Extraction method and application of high-purity kavalactone for cosmetics

Abstract

The invention discloses an extraction method of high-purity kava lactone for cosmetics, which comprises the following steps: extracting kava pepper by using an ethanol solution to obtain an extracting solution A; sequentially filtering, concentrating and crystallizing the extracting solution A to obtain a crude extract B; purifying the crude extract B by adopting a high-speed counter-current chromatography method to obtain high-purity kavalactone; a two-phase solvent used during purification of the high-speed counter-current chromatography is a mixed solution of normal hexane, acetonitrile, ethyl acetate and water in a volume ratio of 1: 1: 4: 2. The method has the characteristics of high extraction efficiency and good extraction effect.

Description

Technical Field

[0001] The invention relates to a method for extracting kavalactone, in particular to a method for extracting high-purity kavalactone for cosmetics and application thereof. Background Art

[0002] Kava is a perennial upright shrub medicinal plant of the Piperaceae family, produced in the South Pacific islands. It is rich in kavalactone, which can reach 3% to 10% in the root of Kava, accounting for 25% to 70% of the total extract. Kavalactone has sedative, anti-inflammatory, antiseptic, antifungal, sleep-enhancing, anti-fatigue, anti-anxiety, soothing, anti-allergic, and anti-irritation effects, and is a natural cosmetic raw material.

[0003] On this basis, there are two existing extraction processes for kava lactones. The first one is shown in patent 201210115386.1, that is, kava lactones are first extracted by ethanol solution, and then the extract is concentrated under reduced pressure and adsorbed with a macroporous resin, and then eluted with an ethanol solution, and finally the eluent is concentrated and dried to obtain kava lactones. However, due to the large loss of active ingredients in kava lactones by processes such as alcohol extraction and column, the content of active ingredients in kava lactones prepared by this method is relatively low, which cannot meet the needs of manufacturers. The second extraction process is shown in patent 201210353568.2, after the root of kava pepper is crushed, it is added to an extraction kettle for supercritical extraction, and then the extract is dissolved in ethyl acetate and passed through an aluminum peroxide short column, and the column liquid is recovered. Ethyl acetate is then dried at low temperature to obtain kava lactones. On the one hand, the extraction process is complicated to operate, and on the other hand, kava pepper needs to be processed by column after supercritical extraction, resulting in a large loss of active ingredients in kava lactones during the column process.

[0004] Therefore, the existing extraction methods for kavalactones have the problems of low extraction efficiency and poor extraction effect. Summary of the invention

[0005] The purpose of the present invention is to provide a method for extracting high-purity kavalactones for cosmetics and its application, which has the characteristics of high extraction efficiency and good extraction effect.

[0006] The technical solution of the present invention is a method for extracting high-purity kavalactones for cosmetics, comprising the following steps:

[0007] ① Extracting Piper methysticum with an ethanol solution to obtain an extract A;

[0008] ② Filter, concentrate and crystallize the A extract in sequence to obtain the B crude extract;

[0009] ③ Purifying the crude extract of B by high-speed countercurrent chromatography to obtain high-purity kavalactones;

[0010] The two-phase solvent used in the high-speed countercurrent chromatography for purification in step ③ is a mixed solution of n-hexane-acetonitrile-ethyl acetate-water in a volume ratio of 1:1:4:2.

[0011] In the aforementioned method for extracting high-purity kavalactones for cosmetics, the volume fraction of the ethanol solution in step ① is 70-90%, and the solid-liquid ratio of kava pepper to the ethanol solution is 1 g:20-30 mL.

[0012] In the aforementioned method for extracting high-purity kavalactones for cosmetics, in step ①, the kava pepper is extracted by Soxhlet extraction using an ethanol solution as a solvent, the extraction temperature is 70-75° C., and the extraction is stopped when the solvent flowing out of the extraction tube is colorless; in step ②, the extract A is concentrated under reduced pressure until there is no alcohol taste, and then crystallized, the temperature during the reduced pressure concentration is 70-75° C., and the vacuum degree is ≤0.08MPa.

[0013] In the aforementioned method for extracting high-purity kavalactones for cosmetics, the main engine speed of the high-speed countercurrent chromatography during purification in step ③ is 800-900 r / min, and the flow rate of the two-phase solvent is 1-3 mL / min.

