Sampling device for pioglitazone hydrochloride and use method thereof

Abstract

The invention discloses a pioglitazone hydrochloride sampling device and a use method thereof, and relates to the technical field of medicine sampling, the pioglitazone hydrochloride sampling device comprises a sampling mechanism and lifting fixing rods mounted around the bottom of the sampling mechanism, a fixing structure is arranged at the bottom of the sampling mechanism, beaker fixing seats are symmetrically mounted on one side of the top of the fixing structure, and the beaker fixing seats are symmetrically mounted on the bottom of the sampling mechanism. The sampling mechanism comprises a horizontal moving support, a horizontal moving motor is fixedly mounted on one side of the horizontal moving support, a horizontal threaded rod is fixedly connected to the output end of the horizontal moving motor, a horizontal threaded sleeve is in threaded connection to the outer side of the horizontal threaded rod, and an electric telescopic rod is fixedly mounted at the bottom of the horizontal threaded sleeve. The pioglitazone hydrochloride white crystal powder can be clamped through the sampling tube and the clamping hopper, and meanwhile, the pioglitazone hydrochloride and a corresponding reagent can be mixed to form a flowing sample, so that the pioglitazone hydrochloride can be conveniently detected.

Description

Technical Field

[0001] The invention relates to the technical field of drug sampling, in particular to a sampling device for pioglitazone hydrochloride and a use method thereof. Background Art

[0002] Aitin is also called pioglitazone hydrochloride tablets. It is indicated for patients with type 2 diabetes (non-insulin-dependent diabetes mellitus). Pioglitazone hydrochloride can be combined with diet control and physical exercise to improve and control blood sugar. Pioglitazone hydrochloride can be used alone. When diet control, physical exercise and monotherapy cannot satisfactorily control blood sugar, it can also be used in combination with sulfonylurea, metformin or insulin. In the preparation process of pioglitazone hydrochloride, it is necessary to sample and test pioglitazone hydrochloride.

[0003] Announcement No. CN221898810U discloses a synthetic drug sampling and analysis device. Through the threaded connection between the sealing cover and the conical collecting tube, it is convenient for the staff to separate the sealing cover together with other components from the conical collecting tube, and then it is convenient for the staff to thoroughly clean the inner wall of the conical collecting tube and the guide tube. At the same time, the spiral drill rod and the guide tube cooperate to form a spiral conveying structure, so that the collected powder is conveyed back to the conical collecting tube during the drilling and sampling work, and the guide tube can be covered near the drill bit of the spiral drill rod to prevent the drug powder from being scattered due to the spiral force, thereby ensuring the stability and comprehensiveness of the collection and avoiding waste. However, the above patent still has the following problems in actual use:

[0004] Although the synthetic drug sampling and analysis device is connected by a threaded connection between the sealing cover and the conical collecting tube, which makes it convenient for the staff to separate the sealing cover together with other components from the conical collecting tube, and then makes it convenient for the staff to thoroughly clean the inner walls of the conical collecting tube and the material guide tube, it is not possible to sample solid samples and liquid samples separately when sampling, resulting in the need to sample two samples in different states separately when sampling and analyzing, which is cumbersome and affects the sampling and detection efficiency.

[0005] Therefore, a sampling device for pioglitazone hydrochloride and a method of using the same are proposed to solve the above-mentioned problems. Summary of the invention

[0006] The object of the present invention is to provide a sampling device for pioglitazone hydrochloride and a method for using the same, so as to solve the problem that although the synthetic drug sampling and analysis device proposed in the above background technology is connected by a thread of a sealing cover and a conical collecting tube, so that it is convenient for the staff to separate the sealing cover together with other components from the conical collecting tube, and then convenient for the staff to thoroughly clean the inner wall of the conical collecting tube and the material guide tube, it is not possible to sample solid samples and liquid samples separately when sampling, resulting in the need to sample two samples in different states separately when sampling and analyzing, which is cumbersome to operate and affects the sampling and detection efficiency.

