Filling device and method for neutral peritoneal dialysis solution

Abstract

The invention relates to a neutral peritoneal dialysis solution filling device and method, and relates to the technical field of liquid filling. According to the filling device provided by the invention, the inert gas protection pipeline provided with the inflation sleeve can ensure that inert protection gas is continuously sprayed out in the filling process, a continuous inert gas protection area is formed, and air near a neutral peritoneal dialysis solution packaging bag is blown away; the situation that air is mixed into a filling area due to dissipation of inert gas protective atmosphere, and then the stability of the neutral peritoneal dialysis solution is affected is avoided. Meanwhile, according to the filling method provided by the invention, by limiting the flow speed of the inert gas in the gas pipeline, it can be guaranteed that the flow speed of the gas is gradually reduced along with the liquid filling degree in the filling process, then liquid splashing caused by the fact that the inert gas blows the filling liquid is avoided, and dialysate pollution caused by the splashed liquid is avoided.

Description

Technical Field

[0001] The invention relates to the technical field of liquid filling, and in particular to a filling device and method for neutral peritoneal dialysis fluid. Background Art

[0002] The double-chamber structure of the neutral peritoneal dialysis fluid packaging bag is obtained by dividing the single-chamber packaging bag through the virtual welding technology. This double-chamber structure packaging bag can prevent the neutral peritoneal dialysis fluid from chemical and physical reactions during storage. At the same time, during use, the solution can be squeezed to break through the virtual welding position to complete the dispensing, avoiding the secondary contamination that may exist in the conventional dispensing process, and effectively ensuring the safety of patients' medication.

[0003] During the filling process of neutral peritoneal dialysis fluid, oxygen and carbon dioxide in the air will directly affect the stability of the peritoneal dialysis fluid. Therefore, inert gas protection is required during the filling process of neutral peritoneal dialysis fluid. At present, commercial filling devices use inert gas protection and liquid filling in steps. Generally, the packaging bag is first transported to the filling position by the production line conveyor belt, and then the filling environment is treated with inert gas before filling. During this process, the protective atmosphere formed by the inert gas will partially dissipate, and air will enter the filling position, which will eventually affect the stability of the peritoneal dialysis fluid. How to solve the problem that the inert gas protective atmosphere cannot continue to exist during the filling process has become a technical problem that needs to be urgently solved in the field of liquid filling technology. Summary of the invention

[0004] In order to provide a method for filling neutral peritoneal dialysis fluid with a continuous inert gas protective atmosphere,

[0005] The invention provides a filling device and method for neutral peritoneal dialysis fluid.

[0006] The present invention provides a filling device for neutral peritoneal dialysis fluid, which adopts the following technical solution:

[0007] A filling device for neutral peritoneal dialysis fluid, comprising a first liquid tank, a second liquid tank, a gas pipeline 22, an inert gas protection gas circuit 31 and a lifting assembly;

[0008] The first liquid tank is connected with a first liquid filling head 111, and the second liquid tank is connected with a second liquid filling head 112. The liquid inlet end of the first liquid filling head 111 is provided with a first liquid control valve 121, and the liquid inlet end of the second liquid filling head 112 is provided with a second liquid control valve 122; the gas outlet end of the gas pipeline 22 is respectively connected with a first gas filling head 211 and a second gas filling head 212, the first liquid filling head 111 and the first gas filling head 211 are arranged adjacent to each other and are both used to communicate with the packaging bag A chamber 511, the second liquid filling head 112 and the second gas filling head 212 are arranged adjacent to each other and are both used to communicate with the packaging bag B chamber 512; the gas pipeline 22 is used to supply gas to the packaging bag A chamber 511 and the packaging bag B chamber 512 or to evacuate the packaging bag A chamber 511 and the packaging bag B chamber 512, and the gas pipeline 22 is provided with a gas circuit control valve;

[0009] The lifting assembly is connected to the first liquid filling head 111, the second liquid filling head 112, the first gas filling head 211 and the second gas filling head 212, and is used to synchronously drive the first liquid filling head 111, the second liquid filling head 112, the first gas filling head 211 and the second gas filling head 212 to move up and down to approach or move away from the packaging bag;

[0010] At least one inflatable sleeve is provided at the gas outlet end of the inert gas protection gas circuit 31, and the inflatable sleeve is used to spray inert protection gas to form an inert gas protection atmosphere around the packaging bag.