[0014] The method for preparing water-soluble kavalactones based on the kavalactones extracted by the aforementioned extraction method comprises the following steps:

[0015] a. Mix the water-soluble modifier, kavalactone and water and stir until dissolved. The stirring reaction time is 4 to 6 hours to obtain a mixture H;

[0016] b. removing the solvent from the H mixture to obtain water-soluble kavalactone;

[0017] The water-soluble modifier in step a is a combination of one or more of α-cyclodextrin, β-cyclodextrin, γ-cyclodextrin, hydroxypropyl-α-cyclodextrin, hydroxypropyl-β-cyclodextrin and hydroxypropyl-γ-cyclodextrin.

[0018] In the aforementioned method for preparing water-soluble kavalactone, in step a, the water-soluble modifier, kavalactone and water are mixed in a mass ratio of 40-50:1:80-100.

[0019] In the aforementioned method for preparing water-soluble kavalactones, in step b, the H mixture is first filtered under reduced pressure, the vacuum degree during the reduced pressure filtration is ≤0.085MPa, and then the solvent in the H mixture is removed by reduced pressure concentration, the temperature during reduced pressure concentration is 70-75°C, the vacuum degree is ≤0.08MPa, and the concentration is stopped when the solid content reaches 50-70%; water-soluble kavalactones are obtained.

[0020] In the aforementioned method for preparing water-soluble kavalactones, the water-soluble modifier is hydroxypropyl-β-cyclodextrin and / or hydroxypropyl-γ-cyclodextrin.

[0021] The water-soluble kavalactone is prepared based on the aforementioned water-soluble kavalactone preparation method.

[0022] The water-soluble kavalactones are used in the preparation of cosmetics, including facial masks, facial creams, sprays, lotions, foundation creams, cleansers, essences or body lotions.

[0023] Compared with the prior art, the present invention has the following characteristics:

[0024] (1) The present invention uses high-speed countercurrent chromatography for purification, and with the limitation of the two-phase solvent, it can effectively separate and purify the kavalactone components in the root of Piper methysticum, thereby improving the extraction rate of kavalactone; on this basis, the kavalactone in Piper methysticum can be extracted to the maximum extent by Soxhlet extraction, thereby improving the utilization rate of Piper methysticum; and the above-mentioned extraction method does not need to pass the extract through a column, that is, it reduces the loss of effective components in kavalactone during the processing process;

[0025] (2) Kavalactone is a fat-soluble component, and the present application can effectively remove the ethanol content in the extract by first concentrating the extract and then recrystallizing it, thereby allowing the kava lactone to be more fully crystallized and precipitated, thereby improving its extraction rate; and under the above-mentioned combination, the kava lactone content in the extract prepared by the present invention can reach more than 99%, that is, effectively improving its extraction efficiency and extraction effect;

[0026] (3) By modifying the water solubility of kavalactone, the kavalactone can have good water solubility after treatment, thereby solving the problem that kavalactone is poorly soluble in water and improving the application range of kavalactone; on this basis, by limiting the composition and ratio of the water-soluble modifier, the water-soluble modification effect of kavalactone can be improved, so that the solubility of the prepared water-soluble kavalactone in water can be increased to 3-6 g / 100 mL;

[0027] Therefore, the present invention has the characteristics of high extraction efficiency and good extraction effect. DETAILED DESCRIPTION

[0028] The present invention will be further described below in conjunction with the embodiments, but they are not intended to limit the present invention.

[0029] Example 1. A method for extracting high-purity kavalactones for cosmetics, comprising the following steps: ① extracting Piper methysticum with an ethanol solution to obtain an extract A;

[0030] ② Filter, concentrate and crystallize the A extract in sequence to obtain the B crude extract;

[0031] ③ Purifying the crude extract of B by high-speed countercurrent chromatography to obtain high-purity kavalactones;

[0032] The two-phase solvent used in the high-speed countercurrent chromatography for purification in step ③ is a mixed solution of n-hexane-acetonitrile-ethyl acetate-water in a volume ratio of 1:1:4:2.

[0033] In the step ①, the volume fraction of the ethanol solution is 70-90%, and the material-liquid ratio of kava pepper to the ethanol solution is 1 g: 20-30 mL.

[0034] In the step ①, the kava pepper is extracted by using the Soxhlet extraction method with an ethanol solution as a solvent; in the step ②, the extract A is concentrated until there is no alcohol taste and then crystallized.

