Composition containing pyrimethanil and fatty acid amide propyl-N, N-dimethylamine compound and application

Abstract

The invention relates to the field of pesticides, in particular to a composition of pyrimethanil and a fatty acid amide propyl-N, N-dimethylamine compound and application of the composition. Wherein the fatty acid amide propyl-N, N-dimethylamine compound is selected from one of cocamidopropyl dimethyl tertiary amine, caprylic capric amide propyl dimethyl tertiary amine and oleamide propyl dimethyl tertiary amine, and the fatty acid amide propyl-N, N-dimethylamine compound is selected from one of cocamidopropyl dimethyl tertiary amine, caprylic capric amide propyl dimethyl tertiary amine and oleamide propyl dimethyl tertiary amine. In the composition disclosed by the invention, the weight ratio of the pyrimethanil to the fatty acid amide propyl-N, N-dimethylamine compound is (10: 1)-(1: 10). The composition disclosed by the invention has an obvious synergistic effect and a relatively good prevention and treatment effect, the dosage is reduced, the cost is saved, and the safety to the environment is improved.

Description

Technical Field

[0001] The present invention relates to the field of pesticides, and in particular to a composition containing pyrimethanil and a fatty amide propyl-N,N-dimethylamine compound and application thereof. Background Art

[0002] The chemical name of pyrimethanil is N-(4,6-dimethylpyrimidin-2-yl)aniline, the common name in English is Pyrimethanil, the CAS registration number is [53112-28-0], and the trade name is Scala. The structural formula of pyrimethanil is as follows:

[0003] Pyrimethanil belongs to the anilinopyrimidine fungicide class. It has both protective and therapeutic effects and is one of the highly effective chemical agents for controlling gray mold in production. Reports on the mechanism of action of this drug are inconsistent. Milling et al. and Liu Changling believe that the drug may prevent infection by inhibiting the activity of the pathogen's hydrolase. Heye et al. believe that the drug can inhibit the growth of hyphae and germ tubes. It has a unique mechanism of action, which is to inhibit the secretion of pathogenic bacteria proteins, including reducing the level of some hydrolases, and is similar to the known broad-spectrum fungicides triazoles, dithiocarbamates, benzimidazoles, etc. Therefore, it has excellent activity against sensitive or resistant pathogens. It is suitable for grapes, fruit trees, vegetables, and ornamental plants to prevent and control various diseases such as gray mold, apple black spot, leaf spot, and peach gray spot.

[0004] Fatty amide propyl dimethyl tertiary amine is an important fine chemical intermediate. It can be used as an emollient, conditioner, lubricant, plastic injection molding and pesticide emulsification. It can also be prepared with brine solution and hydrochloric acid to form a gel acid liquid system for use in oil field acid fracturing production. It has a wide range of industrial application value and a large market demand.

[0005] Document 1: CN113651709A, 2021-11-16 discloses a fatty amide propyl dimethyl tertiary amine and its preparation method and application, wherein the fatty acid and N, N-dimethyl-1, 3-propylene diamine are subjected to amidation reaction and vacuum distillation to obtain the fatty amide propyl dimethyl tertiary amine. The fatty amide propyl dimethyl tertiary amine prepared by the present invention has good shear viscosity and is suitable for the field of oil field fracturing and production increase. When the fracturing fluid gel is used for oil field fracturing and production increase, it will be mixed with proppants such as quartz sand and pumped into the wellbore. If the shear viscosity is too low (less than 50mPa·s), the quartz sand is prone to sink rapidly and block the wellhead. The present invention can further improve the shear viscosity of the fracturing fluid gel by optimizing parameters such as the temperature of the amidation reaction, the molar ratio of fatty acid to N, N-dimethyl-1, 3-propylene diamine, the vacuum distillation temperature, and the vacuum distillation time, which is more suitable for application in the field of oil field fracturing and production increase.

