Integrated microneedle, implantation method thereof and electrode regulation and control device

Abstract

The invention relates to the technical field of biomedical engineering, and provides an integrated microneedle which comprises a first electrode used for positioning the position of a target part and a second electrode used for regulating and controlling the target part, the second electrode is arranged on the first electrode, and after the first electrode is implanted in place, the second electrode is arranged on the first electrode. And the second electrode is implanted at the target part along the first electrode. The invention further provides an electrode regulation and control device which comprises the integrated microneedle. The invention further provides an implantation method of the integrated microneedle. The integrated microneedle is adopted to detect, regulate and control the deep target part of the brain, damage caused by repeated implantation of the electrodes can be avoided, damage to the body is reduced, meanwhile, the first electrode of the integrated microneedle can also play a detection role in the process of implanting the second electrode, the second electrode can accurately reach the target part, and the detection precision is improved. Deviation is avoided, and the regulation and control effect is improved.

Description

Technical Field

[0001] The present invention relates to the field of biomedical engineering technology, and in particular to an integrated microneedle and an implantation method thereof, as well as an electrode control device. Background Art

[0002] When some target parts are located deep in the brain and need to be controlled by electrodes, specifically when stimulating or ablating the target parts, it is often necessary to first use microelectrode recording technology to locate and determine the position of the target part, then pull out the recording microelectrode, and then implant a second electrode for stimulation or ablation. In this process, on the one hand, the process of pulling out and inserting will cause a certain degree of damage to the brain, and on the other hand, because the target part is located deep in the brain, even if the target part is located first, when the second electrode is implanted deeper, deviations may occur, thereby affecting the stimulation and ablation effects. Summary of the invention

[0003] The purpose of the present invention is to provide an integrated microneedle and an implantation method thereof and an electrode control device, which can at least solve some of the defects in the prior art.

[0004] To achieve the above-mentioned purpose, an embodiment of the present invention provides the following technical solution: an integrated microneedle, comprising a first electrode for locating the position of a target part and a second electrode for regulating the target part, wherein the second electrode is arranged on the first electrode, and after the first electrode is implanted in place, the second electrode is implanted into the target part along the first electrode.

[0005] Furthermore, it also includes a binding structure for binding the first electrode and the second electrode into one body, and the binding structure has a binding area for the second electrode and the first electrode to move relative to each other.

[0006] Furthermore, the second electrode has a groove for the first electrode to be embedded in, and when the second electrode is displaced relative to the first electrode, a matching surface between the second electrode and the groove serves as a guide surface.

[0007] Furthermore, a positioning contact is provided on the first electrode, and a regulating contact is provided on the second electrode.

[0008] An embodiment of the present invention provides another technical solution: an electrode control device, comprising at least one integrated microneedle as described above and an implantation mechanism for implanting the integrated microneedle deep into the brain.

[0009] Furthermore, the implantation mechanism includes a driving member, a driving end of which is connected to the second electrode, and the driving end drives the first electrode and the second electrode to move synchronously. After the first electrode is implanted in place, the position of the first electrode is locked, and the driving end drives the second electrode to be implanted into the target site along the first electrode.

[0010] Furthermore, it also includes a plurality of positioning electrodes, each of which is dispersedly arranged to spatially locate the brain, explore the neuronal propagation path, or find the abnormal discharge area; or there are multiple integrated microneedles, each of which is dispersedly arranged to spatially locate the brain, explore the neuronal propagation path, or find the abnormal discharge area.

[0011] Furthermore, when the target site positioned by each of the positioning electrodes is not deeper than the current location of a positioning electrode or the target site positioned by each of the integrated microneedles is not deeper than the current location of a certain integrated microneedle, another integrated microneedle is implanted into the target site.

[0012] The embodiment of the present invention provides another technical solution: a method for implanting an integrated microneedle, using the above-mentioned integrated microneedle, comprising the following steps:

[0013] S1, implanting the first electrode into the brain, and the second electrode enters the brain together with the first electrode;

[0014] S2, the first electrode reaches the target site;

[0015] S3, driving the second electrode to move along the first electrode to the target site.