[0035] In the step ③, the main engine speed of the high-speed countercurrent chromatography during purification is 800-900 r / min, and the flow rate of the two-phase solvent is 1-3 mL / min.

[0036] In this embodiment, kavalactones in Piper mesona are separated and extracted by high-speed countercurrent chromatography, which can effectively improve the extraction rate of kavalactones and reduce the loss of effective ingredients in kavalactones.

[0037] Example 2. A method for extracting high-purity kavalactones for cosmetics, comprising the following steps:

[0038] ① Rinse the kava root raw material and dry it in the shade at low temperature, then crush the kava root raw material to obtain raw material fine powder;

[0039] Weigh 500 g of raw material fine powder, use 80% ethanol solution as solvent, and use Soxhlet extraction method to heat extract the raw material fine powder at a solid-liquid ratio of 1 g:30 mL. The heating temperature is 75°C. Extract until the solvent flowing out of the extraction tube is colorless, to obtain extract A;

[0040] ② The A extract is filtered under reduced pressure, concentrated under reduced pressure and allowed to stand for crystallization in sequence.

[0041] The vacuum degree of the A extract during the reduced pressure filtration is ≤0.085MPa, and the A1 filtrate is obtained after filtration;

[0042] The concentration temperature of the A1 filtrate during the reduced pressure concentration is 70°C, and the vacuum degree is ≤0.08MPa. The A1 filtrate is concentrated until there is no alcohol taste to obtain the A2 concentrate;

[0043] After the A2 concentrate was allowed to stand for crystallization, the upper aqueous solution was removed, and then the crystals were dried by forced air at 45°C to obtain 113.95 g of semi-solid B crude extract;

[0044] ③ Prepare the reagents with a volume ratio of 1:1:4:2 of n-hexane-acetonitrile-ethyl acetate-water, mix thoroughly and degas, let stand to separate into layers, use the upper phase solution as the stationary phase and the lower phase as the mobile phase; then weigh 5 g of crude extract B, add 25 mL of mobile phase and ultrasonically dissolve completely;

[0045] The stationary phase was pumped into the main unit at a flow rate of 20 mL / min and filled the separation spiral tube. The main unit power was turned on and rotated in the forward direction at 850 r / min. After the rotation speed was stable, the mobile phase was pumped in at a flow rate of 2 mL / min. After the mobile phase flowed out from the outlet of the separation spiral tube and the baseline was stable and zeroed, the prepared kavalactone crude extract solution was injected into the injection loop from the injector. The effluent at the outlet of the separation spiral tube was continuously detected at 246 nm, and each chromatographic component was collected according to the countercurrent chromatogram; the target component with a peak time of 75 to 120 min was received and recorded as compound a, and 2.10 g of high-purity kavalactone was obtained.

[0046] Compared with Example 1, this example further defines the extraction method of kavalactones, thereby ensuring the extraction stability of kavalactones and improving the extraction rate and purity of kavalactones.

[0047] Example 3. A method for extracting high-purity kavalactones for cosmetics, comprising the following steps:

[0048] ① Rinse the kava root raw material and dry it in the shade at low temperature, then crush the kava root raw material to obtain raw material fine powder;

[0049] Weigh 500 g of raw material fine powder, use 70% ethanol solution as solvent, and use Soxhlet extraction method to heat extract the raw material fine powder at a solid-liquid ratio of 1 g:20 mL. The heating temperature is 75°C. Extract until the solvent flowing out of the extraction tube is colorless, to obtain extract A;

[0050] ② The A extract is filtered under reduced pressure, concentrated under reduced pressure and allowed to stand for crystallization in sequence.

[0051] The vacuum degree of the A extract during the reduced pressure filtration is ≤0.085MPa, and the A1 filtrate is obtained after filtration;

[0052] The concentration temperature of the A1 filtrate during the reduced pressure concentration is 70°C, and the vacuum degree is ≤0.08MPa. The A1 filtrate is concentrated until there is no alcohol taste to obtain the A2 concentrate;

[0053] After the A2 concentrate was allowed to stand for crystallization, the upper aqueous solution was removed, and then the crystals were dried by air at 45°C to obtain 116.31 g of semi-solid B crude extract;

