Device for purification

Abstract

The present application provides a device for purification. The device for purification comprises a plurality of extraction columns (100), a plurality of liquid source pipes (200) and a driving device. The liquid source pipes (200) are respectively used for providing corresponding reagents for all treatment stages, and the driving device controls the plurality of extraction columns (100) to rotate to respectively correspond to the liquid source pipes (200) at all positions, so that the plurality of extraction columns (100) are respectively in different treatment stages; and the processing stage of each extraction column (100) can be adjusted by rotating the switching position.

Description

Technical Field

[0001] The present application relates to the technical field of solid phase extraction, and in particular to a device for purification. Background Art

[0002] As a sample processing technology, solid phase extraction can separate and enrich target compounds, and plays an increasingly important role in pharmaceuticals, fine chemicals, biomedicine, food analysis, organic synthesis and other fields. At present, most solid phase extraction processes are still manual, with a low degree of automation.

[0003] The Chinese utility model patent with the authorization announcement number CN213433091U discloses an organic solid phase extraction column purification optimization device. The extraction column disclosed in the patent is connected to each reagent bottle through a hose to achieve the addition of various types of liquids. A filler is provided in the extraction column, and the extraction column has openings at both ends. The upper opening can extend into the piston rod to force the liquid to pass through the filler and leave the extraction column through the lower opening.

[0004] However, each of the multiple extraction columns provided in the patent needs to be connected to multiple reagent bottles separately, resulting in a large number of connecting pipes and a complex structure. In addition, when the number of connecting pipes connected to the extraction column needs to be increased or decreased when the substance to be extracted is changed, the number of interfaces of the extraction column needs to be changed and the control logic of the valve needs to be changed, which has poor universality and is difficult to adjust. Summary of the invention

[0005] In order to improve or solve at least one of the problems mentioned in the background technology, the present application provides a device for purification.

[0006] The device for purification provided in the embodiment of the present application comprises:

[0007] multiple extraction columns; and

[0008] A plurality of liquid source tubes and a driving device, each of the liquid source tubes is used to provide corresponding reagents for each processing stage. The driving device controls the rotation of the plurality of extraction columns to correspond to the liquid source tubes at each position, so that the plurality of extraction columns are respectively in different processing stages, and the processing stage of each extraction column can be adjusted by rotating and switching positions.

[0009] In at least one embodiment, the multiple extraction columns are integrated into a cylindrical extraction component, the axial direction of each extraction column is parallel to the axial direction of the extraction component, the multiple extraction columns are evenly spaced in the circumferential direction of the extraction component, and the driving device can control the extraction component to rotate around the axis of the extraction component.

[0010] In at least one embodiment, the device for purification further comprises a plurality of collecting tubes, and the driving device can control the extraction column to rotate to the position of each of the collecting tubes to collect liquid discharged from the extraction column at different processing stages.

[0011] In at least one embodiment, the number of the plurality of extraction columns, the plurality of liquid source tubes and the plurality of collection tubes is the same, and interfaces of the plurality of liquid source tubes and the plurality of collection tubes for connecting the extraction columns are evenly spaced in a circumferential direction.

[0012] In at least one embodiment, the plurality of liquid source tubes are located on one side of the upper and lower sides of the plurality of extraction columns, and the plurality of collection tubes are located on the other side.

[0013] The liquid source tube and the collecting tube can move toward the extraction column until the liquid source tube and the collecting tube are connected to the extraction column, and the liquid source tube and the collecting tube in the connected state are sealed and connected to the extraction column.

[0014] The liquid source tube and the collecting tube in the connected state can move away from the extraction column so that the liquid source tube and the collecting tube are separated from the extraction column.

[0015] In at least one embodiment, the plurality of liquid source tubes are located at the lower side of the plurality of extraction columns, and the plurality of collection tubes are located at the upper side of the extraction columns; and / or,

[0016] The component that drives the liquid source pipe and / or the collecting pipe to move in the vertical direction is a linear cylinder assembly.