[0011] The present invention can ensure that the inert gas protection gas is continuously sprayed during the filling process by providing an inert gas protection gas circuit with an inflation sleeve, forming a continuous inert gas protection area, blowing away the air near the neutral peritoneal dialysis fluid packaging bag, and avoiding the air caused by the dissipation of the inert gas protection atmosphere from mixing into the filling area, thereby affecting the stability of the neutral peritoneal dialysis fluid.

[0012] Optionally, two inflatable sleeves are provided at the gas outlet end of the inert gas protection gas circuit 31, and the two inflatable sleeves extend to the upper and lower sides of the packaging bag in a one-to-one correspondence.

[0013] The present invention can ensure that air is contained near the packaging bag under the protection of the inert gas protective atmosphere by limiting the inert gas protective gas circuit and arranging two inflatable sleeves.

[0014] Optionally, the gas pipeline 22 is provided with a vacuum pipeline 231 at the air inlet end for evacuating the gas pipeline 22 and an inert gas pipeline 232 for supplying inert gas to the gas pipeline 22; the gas circuit control valve includes a vacuum control valve 24 and an inert gas control valve 25 arranged on the gas pipeline 22.

[0015] The present invention can separate the vacuuming process and the inert gas filling process by limiting the gas pipeline to be divided into a vacuum pipeline and an inert gas pipeline, thereby avoiding replacement of the vacuum pump or the inert gas container connected to the gas inlet of the gas pipeline during use.

[0016] Optionally, the filling device for the neutral peritoneal dialysis fluid further includes a controller 41 , and the controller 41 is electrically connected to the first liquid control valve 121 , the second liquid control valve 122 , the vacuum control valve 24 , and the inert gas control valve 25 .

[0017] The present invention connects the controller with the first liquid control valve, the second liquid control valve, the vacuum control valve and the inert gas control valve through electrical connection, so that the opening and closing of the valves can be controlled by the controller during the filling process.

[0018] Optionally, the liquid outlet of the first liquid filling head 111 is lower than the gas outlet of the first gas filling head 211 , and the liquid outlet of the second gas filling head 212 is lower than the gas outlet of the second liquid filling head 112 .

[0019] The present invention limits the liquid outlet of the first liquid filling head 111 to be lower than the gas outlet of the first gas filling head 211, and the liquid outlet of the second gas filling head 212 to be lower than the gas outlet of the second liquid filling head 112, so as to ensure that the gas ejected from the gas outlet during the filling process maintains an inert gas atmosphere near the liquid outlet, thereby further avoiding the influence of air on the stability of the neutral peritoneal dialysis fluid.

[0020] Optionally, the filling device for neutral peritoneal dialysis fluid also includes a first detector 421 and a second detector 422, wherein the first detector 421 is arranged between the first liquid filling head 111 and the first gas filling head 211, and the second detector 422 is arranged between the second liquid filling head 112 and the second gas filling head 212, and the first detector 421 and the second detector 422 both include a dissolved oxygen content detector and a pH detector, and the dissolved oxygen content detector and the pH detector are both electrically connected to the controller 41.

[0021] The present invention can detect the parameters of the filling liquid during the filling process through the detector, timely detect the contamination occurring during the filling process, and effectively ensure the safety of the patient's medication.

[0022] Optionally, the filling device for the neutral peritoneal dialysis fluid further comprises a conveying line for supporting and conveying the packaging belt, and the conveying line is located below the lifting assembly.

[0023] The present invention can realize the automation of filling by arranging a movable assembly line.