[0054] ③ Prepare the reagents with a volume ratio of 1:1:4:2 of n-hexane-acetonitrile-ethyl acetate-water, mix thoroughly and degas, let stand to separate into layers, use the upper phase solution as the stationary phase and the lower phase as the mobile phase; then weigh 5 g of crude extract B, add 25 mL of mobile phase and ultrasonically dissolve completely;

[0055] The stationary phase was pumped into the main unit at a flow rate of 20 mL / min and filled the separation spiral tube. The main unit power was turned on and rotated in the forward direction at 850 r / min. After the rotation speed was stable, the mobile phase was pumped in at a flow rate of 2 mL / min. After the mobile phase flowed out from the outlet of the separation spiral tube and the baseline was stable and zeroed, the prepared kavalactone crude extract solution was injected into the injection loop from the injector. The effluent at the outlet of the separation spiral tube was continuously detected at 246 nm, and each chromatographic component was collected according to the countercurrent chromatogram; the target component with a peak time of 75 to 120 min was received and recorded as compound a, and 2.04 g of high-purity kavalactone was obtained.

[0056] Example 4. A method for extracting high-purity kavalactones for cosmetics, comprising the following steps:

[0057] ① Rinse the kava root raw material and dry it in the shade at low temperature, then crush the kava root raw material to obtain raw material fine powder;

[0058] Weigh 500 g of raw material fine powder, use 90% ethanol solution as solvent, and use Soxhlet extraction method at a solid-liquid ratio of 1 g:25 mL to heat extract the raw material fine powder. The heating temperature is 75°C. Extract until the solvent flowing out of the extraction tube is colorless, to obtain extract A;

[0059] ② The A extract is filtered under reduced pressure, concentrated under reduced pressure and allowed to stand for crystallization in sequence.

[0060] The vacuum degree of the A extract during the reduced pressure filtration is ≤0.085MPa, and the A1 filtrate is obtained after filtration;

[0061] The concentration temperature of the A1 filtrate during the reduced pressure concentration is 70°C, and the vacuum degree is ≤0.08MPa. The A1 filtrate is concentrated until there is no alcohol taste to obtain the A2 concentrate;

[0062] After the A2 concentrate was allowed to stand for crystallization, the upper aqueous solution was removed, and then the crystals were dried by air at 45°C to obtain 108.92 g of semi-solid B crude extract;

[0063] ③ Prepare the reagents with a volume ratio of 1:1:4:2 of n-hexane-acetonitrile-ethyl acetate-water, mix thoroughly and degas, let stand to separate into layers, use the upper phase solution as the stationary phase and the lower phase as the mobile phase; then weigh 5 g of crude extract B, add 25 mL of mobile phase and ultrasonically dissolve completely;

[0064] The stationary phase was pumped into the main unit at a flow rate of 20 mL / min and filled the separation spiral tube. The main unit power was turned on and rotated in the forward direction at 850 r / min. After the rotation speed was stable, the mobile phase was pumped in at a flow rate of 2 mL / min. After the mobile phase flowed out from the outlet of the separation spiral tube and the baseline was stable and zeroed, the prepared kavalactone crude extract solution was injected into the injection loop from the injector. The effluent at the outlet of the separation spiral tube was continuously detected at 246 nm, and each chromatographic component was collected according to the countercurrent chromatogram; the target component with a peak time of 75 to 120 min was received and recorded as compound a, and 2.18 g of high-purity kavalactone was obtained.

[0065] Example 5. A method for preparing water-soluble kavalactones, comprising the following steps:

[0066] a. Mix the water-soluble modifier, kavalactone and water and stir until dissolved. The stirring reaction time is 4 to 6 hours to obtain a mixture H;

[0067] b. removing the solvent from the H mixture to obtain water-soluble kavalactone;

[0068] The water-soluble modifier in step a is a combination of one or more of α-cyclodextrin, β-cyclodextrin, γ-cyclodextrin, hydroxypropyl-α-cyclodextrin, hydroxypropyl-β-cyclodextrin and hydroxypropyl-γ-cyclodextrin.

[0069] In the aforementioned method for preparing water-soluble kavalactone, in step a, the water-soluble modifier, kavalactone and water are mixed in a mass ratio of 40-50:1:80-100.