[0006] Document 2: Cross-linked rheological properties of high-temperature resistant fracturing fluids modified with oleamidopropyl dimethyl tertiary amine (Wei Ping et al., Oilfield Chemistry, Vol. 37, No. 4, pp. 642-648) discloses that in order to obtain a new system of thickeners for high-temperature resistant fracturing fluids, oleamidopropyl dimethyl tertiary amine was used to hydrophobically modify hydroxypropyl guar (HPG) to obtain a new type of hydrophobically modified high-temperature resistant and shear-resistant thickener (O-HPG). Using epichlorohydrin as an intermediate carrier, oleamide long chains were linked to the active hydroxyl groups of hydroxypropyl guar molecules to obtain a new type of high-temperature resistant hydrophobically modified hydroxypropyl guar O-HPG. The gel formed by the cross-linking of the modified O-HPG has stronger elasticity and a tighter structure because the hydrophobic long chains can associate with each other. The gel formed by 0.6% O-HPG base fluid is at 200°C and a shear rate of 100s -1 The retained viscosity of hydroxypropyl guar gum HPG after shearing for 1.5 hours under the same conditions was greater than 80 mPa·s, while the shear retained viscosity of hydroxypropyl guar gum HPG dropped sharply to 1 mPa·s under the same conditions. The modified O-HPG has better high temperature and shear resistance, and the system is easy to break.

[0007] Document 3: CN114736663A, 2022-07-12 disclosed that the present invention discloses a bactericidal foam draining agent with corrosion inhibition function and a preparation method thereof, which solves the problem that the foaming agent and the bactericide in the prior art are incompatible, and affect each other's foaming and bactericidal effects, resulting in the two agents having to be added at different times, and there are technical problems such as large amount of agent addition and high cost. The bactericidal foam draining agent includes the following raw materials in parts by weight: 15-30 parts of cocamidopropyl dimethyl tertiary amine; 10-25 parts of lauryl amide propyl dimethyl tertiary amine; 10-20 parts of hydrogen peroxide; 10-15 parts of benzalkonium bromide; 5-15 parts of glutaraldehyde; 5-15 parts of pyridine quaternary ammonium salt; 10-37 parts of water. The bactericidal foam drainage agent with corrosion inhibition function provided by the present invention can play the role of foam drainage agent and bactericide at the same time when used, and also has the advantages of small filling amount, low cost, low labor intensity of on-site construction, convenient construction, high construction efficiency and good chemical stability and thermal stability.

[0008] Document 4: CN113292553A, 2021-08-24 discloses an aromatic thiazole-tryptamine compound and a combination agent for killing algae of Skeletonella ribes, which discloses that octanamide propyl dimethyl tertiary amine can be used as a non-ionic surfactant.

[0009] Those skilled in the art know that in the field of pesticides, the combination of two active ingredients may result in addition, synergistic enhancement or antagonism, and whether synergistic enhancement can be achieved is unpredictable. After searching, there is no report in the prior art that a fatty amide propyl-N, N-dimethylamine compound composition can be used as an active ingredient to prevent and treat plant diseases, and there is no literature report on the synergistic effect of a composition of pyrimethanil and fatty amide propyl-N, N-dimethylamine compounds on related plant diseases. After long-term research, the applicant found that the composition of pyrimethanil and fatty amide propyl-N, N-dimethylamine compounds has a good synergistic effect, which can reduce the dosage, reduce environmental risks, and delay the development of drug resistance. Summary of the invention

[0010] The object of the present invention is to provide a pesticide composition with synergistic synergy. In order to achieve the object of the present invention, the present invention provides a pesticide composition, comprising pyrimethanil and a fatty amide propyl-N,N-dimethylamine compound composition, wherein the fatty amide propyl-N,N-dimethylamine compound is selected from one of cocoamidopropyl dimethyl tertiary amine, caprylic amide propyl dimethyl tertiary amine and oleic acid amide propyl dimethyl tertiary amine.

[0011] The present invention also provides a pesticide preparation, comprising pyrimethanil, a fatty amide propyl-N,N-dimethylamine compound and a suitable pesticide adjuvant, wherein the fatty amide propyl-N,N-dimethylamine compound is selected from one of cocoamidopropyl dimethyl tertiary amine, caprylic amide propyl dimethyl tertiary amine and oleic acid amide propyl dimethyl tertiary amine.

