Nourishing paste for consolidating basis and strengthening primordial qi based on hot pulping system and preparation method of nourishing paste

Abstract

The preparation method comprises the following steps: the hot pulping system is used for completely separating effective medicinal components from non-medicinal components such as fiber lignin in plant traditional Chinese medicinal materials through the procedures of slicing, feeding, steaming, rubbing and splitting, high-concentration hot pulping and pulp-residue separation; the medicine residues which can only become solid wastes in the prior art can be completely turned into useful light industrial materials; the environment-friendly ecological effect is very prominent. Meanwhile, obtaining of very fine traditional Chinese medicine extracts and further processing of novel traditional Chinese medicine preparations become very simple and convenient, and the economical efficiency is greatly improved.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine extraction, and in particular to a tonic paste for strengthening the foundation and nourishing the essence based on a hot grinding system and a preparation method thereof, and belongs to the field of biomedicine. Background Art

[0002] In the 1930s, Asplund of Sunds developed the first hot refiner in the papermaking industry. Through high-speed rotating grinding discs and heat, wood or other plant fiber raw materials were refined into fibers, so that plant fibers and non-fibrous materials were effectively separated, which made a qualitative leap in mechanical papermaking technology. Entering the 20th century, the latest series of hot refiners have greatly improved the separation quality of fibers and resin glue. The hot refiner has a compact structure, strong power, simple operation and maintenance, and a wider range of applications. For example, the invented high-concentration pulping machine uses a dynamic grinding disc and a static grinding disc to form a grinding zone. The fiber raw material is continuously pushed into the grinding zone by a strong feeding device. In the grinding zone, it is subjected to the strong mechanical action of the grinding disc and the mutual friction between fibers. It is repeatedly crushed, dissociated, torn, and filamented, and finally obtains a pulp with a certain degree of freeness. The high-concentration pulping machine can use a variety of papermaking raw materials that were originally unusable, such as shrubs and branches, to produce high-quality paper.

[0003] While the current Chinese patent medicine manufacturing industry has generated huge economic and social benefits, it has also brought major problems to the ecosystem and sustainable development, mainly reflected in the amount of solid waste from Chinese medicine waste, which accounts for more than 70% of the total solid waste from Chinese medicine. In addition to a large amount of biomass such as cellulose, hemicellulose and lignin, these solid wastes from Chinese medicine also contain a large amount of effective medicinal ingredients such as polysaccharides, polypeptides, nucleic acids, vitamins, etc. Traditional methods of handling solid waste generated during Chinese medicine processing, such as landfill, composting, preparation of fermentation matrix, incineration and other extensive methods, have caused a huge waste of biomass resources. The "Fifty-two Prescriptions for Diseases" written in the Warring States Period at the end of the fourth century BC or the third century BC is the oldest extant medical prescription book in my country. The prescription of "using one dou of water, boil one ginseng and one liter of rice, sip it when it is cooked, and do not eat at night" is the earliest internal ointment-type tonic preparation available in literature; the "Shennong Bencao Jing" written around the Qin and Han Dynasties recorded the technical methods of decocting and making glue for the first time, laying the foundation for the production of modern ointments; the preparation of ointment-type tonic preparations in "Prescriptions for Emergencies Worth a Thousand Gold Pieces" by Sun Simiao, the king of medicine in the Sui and Tang Dynasties, has the characteristics of decocting in water to remove the residue, extracting juice, concentrating and taking internally; early internal ointments were also called "decocting", and all decocted drugs with high viscosity, such as honey, maltose, nourishing medicinal juice, jujube paste, animal fat and skin and bones, can be called decocting. The Dawutou Decoction and Zhugaofa Decoction in "Golden Chamber Synopsis" by Zhang Zhongjing in the late Eastern Han Dynasty are The earliest tonic preparations of paste type were taken internally; the "Wuwei Han Dynasty Medical Bamboo Slips" in the Eastern Han Dynasty named "plaster" for the first time, such as the prescription of plaster for all diseases and the prescription of Qianjin plaster, which had complete records of the formulation and administration method of tonic preparations of paste type. The "Collected Notes on Shennong's Herbal Classic" by Tao Hongjing of the Southern Dynasty stated: "Some diseases are suitable for taking pills, some are suitable for taking powders, some are suitable for taking soups, some are suitable for taking wine, and some are suitable for taking pastes and decoctions. The cause of the disease is also used in the preparation of the medicine." It clearly pointed out that pastes and decoctions are medicines for internal use; especially the Rehmannia decoction for nourishing stomach yin and clearing away heat in the "Prescriptions for Emergencies and Qianjin", and the "Six Decoctions from Ancient and Modern Times" included in the "Secret Prescriptions of the Imperial Court" by Wang Tao of the Tang Dynasty first elevated the medical treatment of tonic preparations of paste type to a new height of nourishing and strengthening to eliminate deficiency and fatigue. That is, around the Tang Dynasty, the medical treatment of tonic preparations of paste type basically formed the dialectical idea of ​​combining tonic and treatment.