[0007] To achieve the above object, the present invention provides the following technical solutions: a sampling device for pioglitazone hydrochloride and a method of using the same, comprising a sampling mechanism and lifting and fixing rods installed around the bottom of the sampling mechanism;

[0008] A fixing structure is provided at the bottom of the sampling mechanism, and a beaker fixing seat is symmetrically installed on one side of the top of the fixing structure;

[0009] Also includes:

[0010] The sampling mechanism comprises a horizontal movable bracket, a horizontal movable motor is fixedly installed on one side of the horizontal movable bracket, a horizontal threaded rod is fixedly connected to the output end of the horizontal movable motor, a horizontal threaded sleeve is threadedly connected to the outer side of the horizontal threaded rod, and an electric telescopic rod is fixedly installed on the bottom of the horizontal threaded sleeve;

[0011] A rotating bracket is symmetrically installed on one side of the bottom of the electric telescopic rod, a rotating motor is fixedly installed on one side of the rotating bracket, a rotating worm is fixedly connected to the output end of the rotating motor, and a rotating worm wheel is meshedly connected to one side of the rotating worm;

[0012] The rotating worm gear is rotatably connected to the electric telescopic rod, a sampling tube is fixedly installed at the bottom of the rotating worm gear, a sampling scale is arranged on the outer side of the sampling tube, and a sampling cylinder is fixedly installed on the inner side of the top of the sampling tube.

[0013] Preferably, a sampling piston is fixedly connected to the bottom of the sampling cylinder, and the sampling piston is fit-connected to the inner wall of the sampling tube. Limited fixed pulleys are symmetrically installed on both sides of the bottom of the sampling tube close to the sampling cylinder. A connecting rope is slidably connected to the outer side of the limited fixed pulley, and one end of the connecting rope is fixedly connected to the sampling piston.

[0014] By adopting the above technical scheme, the horizontal threaded rod is driven to rotate by the horizontal moving motor, so that the horizontal threaded sleeve drives the electric telescopic rod to move horizontally, and the horizontal position of the sampling tube can be adjusted, thereby realizing uninterrupted sampling and placing. The rotating worm is driven to rotate by the rotating motor, and the characteristics of the meshing connection between the rotating worm and the rotating worm wheel are utilized to make the rotating worm wheel drive the sampling tube to rotate, so that the mobile phase can be fully mixed and the residual raw materials inside the clamping bucket can be cleaned to avoid the phenomenon of waste of raw materials. The sampling piston is driven to move up and down inside the sampling tube by the sampling cylinder, so that the liquid solution is sampled by using the sampling needle.

[0015] Preferably, limiting brackets are symmetrically installed on both sides of the bottom of the sampling tube, a limiting sliding rod is fixedly installed inside the limiting bracket, the outer side of the limiting sliding rod is slidably connected to the limiting sliding sleeve, the top of the limiting sliding sleeve is fixedly installed with a first limiting spring, the limiting sliding sleeve is fixedly connected to the connecting rope, one side of the bottom of the limiting sliding sleeve is rotatably connected to a connecting rotating rod, and the top of the connecting rotating rod is rotatably connected to a clamping rotating rod.

[0016] By adopting the above technical solution, while the sampling piston is moving up and down, the sampling piston drives the connecting rope to move, and the limiting sliding sleeve can be lifted and lowered through the limiting fixed pulley. The limiting sliding sleeve drives the connecting rotating rod and the clamping rotating rod to rotate, so that the clamping bucket can be rotated, and the clamping bucket can be used to clamp the white crystalline powder of pioglitazone hydrochloride.

[0017] Preferably, the bottom of the clamping rotating rod is rotatably connected to a clamping bucket, the top of the clamping bucket is rotatably connected to a clamping support block, the top of the clamping support block is fixedly installed with a clamping sleeve, the inside of the clamping sleeve is fixedly installed with a sampling needle tube, the sampling needle tube is fixedly connected to the sampling tube, the clamping sleeve is rotatably connected to the clamping rotating rod, and a magnetic suction block is symmetrically installed on one side of the clamping bucket.

[0018] By adopting the above technical solution, the clamping bucket is clamped by utilizing the magnetic suction block inside the clamping bucket.