[0012] The present invention also provides the use of the above pesticide composition and pesticide preparation for preventing and controlling various diseases on crops.

[0013] Beneficial effects of the present invention:

[0014] 1. The compound of pyrimethanil and fatty amide propyl-N,N-dimethylamine compound of the present invention has a significant synergistic effect.

[0015] 2. The action mechanisms of pyrimethanil and fatty amide propyl-N,N-dimethylamine compounds in the composition of the present invention are different, which can better delay the development of disease resistance and prolong the use time of pesticides. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 Results of toxicity test of different concentrations of pyrimethanil on Botrytis cinerea

[0017] Figure 2 Results of toxicity test of different concentrations of cocamidopropyl dimethyl tertiary amine on grape gray mold

[0018] Figure 3The results of the toxicity test of pyrimethanil:cocamidopropyl dimethyl tertiary amine = 1:9 against Botrytis cinerea

[0019] Figure 4 The results of toxicity test of pyrimethanil:cocamidopropyl dimethyl tertiary amine = 3:7 against Botrytis cinerea

[0020] Figure 5 The results of the toxicity test of pyrimethanil:cocamidopropyl dimethyl tertiary amine = 1:1 against Botrytis cinerea

[0021] Figure 6 The results of toxicity test of pyrimethanil:cocamidopropyl dimethyl tertiary amine = 7:3 against Botrytis cinerea

[0022] Figure 7 The results of the toxicity test of pyrimethanil:cocamidopropyl dimethyl tertiary amine = 9:1 on Botrytis cinerea

[0023] Figure 8 The results of toxicity test of different concentrations of octyl decylamide propyl dimethyl tertiary amine on grape gray mold

[0024] Fig. 9 The results of toxicity test of pyrimethanil:octyl decanoyl propyl dimethyl tertiary amine = 1:9 against Botrytis cinerea

[0025] Fig.10 The results of toxicity test of pyrimethanil:octyl decanoyl propyl dimethyl tertiary amine = 3:7 against Botrytis cinerea

[0026] Fig.11 The results of toxicity test of pyrimethanil:octyl decanoyl propyl dimethyl tertiary amine = 1:1 against Botrytis cinerea

[0027] Fig.12 The results of toxicity test of pyrimethanil:octyl decanoyl propyl dimethyl tertiary amine = 7:3 against Botrytis cinerea

[0028] Fig.13 The results of toxicity test of pyrimethanil:octyl decanoyl propyl dimethyl tertiary amine = 9:1 against Botrytis cinerea

[0029] Fig.14 Results of toxicity test of different concentrations of oleamidopropyl dimethyl tertiary amine on Botrytis cinerea

[0030] Fig.15 The results of toxicity test of pyrimethanil:oleamidopropyl dimethyl tertiary amine = 1:9 against Botrytis cinerea

[0031] Fig.16 The results of toxicity test of pyrimethanil:oleamidopropyl dimethyl tertiary amine = 3:7 against Botrytis cinerea

[0032] Fig.17 The results of toxicity test of pyrimethanil:oleamidopropyl dimethyl tertiary amine = 1:1 against Botrytis cinerea

[0033] Fig.18 Results of toxicity test of pyrimethanil:oleamidopropyl dimethyl tertiary amine = 7:3 against Botrytis cinerea

[0034] Fig.19 The results of toxicity test of pyrimethanil:oleamidopropyl dimethyl tertiary amine = 9:1 against Botrytis cinerea DETAILED DESCRIPTION

[0035] To make the purpose, technical scheme and advantages of the embodiments of the present invention clearer, the technical scheme in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments in the present invention, all other embodiments obtained by ordinary technicians in the field without creative work are within the scope of protection of the present invention. In addition, in order to better illustrate the present invention, numerous specific details are given in the specific embodiments below. It should be understood by those skilled in the art that the present invention can be implemented without certain specific details. In certain embodiments, raw materials, auxiliary agents, methods, means, etc. known to those skilled in the art are not described in detail to highlight the main idea of ​​the present invention.