[0024] The present invention also provides a method for filling a neutral peritoneal dialysis fluid, comprising the following steps:

[0025] (1) Close the first liquid control valve, the second liquid control valve and the gas circuit control valve, and open the inert gas protection pipeline; the first liquid filling head, the second liquid filling head, the first gas filling head and the second gas filling head are driven by the lifting assembly to move downward to the filling position, at which time the first liquid filling head and the first gas filling head are inserted into the packaging bag chamber A, and the second liquid filling head and the second gas filling head are inserted into the packaging bag chamber B;

[0026] (2) Open the gas control valve, evacuate the packaging bag, open the first liquid control valve and the second liquid control valve, and use the gas pipeline to supply inert gas to fill liquid and gas into packaging bag chamber A and packaging bag chamber B;

[0027] (3) After filling is completed, close the first liquid control valve and the second liquid control valve, and then evacuate the packaging bag chamber A and the packaging bag chamber B;

[0028] (4) When there is no gas in the packaging bag, stop vacuuming and use the gas pipeline to supply inert gas to fill the packaging bag A and the packaging bag B with inert gas until no more gas can be added, and close the gas circuit control valve;

[0029] (5) The lifting assembly drives the first liquid filling head, the second liquid filling head, the first gas filling head and the second gas filling head to move up and detach from the packaging bag, completing the filling operation.

[0030] When the filling device is started, the inert gas protection pipeline is in an open state, and the inert gas is continuously ejected through the inflation sleeve to form a continuous inert gas protection area, so as to blow away the air near the neutral peritoneal dialysis fluid packaging bag, thereby preventing the air caused by the dissipation of the inert gas protection atmosphere from mixing into the filling area, thereby affecting the stability of the neutral peritoneal dialysis fluid.

[0031] Optionally, in step (2), S2 is the filling flow rate of the first liquid filling head, S2 = 2-4 L / min, and the filling flow rate of the second liquid filling head is Wherein V1 is the volume of the neutral peritoneal permeable fluid packaging bag A, the unit is L, V2 is the volume of the neutral peritoneal permeable fluid packaging bag B, the unit is L, wherein S3 is L / min, and the flow rate of the inert gas in the gas pipeline is The unit of S1 is L / min, S is a constant, S=2-3L / min, and T is the completed filling time, in min.

[0032] The present invention limits the flow rate of the inert gas in the gas pipeline, thereby ensuring that during the filling process, the gas flow rate gradually decreases with the liquid filling degree, thereby avoiding liquid splashing caused by the inert gas blowing the filling liquid, and thus avoiding dialysate contamination caused by the splashing liquid.

[0033] Optionally, the vacuuming and filling with inert gas operations in steps (3) and (4) are repeated three times.

[0034] The invention ensures that only inert gas exists in the neutral peritoneal dialysis fluid packaging bag by multiple vacuuming and filling with inert gas, thereby further ensuring the stability of the neutral peritoneal dialysis fluid.

[0035] Optionally, the flow rate of the inert gas in step (4) is 0.5-1 L / min.

[0036] The present invention limits the flow rate of the inert gas filled during filling, thereby avoiding liquid splashing caused by the inert gas blowing the filling liquid, and further avoiding dialysate contamination caused by the splashing liquid.

[0037] In summary, the present invention includes at least one of the following beneficial technical effects:

[0038] 1. The filling device provided by the present invention can ensure that the inert protective gas is continuously sprayed during the filling process by means of an inert gas protection pipeline provided with an inflatable sleeve, thereby forming a continuous inert gas protection area, blowing away the air near the neutral peritoneal dialysis fluid packaging bag, and preventing the air from mixing into the filling area due to the dissipation of the inert gas protection atmosphere, thereby affecting the stability of the neutral peritoneal dialysis fluid;

[0039] 2. The filling method provided by the present invention makes the inert gas protection pipeline in an open state when starting, so that the inert gas is continuously ejected through the inflation sleeve to form a continuous inert gas protection area, and the air near the neutral peritoneal dialysis fluid packaging bag is blown away, so as to avoid the air caused by the dissipation of the inert gas protection atmosphere from mixing into the filling area, thereby affecting the stability of the neutral peritoneal dialysis fluid;

[0040] 3. The filling method provided by the present invention can ensure that during the filling process, the gas flow rate gradually decreases with the liquid filling degree by limiting the flow rate of the inert gas in the gas pipeline, thereby avoiding liquid splashing caused by the inert gas blowing the filling liquid, and thus avoiding dialysate contamination caused by the splashing liquid. BRIEF DESCRIPTION OF THE DRAWINGS

[0041] Figure 1 It is a schematic diagram of the structure of the filling device of the neutral peritoneal dialysis fluid according to Example 6 of the present invention.