[0070] In the aforementioned method for preparing water-soluble kavalactones, in step b, the H mixture is first filtered under reduced pressure, the vacuum degree during the reduced pressure filtration is ≤0.085MPa, and then the solvent in the H mixture is removed by reduced pressure concentration, the temperature during reduced pressure concentration is 70-75°C, the vacuum degree is ≤0.08MPa, and the concentration is stopped when the solid content reaches 50-70%; water-soluble kavalactones are obtained.

[0071] In the aforementioned method for preparing water-soluble kavalactones, the water-soluble modifier is hydroxypropyl-β-cyclodextrin and / or hydroxypropyl-γ-cyclodextrin.

[0072] Example 6. A method for preparing water-soluble kavalactones, comprising the following steps:

[0073] a. 45 g of hydroxypropyl-β-cyclodextrin, 90 g of pure water and 1 g of the kavalactone prepared in Example 2 were mixed and stirred at 70 ° C for 5 h to complete the reaction to obtain a mixture H;

[0074] b. Add 5 g of diatomaceous earth to the mixture H and stir evenly, then filter it through medium-speed filter paper by vacuum filtration, repeat several times until the liquid is clear and transparent, and the vacuum degree during vacuum filtration is ≤0.085 MPa to obtain H1 filtrate;

[0075] The H1 filtrate is then concentrated under reduced pressure at a concentration temperature of 75°C and a vacuum degree of ≤0.08MPa until the solid content in the filtrate reaches 50-70%, thereby obtaining a H2 concentrated solution;

[0076] The H2 concentrated liquid is then dried in a vacuum oven at a drying temperature of 75°C and a vacuum degree of ≤0.085KPa to obtain a dried product I;

[0077] c. The dried product was crushed and passed through an 80-mesh vibrating sieve to obtain 45.5 g of water-soluble kavalactone.

[0078] Compared with Example 5, this example further defines the specific preparation method of water-soluble kavalactones, thereby improving the preparation effect and stability of water-soluble kavalactones. By testing the prepared water-soluble kavalactones, the content of kavalactones in the water-soluble kavalactones was measured to be 2.08wt%, indicating that the preparation method of this example can retain about 95% of kavalactones.

[0079] Example 7. A method for preparing water-soluble kavalactones, comprising the following steps:

[0080] a. 50 g of hydroxypropyl-β-cyclodextrin, 80 g of pure water and 1 g of the kavalactone prepared in Example 2 were mixed and stirred at 70 ° C for 5 h to complete the reaction to obtain a mixture H;

[0081] b. Add 5 g of diatomaceous earth to the mixture H and stir evenly, then filter it through medium-speed filter paper by vacuum filtration, repeat several times until the liquid is clear and transparent, and the vacuum degree during vacuum filtration is ≤0.085 MPa to obtain H1 filtrate;

[0082] The H1 filtrate is then concentrated under reduced pressure at a concentration temperature of 75°C and a vacuum degree of ≤0.08MPa until the solid content in the filtrate reaches 50-70%, thereby obtaining a H2 concentrated solution;

[0083] The H2 concentrated liquid is then dried in a vacuum oven at a drying temperature of 75°C and a vacuum degree of ≤0.085KPa to obtain a dried product I;

[0084] c. The dried product was crushed and passed through an 80-mesh vibrating sieve to obtain 50.6 g of water-soluble kavalactone.

[0085] The prepared water-soluble kavalactone was tested, and the content of kavalactone in the water-soluble kavalactone was measured to be 1.88 wt %, indicating that the preparation method of this embodiment can also retain about 95% of kavalactone.

[0086] Experimental example: In this experimental example, comparative example 1 and comparative example 2 are respectively set, wherein comparative example 1 replaces the two-phase solvent in step ③ with n-hexane-methanol-ethyl acetate-aqueous solution with a volume ratio of 1:1:4:2 compared with embodiment 2, and other extraction methods are the same as embodiment 2; comparative example 2 replaces the two-phase solvent in step ③ with n-hexane-acetonitrile-ethyl acetate-aqueous solution with a volume ratio of 0.5:1.5:4:2 compared with embodiment 2, and other extraction methods are the same as embodiment 2.

