Automatic control system for non-invasive vascular endothelial function evaluation and implementation method

Abstract

The invention discloses an automatic control system for non-invasive vascular endothelial function evaluation and an implementation method. The automatic control system comprises an identity information recognition and processing module, a forearm compression ischemia module, a two-arm synchronous blood pressure measurement module and a measurement result display and printing module which are electrically connected with a data processing module. According to the method, based on the combination of a single-side forearm compression ischemia test and two-arm synchronous blood pressure measurement, non-invasive vascular endothelial function evaluation is achieved according to the two sets of two-arm synchronous blood pressure measurement results before and after ischemia of the testee, the diastolic pressure and the change condition of the difference value between diastolic pressure arms, and compared with an existing method, the method has the advantages that the method is simple and convenient to operate. The blood vessel change interference caused by environment, psychology and other factors can be eliminated, the repeatability and reliability of the detection result are higher, the dependency on the technology of operators is lower, and popularization and use in primary medical institutions are facilitated.

Description

Technical Field

[0001] The invention belongs to the technical field of biomedical detection equipment, and in particular relates to an automatic control system and an implementation method for non-invasive vascular endothelial function evaluation. Background Art

[0002] The vascular endothelium is a single cell layer covering the inner surface of blood vessels. Normal endothelial function is the basic condition for maintaining the homeostasis of the cardiovascular system. Endothelial dysfunction has been shown to be closely related to many diseases or their diagnostic markers.

[0003] At present, the main methods of endothelial function testing are invasive testing, non-invasive FMD endothelial testing and Endo-PAT. Invasive testing can detect changes in coronary artery diameter and flow through angiography, and thus judge endothelial function; however, due to its invasiveness, high technical requirements, long time consumption and high cost, it is greatly limited in clinical application. Non-invasive FMD endothelial testing uses the method of cuff pressurization to block the brachial artery blood flow for several minutes, and then quickly decompresses the blood flow, so that the blood flow forms a high fluid shear stress on the endothelium, thereby stimulating the endothelium to release nitric oxide and cause vasodilation. At the same time, in the above process, a high-resolution color Doppler ultrasound probe is used to measure the diameter of the brachial artery, and the change rate of the diameter before and after the ischemic test is calculated to evaluate the endothelial function; this method cannot avoid interfering diameter changes caused by temperature, psychology, nerves and other factors, and the differences in the resolution of ultrasound equipment and the technical level of the testers may affect the repeatability of the test and the reliability of the data. Endo-PAT uses the peripheral arterial tension measurement method (i.e., blood flow detection) to measure changes in the pulsating volume of the fingertip arteries; this measurement method can eliminate interference from vascular changes caused by environmental, psychological and other factors by comparing two sets of signals, and is currently the only non-invasive endothelial function diagnostic system certified by the US FDA. However, its measurement site is the front end of the index finger of both hands, and the obtained signal reflects the endothelial function of the artery terminal, and cannot replace the endothelial function of large and medium arteries.

[0004] To this end, the present invention uses bilateral synchronous blood pressure measurement as a means, designs an automatic control system and implementation method for non-invasive vascular endothelial function assessment based on the combination of unilateral forearm compression ischemia test and bilateral synchronous blood pressure measurement, and according to the changes in diastolic pressure and the difference between diastolic pressure arms in the two groups of bilateral synchronous blood pressure measurement results before and after the ischemia test. Summary of the invention

[0005] The purpose of the present invention is to address the deficiencies in the prior art and to provide an automatic control system and implementation method for non-invasive endothelial function evaluation, based on a unilateral forearm compression ischemia test combined with bilateral synchronous blood pressure measurement, and based on changes in diastolic pressure and inter-arm diastolic pressure difference values ​​in two groups of bilateral synchronous blood pressure measurement results before and after the ischemia test, to achieve non-invasive endothelial function evaluation.

[0006] In order to achieve the above technical objectives, the present invention adopts the following technical solutions.

[0007] The present invention first provides an automatic control system for non-invasive vascular endothelial function assessment, the automatic control system comprises a data processing module, an identity information recognition and processing module, a forearm compression ischemia module, a double-arm synchronous blood pressure measurement module, and a measurement result display and printing module, wherein the data processing module is electrically and signal-connected to the identity information recognition and processing module, the forearm compression ischemia module, the double-arm synchronous blood pressure measurement module, and the measurement result display and printing module respectively;

[0008] The data processing module includes a microcomputer or a main control board, which has an operating system and application software built in it. The microcomputer or the main control board is connected to the identity information recognition and processing module, the forearm compression ischemia module, the double-arm synchronous blood pressure measurement module, and the measurement result display and printing module, and is used to send corresponding command signals to other modules for control and adjustment, data call and processing;

[0009] The identity information recognition and processing module includes a camera 1 and an identity document image recognition processing software unit. The camera 1 is used to take a photo of the identity document and send it to the identity document image recognition processing software unit after receiving a command signal from the data processing module. The identity document image recognition processing software unit is used to recognize the identity document image sent from the camera 1 and generate text information after successful recognition for the data processing module to call;