[0004] In the Ming and Qing Dynasties, the medical science of paste prescriptions for nourishing preparations had completed systematic scientific construction. The naming and preparation methods of paste prescriptions for nourishing preparations had been basically fixed, and their clinical application was increasingly widespread. Many tonic pastes, such as the Motherwort Paste in Li Shizhen's Compendium of Materia Medica in the Ming Dynasty, the Ginseng Paste and Poria Paste in Gong Tingxian's Shoushibaoyuan, are still in use today. The Buzhen Paste in Sun Yikui's Chishui Xuanzhu, which is used to treat weakness, fatigue and timidity, is a representative prescription of tonic pastes in traditional Chinese medicine, and it is the first to set a precedent for modern customized tonic pastes with many components. By the Qing Dynasty, tonic pastes had become a common means of clinical treatment of diseases. The "Pei Shi Kong Qiao Paste" in Ye Tianshi's "Ye's Medical Cases Cunzhen" in the Qing Dynasty and the "Yuling Paste" in Wang Shixiong's "Sui Xi Ju Diet", the trend of using tonic pastes to regulate the body was prevalent from the Qing Palace to the folk. For example, "Qing Imperial Hospital Prescriptions" and "Cixi Guangxu Medical Prescriptions Selection" collected a total of 30 tonic pastes for internal use. Here we finally extract that as long as it is beneficial to the disease, tonic pastes can be used in all seasons.

[0005] The scientific and technological achievements of tonic paste preparations have made great progress in modern times. In 1939, Qin Boyi's "Compendium of Paste Prescriptions" systematically organized some basic concepts, key points and principles in the treatment of tonic paste preparations for the first time, and summarized his clinical experience in the treatment of diseases with tonic paste preparations in the form of medical records. This book is still the basic principle followed in the use of tonic paste preparations to treat diseases; in 1962, the "National Collection of Chinese Medicine Prescriptions" co-edited by the Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences and Shenyang Pharmaceutical College contained 58 tonic paste preparations, the number of tonic paste preparations was more than any previous prescription book. In 1989, the National Collection of Chinese Patent Medicine Products compiled by China National Pharmaceutical Company and the Chinese Patent Medicine Information Center of the State Drug Administration increased the number of paste-type tonic preparations to 152, including traditional paste-type tonic preparations, such as Liangyi paste, Guilu Erxian paste, etc., and some modified from other dosage forms of prescriptions, such as Shiquan Dabu Decoction changed to Shiquan Dabu Paste, Shuilu Erxian Dan changed to Jinying Euryale Paste, etc. In particular, the "Chinese Paste Prescriptions" written by Yan Xin and Hu Dongpei in 2004, "Chinese Paste Prescription Therapeutics" written by Wu Yingen in 2011, and "Chinese Plaster Medicine" written by Wang Qingguang in 2014 have pushed Chinese paste-type tonic medicine to a new theoretical and technological height.

[0006] The present invention is based on the inheritance and innovation of "Shiquan Powder". "Shiquan Powder" comes from Volume 2 of "Chuanxin Shiyong Fang", which is used to "replenish various deficiencies, nourish the three burners of the Rongwei, and the five internal organs and six bowels". Tracing its source, it is made by combining Sijunzi Decoction with Siwu Decoction and adding Astragalus and Cinnamon; when "Taiping Huimin Hejiju Fang" recorded this prescription, it was renamed "Shiquan Dabu Tang", which is used to treat "all kinds of deficiencies in men and women, five kinds of fatigue and seven kinds of injuries, and loss of appetite; long-term illness and weakness, occasional hot flashes, Qi attacking the bones and spine, tightness and pain, nocturnal emission, sallow complexion, weak feet and knees, all kinds of qi after illness are not as good as before, worries and worries hurt the blood and qi, wheezing and coughing, spleen and kidney qi are weak, and the five hearts are upset", thus confirming the status of this prescription as a major prescription for replenishing qi and blood.