[0042] In the figure, 111, the first liquid filling head; 112, the second liquid filling head; 121, the first liquid control valve; 122, the second liquid control valve; 211, the first gas filling head; 212, the second gas filling head; 22, the gas pipeline; 231, the vacuum pipeline; 232, the inert gas pipeline; 24, the vacuum control valve; 25, the inert gas control valve; 31, the inert gas protection gas circuit; 321, the inflation sleeve; 322, the inflation sleeve; 41, the controller; 421, the first detector; 422, the second detector; 511, the packaging bag chamber A; 512, the packaging bag chamber B. DETAILED DESCRIPTION

[0043] In order to make the purpose, technical solution and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with the embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0044] In order to better illustrate the present invention, further examples are given below. Embodiment 1:

[0045] A filling device for neutral peritoneal dialysis fluid, comprising a first liquid tank, a second liquid tank, a gas pipeline 22, an inert gas protection gas circuit 31 and a lifting assembly;

[0046] The first liquid tank is connected with a first liquid filling head 111, the second liquid tank is connected with a second liquid filling head 112, the liquid inlet end of the first liquid filling head is provided with a first liquid control valve 121, and the liquid inlet end of the second liquid filling head is provided with a second liquid control valve 122; the gas outlet end of the gas pipeline 22 is respectively connected with a first gas filling head 211 and a second gas filling head 212, the first liquid filling head 111 and the first gas filling head 211 are arranged adjacent to each other and are both used to communicate with the packaging bag A chamber 511, the second liquid filling head 112 and the second gas filling head 212 are arranged adjacent to each other and are both used to communicate with the packaging bag B chamber 512; the gas pipeline 22 is used to supply gas to the packaging bag A chamber 511 and the packaging bag B chamber 512 or to evacuate the packaging bag A chamber 511 and the packaging bag B chamber 512, and the gas pipeline 22 is provided with a gas circuit control valve;

[0047] The lifting component is connected to the first liquid filling head 111, the second liquid filling head 112, the first gas filling head 211 and the second gas filling head 212, and is used to synchronously drive the first liquid filling head 111, the second liquid filling head 112, the first gas filling head 211 and the second gas filling head 212 to move up and down to get closer to or away from the packaging bag; the lifting component can be a device in the prior art, for example, the lifting component can be composed of a working platform, a screw rod and a stepping motor vertically connected to the working platform, the first liquid filling head, the second liquid filling head, the first gas filling head and the second gas filling head are fixed on the working platform, and the lifting of the first liquid filling head, the second liquid filling head, the first gas filling head and the second gas filling head is realized by the screw rod and the stepping motor;

[0048] An inflatable sleeve is provided at the gas outlet end of the inert gas protection gas circuit 31, and the inflatable sleeve is used to spray inert protection gas to form an inert gas protection atmosphere around the packaging bag. Embodiment 2:

[0049] The difference between Example 2 and Example 1 is that in Example 2, two inflatable sleeves are provided at the gas outlet end of the inert gas protection gas circuit 31, and the two inflatable sleeves extend to the upper and lower sides of the packaging bag in a one-to-one correspondence. Embodiment 3:

[0050] The difference between Example 3 and Example 2 is that the gas pipeline 22 in Example 3 is provided with a vacuum pipeline 231 at the air inlet end for evacuating the gas pipeline 22 and an inert gas pipeline 232 for supplying inert gas to the gas pipeline 22; the gas circuit control valve includes a vacuum control valve 24 and an inert gas control valve 25 arranged on the gas pipeline 22. Embodiment 4:

[0051] The difference between Example 4 and Example 3 is that the filling device for neutral peritoneal dialysis fluid in Example 4 further includes a controller 41 , and the controller 41 is electrically connected to the first liquid control valve 121 , the second liquid control valve 122 , the vacuum control valve 24 and the inert gas control valve 25 . Embodiment 5:

[0052] The difference between Example 5 and Example 4 is that in Example 4, the liquid outlet of the first liquid filling head 111 is lower than the gas outlet of the first gas filling head 211 , and the liquid outlet of the second gas filling head 212 is lower than the gas outlet of the second liquid filling head 112 . Embodiment 6:

[0053] The difference between Example 6 and Example 5 is that the filling device for the neutral peritoneal dialysis fluid in Example 5 also includes a first detector 421 and a second detector 422, the first detector 421 is arranged between the first liquid filling head 111 and the first gas filling head 211, the second detector 422 is arranged between the second liquid filling head 112 and the second gas filling head 212, the first detector and the second detector both include a dissolved oxygen content detector and a pH detector, and the dissolved oxygen content detector and the pH detector are both electrically connected to the controller 41. Embodiment 7:

[0054] The method for filling using the filling device of the neutral peritoneal dialysis fluid of Example 1 comprises the following steps:

[0055] (1) Close the first liquid control valve, the second liquid control valve and the gas circuit control valve, and open the inert gas protection pipeline; the first liquid filling head, the second liquid filling head, the first gas filling head and the second gas filling head are driven by the lifting assembly to move downward to the filling position, at which time the first liquid filling head and the first gas filling head are inserted into the packaging bag chamber A, and the second liquid filling head and the second gas filling head are inserted into the packaging bag chamber B;

[0056] (2) Open the gas control valve, evacuate the packaging bag, open the first liquid control valve and the second liquid control valve, and use the gas pipeline to supply inert gas to fill liquid and gas into packaging bag chamber A and packaging bag chamber B;

[0057] (3) After filling is completed, close the first liquid control valve and the second liquid control valve, and then evacuate the packaging bag chamber A and the packaging bag chamber B;

[0058] (4) When there is no gas in the packaging bag, stop vacuuming and use the gas pipeline to supply inert gas to fill the packaging bag A and the packaging bag B with inert gas until no more gas can be added, and close the gas circuit control valve;

[0059] (5) The lifting assembly drives the liquid filling head, gas filling head and detector to move upward and detach from the packaging bag to complete the filling operation. Embodiment 8:

[0060] The method for filling using the filling device of the neutral peritoneal dialysis fluid of Example 3 comprises the following steps:

[0061] (1) Close the first liquid control valve, the second liquid control valve, the vacuum control valve and the inert gas control valve, and open the inert gas protection pipeline; the first liquid filling head, the second liquid filling head, the first gas filling head and the second gas filling head are driven by the lifting assembly to move downward to the filling position, at which time the first liquid filling head and the first gas filling head are inserted into the packaging bag chamber A, and the second liquid filling head and the second gas filling head are inserted into the packaging bag chamber B;

[0062] (2) Open the vacuum control valve, evacuate the packaging bag, close the vacuum control valve, open the first liquid control valve, the second liquid control valve and the inert gas control valve, and fill the liquid and gas into the packaging bag chamber A and the packaging bag chamber B;

[0063] (3) After filling is completed, close the first liquid control valve, the second liquid control valve and the inert gas control valve, then open the vacuum valve, and then evacuate the packaging bag chamber A and the packaging bag chamber B;

[0064] (4) When there is no gas in the packaging bag, close the vacuum valve, open the inert gas control valve, fill the packaging bag A and the packaging bag B with inert gas until no more gas can be added, and close the inert gas control valve;

[0065] (5) The lifting assembly drives the first liquid filling head, the second liquid filling head, the first gas filling head and the second gas filling head to move up and detach from the packaging bag, completing the filling operation. Embodiment 9:

[0066] The method for filling using the filling device of the neutral peritoneal dialysis fluid of Example 4 comprises the following steps:

[0067] (1) The controller closes the first liquid control valve, the second liquid control valve, the vacuum control valve and the inert gas control valve, and opens the inert gas protection pipeline; the first liquid filling head, the second liquid filling head, the first gas filling head and the second gas filling head are driven by the lifting assembly to move downward to the filling position, at which time the first liquid filling head and the first gas filling head are inserted into the packaging bag chamber A, and the second liquid filling head and the second gas filling head are inserted into the packaging bag chamber B;

[0068] (2) The controller opens the vacuum control valve, and after evacuating the packaging bag, the controller closes the vacuum control valve, and the controller opens the first liquid control valve, the second liquid control valve, and the inert gas control valve to fill the liquid and gas into the packaging bag chamber A and the packaging bag chamber B;