[0010] The forearm compression ischemia module comprises a forearm cuff, a cuff air pressure control unit, an air pump, a pressure sensor, an air inlet channel and an air exhaust channel, wherein the air inlet channel is fixedly installed with an air inlet valve, and the air exhaust channel is fixedly installed with an air exhaust valve; the forearm cuff is connected to the pressure sensor through a gas conduit, the pressure sensor is connected to the cuff air pressure control unit, and the cuff air pressure control unit is respectively connected to the air pump, the air inlet valve and the air exhaust valve;

[0011] The dual-arm synchronous blood pressure measurement module includes an external electronic sphygmomanometer, a control card, a camera 2 and a sphygmomanometer image recognition processing software unit. The control card is equipped with a measurement process control system software. Under the control and regulation of the data processing module, the control card starts the sphygmomanometer according to a preset program by the built-in measurement process control system software, and performs a group of dual-arm synchronous blood pressure measurements. The measurement result of each time is obtained by the camera 2 taking a picture of the electronic sphygmomanometer display panel, and is sent to the sphygmomanometer image recognition processing software unit in real time, and structured numerical value recognition is performed and recognition signals are fed back, and a text information list is generated for the data processing module to call, thereby calculating the average value of the blood pressure measurement and the difference between the arms;

[0012] The measurement result display and printing module includes a display screen and a printer, which are respectively connected to the data processing module. The display screen is used to prompt and display the information during the working process of the identity information recognition module, the double-arm synchronous blood pressure measurement module, and the forearm compression ischemia module. The printer is started, printed and shut down under the control of the data processing module, and is used to print the result information of each module.

[0013] Specifically, the cuff air pressure control unit is used to receive signal feedback from the pressure sensor, and realizes the inflation, air pressure maintenance and rapid deflation operations of the forearm cuff by controlling the air inlet valve, the air exhaust valve and the air pump; under the control and regulation of the data processing module, the cuff air pressure control unit controls the air inlet valve and the air exhaust valve to open or close the corresponding air inlet channel and the air exhaust channel of the forearm cuff according to a preset program, and the air pump completes the inflation of the forearm cuff and maintains it at the maximum pressure value for a few minutes; the maximum pressure value is obtained by adding a preset fixed value to the basic value of the average systolic pressure of the right upper arm, and the The average systolic blood pressure of the right upper arm is obtained by taking the average of the systolic blood pressure of the upper arm on the same side three times by the double-arm synchronous blood pressure measurement module; during the air pressure holding stage of the forearm cuff, the pressure in the forearm cuff is transmitted to the pressure sensor through the gas duct, and the built-in signal conditioning and A / D acquisition circuit of the cuff air pressure control unit completes the conditioning and real-time sampling of the pressure sensor signal. When the maximum pressure value is reached, the double-arm synchronous blood pressure measurement module obtains and processes the measurement data and displays it on the display panel of the electronic sphygmomanometer; after the air pressure holding stage ends, the cuff air pressure control unit controls the exhaust valve to open for rapid deflation.

[0014] Specifically, after the forearm cuff of the forearm compression ischemia module of the dual-arm synchronous blood pressure measurement module is quickly deflated, the control card immediately starts the electronic sphygmomanometer to perform three measurements after the ischemia test according to the preset program, and the camera 2 and the sphygmomanometer image recognition processing software unit acquire the image and recognize the numerical value of each measurement result, and generate text information of each measurement result for the data processing module to call and calculate, and respectively obtain the diastolic pressure arm difference value of each measurement, the average diastolic pressure of the two upper arms and the arm difference value of the three measurements, and then compare them with the basic diastolic pressure average value and the arm difference value, and calculate the absolute value and change rate of the difference before and after ischemia.

[0015] On the basis of the above technical solution, the present invention also provides a method for non-invasively evaluating vascular endothelial function using the above automatic control system, comprising the following steps:

[0016] Step S1, tie cuffs for the subject as required, including double upper arm cuffs and forearm cuffs, place the identity card in the designated position, and then click the function key for starting detection on the display screen to put the system into automatic operation state;

[0017] Step S2, the identity document information recognition and processing module starts working, takes a photo of the identity document and performs image recognition processing, and generates an identity information text list for subsequent data processing module to call;

[0018] Step S3: After the identity information is successfully identified, the dual-arm synchronous blood pressure measurement module performs a set of blood pressure measurements under normal conditions according to a preset process under system control;

[0019] Step S4: After the basic blood pressure measurement is completed, the washout period begins and the system counts down for 5 minutes;

[0020] Step S5: After the 5-minute countdown is over, the forearm ischemia compression module, under the control and regulation of the data processing module, causes the subject's forearm to enter an ischemic state and maintains it for 5 minutes;

[0021] Step S6: After the forearm ischemia test of the subject is completed, the dual-arm synchronous blood pressure measurement module performs three blood pressure measurements after the ischemia test according to a preset program under the control of the system;

[0022] Step S7: The information display and printing module displays the blood pressure measurement results of step S3 and step S6, and reminds the staff on the display interface whether to save and print the measurement results or exit directly;

[0023] Step S8: After the test is completed, the system enters a standby state, removes the cuff of the subject, and stores it or performs the next test.