[0016] Further, an implantation mechanism is used to drive the first electrode and the second electrode to perform an implantation operation, and a driving end of the implantation mechanism is connected to the second electrode;

[0017] In a first stage of implantation, the driving end drives the first electrode and the second electrode to move synchronously;

[0018] In the second stage of implantation, after the first electrode is implanted and reaches the target site, the position of the first electrode is locked, and the driving end drives the second electrode to be implanted into the target site along the first electrode.

[0019] Compared with the prior art, the beneficial effects of the present invention are: using integrated microneedles to detect and regulate target areas deep in the brain can avoid damage caused by repeated implantation of electrodes, reducing damage to the body. At the same time, the first electrode of the integrated microneedle can also play a detection role during the implantation process with the second electrode, so that the second electrode can accurately reach the target area, avoid deviation, and improve the regulation effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 A partial schematic diagram of an integrated microneedle provided by an embodiment of the present invention (first viewing angle);

[0021] Figure 2 A partial schematic diagram of an integrated microneedle provided by an embodiment of the present invention (second viewing angle);

[0022] Figure 3 Schematic diagram of various cross-sectional shapes of a second electrode of an integrated microneedle provided in an embodiment of the present invention (the notch is a schematic diagram of a groove);

[0023] Figure 4 A schematic diagram of implantation of an electrode control device provided by an embodiment of the present invention;

[0024] In the figure markings: 1-first electrode; 2-second electrode; 3-positioning contact; 4-regulating contact; 5-groove; 6-binding structure; 7-guide ring; 8-fixing component; 9-driving member. DETAILED DESCRIPTION

[0025] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0026] See also Figure 1 , Figure 2 and Figure 3The embodiment of the present invention provides an integrated microneedle, comprising a first electrode 1 for locating the position of a target part and a second electrode 2 for regulating the target part, wherein the second electrode 2 is arranged on the first electrode 1, and after the first electrode 1 is implanted in place, the second electrode 2 is implanted along the first electrode 1 at the target part. In this embodiment, the integrated microneedle is used to detect and regulate the target part deep in the brain, which can avoid the damage caused by repeated implantation of electrodes and reduce the damage to the body. At the same time, the first electrode of the integrated microneedle can also play a detection role in the process of implanting with the second electrode, so that the second electrode can accurately reach the target part, avoid deviation, and improve the regulation effect. Specifically, the integrated microneedle can be used for brain implantation to carry out related intracranial treatment, and can also be used for treatment experiments simulating brain products. With different target objects, the integrated microneedle can be used in different scenarios. It includes a first electrode 1 and a second electrode 2, which are integrated together to form a whole. The first electrode can be a detection electrode, and the second electrode can be a treatment electrode. The first electrode 1 is used to detect the position of the target part, which can be a target, a lesion, or a point of interest to be studied. The regulation of the second electrode 2 includes functions such as collection, stimulation, and ablation. The target site can be collected, stimulated, or ablated as needed to reduce the patient's symptoms. The indications can be, but are not limited to, Parkinson's, epilepsy, Alzheimer's, severe depression, obsessive-compulsive disorder, addiction, and vegetative awakening. When the integrated microneedle is in operation, since it does not need to be pulled out and inserted again, the damage to the body will be much smaller, and the second electrode 2 with the first electrode 1 can still have a precise positioning function when implanted, ensuring that the second electrode 2 can smoothly reach the target site deep in the brain, thereby achieving high-precision positioning, improving surgical efficiency, and reducing surgical risks. Preferably, the material of the first electrode 1 includes, but is not limited to, stainless steel, tungsten steel, titanium alloy, and other materials, which can be made by laser processing, micro-nano processing technology, printing technology, electroplating technology, and the like. The number of detection channels of the first electrode 1 can be 8 / 16 / 32 / 64 / 128 channels. Preferably, the shape of the first electrode 1 can be a chamfered square, a circle, an ellipse, and the like, and the first electrode 1 is smooth and burr-free by polishing, and will not cause damage to the tissue.