[0017] In at least one embodiment, a back-pressure valve is provided in the extraction column, or a back-pressure valve and a one-way membrane are provided simultaneously.

[0018] In at least one embodiment, the device for purification also includes a liquid inlet component and a liquid outlet component, the liquid inlet component includes a liquid inlet flange, one ends of the multiple liquid source tubes are evenly spaced in the circumferential direction of the liquid inlet flange, the liquid outlet component includes a liquid outlet flange, one ends of the multiple collection tubes are evenly spaced in the circumferential direction of the liquid outlet flange, and the liquid inlet flange and the liquid outlet flange can be controlled to move toward or away from each other.

[0019] In at least one embodiment, the liquid inlet flange includes a liquid inlet hole, the liquid inlet assembly also includes a liquid inlet head, one end of the liquid inlet head is connected to the liquid inlet flange, and one end of the liquid source tube passes through the liquid inlet hole and is fixed to the liquid inlet head.

[0020] In at least one embodiment, the liquid inlet head includes a tapered guide structure for extending into the extraction column.

[0021] The rotatable extraction column provided in the embodiment of the present application makes it unnecessary for the extraction column to be fixedly connected to multiple liquid source tubes. When there are multiple extraction columns, the number of connecting tubes can be relatively reduced, making the overall structure simpler. The multiple extraction columns correspond to the liquid source tubes at different positions for providing corresponding reagents in each processing stage by rotating, so that the multiple extraction columns in the device for purification can be in different processing stages at the same time and complete the extraction in time, which helps to realize the continuous extraction process and the automation of the device for purification. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 A schematic structural diagram showing a liquid inlet component, a liquid outlet component and an extraction component of a purification device according to an embodiment of the present application in a separated state.

[0023] Figure 2 A schematic structural diagram showing a liquid inlet component, a liquid outlet component and an extraction component of a purification device in a connected state according to an embodiment of the present application is shown.

[0024] Figure 3 A top view of a liquid inlet assembly of a purification device according to an embodiment of the present application is shown.

[0025] Figure 4 An axonometric view of a liquid inlet assembly of an apparatus for purification according to an embodiment of the present application is shown.

[0026] Figure 5 A comparison diagram of the absorption spectra of quantum dots before and after purification by a purification device according to an embodiment of the present application is shown.

[0027] Figure 6 The dot film morphology of the purified quantum dot solution according to an embodiment of the present application is shown.

[0028] Description of Reference Numerals

[0029] 100 extraction column; 101 first extraction column; 102 second extraction column; 103 third extraction column; 104 fourth extraction column; 105 fifth extraction column; 110 extraction assembly;

[0030] 200 liquid source tube; 201 first liquid source tube; 202 second liquid source tube; 203 third liquid source tube; 204 fourth liquid source tube; 205 fifth liquid source tube;

[0031] 300 collecting tube; 301 first collecting tube; 302 second collecting tube; 303 third collecting tube; 304 fourth collecting tube; 305 fifth collecting tube;

[0032] 400 liquid inlet assembly; 410 liquid inlet flange; 420 liquid inlet head; 421 cone guide structure; 422 columnar structure; 423 sealing ring;

[0033] 500 liquid outlet assembly; 510 liquid outlet flange; 520 liquid outlet head;

[0034] 600 linear cylinder assembly; 610 first piston rod; 620 second piston rod;

[0035] 701 is a first gear; 702 is a second gear. DETAILED DESCRIPTION

[0036] The exemplary embodiments of the present application are described below with reference to the accompanying drawings. It should be understood that these specific descriptions are only used to teach those skilled in the art how to implement the present application, and are not intended to exhaust all possible methods of the present application, nor to limit the scope of the present application.

[0037] See also Figure 1 , Figure 2 The device for purification provided in the embodiment of the present application may include a plurality of extraction columns 100, a plurality of liquid source tubes 200 and a driving device.