[0024] Specifically, the dual-arm synchronous blood pressure measurement module in step S3 performs blood pressure measurement under normal conditions according to a preset process under system control, and the measurement process includes the following steps:

[0025] Step S31, the control card of the dual-arm synchronous blood pressure measurement module starts the external electronic blood pressure meter according to the preset program, and performs a set of dual-arm synchronous blood pressure measurement checks in the order of countdown for 3 minutes - first blood pressure measurement - countdown for 1 minute - second blood pressure measurement - countdown for 1 minute - third blood pressure measurement, to obtain the blood pressure data of the subject in a normal state before forearm compression ischemia;

[0026] Step S32: the data processing module issues an instruction to instruct the camera 1 to take a picture of the display panel of the external electronic sphygmomanometer, and sends the picture taking result to the sphygmomanometer image recognition processing software unit in real time for recognition and processing, so as to obtain the blood pressure measurement values ​​of both arms of the subject in the normal state before forearm compression ischemia for three times, and generate a text information list of the measurement results for subsequent data processing module to call;

[0027] Step S33: The data processing module calls and calculates the blood pressure measurements of the two arms of the subject in the normal state three times before forearm compression ischemia, and obtains a set of average values ​​and inter-arm difference values ​​of blood pressure measurements; and for the right arm selected for compression test, the average systolic blood pressure SBP 右基 A fixed value between 30-50 mmHg is added as the maximum inflation pressure value and sent to the forearm compression ischemia module.

[0028] Specifically, in step S5, the forearm compression ischemia module causes the subject's forearm to enter an ischemic state under the control and regulation of the data processing module, and the process is as follows:

[0029] Step S51: Under the control and regulation of the data processing module, the cuff air pressure control unit opens the air inlet channel and closes the air outlet channel of the forearm cuff through the electronic control valve according to a preset process, and the forearm cuff is inflated by the air pump to quickly reach the maximum inflation pressure value;

[0030] Step S52, the cuff air pressure control unit closes the air inlet channel and the exhaust channel at the same time to maintain the maximum inflation pressure state, and continuously compresses the forearm for 5 minutes; during the air pressure maintenance stage of the forearm cuff, the pressure in the cuff is transmitted to the pressure sensor through the gas duct, and the signal conditioning and real-time sampling of the pressure sensor signal are completed by the built-in signal conditioning and A / D acquisition circuit of the cuff air pressure control unit, and the sampled data is processed and displayed;

[0031] Step S53, after the air pressure holding stage ends, the cuff air pressure control unit controls the exhaust valve to open, and while the air is quickly deflated, the control center and the data processing module send the measurement command to the double-arm synchronous blood pressure measurement module.

[0032] Specifically, the dual-arm synchronous blood pressure measurement module in step S6 performs blood pressure measurement after the forearm ischemia test according to a preset program under system control, and the process is as follows:

[0033] Step S61, after receiving the measurement instruction sent by the control center and the data processing module, the double-arm synchronous blood pressure measurement module performs a set of double-arm synchronous blood pressure measurement checks in the order of immediately starting the sphygmomanometer to perform the first double-arm synchronous blood pressure measurement after the forearm ischemia test - countdown for 1 minute - second double-arm synchronous blood pressure measurement - countdown for 1 minute - third double-arm synchronous blood pressure measurement to obtain the blood pressure data after the forearm compression ischemia test;

[0034] Step S62: The data processing module issues an instruction to instruct the camera 2 to take a picture of the display panel of the external electronic sphygmomanometer, and sends the picture taking result to the sphygmomanometer image recognition processing software unit in real time for recognition and processing, so as to obtain the blood pressure measurement values ​​of both arms after the forearm compression ischemia test for three times, and generate a text information list of the measurement results for subsequent data processing module to call;

[0035] Step S63, the data processing module calls the two generated measurement result text information lists, compares the average diastolic blood pressure of the subjects before and after the forearm compression ischemia test with the inter-arm difference value, and obtains the absolute value and change rate of the diastolic blood pressure and the inter-arm difference value.

[0036] Compared with the prior art, the present invention has the following beneficial effects:

[0037] 1. Compared with the non-invasive peripheral arterial tension measurement method, the method of the present invention uses the brachial artery of the upper arm as the measurement site. Compared with measuring the arteries at the end of the limbs, the synchronous measurement of blood pressure in both arms can eliminate the interference of vascular changes caused by environmental, psychological and other factors by comparing the two groups of signals, and the repeatability and reliability of the test results are higher.

[0038] 2. Compared with the non-invasive FMD method, the method of the present invention mainly evaluates the dilatation function of medium-sized arteries, while the dIAD method can more comprehensively reflect the functions of small and medium-sized arteries and microcirculation; and this method has the significant characteristics of high automation and standardization, the equipment operation is more convenient, practical, and has low risk, and is less dependent on the operator's skills, which is conducive to its widespread implementation in primary medical institutions to detect abnormal conditions in a timely manner. BRIEF DESCRIPTION OF THE DRAWINGS

[0039] In order to more clearly illustrate the technical solutions of the embodiments of the present disclosure, the drawings required for use in the embodiments will be briefly introduced below. It should be understood that the following drawings only show certain embodiments of the present disclosure and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other relevant drawings can be obtained based on these drawings without paying creative work.

