auxiliary protective effect on chemical liver damage according to claim 7, characterized in that: The rotating speed of the mixer is controlled at 100-200 rpm, and the mixing time is controlled at 20-40 minutes.

9. The method for preparing a health food having an auxiliary protective effect on chemical liver damage according to claim 7, characterized in that: The adhesive is one of ethanol, purified water and polyvidone solution, and the added amount is 5-15% of the total amount of raw materials.

10. The method for preparing a health food having an auxiliary protective effect on chemical liver damage according to claim 7, characterized in that: The drying process is a hot air drying method, and the temperature is controlled at 40-60°C.

Images