[0019] Preferably, a lifting top plate is fixedly installed on the top of the lifting fixing rod, a motor cover is fixedly installed on the top side of the lifting top plate, a lifting motor is fixedly installed on the inner side of the motor cover, the output end of the lifting motor is fixedly connected to a sprocket transmission assembly, and lifting threaded rods are symmetrically installed on the bottom of the sprocket transmission assembly, the outer sides of the two lifting threaded rods are threadedly connected with lifting thread sleeves, and a lifting plate is fixedly installed between the two lifting thread sleeves.

[0020] By adopting the above technical solution, the lifting motor drives the sprocket transmission assembly and the lifting threaded rod to rotate, so that the lifting threaded sleeve and the lifting sliding sleeve drive the lifting plate to move up and down, so that pioglitazone hydrochloride can be sampled and tested.

[0021] Preferably, a lifting sliding sleeve is symmetrically installed on the side of the lifting plate away from the lifting threaded sleeve, and the lifting sliding sleeve is slidably connected to the lifting sliding rod inside the lifting sliding sleeve, and a longitudinal sliding groove is symmetrically opened on the bottom of the lifting sliding rod, and a longitudinal fixed bracket is fixedly installed on the bottom of the lifting plate, and a longitudinal motor is fixedly installed on one side of the longitudinal fixed bracket, and a longitudinal motor is fixedly installed on the output end of the longitudinal motor, and a longitudinal bidirectional threaded rod is fixedly connected to the output end of the longitudinal motor, and the outer side of the longitudinal bidirectional threaded rod is symmetrically threaded with the longitudinal threaded sleeve, and the outer side of the longitudinal threaded sleeve is rotatably connected to the longitudinal rotating rod, and the end of the longitudinal rotating rod is rotatably connected to the longitudinal sliding sleeve, and the inner side of the longitudinal sliding sleeve is slidably connected to the longitudinal sliding rod, and the outer side of the longitudinal sliding rod is fixedly installed with the longitudinal sliding bracket, and a longitudinal sliding slider is symmetrically installed on the top of the longitudinal sliding bracket, the longitudinal slider is slidably connected to the longitudinal sliding groove, and the longitudinal sliding bracket is fixedly connected to the horizontal moving bracket.

[0022] By adopting the above technical scheme, the longitudinal bidirectional threaded rod is driven to rotate by the longitudinal motor so that the two longitudinal threaded sleeves move relatively on the outside of the longitudinal bidirectional threaded rod and the longitudinal rotating rod is driven to rotate, so that the longitudinal sliding sleeve slides relatively on the outside of the longitudinal sliding rod, and the longitudinal sliding bracket realizes the longitudinal movement of the sampling tube under the limiting action of the longitudinal sliding block, thereby realizing all-round sampling and placing. The sampling tube and the clamping bucket can not only realize the clamping of the white crystalline powder of pioglitazone hydrochloride, but also can realize the sampling of the fluidity formed by the mixture of pioglitazone hydrochloride and the corresponding reagent, so as to facilitate the detection of pioglitazone hydrochloride.

[0023] Preferably, the fixed structure includes a sampling workbench, a first mounting base is fixedly installed on the top of the sampling workbench, a test tube holder is symmetrically installed on the top of the first mounting base, a plurality of test tube limiting holes are opened inside the test tube holder, a plurality of test tube mounting bases are fixedly installed on the top of the first mounting base, a limiting base is fixedly installed on the inner side of the bottom of the test tube mounting base, the limiting base is rotatably connected to a limiting clamping rod around the inside of the limiting base, a second limiting spring is fixedly installed at the inner center position of the limiting base, the top of the second limiting spring is fixedly connected to a limiting conical block, a limiting connecting rod is fixedly installed around the top of the limiting conical block, the limiting connecting rod is fittedly connected to the surface of the limiting clamping rod, a limiting support disk is fixedly installed on the top of the limiting conical block, and a test tube body is arranged on the top of the limiting support disk.

[0024] By adopting the above technical solution, the test tube limiting hole inside the test tube holder is used to initially limit the test tube body, and the test tube body's own gravity squeezes the limiting support plate and the second limiting spring, so that the limiting conical block drives the limiting connecting rod to descend and drives the limiting clamping rod to rotate, thereby limiting the bottom of the test tube body and improving the placement stability of the test tube body.