[0040] Figure 1 This is a functional module diagram of an automatic control system for non-invasive vascular endothelial function assessment of the present invention;

[0041] Figure 2 A flowchart of a method for implementing non-invasive vascular endothelial function assessment of the present invention;

[0042] Figure 3 This is a flow chart of the automatic control system for synchronous blood pressure measurement of both arms of the present invention;

[0043] Figure 4 Schematic diagram of pulse wave pressure sampling before and after a single cuff pressurization in a single-arm ischemic state in an embodiment of the present invention.

[0044] In the figure: 101, data processing module; 102, identity information recognition and processing module; 103, forearm compression ischemia module; 104, double-arm synchronous blood pressure measurement module; 105, measurement result display and printing module. DETAILED DESCRIPTION

[0045] In order to facilitate those of ordinary skill in the art to understand and implement the present invention, the following detailed description is given to each step of the method proposed by the present invention, and it should be understood that these embodiments are only used to illustrate the present invention and are not used to limit the scope of the present invention. In addition, it should be understood that after reading the content taught by the present invention, those skilled in the art can make various changes or modifications to the present invention, and these equivalent forms also fall within the scope defined by the appended claims of the present application.

[0046] Example

[0047] like Figure 1 As shown, the present invention provides an automatic control system for non-invasive vascular endothelial function assessment, the automatic control system includes a data processing module, an identity information recognition and processing module, a forearm compression ischemia module, a double-arm synchronous blood pressure measurement module, and a measurement result display and printing module, wherein the data processing module is electrically and signal-connected to the identity information recognition and processing module, the forearm compression ischemia module, the double-arm synchronous blood pressure measurement module, and the measurement result display and printing module respectively;

[0048] The data processing module includes a microcomputer or a main control board, which has an operating system and application software built in it. The microcomputer or the main control board is connected to the identity information recognition and processing module, the forearm compression ischemia module, the double-arm synchronous blood pressure measurement module, and the measurement result display and printing module, and is used to send corresponding command signals to other modules for control and adjustment, data call and processing;

[0049] The identity information recognition and processing module includes a camera 1 and an identity document image recognition processing software unit. The camera 1 is used to take a photo of the identity document and send it to the identity document image recognition processing software unit after receiving a command signal from the data processing module. The identity document image recognition processing software unit is used to recognize the identity document image sent from the camera 1 and generate text information after successful recognition for the data processing module to call;

[0050] The forearm compression ischemia module comprises a forearm cuff, a cuff air pressure control unit, an air pump, a pressure sensor, an air inlet channel and an air exhaust channel, wherein the air inlet channel is fixedly installed with an air inlet valve, and the air exhaust channel is fixedly installed with an air exhaust valve; the forearm cuff is connected to the pressure sensor through a gas conduit, the pressure sensor is connected to the cuff air pressure control unit, and the cuff air pressure control unit is respectively connected to the air pump, the air inlet valve and the air exhaust valve;

[0051] The dual-arm synchronous blood pressure measurement module includes an external electronic sphygmomanometer, a control card, a camera 2 and a sphygmomanometer image recognition processing software unit. The control card is equipped with a measurement process control system software. Under the control and regulation of the data processing module, the control card starts the sphygmomanometer according to a preset program by the built-in measurement process control system software, and performs a group of dual-arm synchronous blood pressure measurements. The measurement result of each time is obtained by the camera 2 taking a picture of the electronic sphygmomanometer display panel, and is sent to the sphygmomanometer image recognition processing software unit in real time, and structured numerical value recognition is performed and recognition signals are fed back, and a text information list is generated for the data processing module to call, thereby calculating the average value of the blood pressure measurement and the difference between the arms;

[0052] The measurement result display and printing module includes a display screen and a printer, which are electrically connected to the data processing module respectively. The display screen is used to prompt and display the information during the working process of the identity information recognition module, the double-arm synchronous blood pressure measurement module, and the forearm compression ischemia module. The printer is started, printed and shut down under the control of the data processing module, and is used to print the result information of each module.