[0038] The extraction column 100 may be provided with a filler for adsorbing the substance to be extracted. Different fillers may be selected based on the different materials to be extracted, purified, and enriched (for example, purification of nanomaterials, pretreatment of macromolecular proteins, extraction, separation, and purification of trace organic matter in sample extracts such as water samples, blood, and urine, etc.).

[0039] Each liquid source tube 200 is used to provide a corresponding reagent for each processing stage. For example, each liquid source tube 200 can be connected to a liquid source of each reagent through a pump. The pump can be a peristaltic pump to accurately control the injection time and liquid flow rate.

[0040] The driving device can control the rotation of the plurality of extraction columns 100 to correspond to the liquid source tube 200 at each position, so that the plurality of extraction columns 100 are respectively in different processing stages, and the processing stage of each extraction column 100 can be adjusted by switching positions.

[0041] Compared with the technical solutions of the background art, the rotatable extraction column provided by the present application makes it unnecessary to fix the extraction column to multiple liquid source pipes. When there are multiple extraction columns, the number of connecting pipes can be relatively reduced, making the overall structure simpler. Multiple extraction columns correspond to liquid source pipes at different positions by rotating, so that multiple extraction columns in the device for purification can be in different processing stages at the same time and complete the extraction in time, which helps to realize the continuous extraction process and the automation of the device for purification.

[0042] See also Figure 1 , Figure 2 Furthermore, the purification device may further include a plurality of collecting tubes 300, and the driving device may control the extraction column 100 to rotate to the position of each collecting tube 300 to collect the liquid discharged from the extraction column 100 at different processing stages (described later). The collecting tube 300 may directly collect the liquid, or connect the liquid to a waste liquid pool or a quantum dot collection device.

[0043] Compared to the design of directly connecting the collection tube to the extraction column and controlling the collection liquid to be directed to the corresponding collection bottle through components such as a three-way joint and a valve, the design of moving the extraction column 100 provided in the present application to each collection tube 300 facilitates the classification and collection of materials, eliminates the control design of the valve, and reduces the problem of the material to be collected being contaminated by waste liquid due to passing through the same pipeline.

[0044] The movement of the plurality of extraction columns 100 may be formed into a circular motion. For example, in one embodiment of the present application, the plurality of extraction columns 100 may be integrated into a cylindrical extraction assembly 110. The axial direction of each extraction column 100 is parallel to the axial direction of the extraction assembly 110, and the plurality of extraction columns 100 are evenly spaced in the circumferential direction of the extraction assembly 110. The driving device controls the extraction assembly 110 to rotate around the axis of the extraction assembly 100, so that the movement of the plurality of extraction columns 100 is formed into a circular motion.

[0045] Accordingly, the number of the extraction columns 100, the number of the liquid source tubes 200 and the number of the collection tubes 300 may be the same. The interfaces of the liquid source tubes 200 and the collection tubes 300 for connecting the extraction columns 100 are evenly spaced on the circumference.

[0046] For example, see Figure 1 According to the five steps of pretreatment, loading, cleaning, elution and regeneration usually involved in solid phase extraction, five extraction columns (a first extraction column 101, a second extraction column 102, a third extraction column 103, a fourth extraction column 104, and a fifth extraction column 105) can be set, see Figures 2 to 4 Correspondingly, five liquid source tubes (the first liquid source tube 201, the second liquid source tube 202, the third liquid source tube 203, the fourth liquid source tube 204, and the fifth liquid source tube 205) and five collecting tubes (the first collecting tube 301, the second collecting tube 302, the third collecting tube 303, the fourth collecting tube 304, and the fifth collecting tube 305) can be set.

[0047] In one example, the first liquid source tube 201 is used to provide a pretreatment solvent, the second liquid source tube 202 is used to provide a sample, the third liquid source tube 203 is used to provide a cleaning agent, the fourth liquid source tube 204 is used to provide an eluent, and the fifth liquid source tube 205 is used to provide a column regeneration agent. The fourth collection tube 304 corresponding to the discharge of the extraction column 100 in the elution step can be connected to a collection container, and the liquid collected is a liquid that has been extracted, enriched or purified. Collection tubes other than the fourth collection tube 304 can be connected to the same or different waste liquid containers, and the liquid collected can be disposed of as waste liquid.