[0025] Preferably, the beaker fixing seat is symmetrically installed on the top of the sampling workbench, a fixed sleeve is fixedly installed at the inner center position of the sampling workbench, fixed horizontal grooves are opened on both sides of the interior of the fixed sleeve, a fixed spring buckle is fixedly installed on one side of the fixed horizontal groove, a locking slider is slidably connected inside the fixed horizontal groove, a first locking sliding rod is fixedly installed between the two locking sliders, and an anti-slip rotating disk is fixedly connected to the top of the first locking sliding rod.

[0026] By adopting the above technical solution, by placing the beaker body on the anti-slip rotating disk and pressing the clamping bracket downward, under the action of the locking rotating rod, the locking sliding sleeve can drive the locking clamping plate to move relative to each other, thereby clamping and fixing the beaker body.

[0027] Preferably, a locking rotating rod is rotatably connected to the top of the beaker fixing seat, a locking sliding sleeve is rotatably connected to the top of the locking rotating rod, a second locking sliding rod is slidably connected to the inside of the locking sliding sleeve, a locking spring is fixedly connected to one side of the locking sliding sleeve, a locking clamp is fixedly installed on the top of the locking sliding sleeve, a beaker body is provided on the top of the anti-slip rotating disk, and a clamping bracket is fixedly installed on the outer side of the second locking sliding rod.

[0028] By adopting the above technical solution, the anti-slip rotating disk and the first locking sliding rod are driven to rotate by rotating the beaker body, so that the locking sliders on both sides of the bottom of the first locking sliding rod slide inside the fixed horizontal groove and are fixed by the fixed spring buckle, thereby realizing the locking clamping plate, which is convenient for taking and placing the locked beaker body.

[0029] Compared with the prior art, the invention has the following beneficial effects: the sampling device for pioglitazone hydrochloride and the method for using the same can not only realize the clamping of pioglitazone hydrochloride white crystalline powder through the sampling tube and the clamping bucket, but also can sample the fluidity formed by mixing pioglitazone hydrochloride with the corresponding reagent, which is convenient for detecting pioglitazone hydrochloride, and the anti-skid rotating disk and the first locking sliding rod are driven to rotate by rotating the beaker body, so that the locking sliders on both sides of the bottom of the first locking sliding rod slide inside the fixed horizontal groove, and are fixed by the fixed spring buckle, thereby realizing the locking clamping plate, which is convenient for taking and placing the locking beaker body, and the specific contents are as follows:

[0030] 1. By setting a horizontal movable bracket, not only can the horizontal movable motor be used to drive the horizontal threaded rod to rotate, so that the horizontal threaded sleeve drives the electric telescopic rod to move horizontally, but also the horizontal position of the sampling tube can be adjusted, thereby realizing uninterrupted sampling and placing. By driving the rotating worm gear to rotate by the rotating motor, and utilizing the characteristics of the meshing connection between the rotating worm gear and the rotating worm gear, the rotating worm gear drives the sampling tube to rotate, so that the mobile phase can be fully mixed, and at the same time, the residual raw materials inside the clamping bucket can be cleaned up to avoid the phenomenon of waste of raw materials. The sampling cylinder drives the sampling piston to move up and down inside the sampling tube, so that the sampling needle tube is used to sample the liquid solution. At the same time, when the sampling piston is lifted and moved, the sampling piston drives the connecting rope to move, and the lifting and lowering movement of the limiting sliding sleeve can be realized through the limiting fixed pulley. The limiting sliding sleeve drives the connecting rotating rod and the clamping rotating rod to rotate, so as to realize the rotation of the clamping bucket. The clamping bucket can be used to realize The white crystalline powder of pioglitazone hydrochloride is clamped, which is convenient for clamping pioglitazone hydrochloride into the mobile phase for mixing. At the same time, the magnetic suction block inside the clamping bucket is used to clamp the clamping bucket. The lifting motor drives the sprocket transmission component and the lifting threaded rod to rotate, so that the lifting threaded sleeve and the lifting sliding sleeve drive the lifting plate to lift and move, so that the sampling and detection of pioglitazone hydrochloride can be carried out. The longitudinal motor drives the longitudinal bidirectional threaded rod to rotate so that the two longitudinal threaded sleeves move relative to each other on the outer side of the longitudinal bidirectional threaded rod, and at the same time drives the longitudinal rotating rod to rotate, so that the longitudinal sliding sleeve slides relative to each other on the outer side of the longitudinal sliding rod, so that the longitudinal sliding bracket realizes the longitudinal movement of the sampling tube under the limiting action of the longitudinal sliding block, thereby realizing all-round sampling and setting out. The sampling tube and the clamping bucket can not only realize the clamping of the white crystalline powder of pioglitazone hydrochloride, but also can sample the fluidity formed by mixing pioglitazone hydrochloride with the corresponding reagent, so as to facilitate the detection of pioglitazone hydrochloride.