[0053] Specifically, the cuff air pressure control unit is used to receive signal feedback from the pressure sensor, and realizes the inflation, air pressure maintenance and rapid deflation operations of the forearm cuff by controlling the air inlet valve, the air exhaust valve and the air pump; under the control and regulation of the data processing module, the cuff air pressure control unit controls the air inlet valve and the air exhaust valve to open or close the corresponding air inlet channel and the air exhaust channel of the forearm cuff according to a preset program, and the air pump completes the inflation of the forearm cuff and maintains it at the maximum pressure value for a few minutes; the maximum pressure value is obtained by adding a preset fixed value to the basic value of the average systolic pressure of the right upper arm, and the The average systolic pressure of the right upper arm is obtained by taking the average of the systolic pressure of the right upper arm three times by the double-arm synchronous blood pressure measurement module; during the air pressure holding stage of the forearm cuff, the pressure in the forearm cuff is transmitted to the pressure sensor through the gas duct, and the signal conditioning and A / D acquisition circuit built into the cuff air pressure control unit completes the conditioning and real-time sampling of the pressure sensor signal. When the maximum pressure value is reached, the double-arm synchronous blood pressure measurement module obtains and processes the measurement data and displays it on the display panel of the electronic sphygmomanometer; after the air pressure holding stage ends, the cuff air pressure control unit controls the exhaust valve to open for rapid deflation.

[0054] Specifically, after the forearm cuff of the forearm compression ischemia module of the dual-arm synchronous blood pressure measurement module is quickly deflated, the control card immediately starts the electronic sphygmomanometer to perform three measurements after the ischemia test according to the preset program, and the camera 2 and the sphygmomanometer image recognition processing software unit acquire the image and recognize the numerical value of each measurement result, and generate text information of each measurement result for the data processing module to call and calculate, and respectively obtain the diastolic pressure arm difference value of each measurement, the average diastolic pressure of the two upper arms and the arm difference value of the three measurements, and then compare them with the basic diastolic pressure average value and the arm difference value, and calculate the absolute value and change rate of the difference before and after ischemia.

[0055] like Figure 2 As shown, the present invention also provides a method for non-invasively evaluating vascular endothelial function using the automatic control system, comprising the following steps:

[0056] Step S1, tie cuffs for the subject as required, including double upper arm cuffs and forearm cuffs, place the identity card in the designated position, and then click the function key for starting detection on the display screen to put the system into automatic operation state;

[0057] Step S2, the identity document information recognition and processing module starts working, takes a photo of the identity document and performs image recognition processing, and generates an identity information text list for subsequent data processing module to call;

[0058] Step S3: After the identity information is successfully identified, Figure 3As shown, the dual-arm synchronous blood pressure measurement module performs a set of blood pressure measurements under normal conditions according to a preset process under system control;

[0059] Step S4: After the basic blood pressure measurement is completed, the washout period begins and the system counts down for 5 minutes;

[0060] Step S5: After the 5-minute countdown is over, the forearm ischemia compression module, under the control and regulation of the data processing module, causes the subject's forearm to enter an ischemic state and maintains it for 5 minutes;

[0061] Step S6: After the forearm ischemia test of the subject is completed, the dual-arm synchronous blood pressure measurement module performs three blood pressure measurements after the ischemia test according to a preset program under the control of the system;

[0062] Step S7: The information display and printing module displays the blood pressure measurement results of step S3 and step S6, and reminds the staff on the display interface whether to save and print the measurement results or exit directly;

[0063] Step S8: After the test is completed, the system enters a standby state, removes the cuff of the subject, and stores it or performs the next test.

[0064] Specifically, the dual-arm synchronous blood pressure measurement module in step S3 performs blood pressure measurement under normal conditions according to a preset process under system control, and the measurement process includes the following steps:

[0065] Step S31, the control card of the dual-arm synchronous blood pressure measurement module starts the external electronic blood pressure meter according to the preset program, and performs a set of dual-arm synchronous blood pressure measurement checks in the order of countdown for 3 minutes - first blood pressure measurement - countdown for 1 minute - second blood pressure measurement - countdown for 1 minute - third blood pressure measurement, to obtain the blood pressure data of the subject in a normal state before forearm compression ischemia;

[0066] Step S32: the data processing module issues an instruction to instruct the camera 1 to take a picture of the display panel of the external electronic sphygmomanometer, and sends the picture taking result to the sphygmomanometer image recognition processing software unit in real time for recognition and processing, so as to obtain the blood pressure measurement values ​​of both arms of the subject in the normal state before forearm compression ischemia for three times, and generate a text information list of the measurement results for subsequent data processing module to call;

[0067] Step S33: The data processing module calls and calculates the blood pressure measurements of the two arms of the subject in the normal state three times before forearm compression ischemia, and obtains a set of average values ​​and inter-arm difference values ​​of blood pressure measurements; and for the right arm selected for compression test, the average systolic blood pressure SBP 右基 A fixed value between 30-50 mmHg is added as the maximum inflation pressure value and sent to the forearm compression ischemia module.