[0036] Unless otherwise expressly stated, throughout the specification and claims, the term "comprise" or its variations such as "include" or "comprising", "containing", etc. will be understood to include the stated active ingredients or components but not to exclude other active ingredients or other components.

[0037] Specifically, the present invention provides a composition containing pyrimethanil and a fatty amide propyl-N,N-dimethylamine compound, wherein the fatty amide propyl-N,N-dimethylamine compound is selected from one of cocoamidopropyl dimethyl tertiary amine, caprylic amide propyl dimethyl tertiary amine and oleic acid amide propyl dimethyl tertiary amine.

[0038] In some preferred embodiments, the weight ratio of pyrimethanil to the fatty amide propyl-N,N-dimethylamine compound is 1:10-10:1, preferably 1:9-9:1, particularly preferably 1:9, 3:7, 1:1, 7:3 or 9:1.

[0039] Preferably, in the above composition, the fatty amide propyl-N,N-dimethylamine compound is selected from one of octyl decyl amide propyl dimethyl tertiary amine and cocoamide propyl dimethyl tertiary amine.

[0040] The present invention also provides a pesticide preparation, which comprises the composition of the present invention and a suitable pesticide adjuvant. Preferably, the pesticide preparation of the present invention can be made into a suitable dosage form, and the dosage form is one of a suspension, a wettable powder or a water dispersible granule. In the pesticide preparation, the pyrimethanil and the fatty amide propyl-N,N-dimethylamine compound account for 1%-95% of the total weight of the preparation, preferably 0.5%-60%.

[0041] Furthermore, the above pesticide preparation can be prepared into a suitable dosage form, which is a suspension, a wettable powder or a water dispersible granule.

[0042] The auxiliary agent mentioned above includes one or more of a dispersant, a wetting agent, an antifreeze agent, a stabilizer, a preservative, a thickener, a binder, a defoaming agent, an acid regulating medium and a solid inert carrier.

[0043] Optionally, the dispersant is selected from one or more of alkylnaphthalene sulfonates, alkylbenzene sulfonate calcium salts, bis(alkyl)naphthalene sulfonate formaldehyde condensates, naphthalenesulfonic acid formaldehyde condensates, naphthalenesulfonic acid formaldehyde condensates sodium salts, alkylphenol polyoxyethylene ethers, arylphenol polyoxyethylene succinate sulfonates, octylphenol polyoxyethylene ether sulfates, polycarboxylates, lignin sulfonic acid sodium salts, alkylphenol polyoxyethylene ether formaldehyde condensate sulfates, fatty acid polyoxyethylene esters and fatty acid polyoxyethylene ethers, preferably one or more of arylphenol polyoxyethylene succinate sulfonates, naphthalenesulfonic acid formaldehyde condensates sodium salts, polycarboxylates and lignin sulfonic acid sodium salts.

[0044] Optionally, the wetting agent is selected from one or more of Lakai powder BX, sodium dodecyl sulfate, sodium dodecylbenzene sulfonate, Nongru 2000# series, isomeric alcohol polyoxyethylene ether, and saponin powder. Preferably, the wetting agent is selected from one or more of Lakai powder BX, sodium dodecyl sulfate, sodium dodecylbenzene sulfonate, and dioctyl sodium sulfonate.

[0045] Optionally, the antifreeze agent may be one or more of ethylene glycol, 1,2-propylene glycol, glycerol and urea, preferably ethylene glycol.

[0046] Optionally, the binder may be one or more of starch, gypsum, glucose, polyvinyl alcohol, gum arabic and dextrin, preferably one or more of glucose, starch and polyvinyl alcohol.

[0047] Optionally, the thickener may be one or more of magnesium aluminum silicate, xanthan gum, polyethylene glycol, polyvinyl alcohol, carboxymethyl cellulose and phenolic resin, preferably one or more of magnesium aluminum silicate and xanthan gum.