[0027] See also Figure 1 , Figure 2 and Figure 3, the integrated microneedle also includes a binding structure 6 for binding the first electrode 1 and the second electrode 2 as a whole, and the binding structure 6 has a binding interval for the second electrode 2 and the first electrode 1 to move relative to each other. In this embodiment. The first electrode 1 and the second electrode 2 are bound as a whole by the binding structure 6. When implanted, the same driving end can make the first electrode 1 and the second electrode 2 move synchronously, because when the first electrode 1 and the second electrode 2 are integrated together, only one of the electrodes needs to be driven to drive the two electrodes to move together. Since the binding interval of the binding structure 6 can make the second electrode 2 and the first electrode 1 move relative to each other, it is only necessary to act on the second electrode 2 with the driving end, and then limit the displacement of the first electrode 1, so that the second electrode 2 can be displaced to reach the target site. When designing, in order to improve the implantation efficiency of the first electrode 1, the second electrode 2 can be designed not at the end where the first electrode 1 first enters the brain. After the first electrode 1 reaches the target site, the driving end can be used to drive the second electrode 2. Of course, it is also feasible to use two driving ends to drive the first electrode 1 and the second electrode 2 respectively. This can be achieved by designing smaller driving ends to be arranged side by side, but this method is slightly more expensive than using one driving end, and using one driving end is more clever. Preferably, the restraining structure 6 uses a flexible material to form a wrapping layer to wrap the first electrode 1 and the second electrode 2. If the first electrode 1 is not locked, under the action of the wrapping force, the first electrode 1 and the second electrode 2 can move synchronously under the action of the same driving end, and when the first electrode 1 is locked, the flexible wrapping layer is soft and has deformation properties, so that the second electrode 2 can move inside it. The tension of the restraining structure 6 can be designed to ensure that it can wrap the first electrode 1 and the second electrode 2 to move together, and the second electrode 2 can move alone after the first electrode 1 is locked. Moreover, the material of the restraining structure 6 is harmless and does not cause damage to the brain.

[0028] See also Figure 1 , Figure 2 and Figure 3 , the second electrode 2 has a groove 5 for the first electrode 1 to be embedded. When the second electrode 2 is displaced relative to the first electrode 1, the mating surface between the second electrode 2 and the groove 5 is a guide surface. In this embodiment, a groove 5 is designed on the second electrode 2, so that the first electrode 1 can be embedded in the groove 5. The first electrode 1 is relatively long and will not be fully embedded in the groove 5, but only a small part of the groove 5. With such a design, on the one hand, the volume of the entire integrated microneedle can be reduced and the scope of damage can be reduced. On the other hand, after the first electrode 1 is implanted in place, the first electrode 1 can be used as a guide column to cooperate with the groove 5 of the second electrode 2 to achieve guidance and improve the implantation accuracy. Preferably, the shape of the second electrode 2 can be but not limited to a circle and a chamfered square, and the form of the groove 5 can be various, such as Figure 3As shown, the groove 5 can be processed by electrospark, wire cutting, laser processing, photolithography and mechanical milling processes, such as square, semicircle, ellipse, chamfered square, etc. Figure 3 In the embodiment, each black pattern is a second electrode 2 , and the groove 5 of each second electrode 2 has a different shape, and the shape is also limited to the several forms shown in the present application, as long as it is a groove 5 .

[0029] See also Figure 1 , Figure 2 and Figure 3 , the first electrode 1 is provided with a positioning contact 3, and the second electrode 2 is provided with a regulating contact 4. In this embodiment, the positioning contacts 3 on the first electrode 1 are distributed in two columns on the left and right, which can realize accurate positioning of neurons or nuclei, and the materials of the positioning contacts 3 include but are not limited to biocompatible materials such as platinum iridium, platinum black, iridium oxide, PEDOT, and titanium nitride. Preferably, the positioning contacts 3 of the first electrode 1 and the regulating contacts 4 of the second electrode 2 are both protruding outward, so as to realize detection and regulation of the target area.

[0030] See also Figure 1 , Figure 2 , Figure 3 and Figure 4 , an embodiment of the present invention provides an electrode control device, comprising at least one integrated microneedle as described above and an implantation mechanism for implanting the integrated microneedle deep in the brain. The use of an implantation mechanism can ensure that the position does not shift during the implantation process, and even if there is a shift, the first electrode 1 can also know it. The integrated microneedle is used in the electrode control device to detect and control the target part deep in the brain, which can avoid damage caused by repeated implantation of electrodes and reduce damage to the body. At the same time, the first electrode of the integrated microneedle can also play a detection role during the implantation process with the second electrode, so that the second electrode can accurately reach the target part, avoid deviation, and improve the treatment effect.