[0068] Furthermore, the average value of the blood pressure measurement is calculated as follows (taking the right arm as an example):

[0069] SBP 右基 =(SBP 右1 +SBP 右2 +SBP 右3 ) / 3;

[0070] DBP 右基 =(DBP 右1 +DBP 右2 +DBP 右3 ) / 3;

[0071] The inter-arm difference value calculation formula is: dIAD 基 =|DBP 左均 -DBP 右均 |;

[0072] The calculation formula of the maximum inflation pressure value is:

[0073] P 极 =SBP 右基 +50 mmHg;

[0074] Specifically, in step S5, the forearm compression ischemia module causes the subject's forearm to enter an ischemic state under the control and regulation of the data processing module, and the process is as follows:

[0075] Step S51: Under the control and regulation of the data processing module, the cuff air pressure control unit opens the air inlet channel and closes the air outlet channel of the forearm cuff through the electronic control valve according to a preset process, and the forearm cuff is inflated by the air pump to quickly reach the maximum inflation pressure value;

[0076] Step S52, the cuff air pressure control unit closes the air inlet channel and the exhaust channel at the same time to maintain the maximum inflation pressure state, and continuously compresses the forearm for 5 minutes; during the air pressure maintenance stage of the forearm cuff, the pressure in the cuff is transmitted to the pressure sensor through the gas duct, and the signal conditioning and real-time sampling of the pressure sensor signal are completed by the built-in signal conditioning and A / D acquisition circuit of the cuff air pressure control unit, and the sampled data is processed and displayed;

[0077] Step S53, after the air pressure holding stage ends, the cuff air pressure control unit controls the exhaust valve to open, and while the air is quickly deflated, the control center and the data processing module send the measurement command to the double-arm synchronous blood pressure measurement module.

[0078] Specifically, the dual-arm synchronous blood pressure measurement module in step S6 performs blood pressure measurement after the forearm ischemia test according to a preset program under system control, and the process is as follows:

[0079] Step S61, after receiving the measurement instruction sent by the control center and the data processing module, the double-arm synchronous blood pressure measurement module performs a set of double-arm synchronous blood pressure measurement checks in the order of immediately starting the sphygmomanometer to perform the first double-arm synchronous blood pressure measurement after the forearm ischemia test - countdown for 1 minute - second double-arm synchronous blood pressure measurement - countdown for 1 minute - third double-arm synchronous blood pressure measurement to obtain the blood pressure data after the forearm compression ischemia test;

[0080] Step S62: The data processing module issues an instruction to instruct the camera 2 to take a picture of the display panel of the external electronic sphygmomanometer, and sends the picture taking result to the sphygmomanometer image recognition processing software unit in real time for recognition and processing, so as to obtain the blood pressure measurement values ​​of both arms after the forearm compression ischemia test for three times, and generate a text information list of the measurement results for subsequent data processing module to call;

[0081] Step S63, the data processing module calls the two generated measurement result text information lists, compares the average diastolic blood pressure of the subjects before and after the forearm compression ischemia test with the inter-arm difference value, and obtains the absolute value and change rate of the diastolic blood pressure and the inter-arm difference value.

[0082] The calculation formula for the inter-arm difference value of the diastolic pressure of the subject in the ischemic state after forearm compression ischemia is:

[0083] dIAD 阻1 =|DBP 左阻1 -DBP 右阻1

[0084] dIAD 阻3 =|DBP 左阻3 -DBP 右阻3

[0085] dIAD 阻5 =|DBP 左阻5 -DBP 右阻5

[0086] dIAD 阻 =|DBP 左阻均 -DBP 右阻均

[0087] The calculation formula for the absolute value of the change in the difference in diastolic pressure between arms of the subjects in the ischemic state after forearm compression ischemia is further obtained as follows:

[0088] ΔdIAD1=|dIAD 阻1 -dIAD 基

[0089] ΔdIAD3=|dIAD 阻3 -dIAD 基

[0090] ΔdIAD5=|dIAD 阻5 -dIAD 基

[0091] ΔdIAD 均 =|dIAD 阻 -dIAD 基

[0092] Furthermore, the calculation formula for the change rate of the inter-arm difference value of the diastolic pressure of the subjects in the ischemic state after forearm compression is obtained as follows:

[0093]

[0094] Formula description: The measurement starts immediately after deflation. It takes 1 minute for the cuff to inflate and deflate, so it is defined as 1 minute, 3 minutes, and 5 minutes respectively; DBP 右阻 DBP refers to the average of the right arm diastolic blood pressure measured three times after the ischemia test; 右阻1 、DBP 右阻3 、DBP 右阻5 They refer to the right arm diastolic pressure at the first, second, and third measurements after ischemia, respectively; "base" represents the basal value before occlusion, and "block" represents the value measured after ischemia. Figure 4 As shown, the relevant parameters can be used to evaluate the vascular elastic function of the subjects' upper arm blood vessels at different time points after ischemia and rapid reopening, thereby realizing automatic and non-invasive vascular endothelial function evaluation.

[0095] The above is only a preferred embodiment of the present invention, and does not limit the present invention in other forms. Any technician familiar with the profession may use the above disclosed technical content to change or modify it into an equivalent embodiment with equivalent changes. However, any simple modification, equivalent change and modification made to the above embodiment according to the technical essence of the present invention without departing from the technical solution of the present invention still belongs to the protection scope of the technical solution of the present invention.

Claims

1. An automatic control system for non-invasive endothelial function assessment, characterized in that: The automatic control system includes a data processing module, an identity information recognition and processing module, a forearm compression ischemia module, a double-arm synchronous blood pressure measurement module and a measurement result display and printing module. The data processing module is respectively communicated with the identity information recognition and processing module, the forearm compression ischemia module, the double-arm synchronous blood pressure measurement module, and the measurement result display and printing module.