[0069] (3) After the filling is completed, the controller closes the first liquid control valve, the second liquid control valve and the inert gas control valve, and then opens the vacuum valve, and then evacuates the packaging bag chamber A and the packaging bag chamber B;

[0070] (4) When there is no gas in the packaging bag, the controller closes the vacuum valve, opens the inert gas control valve, fills the packaging bag A and the packaging bag B with inert gas until no more gas can be filled, and closes the inert gas control valve;

[0071] (5) The lifting assembly drives the first liquid filling head, the second liquid filling head, the first gas filling head and the second gas filling head to move up and detach from the packaging bag, completing the filling operation. Embodiment 10:

[0072] The method for filling using the filling device of the neutral peritoneal dialysis fluid of Example 6 comprises the following steps:

[0073] (1) The controller closes the first liquid control valve, the second liquid control valve, the vacuum control valve and the inert gas control valve, and opens the inert gas protection pipeline; the first liquid filling head, the second liquid filling head, the first gas filling head and the second gas filling head are driven by the lifting assembly to move downward to the filling position, at which time the first liquid filling head and the first gas filling head are inserted into the packaging bag chamber A, and the second liquid filling head and the second gas filling head are inserted into the packaging bag chamber B;

[0074] (2) The controller opens the vacuum control valve, and after evacuating the packaging bag, the controller closes the vacuum control valve. The controller opens the first liquid control valve, the second liquid control valve, and the inert gas control valve, and fills liquid and gas into the packaging bag chamber A and the packaging bag chamber B. The volume of the neutral peritoneal permeable fluid packaging bag chamber A 511 is 1.75 L, the volume of the neutral peritoneal permeable fluid packaging bag chamber B 512 is 0.25 L, the filling flow rate of the first liquid filling head is 2 L / min, and the filling flow rate of the second liquid filling head is The inert gas flow rate is

[0075] (3) After the filling is completed, the controller closes the first liquid control valve, the second liquid control valve and the inert gas control valve, and then opens the vacuum valve, and then evacuates the packaging bag chamber A and the packaging bag chamber B;

[0076] (4) When there is no gas in the packaging bag, the controller closes the vacuum valve, opens the inert gas control valve, and fills the packaging bag A and the packaging bag B with inert gas at a rate of 0.1 L / min until no more gas can be filled, and then closes the inert gas control valve;

[0077] (5) The lifting assembly drives the first liquid filling head, the second liquid filling head, the first gas filling head and the second gas filling head to move up and detach from the packaging bag, completing the filling operation. Embodiment 11:

[0078] The method for filling using the filling device of the neutral peritoneal dialysis fluid of Example 6 comprises the following steps:

[0079] (1) The controller closes the first liquid control valve, the second liquid control valve, the vacuum control valve and the inert gas control valve, and opens the inert gas protection pipeline; the first liquid filling head, the second liquid filling head, the first gas filling head and the second gas filling head are driven by the lifting assembly to move downward to the filling position, at which time the first liquid filling head and the first gas filling head are inserted into the packaging bag chamber A, and the second liquid filling head and the second gas filling head are inserted into the packaging bag chamber B;

[0080] (2) The controller opens the vacuum control valve, and after evacuating the packaging bag, the controller closes the vacuum control valve. The controller opens the first liquid control valve, the second liquid control valve, and the inert gas control valve, and fills liquid and gas into the packaging bag chamber A and the packaging bag chamber B. The volume of the neutral peritoneal permeable fluid packaging bag chamber A 511 is 1.25 L, the volume of the neutral peritoneal permeable fluid packaging bag chamber B 512 is 0.75 L, the filling flow rate of the first liquid filling head is 3 L / min, and the filling flow rate of the second liquid filling head is The inert gas flow rate is

[0081] (3) After the filling is completed, the controller closes the first liquid control valve, the second liquid control valve and the inert gas control valve, and then opens the vacuum valve, and then evacuates the packaging bag chamber A and the packaging bag chamber B;

[0082] (4) When there is no gas in the packaging bag, the controller closes the vacuum valve, opens the inert gas control valve, and fills the packaging bag A and the packaging bag B with inert gas at a rate of 0.3 L / min until no more gas can be filled, and then closes the inert gas control valve;

[0083] (5) The lifting assembly drives the first liquid filling head, the second liquid filling head, the first gas filling head and the second gas filling head to move up and detach from the packaging bag, completing the filling operation.