[0007] "Shiquan Dabu Soup" was originally a boiled powder. Some doctors in later generations changed it into pills or ointments, named "Shiquan Dabu Pills" (see "The Complete Book of Measles") and "Shiquan Dabu Paste" (see "The Complete Book of Chinese Medicine Formulas") respectively. In modern times, it has been made into oral liquid and other dosage forms, which is more convenient for long-term use.

[0008] The prescription of Shiquan Dabu Decoction is composed of equal parts of ginseng, cinnamon bark (peeled off and not exposed to fire), Chuanxiong, Rehmannia root (washed with wine, steamed and roasted), Poria (roasted), Atractylodes macrocephala (roasted), Licorice root (roasted), Tragacanth (stalk removed), Chuanxiong, Angelica sinensis (washed and stalk removed), and white peony root. The preparation method is to prepare the above ten ingredients, process them into coarse powder, add ginger and jujube, boil them in water until 70% of the ingredients are left, and take them as a decoction.

[0009] Functions and indications: Treats various deficiency in men and women, five kinds of fatigue and seven kinds of injuries, loss of appetite, long-term illness, occasional hot flashes, Qi attacking the bones and spine, cramps and pain, nocturnal emission, sallow complexion, weak feet and knees, all kinds of qi not as good as before after illness, worry and anxiety hurting blood and qi, wheezing and coughing, spleen and kidney qi weakness, and five-heart upset. This medicine is warm in nature but not hot, and is effective in nourishing Qi and nourishing spirit, awakening the spleen and quenching thirst, following the right path and warding off evil spirits, and warming the spleen and kidneys. Its effects are beyond description.

[0010] Modern pharmacological research shows that the combination of drugs related to "Shiquan Dabu Tang" has significant effects of replenishing qi and blood, enhancing the body's immunity, and resisting aging and prolonging life. Combined with the new ointment dosage form, it is convenient for long-term use, and the market application prospects are very broad. Summary of the invention

[0011] In view of this, the present invention provides a nourishing paste for strengthening the foundation and nourishing the essence based on a hot pulping system and a preparation method thereof. The present invention not only obtains the full extraction rate of effective components of traditional Chinese medicine, but also realizes the complete separation of fiber, lignin and other substances in plant traditional Chinese medicine from medicinal components, and solid wastes such as traditional Chinese medicine residues are turned into useful light industrial materials that can be turned into papermaking or wood boards, etc.; the very fine traditional Chinese medicine extracts obtained are further used to prepare anti-aging and longevity medicines.

[0012] In a first aspect of the present disclosure, the present disclosure provides a hot refining system for extracting effective ingredients of traditional Chinese medicine, which comprises the following steps: S101 Feed the clean raw materials of Chinese medicinal plants into a special forging and crushing machine to crush them separately, and then mix them to obtain mixed medicinal powder; S102 The mixed powder obtained in S101 is fed into the steaming pipe through a forced feeding motor, and high-temperature steam is introduced into the steaming pipe to maintain the temperature at 105-165°C (for example: 105°C, 125°C, 145°C, 165°C); S103: starting the mechanical kneading function in the steaming pipe at a speed of 100-1500 rpm (for example, 100, 300, 500, 700, 900, 1100, 1300, 1500 rpm) to obtain mixed medicinal material fines; S104: The mixed medicinal material fine material after mechanical kneading is fed into a high-concentration pulping machine through a forced feeding motor, the motor is started, the speed is controlled at 500-1500 rpm (for example: 500, 750, 1000, 1250, 1500 rpm), and the pulping time is maintained for 30-75 minutes (profit: 30, 45, 60, 75 minutes), and a mixed medicinal material high-concentration pulp is obtained; S105 The mixed medicinal material high-concentration slurry obtained in S104 is sent to a press dewatering machine through a forced feeding motor for pulp-residue separation, and the residue is recycled. The coarse high-concentration slurry is filtered twice using a plate and frame filter to obtain a fine mixed high-concentration slurry.

[0013] In a second aspect of the present disclosure, the present disclosure provides a fine mixed high-concentration slurry prepared by the hot refining system of the first aspect; In some optional embodiments of the present disclosure, the fine mixed high-concentration medicinal slurry contained in the tonic paste for strengthening the foundation and nourishing the essence contains 18 parts of roasted polygonatum, 18 parts of dendrobium, 8 parts of codonopsis, 8 parts of stir-fried atractylodes, 8 parts of poria, 12 parts of angelica, 6 parts of chuanxiong, 8 parts of wine-roasted white peony, 18 parts of prepared rehmannia, 8 parts of roasted astragalus, 2 parts of cinnamon, 4 parts of burdock, 5 parts of wolfberry, 3 parts of Achyranthes bidentata, 8 parts of roasted licorice, 5 parts of red dates, and 3 parts of ginger.