[0048] Exemplarily, after the first extraction column 101 is injected with liquid from the first liquid source tube 201 and discharged into the first collection tube 301, and pretreatment is completed, the first extraction column 101 rotates to the position corresponding to the second liquid source tube 202 and the second collection tube 302 to perform the loading step. Correspondingly, when the extraction component 110 rotates, the second extraction column 102 synchronously arrives at the position corresponding to the third liquid source tube 203 and the third collection tube 303 to perform the cleaning step. By analogy, each rotation position corresponds to a step in the solid phase extraction process, and the rotation causes the five extraction columns 100 to change their working positions together, realizing a circular assembly line operation, facilitating the extraction of multiple groups of samples at the same time, and being able to realize continuous solid phase extraction of large batches of samples and collection of processed materials, with high work efficiency.

[0049] The present application does not limit the specific number of extraction columns 100, liquid source tubes 200 and collection tubes 300. For example, the number of extraction columns 100 evenly spaced within the circumference can be set to 4, 6 or other numbers as needed.

[0050] The present application does not limit the movement form involved in the movement of the extraction column to the liquid source tube 200 and the collection tube 300. For example, the movement of each extraction column 100 can be controlled individually, and a circular or elliptical track is designed for the extraction column 100, so that each extraction column 100 moves on the track and sequentially contacts the liquid source tube 200 and the collection tube 300 at the corresponding position on the track. The movement of the extraction column 100 can be controlled by a trolley, a robotic arm, a suspension device, etc.

[0051] It can be understood that the circular assembly line operation formed by integrating each extraction column 100 into the extraction assembly 110 is easy to control and can easily improve the conversion efficiency of the extraction step.

[0052] Further, see Figure 1 , Figure 2 In the embodiment where the extraction column 100 is integrated into the extraction assembly 110, the plurality of liquid source tubes 200 are located on one side of the upper and lower sides of the plurality of extraction columns 100, and the plurality of collection tubes 300 are located on the other side. Figure 2The liquid source tube 200 and the collecting tube 300 can move toward the extraction column 100 until the liquid source tube 200 and the collecting tube 300 are connected to the extraction column 100 to achieve the circulation of the liquid. The liquid source tube 200 and the collecting tube 300 in the connected state are sealed and connected to the extraction column 100 (described later).

[0053] See also Figure 1 The liquid source tube 200 and the collecting tube 300 in the connected state can move away from the extraction column 100, so that the liquid source tube 200 and the collecting tube 300 are separated from the extraction column 100, and the liquid stops flowing, waiting for the extraction component 110 to rotate.

[0054] Furthermore, multiple liquid source tubes 200 can be located at the lower side of multiple extraction columns 100, and the collection tube 300 can be located at the upper side of the extraction column 100. The liquid flow direction from bottom to top can greatly increase the contact area between the liquid and the stationary phase in the extraction column, so that the relevant reactions can be carried out more thoroughly. A back pressure valve can be provided in the extraction column 100 to provide pressure. The back pressure valve can be provided at the outlet end of the liquid (the upper end of the extraction column) to ensure that the pressure at different height positions in the extraction column is consistent and the reaction degree is more uniform. A one-way membrane can also be provided in the extraction column 100.

[0055] Furthermore, the driving device may include a motor and a gear set, and the motor controls the rotation of the extraction component 110 through gear transmission. Figure 1 , the first gear 701 can be sleeved outside the extraction component 110, the output shaft of the motor can be connected to the second gear 702, the first gear 701 and the second gear 702 are meshed, and the motor drives the second gear 702 to rotate, thereby driving the first gear 701 and the extraction component 110 to rotate. The motor can be a servo motor, and sensors can be set on the extraction component 110 and on the mounting frame corresponding to the extraction component 110 to monitor the rotation angle, thereby more accurately controlling the rotation accuracy.