[0084] The liquids in the first liquid tank and the second liquid tank were taken and mixed to form the standard solution; the neutral peritoneal dialysis solution packaging bag after filling of Examples 7-10 was squeezed to allow the solution to break through the virtual welding position to complete the mixing, and the mixed neutral peritoneal dialysis solution was used as the experimental solution. The pH and total chlorine content of the standard solution and the experimental example were tested, and the results are shown in Table 1.

[0085] Among them, the pH detection method is to calibrate the pH detector, rinse the electrode with purified water, dry it with filter paper, insert the motor into the solution to be tested, and wait for the motor reaction to be balanced, which is the pH value of the test solution. Repeat the measurement twice and take the average value as the pH value of the test solution; the total chlorine content detection method is to titrate the solution to be tested with silver nitrate titration solution (0.1mol / L). The solution changes from yellow-green to pink, which is the end point. Avoid strong light exposure during the titration process. The calculation formula is: Wherein, F is the correction factor of silver nitrate titrant (0.1 mol / L), V is the milliliters of silver nitrate titrant (0.1 mol / L) consumed, 0.003545 is the number of grams of Cl equivalent to each 1 ml of silver nitrate titrant (0.1 mol / L), and 0.03406 is the theoretical number of grams of total chlorine in each 10 ml of peritoneal dialysis fluid. Table 1 pH value and total chlorine content of standard solution and experimental solution in Examples 7-10 project pH Total chlorine content (mg / ml) Standard solution 5.5 3.52 Example 7 5.7 3.57 Example 8 5.6 3.56 Example 9 5.6 3.54 Example 10 5.6 3.54

[0086] It can be seen from Table 1 and Examples 7-10 that the use of the neutral peritoneal dialysis fluid filling device provided by the present invention for filling can ensure that the pH value and total chlorine content of the liquid after filling change within a controllable range, proving that the neutral peritoneal dialysis fluid filling device and filling method provided by the present invention can prevent air from mixing into the filling area due to the dissipation of the inert gas protective atmosphere during the filling process, thereby affecting the stability of the neutral peritoneal dialysis fluid.

[0087] The above are all preferred embodiments of the present invention, and are not intended to limit the protection scope of the present invention. Therefore, any equivalent changes made based on the structure, shape, and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A filling device for neutral peritoneal dialysis fluid, characterized in that: It comprises a first liquid tank, a second liquid tank, a gas pipeline (22), an inert gas protection gas circuit (31) and a lifting assembly; The first liquid tank is connected to a first liquid filling head (111), the second liquid tank is connected to a second liquid filling head (112), the liquid inlet end of the first liquid filling head (111) is provided with a first liquid control valve (121), the liquid inlet end of the second liquid filling head (112) is provided with a second liquid control valve (122); the gas outlet end of the gas pipeline (22) is respectively connected to the first gas filling head (211) and the second gas filling head (212), the first liquid filling head (111) and the second liquid filling head (212) are connected to the first liquid filling head (111) and the second liquid filling head (112) are connected to the second liquid filling head (112) respectively; 1) is disposed adjacent to the first gas filling head (211) and is used to communicate with the packaging bag A chamber (511); the second liquid filling head (112) and the second gas filling head (212) are disposed adjacent to each other and are used to communicate with the packaging bag B chamber (512); the gas pipeline (22) is used to supply gas to the packaging bag A chamber (511) and the packaging bag B chamber (512) or to evacuate the packaging bag A chamber (511) and the packaging bag B chamber (512); the gas pipeline (22) is provided with a gas circuit control valve; The lifting assembly is connected to the first liquid filling head (111), the second liquid filling head (112), the first gas filling head (211) and the second gas filling head (212), and is used to synchronously drive the first liquid filling head (111), the second liquid filling head (112), the first gas filling head (211) and the second gas filling head (212) to move up and down so as to approach or move away from the packaging bag; The outlet end of the inert gas protection gas circuit (31) is provided with at least one inflation sleeve, and the inflation sleeve is used to spray the inert protection gas to form an inert gas protection atmosphere around the packaging bag.