[0087] Then according to the formula The kavalactone extraction rates in Example 2, Example 3, Example 4, Comparative Example 1 and Comparative Example 2 were calculated respectively; wherein P is the extraction rate of high-purity kavalactone in Kava pepper, R1 is the kavalactone content of compound a in step ③%, M1 is the mass of compound a in step ③, R2 is the kavalactone content of the raw material fine powder in step ①%, M2 is the added mass of the raw material fine powder in step ①, M3 is the mass of the crude extract of B in step ②, and M4 is the mass of the crude extract of B weighed and used in step ③. The test results are shown in Table 1:

[0088] Table 1 Relevant parameters of high purity kavalactone extract

[0089] <![CDATA[R1 / %]]> <![CDATA[R2 / %]]> <![CDATA[M1 / g]]> <![CDATA[M2 / g]]> <![CDATA[M3 / g]]> <![CDATA[M4 / g]]> P(％) Example 2 99.62 9.82 2.10 500 113.95 5.0 97.10 Example 3 99.47 9.82 2.04 500 116.31 5.0 96.14 Example 4 99.57 9.82 2.18 500 108.92 5.0 96.30 Comparative Example 1 80.32 9.82 1.93 500 113.95 5.0 71.95 Comparative Example 2 61.36 9.82 1.87 500 113.95 5.0 53.26

[0090] It can be seen from the test results that the purity of the kavalactones prepared by the process of the present application is above 99%, and the extraction rate of the kavalactones in Piper methysticum is above 95%, indicating that the present application can effectively improve the extraction efficiency and effect of the kavalactones. The test results of Comparative Examples 1 and 2 are significantly lower than those of the embodiment, indicating that the extraction rate and purity of the kavalactones will be reduced by selecting solutions with different compositions or ratios as two-phase solvents for extracting the kavalactones in the high-speed countercurrent chromatography method.

Claims

1. A method for extracting high-purity kavalactones for cosmetics, characterized in that: The following steps are involved: ① Extracting Piper methysticum with an ethanol solution to obtain an extract A; ② Filter, concentrate and crystallize the A extract in sequence to obtain the B crude extract; ③ Purifying the crude extract of B by high-speed countercurrent chromatography to obtain high-purity kavalactones; The two-phase solvent used in the high-speed countercurrent chromatography for purification in step ③ is a mixed solution of n-hexane-acetonitrile-ethyl acetate-water in a volume ratio of 1:1:4:

2.

2. The method for extracting high-purity kavalactones for cosmetics according to claim 1, characterized in that: In the step ①, the volume fraction of the ethanol solution is 70-90%, and the material-liquid ratio of kava pepper to the ethanol solution is 1 g: 20-30 mL.

3. The method for extracting high-purity kavalactones for cosmetics according to claim 1, characterized in that: In the step ①, the kava pepper is extracted by using the Soxhlet extraction method with an ethanol solution as a solvent; in the step ②, the extract A is concentrated until there is no alcohol taste and then crystallized.

4. The method for extracting high-purity kavalactones for cosmetics according to claim 1, characterized in that: In the step ③, the main engine speed of the high-speed countercurrent chromatography during purification is 800-900 r / min, and the flow rate of the two-phase solvent is 1-3 mL / min.

5. A method for preparing water-soluble kavalactones based on the kavalactones extracted from any one of claims 1 to 4, characterized in that: The following steps are involved: a. The water-soluble modifier, kavalactone and water are mixed and stirred until dissolved to obtain a mixture H; b. removing the solvent from the H mixture to obtain water-soluble kavalactone; The water-soluble modifier in step a is a combination of one or more of α-cyclodextrin, β-cyclodextrin, γ-cyclodextrin, hydroxypropyl-α-cyclodextrin, hydroxypropyl-β-cyclodextrin and hydroxypropyl-γ-cyclodextrin.

6. The method for preparing water-soluble kavalactones according to claim 5, characterized in that: In the step a, the water-soluble modifier, kava lactone and water are mixed in a mass ratio of 40-50:1:80-100.

7. The method for preparing water-soluble kavalactones according to claim 5, characterized in that: In the step b, the H mixture is first filtered, and then the solvent in the H mixture is removed to obtain water-soluble kavalactones.

8. The method for preparing water-soluble kavalactones according to claim 5, characterized in that: The water-soluble modifier is hydroxypropyl-β-cyclodextrin and / or hydroxypropyl-γ-cyclodextrin.

9. A water-soluble kavalactone prepared according to the method for preparing a water-soluble kavalactone according to any one of claims 5 to 8.

10. Use of the water-soluble kavalactone according to claim 9 in the preparation of cosmetics.