[0031] 2. By setting the fixed structure, not only can the test tube limiting hole inside the test tube holder be used to perform preliminary limiting on the test tube body, but the test tube body's own gravity can also squeeze the limiting support plate and the second limiting spring, so that the limiting conical block drives the limiting connecting rod to descend, and drives the limiting clamping rod to rotate, thereby limiting the bottom of the test tube body and improving the placement stability of the test tube body; by placing the beaker body on the anti-slip rotating disk and pressing the clamping bracket downward, under the action of the locking rotating rod, the locking sliding sleeve can drive the locking clamping plate to move relatively, thereby clamping and fixing the beaker body; by rotating the beaker body to drive the anti-slip rotating disk and the first locking sliding rod to rotate, the locking sliders on both sides of the bottom of the first locking sliding rod slide in the fixed horizontal groove, and are fixed by the fixed spring buckle, thereby realizing the locking clamping plate, which is convenient for locking the beaker body to be taken and placed. BRIEF DESCRIPTION OF THE DRAWINGS

[0032] Figure 1 It is a schematic diagram of the overall three-dimensional structure of the present invention;

[0033] Figure 2 It is a schematic diagram of the three-dimensional structure of the sampling mechanism in the present invention;

[0034] Figure 3 It is a schematic diagram of the three-dimensional structure of the lifting plate in the present invention;

[0035] Figure 4 It is a schematic diagram of the three-dimensional structure of the longitudinal rotating rod in the present invention;

[0036] Figure 5 It is a schematic diagram of the three-dimensional structure of the rotating worm gear in the present invention;

[0037] Figure 6 It is a schematic diagram of the three-dimensional structure of the sampling cylinder in the present invention;

[0038] Figure 7 It is a schematic diagram of the three-dimensional structure of the connecting rotating rod in the present invention;

[0039] Figure 8 It is a schematic diagram of the three-dimensional structure of the clamping bucket in the present invention;

[0040] Fig. 9 It is a schematic diagram of the three-dimensional structure of the fixed structure in the present invention;

[0041] Fig.10 It is a schematic diagram of the three-dimensional structure of the test tube mounting base and the limiting base in the present invention;

[0042] Fig.11 It is a schematic diagram of the three-dimensional structure of the cross section of the test tube mounting base and the limiting base in the present invention.