2. The automatic control system for non-invasive endothelial function assessment according to claim 1, characterized in that: The data processing module includes a microcomputer or a main control board, which has an operating system and application software built in it. The microcomputer or the main control board is connected to the identity information recognition and processing module, the forearm compression ischemia module, the double-arm synchronous blood pressure measurement module, and the measurement result display and printing module, and is used to send corresponding command signals to other modules for control and adjustment, data call and processing; The identity information recognition and processing module includes a camera 1 and an identity document image recognition processing software unit. The camera 1 is used to take a photo of the identity document and send it to the identity document image recognition processing software unit after receiving a command signal from the data processing module. The identity document image recognition processing software unit is used to recognize the identity document image sent from the camera 1 and generate text information after successful recognition for the data processing module to call; The forearm compression ischemia module comprises a forearm cuff, a cuff air pressure control unit, an air pump, a pressure sensor, an air inlet channel and an air exhaust channel, wherein the air inlet channel is fixedly installed with an air inlet valve, and the air exhaust channel is fixedly installed with an air exhaust valve; the forearm cuff is connected to the pressure sensor through a gas conduit, the pressure sensor is connected to the cuff air pressure control unit, and the cuff air pressure control unit is electrically connected to the air pump, the air inlet valve and the air exhaust valve respectively; The dual-arm synchronous blood pressure measurement module includes an external electronic sphygmomanometer, a control card, a camera 2 and a sphygmomanometer image recognition processing software unit. The control card is equipped with a measurement process control system software. Under the control and regulation of the data processing module, the control card starts the sphygmomanometer according to a preset program by the built-in measurement process control system software to perform a set of dual-arm synchronous blood pressure measurements. The camera 2 takes a picture of the electronic sphygmomanometer display panel to obtain each measurement result, and sends it to the sphygmomanometer image recognition processing software unit in real time, performs structured numerical recognition and feeds back recognition signals, generates a text information list, and is called by the data processing module, thereby calculating the average value of the blood pressure measurement and the difference between the arms; The measurement result display and printing module includes a display screen and a printer, which are respectively connected to the data processing module. The display screen is used to prompt and display the information during the working process of the identity information recognition module, the double-arm synchronous blood pressure measurement module, and the forearm compression ischemia module. The printer is started, printed and shut down under the control of the data processing module, and is used to print the result information of each module.

3. The automatic control system for non-invasive endothelial function assessment according to claim 1, characterized in that: The cuff air pressure control unit is used to receive signal feedback from the pressure sensor, and realizes the inflation, air pressure maintenance and rapid deflation of the forearm cuff by controlling the air inlet valve, the air exhaust valve and the air pump; under the control and regulation of the data processing module, the cuff air pressure control unit controls the air inlet valve and the air exhaust valve to open or close the corresponding air inlet channel and the air exhaust channel of the forearm cuff according to a preset program, and the air pump completes the inflation of the forearm cuff and maintains it at the maximum pressure value for a few minutes; the maximum pressure value is obtained by adding a preset fixed value to the basic value of the average systolic pressure of the right upper arm, and the right The average systolic blood pressure of the upper arm is obtained by taking the average of the systolic blood pressure of the right upper arm three times by the double-arm synchronous blood pressure measurement module; during the air pressure holding stage of the forearm cuff, the pressure in the forearm cuff is transmitted to the pressure sensor through the gas duct, and the built-in signal conditioning and A / D acquisition circuit of the cuff air pressure control unit completes the conditioning and real-time sampling of the pressure sensor signal. When the maximum pressure value is reached, the double-arm synchronous blood pressure measurement module obtains and processes the measurement data and displays it on the display panel of the electronic sphygmomanometer; after the air pressure holding stage ends, the cuff air pressure control unit controls the exhaust valve to open for rapid deflation.

4. The automatic control system for non-invasive endothelial function assessment according to claim 1, characterized in that: After the forearm cuff of the forearm compression ischemia module of the dual-arm synchronous blood pressure measurement module is quickly deflated, the control card immediately starts the electronic sphygmomanometer to perform three measurements after the ischemia test according to the preset program, and the camera 2 and the sphygmomanometer image recognition processing software unit obtain the image and recognize the value of each measurement result, and generate text information of each measurement result for the data processing module to call and calculate, and respectively obtain the diastolic pressure arm difference value of each measurement, the average diastolic pressure of the two upper arms and the arm difference value of the three measurements, and then compare them with the basic diastolic pressure average value and the arm difference value, and calculate the absolute value and change rate of the difference before and after ischemia.