[0056] Further, see Figure 1 , Figure 2 The device for purification may include a liquid inlet assembly 400 and a liquid outlet assembly 500. The liquid inlet assembly 400 includes a liquid inlet flange 410, and one end of a plurality of liquid source pipes 200 is evenly spaced in the circumferential direction of the liquid inlet flange 410. The liquid outlet assembly 500 includes a liquid outlet flange 510, and one end of a plurality of collection pipes 300 is evenly spaced in the circumferential direction of the liquid outlet flange 510. The liquid inlet flange 410 and the liquid outlet flange 510 can be controlled to move toward or away from each other.

[0057] The device for purification may include a component for driving the liquid source pipe 200 and / or the collection pipe 300 to move in the vertical direction, such as a linear cylinder assembly 600. The linear cylinder assembly 600 may include a first piston rod 610 and a second piston rod 620, the first piston rod 610 may be connected to the liquid inlet flange 410, and the second piston rod 620 may be connected to the liquid outlet flange 510. By controlling the movement of the first piston rod 610 and the second piston rod 620, the liquid inlet flange 410 and the liquid outlet flange 510 are controlled to approach or move away from the extraction assembly 110, thereby controlling the liquid source pipe 200 and the collection pipe 300 to enter or leave the extraction column 100.

[0058] Furthermore, the liquid inlet assembly 400 further includes a liquid inlet head 420, and the liquid outlet assembly 500 further includes a liquid outlet head 520. Taking the liquid inlet assembly 400 as an example, see Figure 3 , Figure 4 One end of the liquid inlet head 420 is connected to the liquid inlet flange 410 , the liquid inlet flange 410 includes a liquid inlet hole, and one end of the liquid source tube 200 passes through the liquid inlet hole and is fixed to the liquid inlet head 420 .

[0059] The liquid inlet head 420 may include a conical guide structure 421 for extending into the extraction column 100 and a columnar structure 422 connected to the liquid inlet flange 410. The conical guide structure 421 is easy to extend into the cylindrical extraction column 100, so that the liquid inlet head 420 and the extraction column 100 are aligned. A sealing ring 423 is provided on the columnar structure 422. When the liquid inlet head 420 extends into the opening of the extraction column 100, the sealing ring 423 is clamped between the extraction column 100 and the columnar structure 422, so that a sealed state can be formed between the extraction column 100 and the liquid source tube 200 to prevent leakage. Of course, the present application does not limit the specific structure for achieving a sealed connection.

[0060] The structure of the liquid outlet assembly 500 may be the same or similar to that of the liquid inlet assembly 400, and the present application will not repeat them one by one. The liquid source pipe 200 and the collection pipe 300 may both be hoses.

[0061] Further, the device for purification may include a controller. In one example, the controller may be a computer. The controller may control the rotation of the extraction component 110, the movement of the liquid inlet component 400 and the liquid outlet component 500, the flow rate of the liquid in the liquid source tube 200 and the injection time, etc., to achieve automation of solid phase extraction. After the controller is started, the device for purification automatically injects and rotates according to the set program, performs each extraction step in sequence, and can perform cyclic work, so that the extraction process of each batch of materials can be replicated, thereby improving consistency.

[0062] The present application solves the problems of insufficient automation and low throughput (low efficiency) of existing solid phase extraction technologies, eliminates the trouble of manually dividing samples into cups and extracting them one by one before extraction, and realizes automated and continuous processing of large batches of samples.

[0063] Illustratively, the present application provides an embodiment of a working process of a device for purification.

[0064] Taking the purification of quantum dot nanocrystals as an example, the cross-sectional area of ​​the extraction column 100 is 10 mm 2 The filling material in the extraction column 100 has an adsorption effect on quantum dots.

[0065] Taking the first extraction column 101 as the observation angle, the specific working process of the device for purification is as follows:

[0066] (1) The first liquid source tube 201 and the first collection tube 301 are both connected to the first extraction column 101. The first liquid source tube 201 passes the pretreatment solvent (e.g., methanol) into the first extraction column 101, the flow rate is controlled to be 20 mL / min (milliliters / minute), the liquid passing time is 120 seconds (seconds), and the first extraction column 101 discharges the liquid into the first collection tube 301. The first liquid source tube 201 and the first collection tube 301 are restored to a separated state from the first extraction column 101.