[0031] See also Figure 1 , Figure 2 , Figure 3 and Figure 4, the implantation mechanism includes a driver 9, the driving end of the driver 9 is connected to the second electrode 2, the driving end drives the first electrode 1 and the second electrode 2 to move synchronously, after the first electrode 1 is implanted in place, the position of the first electrode 1 is locked, and the driving end drives the second electrode 2 to be implanted along the first electrode 1 at the target site. In this embodiment, the driver 9 is used for driving, and the driver 9 can be a precise micro-push device, such as a precise stepping motor, which can realize the implantation of the integrated microneedle with micron-level precision, so that the position of the implantation process is controllable and adjustable. The implantation is divided into two stages. The first stage is that the driver end carries the first electrode 1 and the second electrode 2 to be implanted into the brain synchronously, and the second stage is that the first electrode 1 is locked in position after reaching the target site. The locking position is locked by, for example, using a locking component and a bracket outside the brain. At this time, the driver end continues to drive to push the second electrode 2, and the second electrode 2 can be implanted along the direction of the first electrode 1 to ensure accurate arrival at the target site and realize the exploration and treatment of the deep brain area.

[0032] See also Figures 1 to 4 When locating the target part, exploring the neuron propagation path or finding the abnormal discharge area, there are two detection methods. One is to use ordinary positioning electrodes. Several positioning electrodes are distributed in the brain to form spatial positioning, which can locate the target part more quickly. Another method is to directly use the integrated microneedles described in the above embodiment, and each integrated microneedle is distributed on the brain. The first electrode 1 on the integrated microneedle can achieve spatial positioning. Preferably, the first electrode 1 on the integrated microneedle can be an ordinary positioning electrode.

[0033] Based on the above two positioning methods, when the target part of each positioning electrode is not located deep in the current location of a positioning electrode or the target part of each integrated microneedle is not located deep in the current location of a certain integrated microneedle, another integrated microneedle is implanted into the target part. In simple terms, if the integrated microneedle used for positioning is directly in the shallow part of the brain corresponding to the target part deep in the brain, then the integrated microneedle is directly implanted into the target part. If the integrated microneedle used for positioning is not in the shallow part of the brain corresponding to the target part deep in the brain, then a new integrated microneedle is implanted from the position according to the positioning position. During the implantation process, since the first electrode 1 in the integrated microneedle is implanted with the second electrode 2, the implantation direction can also be detected in real time to ensure that the implantation direction is accurate and without deviation. Here is an explanation of the definition of deep brain and shallow brain. During the implantation process, the electrode cannot change its position in the brain at will. If the implantation position is determined, it can only continue to go deeper in the brain according to the established position. Therefore, after finding the target part, the electrode is implanted from the shallow part of the brain corresponding to the part until it reaches the target part deep in the brain.

[0034] See also Figures 1 to 4 The implantation mechanism also includes a guide ring 7 and a fixing assembly 8, wherein the guide ring 7 can guide the first electrode 1 outside the brain, and the fixing assembly 8 can ensure the stability of the entire implantation process.