5. A method for implementing non-invasive endothelial function assessment, using the automatic control system as described in claims 1-4, characterized in that: The following steps are involved: Step S1, tie cuffs for the subject as required, including double upper arm cuffs and forearm cuffs, place the identity card in the designated position, and then click the function key for starting detection on the display screen to put the system into automatic operation state; Step S2, the identity document information recognition and processing module starts working, takes a photo of the identity document and performs image recognition processing, and generates an identity information text list for subsequent data processing module to call; Step S3: After the identity information is successfully identified, the dual-arm synchronous blood pressure measurement module performs a set of blood pressure measurements under normal conditions according to a preset process under system control; Step S4: After the basic blood pressure measurement is completed, the washout period begins and the system counts down for 5 minutes; Step S5: After the 5-minute countdown is over, the forearm ischemia compression module, under the control and regulation of the data processing module, causes the subject's forearm to enter an ischemic state and maintains it for 5 minutes; Step S6: After the forearm ischemia test of the subject is completed, the dual-arm synchronous blood pressure measurement module performs three blood pressure measurements after the ischemia test according to a preset program under the control of the system; Step S7: The information display and printing module displays the blood pressure measurement results of step S3 and step S6, and reminds the staff on the display interface whether to save and print the measurement results or exit directly; Step S8: After the test is completed, the system enters a standby state, removes the cuff of the subject, and stores it or performs the next test.

6. A method for implementing non-invasive endothelial function assessment according to claim 5, characterized in that: In step S3, the dual-arm synchronous blood pressure measurement module performs blood pressure measurement under normal conditions according to a preset process under system control. The measurement process includes the following steps: Step S31, the control card of the dual-arm synchronous blood pressure measurement module starts the external electronic blood pressure meter according to the preset program, and performs a set of dual-arm synchronous blood pressure measurement checks in the order of countdown for 3 minutes - first blood pressure measurement - countdown for 1 minute - second blood pressure measurement - countdown for 1 minute - third blood pressure measurement, to obtain the blood pressure data of the subject in a normal state before forearm compression ischemia; Step S32: the data processing module issues an instruction to instruct the camera 1 to take a picture of the display panel of the external electronic sphygmomanometer, and sends the picture taking result to the sphygmomanometer image recognition processing software unit in real time for recognition and processing, so as to obtain the blood pressure measurement values ​​of both arms of the subject in the normal state before forearm compression ischemia for three times, and generate a text information list of the measurement results for subsequent data processing module to call; Step S33: The data processing module calls and calculates the blood pressure measurements of the two arms of the subject in the normal state three times before forearm compression ischemia, and obtains a set of average values ​​and inter-arm difference values ​​of blood pressure measurements; and for the right arm selected for compression test, the average systolic blood pressure SBP 右基 A fixed value between 30-50 mmHg is added as the maximum inflation pressure value and sent to the forearm compression ischemia module.

7. The method for implementing non-invasive endothelial function assessment according to claim 5, characterized in that: In step S5, the forearm compression ischemia module causes the subject's forearm to enter an ischemic state under the control and regulation of the data processing module. The process is as follows: Step S51: Under the control and regulation of the data processing module, the cuff air pressure control unit opens the air inlet channel and closes the air outlet channel of the forearm cuff through the electronic control valve according to a preset process, and the forearm cuff is inflated by the air pump to quickly reach the maximum inflation pressure value; Step S52, the cuff air pressure control unit closes the air inlet channel and the exhaust channel at the same time to maintain the maximum inflation pressure state, and continuously compresses the forearm for 5 minutes; during the air pressure maintenance stage of the forearm cuff, the pressure in the cuff is transmitted to the pressure sensor through the gas duct, and the signal conditioning and real-time sampling of the pressure sensor signal are completed by the built-in signal conditioning and A / D acquisition circuit of the cuff air pressure control unit, and the sampled data is processed and displayed; Step S53, after the air pressure holding stage ends, the cuff air pressure control unit controls the exhaust valve to open, and while the air is quickly deflated, the control center and the data processing module send the measurement command to the double-arm synchronous blood pressure measurement module.

8. The method for implementing non-invasive endothelial function assessment according to claim 5, characterized in that: In step S6, the dual-arm synchronous blood pressure measurement module performs blood pressure measurement after the forearm ischemia test according to a preset program under system control, and the process is as follows: Step S61, after receiving the measurement instruction sent by the control center and the data processing module, the double-arm synchronous blood pressure measurement module performs a set of double-arm synchronous blood pressure measurement checks in the order of immediately starting the sphygmomanometer to perform the first double-arm synchronous blood pressure measurement after the forearm ischemia test - countdown for 1 minute - second double-arm synchronous blood pressure measurement - countdown for 1 minute - third double-arm synchronous blood pressure measurement to obtain the blood pressure data after the forearm compression ischemia test; Step S62: The data processing module issues an instruction to instruct the camera 2 to take a picture of the display panel of the external electronic sphygmomanometer, and sends the picture taking result to the sphygmomanometer image recognition processing software unit in real time for recognition and processing, so as to obtain the blood pressure measurement values ​​of both arms after the forearm compression ischemia test for three times, and generate a text information list of the measurement results for subsequent data processing module to call; Step S63, the data processing module calls the two generated measurement result text information lists, compares the average diastolic blood pressure of the subjects before and after the forearm compression ischemia test with the inter-arm difference value, and obtains the absolute value and change rate of the diastolic blood pressure and the inter-arm difference value.

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