[0067] (2) The extraction assembly 110 is rotated, and the second liquid source tube 202 and the second collection tube 302 are both connected to the first extraction column 101. The second liquid source tube 202 passes the sample (e.g., unpurified quantum dots) into the first extraction column 101, the flow rate is controlled to be 5 mL / min, and the liquid flow time is 72 s. The first extraction column 101 discharges the liquid into the second collection tube 302. The second liquid source tube 202 and the second collection tube 302 are restored to a separated state from the first extraction column 101.

[0068] (3) The extraction assembly 110 is rotated, and the third liquid source tube 203 and the third collection tube 303 are both connected to the first extraction column 101. The third liquid source tube 203 passes the cleaning agent (e.g., ethanol) into the first extraction column 101, and the flow rate is controlled to be 30 mL / min, and the liquid passing time is 180 s. The first extraction column 101 discharges the liquid into the third collection tube 303. The third liquid source tube 203 and the third collection tube 303 are restored to a separated state from the first extraction column 101.

[0069] (4) Rotate the extraction assembly 110, and connect the fourth liquid source tube 204 and the fourth collection tube 304 to the first extraction column 101. The fourth liquid source tube 204 passes the eluent (e.g., n-hexane) into the first extraction column 101, the flow rate is controlled to be 20 mL / min, and the liquid passing time is 60 s. The first extraction column 101 discharges the liquid into the fourth collection tube 304. The fourth liquid source tube 204 and the fourth collection tube 304 are restored to a separated state from the first extraction column 101.

[0070] (5) Rotate the extraction assembly 110, and connect the fifth liquid source tube 205 and the fifth collection tube 305 to the first extraction column 101. The fifth liquid source tube 205 passes the regeneration agent (e.g., a mixture of methanol and n-hexane, the volume fraction ratio of which can be 1:1) into the first extraction column 101, the flow rate is controlled to be 20 mL / min, the liquid flow time is 120 s, and the first extraction column 101 discharges the liquid to the fifth collection tube 305. The fifth liquid source tube 205 and the fifth collection tube 305 are restored to a separated state from the first extraction column 101. After regeneration and cleaning, the impurities remaining in the first extraction column 101 can be cleaned and discharged to prepare for the next use of the first extraction column 101.

[0071] (6) Rotate the extraction assembly 110 and connect the first liquid source tube 201 and the first collection tube 301 to the first extraction column 101.

[0072] The above steps were repeated again to achieve continuous solid phase extraction.

[0073] The absorption spectra of quantum dots before and after purification are shown in Figure 2. Figure 5 ( Figure 5 It can be understood that the absorption spectra of quantum dots before and after purification overlap, and the performance of quantum dots has not changed, indicating that the quantum dots purified by the embodiment of the present application can be used normally. Figure 6 As shown, the purified quantum dots are free of oil and insoluble impurities and have a uniform and regular coffee ring shape. It can be understood that the purification device provided in the embodiment of the present application can successfully remove the impurities contained therein without affecting the spectral performance of the quantum dots.

[0074] From a macroscopic perspective, the liquid source tube 200 of the present application can continuously inject liquid, thereby realizing a large-scale, uninterrupted solid phase extraction process.

[0075] The device for purification provided in the present application can be used in conjunction with, for example, a quantum dot synthesis device. For example, the quantum dots produced by the quantum dot synthesis device can be passed into, for example, the second liquid source tube 202 of the device for purification. A buffer zone can be added between the second liquid source tube 202 and the quantum dot synthesis device. When there are more quantum dot samples produced by the quantum dot synthesis device, they can enter the buffer zone first, and the buffer zone continuously supplies liquid to the second liquid source tube 202 at a set speed.