2. The filling device for neutral peritoneal dialysis fluid according to claim 1, characterized in that: The outlet end of the inert gas protection gas circuit (31) is provided with two inflatable sleeves, and the two inflatable sleeves extend to the upper and lower sides of the packaging bag in a one-to-one correspondence.

3. The filling device for neutral peritoneal dialysis fluid according to claim 1, characterized in that: The gas pipeline (22) is provided with a vacuum pipeline (231) at the gas inlet end for evacuating the gas pipeline (22) and an inert gas pipeline (232) for supplying inert gas to the gas pipeline (22); the gas circuit control valve comprises a vacuum control valve (24) and an inert gas control valve (25) arranged on the gas pipeline (22).

4. The filling device for neutral peritoneal dialysis fluid according to claim 3, characterized in that: The filling device for neutral peritoneal dialysis fluid also includes a controller (41), and the controller (41) is electrically connected to the first liquid control valve (121), the second liquid control valve (122), the vacuum control valve (24) and the inert gas control valve (25).

5. The filling device for neutral peritoneal dialysis fluid according to claim 1, characterized in that: The liquid outlet of the first liquid filling head (111) is lower than the gas outlet of the first gas filling head (211), and the liquid outlet of the second gas filling head (212) is lower than the gas outlet of the second liquid filling head (112).

6. The filling device for neutral peritoneal dialysis fluid according to claim 1, characterized in that: The filling device for neutral peritoneal dialysis fluid also includes a first detector (421) and a second detector (422), wherein the first detector (421) is arranged between the first liquid filling head (111) and the first gas filling head (211), and the second detector (422) is arranged between the second liquid filling head (112) and the second gas filling head (212), and the first detector (421) and the second detector (422) both include a dissolved oxygen content detector and a pH detector, and the dissolved oxygen content detector and the pH detector are both electrically connected to the controller (41).

7. The filling device for neutral peritoneal dialysis fluid according to claim 1, characterized in that: The filling device for neutral peritoneal dialysis fluid also includes a conveying line for supporting and conveying the packaging belt, and the conveying line is located below the lifting component.

8. A method for filling a neutral peritoneal dialysis fluid, characterized in that: The following steps are involved: (1) Close the first liquid control valve, the second liquid control valve and the gas circuit control valve, and open the inert gas protection pipeline; the first liquid filling head, the second liquid filling head, the first gas filling head and the second gas filling head are driven by the lifting assembly to move downward to the filling position, at which time the first liquid filling head and the first gas filling head are inserted into the packaging bag chamber A, and the second liquid filling head and the second gas filling head are inserted into the packaging bag chamber B; (2) Open the gas control valve, evacuate the packaging bag, open the first liquid control valve and the second liquid control valve, and use the gas pipeline to supply inert gas to fill liquid and gas into packaging bag chamber A and packaging bag chamber B; (3) After filling is completed, close the first liquid control valve and the second liquid control valve, and then evacuate the packaging bag chamber A and the packaging bag chamber B; (4) When there is no gas in the packaging bag, stop vacuuming and use the gas pipeline to supply inert gas to fill the packaging bag A and the packaging bag B with inert gas until no more gas can be added, and close the gas circuit control valve; (5) The lifting assembly drives the first liquid filling head, the second liquid filling head, the first gas filling head and the second gas filling head to move up and detach from the packaging bag, completing the filling operation.

9. The method for filling neutral peritoneal dialysis fluid according to claim 8, characterized in that: In step (2), S2 is the filling flow rate of the first liquid filling head, S2 = 2-4 L / min, and the filling flow rate of the second liquid filling head is Wherein V1 is the volume of the neutral peritoneal permeation fluid packaging bag A chamber (511), the unit is L, V2 is the volume of the neutral peritoneal permeation fluid packaging bag B chamber (512), the unit is L, wherein S3 is L / min, and the flow rate of the inert gas in the gas pipeline is The unit of S1 is L / min, S is a constant, S=2-3L / min, and T is the completed filling time, in min.

10. The method for filling neutral peritoneal dialysis fluid according to claim 8, characterized in that: The flow rate of the inert gas in step (4) is 0.1-0.5 L / min.

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