[0035] See also Figures 1 to 4 , an embodiment of the present invention provides an implantation method of an integrated microneedle, which can be combined with the above-mentioned integrated microneedle and implantation mechanism to form logic. Specifically comprising the following steps: S1, implanting the first electrode 1 into the brain, and the second electrode 2 enters the brain together with the first electrode 1; S2, the first electrode 1 arrives at the target site; S3, driving the second electrode 2 to move along the first electrode 1 to the target site. In this embodiment, through this implantation method, the second electrode 2 can be accurately delivered to the target site. Preferably, an implantation mechanism is used to drive the first electrode 1 and the second electrode 2 to perform the implantation operation, and the driving end of the implantation mechanism is connected to the second electrode 2; in the first stage of implantation, the driving end drives the first electrode 1 and the second electrode 2 to move synchronously; in the second stage of implantation, after the first electrode 1 is implanted and arrives at the target site, the position of the first electrode 1 is locked, and the driving end drives the second electrode 2 to be implanted along the first electrode 1 to the target site. In this embodiment, first, the location of the target brain region for implantation is determined through preoperative planning, and the first electrode 1 is first implanted in a minimally invasive manner in conjunction with a head frame or a surgical robot. The number of implanted first electrodes 1 includes but is not limited to 1, 2, 4, 10, and 20 for lesion point analysis or neuronal signal detection at a location of interest. The first electrode 1 is implanted accurately and slowly using an implantation mechanism. If the target or lesion location is detected and the target or lesion needs to be neuromodulated or radiofrequency ablated, the second electrode 2 can be slowly implanted from the groove 5 along the first electrode 1 in conjunction with the implantation mechanism. The second electrode 2 needs to be accurately and slowly implanted by the implantation mechanism. After the driver 9 controls the position, it can collect, stimulate or ablate the lesion area or target area. The first electrode 1 and the second electrode 2 work in coordination to monitor deep brain lesions, targets, and areas of interest. The second electrode 2 can be implanted along the first electrode 1 to treat areas that require stimulation or ablation, thereby achieving high-precision positioning and improving surgical efficiency. Multiple electrodes can be implanted at the same craniotomy position to reduce intraoperative damage, improve surgical efficiency, and reduce surgical risks.

[0036] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. An integrated microneedle, comprising a first electrode for locating a target site and a second electrode for regulating the target site, characterized in that: The second electrode is disposed on the first electrode. After the first electrode is implanted in place, the second electrode is implanted into the target site along the first electrode.

2. The integrated microneedle according to claim 1, characterized in that: The device further comprises a binding structure for binding the first electrode and the second electrode together, wherein the binding structure has a binding section for allowing the second electrode and the first electrode to move relative to each other.

3. The integrated microneedle according to claim 1, characterized in that: The second electrode has a groove for the first electrode to be embedded in. When the second electrode is displaced relative to the first electrode, a matching surface between the second electrode and the groove serves as a guide surface.

4. The integrated microneedle according to claim 1, characterized in that: The first electrode is provided with a positioning contact, and the second electrode is provided with a regulating contact.

5. An electrode control device, characterized in that: The method comprises at least one integrated microneedle as claimed in any one of claims 1 to 4 and an implantation mechanism for implanting the integrated microneedle deep into the brain.

6. The electrode control device according to claim 5, characterized in that: The implantation mechanism includes a driving member, a driving end of which is connected to the second electrode, and the driving end drives the first electrode and the second electrode to move synchronously. After the first electrode is implanted in place, the position of the first electrode is locked, and the driving end drives the second electrode to be implanted into the target site along the first electrode.

7. The electrode control device according to claim 5, characterized in that: It also includes a plurality of positioning electrodes, each of which is dispersedly arranged to spatially locate the brain, explore the neuronal propagation path, or find the abnormal discharge area; or there are multiple integrated microneedles, each of which is dispersedly arranged to spatially locate the brain, explore the neuronal propagation path, or find the abnormal discharge area.

8. The electrode control device according to claim 7, characterized in that: When the target site positioned by each positioning electrode is not deep within the current location of a positioning electrode or the target site positioned by each integrated microneedle is not deep within the current location of a certain integrated microneedle, another integrated microneedle is implanted into the target site.

9. A method for implanting an integrated microneedle, characterized in that: The integrated microneedle according to any one of claims 1 to 4 is used, comprising the following steps: S1, implanting the first electrode into a target object, and the second electrode enters the target object together with the first electrode; S2, the first electrode reaches the target part of the target object; S3, driving the second electrode to move along the first electrode to the target site.

10. The method for implanting an integrated microneedle according to claim 9, characterized in that: An implantation mechanism is used to drive the first electrode and the second electrode to perform an implantation operation, wherein a driving end of the implantation mechanism is connected to the second electrode; In a first stage of implantation, the driving end drives the first electrode and the second electrode to move synchronously; In the second stage of implantation, after the first electrode is implanted and reaches the target site, the position of the first electrode is locked, and the driving end drives the second electrode to be implanted into the target site along the first electrode.

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