[0076] The above is a preferred embodiment of the present application. It should be pointed out that for those skilled in the art, several improvements and modifications can be made without departing from the principles of the present application. These improvements and modifications should also be regarded as the scope of protection of the present application.

Claims

1. A device for purification, characterized in that include: A plurality of extraction columns (100); as well as A plurality of liquid source tubes (200) and a driving device, each of the liquid source tubes (200) is used to provide a corresponding reagent in each processing stage, and the driving device controls the rotation of the plurality of extraction columns (100) to correspond to the liquid source tubes (200) at each position, so that the plurality of extraction columns (100) are respectively in different processing stages, and the processing stage in which each extraction column (100) is located can be adjusted by rotating and switching positions.

2. The device for purification according to claim 1, characterized in that The multiple extraction columns (100) are integrated into a cylindrical extraction component (110); the axial direction of each extraction column (100) is parallel to the axial direction of the extraction component (110); the multiple extraction columns (100) are evenly spaced in the circumferential direction of the extraction component (110); and the driving device is capable of controlling the extraction component (110) to rotate around the axis of the extraction component (110).

3. The device for purification according to claim 2, characterized in that The device for purification further comprises a plurality of collecting tubes (300), and the driving device can control the extraction column (100) to rotate to the position of each of the collecting tubes (300) to collect liquid discharged from the extraction column (100) at different processing stages.

4. The device for purification according to claim 3, characterized in that The number of the plurality of extraction columns (100), the plurality of liquid source tubes (200) and the plurality of collection tubes (300) is the same, and the interfaces of the plurality of liquid source tubes (200) and the plurality of collection tubes (300) for connecting the extraction columns (100) are evenly spaced in a circumferential direction.

5. The device for purification according to claim 4, characterized in that The plurality of liquid source tubes (200) are located on one side of the upper and lower sides of the plurality of extraction columns (100), and the plurality of collection tubes (300) are located on the other side. The liquid source tube (200) and the collecting tube (300) can move toward the extraction column (100) until the liquid source tube (200) and the collecting tube (300) are in a connected state with the extraction column (100), and the liquid source tube (200) and the collecting tube (300) in the connected state are sealed and connected with the extraction column (100). The liquid source tube (200) and the collecting tube (300) in the connected state can move away from the extraction column (100) so that the liquid source tube (200) and the collecting tube (300) are both in a separated state from the extraction column (100).

6. The device for purification according to claim 5, characterized in that The plurality of liquid source tubes (200) are located at the lower side of the plurality of extraction columns (100), and the plurality of collection tubes (300) are located at the upper side of the extraction columns (100); and / or, The component that drives the liquid source pipe (200) and / or the collecting pipe (300) to move in the vertical direction is a linear cylinder assembly (600).

7. The device for purification according to claim 6, characterized in that The extraction column (100) is provided with a back pressure valve, or a back pressure valve and a one-way membrane are provided at the same time.

8. The device for purification according to claim 5 or 6, characterized in that The device for purification also includes a liquid inlet component (400) and a liquid outlet component (500), wherein the liquid inlet component (400) includes a liquid inlet flange (410), one end of the plurality of liquid source tubes (200) are evenly spaced in the circumferential direction of the liquid inlet flange (410), and the liquid outlet component (500) includes a liquid outlet flange (510), one end of the plurality of collection tubes (300) are evenly spaced in the circumferential direction of the liquid outlet flange (510), and the liquid inlet flange (410) and the liquid outlet flange (510) can be controlled to move toward or away from each other.

9. The device for purification according to claim 8, characterized in that The liquid inlet flange (410) includes a liquid inlet hole, and the liquid inlet assembly (400) also includes a liquid inlet head (420), one end of the liquid inlet head (420) is connected to the liquid inlet flange (410), and one end of the liquid source tube (200) passes through the liquid inlet hole and is fixed to the liquid inlet head (420).

10. The device for purification according to claim 9, characterized in that The liquid inlet head (420) comprises a conical guide structure (421) for extending into the extraction column (100).

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