[0048] Optionally, the solid inert carrier may be one or more of clay, white carbon black, diatomaceous earth, kaolin, attapulgite, montmorillonite, bentonite, talc and light calcium carbonate, preferably one or more of white carbon black, diatomaceous earth and kaolin.

[0049] Optionally, the defoaming agent is selected from silicone, C 8-10 Fatty alcohol, C 10-20 Saturated fatty acids (such as capric acid) and one or more of amides, silicone oils and silicone compounds. Silicone defoamers are preferred.

[0050] Optionally, the acid-adjusting medium is selected from one or more of ammonium sulfate, ammonium nitrate, ammonium chloride, hydrochloric acid, citric acid, and acetic acid, preferably citric acid and acetic acid.

[0051] Optionally, the preservative is selected from sodium benzoate. The stabilizer may be a substance commonly used in the art, which is well known to those skilled in the art and will not be described in detail herein.

[0052] In the present invention, there is no special requirement for the preparation method of various dosage forms, and various methods known in the art can be used, which will not be described in detail here.

[0053] The present invention also provides the use of the above composition and / or a pesticide preparation containing the composition in preventing and controlling crop diseases.

[0054] Preferably, the crop diseases are grape gray mold, strawberry gray mold, strawberry wilt, tomato gray mold, tomato wilt, pepper gray mold, pepper wilt, cucumber gray mold, cucumber wilt, tobacco gray mold, apple scab, apple leaf spot, pear scab, and pear leaf spot.

[0055] The pesticide preparation of the present invention can be diluted according to actual needs when used in practice.

[0056] The following examples further illustrate the present invention, but should not be construed as limiting the present invention.

[0057] The pesticide composition of the embodiment of the present invention can be provided in the form of a finished product, that is, the components in the composition have been mixed; or it can be provided in the form of a separate preparation of each component, which can be mixed evenly before use.

[0058] I. Preparation Example

[0059] Example 1

[0060] Preparation of 9% pyrimethanil·21% cocamidopropyl dimethyl tertiary amine suspension

[0061] The distribution ratio of each component is 9% pyrimethanil, 21% cocamidopropyl dimethyl tertiary amine, 4% naphthalenesulfonic acid formaldehyde condensate sodium salt, 2% sodium lauryl sulfate, 4% ethylene glycol, 0.2% xanthan gum, 0.5% magnesium aluminum silicate, 2% acetic acid, 0.2% sodium benzoate, 0.2% silicone defoamer, and water is used to make up the balance. The mixture is mixed evenly and ground to obtain the product.

[0062] Example 2

[0063] Preparation of 10% pyrimethanil·10% cocamidopropyl dimethyl tertiary amine wettable powder

[0064] The distribution ratio of each component is 10% pyrimethanil, 10% cocamidopropyl dimethyl tertiary amine, 6% sodium lignin sulfonate, 4% sodium dioctyl sulfosuccinate, 6% white carbon black, 2% citric acid, 0.1% organosilicon defoamer, and diatomaceous earth is used to make up the balance. The mixture is evenly mixed and crushed to obtain the product.

[0065] Example 3

[0066] Preparation of 36% pyrimethanil·4% cocamidopropyl dimethyl tertiary amine water dispersible granules

[0067] The components are distributed in a ratio of 36% pyrimethanil, 4% cocamidopropyl dimethyl tertiary amine, 5% polycarboxylate, 5% sodium lignin sulfonate, 3% pull open powder BX, 10% glucose, 4% white carbon black, 0.5% citric acid, 0.2% organosilicon defoamer, and diatomaceous earth as the balance. The components are mixed evenly, and the product is obtained after crushing, granulating and drying.

[0068] Example 4

[0069] Preparation of 2% pyrimethanil·18% octyl decanoyl propyl dimethyl tertiary amine suspension

[0070] The distribution ratio of each component is 2% pyrimethanil, 18% octyl decanoyl propyl dimethyl tertiary amine, 5% naphthalenesulfonic acid formaldehyde condensate sodium salt, 3% dioctyl sodium sulfosuccinate, 4% ethylene glycol, 0.25% xanthan gum, 1% magnesium aluminum silicate, 2% acetic acid, 0.25% sodium benzoate, 0.2% silicone defoamer, and water is used to make up the balance. The mixture is mixed evenly and ground to obtain the product.