[0014] In a third aspect of the present disclosure, the present disclosure provides a method for preparing a nourishing paste for strengthening the body and nourishing the essence, comprising the following steps: S201 Put tortoise shell glue and donkey hide glue into the paste pot, add 4-6 times the amount of pure water (for example: 4 times, 5 times, 6 times), start the mixer and heat to 45-75℃ (for example: 45, 55, 65, 75℃), keep warm for 6-12 hours (for example: 6, 8, 10, 12 hours); S202 Add thyme and magnolia to 4-6 times the total weight of pure water, start the mixer and heat to 95°C, keep warm for 6-12 hours (for example: 6, 8, 10, 12 hours), and finally filter to obtain the liquid medicine; S202 Add the finely mixed and highly concentrated medicinal slurry obtained in S105 into the paste-making pot in S201, start the mixer and raise the temperature to 75-95°C (for example: 75, 85, 95°C), when the medicinal slurry becomes thicker, add the medicinal solution obtained in S202, then add brown sugar and honey, stir evenly, stop heating and cool, and after passing the quality inspection, fill it to obtain the nourishing paste for strengthening the foundation and nourishing the essence.

[0015] The disclosed nourishing paste for strengthening the foundation and nourishing the essence includes a new pharmaceutical composition, and the composition ratio is calculated by weight: 18-20 parts of roasted Polygonatum, 18-20 parts of Dendrobium, 6-8 parts of Codonopsis, 6-8 parts of stir-fried Atractylodes, 6-8 parts of Poria, 10-12 parts of Angelica, 4-6 parts of Chuanxiong, 6-8 parts of wine-roasted White Peony Root, 18-20 parts of Rehmannia Glue, 6-8 parts of roasted Astragalus, 2-3 parts of cinnamon, 4-5 parts of burdock, 5-6 parts of wolfberry, 3-4 parts of Achyranthes Bidentata, 8-12 parts of roasted Licorice, 5-8 parts of red dates, 3-4 parts of ginger, 2-3 parts of tortoise shell glue, 2-3 parts of donkey-hide gelatin, 1-2 parts of thyme, 0.5-1 parts of Magnolia officinalis, 3-5 parts of brown sugar, and 7-9 parts of honey.

[0016] In an optional embodiment of the present disclosure, the new drug combination of Guben Peiyuan Zibu Paste is calculated by weight: 18 parts of roasted polygonatum, 18 parts of dendrobium, 8 parts of codonopsis, 8 parts of stir-fried atractylodes, 8 parts of tuckahoe, 12 parts of angelica, 6 parts of chuanxiong, 8 parts of wine-roasted white peony root, 18 parts of prepared rehmannia, 8 parts of roasted astragalus, 2 parts of cinnamon, 4 parts of burdock, 5 parts of wolfberry, 3 parts of achyranthes, 8 parts of roasted liquorice, 5 parts of red dates, 3 parts of ginger, 2 parts of tortoise shell glue, 2 parts of donkey-hide gelatin, 1 part of thyme, 0.5 parts of magnolia, 3 parts of brown sugar, and 7 parts of honey.

[0017] In summary, the present invention utilizes a hot pulping system to extract effective components of traditional Chinese medicine, and realizes complete separation of medicinal components from non-medicinal components (such as fiber and lignin) of traditional Chinese medicine, and the drug residue can be completely transformed into useful light industrial materials; the environmental protection and ecological effects are very prominent. It also becomes very simple to further process traditional Chinese medicine preparations by extracting very fine drug liquid, and the economic efficiency is greatly improved.

[0018] The tonic paste prepared by the present invention has significant advantages compared with conventional dosage forms: .

[0019] At the same time, the new drug composition obtained by the present invention completely eliminates the "return of sand (separation of sugar and water)" phenomenon caused by unstable amount of refined honey in traditional creams due to its unique process and innovative prescription, as well as the problem of poor palatability of traditional creams due to excessive viscosity. The relevant indicators are compared as follows: .

[0020] It can be seen that the preparation method disclosed in the present invention is unique and novel, and has huge technical and economic costs, as well as environmental advantages over traditional preparation processes. DETAILED DESCRIPTION Example

[0021] The present disclosure is further described in detail below in conjunction with embodiments.

[0022] S001 Add 18 parts of roasted polygonatum, 18 parts of dendrobium, 8 parts of codonopsis, 8 parts of stir-fried atractylodes, 8 parts of poria, 12 parts of angelica, 6 parts of chuanxiong, 8 parts of white peony root roasted with wine, 18 parts of prepared rehmannia, 8 parts of roasted astragalus, 2 parts of cinnamon, 4 parts of burdock, 5 parts of wolfberry, 3 parts of cyathula, 8 parts of roasted liquorice, 5 parts of red dates, 3 parts of ginger and other medicinal materials into the hot refining system, add 8 times the total mass of pure water to the mixed medicinal materials when they enter the high-concentration hot refining machine for refining, and finally perform pulp-residue separation to remove the medicinal residue to obtain fine medicinal pulp; S002 Add thyme and magnolia to 4 times the total weight of pure water, start the mixer and heat to 95°C, keep warm for 8 hours, and finally filter to obtain the liquid medicine; S003 Put tortoise shell glue and donkey-hide gelatin into the paste pot, add 4 times the amount of purified water, start the mixer and heat it to 60℃, keep it warm for 8 hours; S004 adds the finely mixed and highly concentrated medicinal slurry obtained in S001 into the paste-making pot of S003, starts the mixer and raises the temperature to 95°C. When the medicinal slurry becomes thicker, adds the medicinal liquid obtained in S002, and then adds 3 parts of brown sugar and 7 parts of honey. Stir evenly, stop heating and cool. After passing the quality inspection, fill it to obtain the nourishing paste for strengthening the foundation and nourishing the essence.

[0023] The hot pulping system in this embodiment is based on the present disclosure and is composed of non-standard equipment including a forging crusher, a rotary kneading wire separator, a high-concentration hot pulping machine, a screw pulp-residue separator, etc., and is professionally used for the extraction of effective ingredients of traditional Chinese medicine containing plant fiber and lignin and the separation of non-medicinal ingredients.

[0024] In this embodiment, the hot pulping system described in the present disclosure includes processes such as slicing of plant-based Chinese medicinal materials, loading, steaming, kneading and silk separation, high-concentration hot pulping, and pulp-residue separation, forming a set of efficient and continuous Chinese herbal medicine effective ingredient extraction production line.

[0025] It is to be understood that the above embodiments are merely exemplary embodiments used to illustrate the principles of the present disclosure, but the present disclosure is not limited thereto. For those of ordinary skill in the art, various modifications and improvements can be made without departing from the spirit and substance of the present disclosure, and these modifications and improvements are also considered to be within the scope of protection of the present disclosure.

Claims

1. The mixed medicinal materials are sent to the hot pulping machine system for pulping through a forced feeding motor. The coarse high-concentration slurry is first obtained and then filtered by a plate and frame filter to obtain a fine mixed high-concentration slurry.

2. A nourishing paste for strengthening the body and nourishing the essence and a preparation method thereof, characterized in that: It includes the following steps: S201 Put tortoise shell glue and donkey hide glue into the paste pot, add 4-6 times the amount of purified water, start the mixer and heat to 45-75℃, keep warm for 6-12 hours; S202 Add thyme and magnolia to 4-6 times the total weight of pure water, start the mixer and heat to 75-95°C, keep warm for 6-12 hours, and finally filter to obtain the liquid medicine; S203 Put the finely mixed high-concentration slurry obtained in claim 1 into the paste-making pot of S201, start the mixer and raise the temperature to 95°C, when the slurry becomes thicker, add the medicine obtained in S202, then add brown sugar and honey, stir evenly, stop heating and cool, and after passing the quality inspection, fill it to obtain the nourishing paste for strengthening the body and replenishing the essence.

3. The nourishing paste for strengthening the body and nourishing the essence according to claim 2, characterized in that: The novel pharmaceutical composition comprises the following components in parts by weight: 18-20 parts of roasted Polygonatum, 18-20 parts of Dendrobium, 6-8 parts of Codonopsis, 6-8 parts of stir-fried Atractylodes, 6-8 parts of Poria, 10-12 parts of Angelica, 4-6 parts of Chuanxiong, 6-8 parts of wine-roasted White Peony Root, 18-20 parts of Rehmannia Glue, 6-8 parts of roasted Astragalus, 2-3 parts of cinnamon, 4-5 parts of burdock, 5-6 parts of wolfberry, 3-4 parts of Achyranthes Bidentata, 8-12 parts of roasted Licorice, 5-8 parts of red dates, 3-4 parts of ginger, 2-3 parts of tortoise shell glue, 2-3 parts of donkey-hide gelatin, 1-2 parts of thyme, 0.5-1 parts of Magnolia officinalis, 3-5 parts of brown sugar, and 7-9 parts of honey.