[0071] Example 5

[0072] Preparation of 25% pyrimethanil·5% octyl decanoyl propyl dimethyl tertiary amine wettable powder

[0073] The distribution ratio of each group is 25% pyrimethanil, 5% octanamide propyl dimethyl tertiary amine, 5% naphthalenesulfonic acid formaldehyde condensate sodium salt, 5% pull open powder BX, 5% white carbon black, 1.2% citric acid, 0.1% silicone defoamer, and kaolin is used to make up the balance. The mixture is mixed evenly and crushed to obtain the product.

[0074] Example 6

[0075] Preparation of 15% pyrimethanil·15% octyl decanoyl propyl dimethyl tertiary amine water dispersible granules

[0076] The components are distributed in a ratio of 15% pyrimethanil, 15% octyl decanoic acid propyl dimethyl tertiary amine, 8% sodium lignin sulfonate, 5% sodium lauryl sulfate, 1% polyvinyl alcohol, 8% white carbon black, 2% citric acid, 0.2% organosilicon defoaming agent, and diatomaceous earth as the balance. The components are mixed evenly, and the product is obtained after crushing, granulating and drying.

[0077] Example 7

[0078] Preparation of 12.5% ​​pyrimethanil·12.5% ​​oleamidopropyl dimethyl tertiary amine suspension

[0079] The distribution ratio of each group is 12.5% ​​pyrimethanil, 12.5% ​​oleamidopropyl dimethyl tertiary amine, 4% polycarboxylate, 2% sodium dioctyl sulfosuccinate, 4% ethylene glycol, 0.2% xanthan gum, 1% magnesium aluminum silicate, 1.5% acetic acid, 0.2% sodium benzoate, 0.2% silicone defoamer, and water is used to make up the balance. The mixture is mixed evenly and ground to obtain the product.

[0080] Example 8

[0081] Preparation of 15% pyrimethanil·15% oleamidopropyl dimethyl tertiary amine wettable powder

[0082] The components are distributed in a ratio of 15% pyrimethanil, 15% oleamidopropyl dimethyl tertiary amine, 6% sodium lignin sulfonate, 3% sodium dioctyl sulfosuccinate, 8% white carbon black, 1.5% citric acid, 0.1% organosilicon defoamer, and diatomaceous earth as the balance. The components are mixed evenly and crushed to obtain the product.

[0083] Example 9

[0084] Preparation of 5% pyrimethanil·5% oleamidopropyl dimethyl tertiary amine water dispersible granules

[0085] The components are distributed in a ratio of 5% pyrimethanil, 5% oleamidopropyl dimethyl tertiary amine, 5% sodium lignin sulfonate, 2% polycarboxylate, 4% BX powder, 5% starch, 5% white carbon black, 1% citric acid, 0.1% organosilicon defoamer, and the balance is made up of kaolin. The components are mixed evenly, and the product is obtained after crushing, granulating, and drying.

[0086] II. Bioassay Example

[0087] 1 Materials and methods

[0088] 1.1 Test strains, reagents and culture media, etc.

[0089] Test strain: Botrytis cinerea (preserved in the laboratory).

[0090] Test equipment: clean bench, autoclave, incubator, etc.

[0091] Test reagents: 98% pyrimethanil technical drug (preserved in the laboratory), cocamidopropyl dimethyl tertiary amine, caprylic decanoic propyl dimethyl tertiary amine and oleic acid amide propyl dimethyl tertiary amine;

[0092] PDA medium: 3.0g potato powder, 14.0g glucose, 18.0g agar, 1L deionized water, mix well and sterilize at high temperature for later use;

[0093] 1.2 Test methods

[0094] The mycelium growth rate method was used to detect the effect of single and compound agents on the growth of pathogens. The different concentration gradients (5 gradients for each ratio) of single agents of pyrimethanil and three kinds of fatty amide propyl dimethyl tertiary amine antibacterial active substances and compound agents in various proportions on Botrytis cinerea were determined through preliminary experiments. Pyrimethanil and three kinds of fatty amide propyl dimethyl tertiary amine antibacterial active substances were pre-configured into five different ratios of mother liquor of 9:1, 7:3, 1:1, 3:7 and 1:9. The mother liquors of different concentrations were mixed with PDA to prepare a culture medium with a final concentration of the concentration gradient corresponding to each ratio (the specific concentration gradient is summarized in the original data). The Botrytis cinerea cake with a diameter of 5 mm was inoculated on the above-mentioned drug-containing PDA culture medium plate and cultured at 25°C for 4 days. There were 3 culture dishes for each concentration, and the experiment was repeated twice. The inhibition rate and EC of different concentrations of agents on the growth of Botrytis cinerea hyphae were calculated. 50 .

[0095] 1.3 Statistical and analytical methods

[0096] SPSS20 was used to analyze the data and calculate the regression equation, correlation coefficient r and EC 50 The Wadley method was used to evaluate the synergistic effect. When the synergistic coefficient SR>1.5, it was a synergistic effect, 0.5≤SR≤1.5 was an additive effect, and SR<0.5 was antagonistic.

[0097]

[0098] Wherein: the diameter of the inoculated cake is 5 mm here.

[0099]

[0100] In the formula: A and B represent two agents respectively, a and b represent the proportion of the two agents in the mixture respectively, obs is the measured value, and EXP is the theoretical value.

[0101] 2 Test results Table 1 Indoor toxicity test of pyrimethanil, cocamidopropyl dimethyl tertiary amine and the combination against Botrytis cinerea

[0102]

[0103]

[0104] Table 2 Indoor toxicity test of pyrimethanil, octyl decanoyl propyl dimethyl tertiary amine and combination to Botrytis cinerea

[0105]

[0106]

[0107] Table 3 Indoor toxicity test of pyrimethanil, oleamidopropyl dimethyl tertiary amine and the combination against Botrytis cinerea

[0108]

[0109] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some of the technical features therein. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A composition, characterized in that The invention contains pyrimethanil and a fatty amide propyl-N,N-dimethylamine compound, wherein the fatty amide propyl-N,N-dimethylamine compound is selected from one of cocoamidopropyl dimethyl tertiary amine, caprylic amide propyl dimethyl tertiary amine and oleic acid amide propyl dimethyl tertiary amine.

2. The composition according to claim 1, characterized in that The weight ratio of pyrimethanil to the fatty amide propyl-N,N-dimethylamine compound is 1:10-10:1, preferably 1:9-9:1, and particularly preferably 1:9, 3:7, 1:1, 7:3 or 9:

1.

3. The composition according to claim 1 or 2, characterized in that The fatty amide propyl-N,N-dimethylamine compound is selected from one of octyl decyl amide propyl dimethyl tertiary amine and cocoamidopropyl dimethyl tertiary amine.

4. A pesticide preparation, characterized in that: The invention comprises the composition according to any one of claims 1 to 3 and a suitable pesticide adjuvant.

5. The composition preparation according to claim 4, characterized in that: The composition can be prepared into a suitable dosage form, which is a suspension, a wettable powder or a water dispersible granule.

6. The bactericidal composition preparation according to claim 4 or 5, characterized in that: The pyrimethanil and fatty amide propyl-N,N-dimethylamine compounds account for 1%-95% of the total weight of the preparation, preferably 0.5%-60%.

7. Use of the composition according to any one of claims 1 to 3 and / or the preparation according to any one of claims 4 to 6 in preventing and controlling crop diseases.

8. The use according to claim 7, wherein the crops are grapes, strawberries, tomatoes, peppers, eggplants, cucumbers, tobacco, apple trees, pear trees, etc.

9. The use according to claim 7, characterized in that: The crop diseases are gray mold, wilt, black spot, leaf spot and the like.

Images