[0043] In the figure: 1. sampling mechanism; 101. horizontal moving bracket; 102. horizontal moving motor; 103. horizontal threaded rod; 104. horizontal threaded sleeve; 105. electric telescopic rod; 106. rotating bracket; 107. rotating motor; 108. rotating worm; 109. rotating worm gear; 110. sampling tube; 111. sampling scale; 112. sampling cylinder; 113. sampling piston; 114. limit fixed pulley; 115. connecting rope; 116. limit bracket; 117. limit sliding rod; 118. limit sliding sleeve ; 119, first limit spring; 120, connecting rotating rod; 121, clamping rotating rod; 122, clamping bucket; 123, clamping support block; 124, clamping sleeve; 125, sampling needle tube; 126, magnetic block; 127, lifting fixed rod; 128, lifting top plate; 129, motor cover; 130, lifting motor; 131, sprocket transmission assembly; 132, lifting threaded rod; 133, lifting threaded sleeve; 134, lifting plate; 135, lifting sliding sleeve; 136, lifting sliding rod; 137, longitudinal slide groove ; 138, longitudinal fixed bracket; 139, longitudinal motor; 140, longitudinal bidirectional threaded rod; 141, longitudinal threaded sleeve; 142, longitudinal rotating rod; 143, longitudinal sliding sleeve; 144, longitudinal sliding rod; 145, longitudinal sliding bracket; 146, longitudinal slider; 2, fixed structure; 201, sampling workbench; 202, first mounting base; 203, test tube bracket; 204, test tube limiting hole; 205, test tube mounting base; 206, limiting base; 207, limiting clamping rod; 208, second limiting spring Spring; 209, limiting conical block; 210, limiting connecting rod; 211, limiting support plate; 212, test tube body; 213, beaker fixing seat; 214, fixing sleeve; 215, fixing horizontal groove; 216, fixing spring buckle; 217, locking slider; 218, first locking sliding rod; 219, anti-slip rotating disk; 220, locking rotating rod; 221, locking sliding sleeve; 222, second locking sliding rod; 223, locking spring; 224, locking clamp; 225, beaker body; 226, clamping bracket. DETAILED DESCRIPTION

[0044] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the implementation regulations described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0045] See also Figure 1-Figure 11The present invention provides a technical solution: a sampling device for pioglitazone hydrochloride and a method of using the same, comprising a sampling mechanism 1, and a lifting and fixing rod 127 installed around the bottom of the sampling mechanism 1, a fixing structure 2 is provided at the bottom of the sampling mechanism 1, and a beaker fixing seat 213 is symmetrically installed on one side of the top of the fixing structure 2, the sampling mechanism 1 comprises a horizontal movable bracket 101, a horizontal movable motor 102 is fixedly installed on one side of the horizontal movable bracket 101, a horizontal threaded rod 103 is fixedly connected to the output end of the horizontal movable motor 102, a horizontal threaded sleeve 104 is threadedly connected to the outer side of the horizontal threaded rod 103, and an electric telescopic rod 103 is fixedly installed on the bottom of the horizontal threaded sleeve 104 05, wherein a rotating bracket 106 is symmetrically installed on one side of the bottom of the electric telescopic rod 105, a rotating motor 107 is fixedly installed on one side of the rotating bracket 106, an output end of the rotating motor 107 is fixedly connected with a rotating worm 108, one side of the rotating worm 108 is meshingly connected with a rotating worm wheel 109, wherein the rotating worm wheel 109 is rotationally connected to the electric telescopic rod 105, a sampling tube 110 is fixedly installed on the bottom of the rotating worm wheel 109, the horizontal moving motor 102 is used to drive the horizontal threaded rod 103 to rotate, so that the horizontal threaded sleeve 104 drives the electric telescopic rod 105 to move horizontally, and the horizontal position of the sampling tube 110 can be adjusted, thereby realizing uninterrupted sampling and setting out.

[0046] A sampling scale 111 is provided on the outside of the sampling tube 110, a sampling cylinder 112 is fixedly installed on the inner side of the top of the sampling tube 110, a sampling piston 113 is fixedly connected to the bottom of the sampling cylinder 112, and the sampling piston 113 is closely connected to the inner wall of the sampling tube 110. The sampling tube 110 is symmetrically installed with limited fixed pulleys 114 on both sides of the bottom of the sampling cylinder 112, and a connecting rope 115 is slidably connected to the outer side of the limited fixed pulley 114. One end of the connecting rope 115 is fixedly connected to the sampling piston 113. A limit bracket 116 is symmetrically installed on the side, a limit sliding rod 117 is fixedly installed inside the limit bracket 116, the outer side of the limit sliding rod 117 is slidably connected to a limit sliding sleeve 118, a first limit spring 119 is fixedly installed on the top of the limit sliding sleeve 118, the limit sliding sleeve 118 is fixedly connected to the connecting rope 115, one side of the bottom of the limit sliding sleeve 118 is rotatably connected to a connecting rotating rod 120, the top of the connecting rotating rod 120 is rotatably connected to a clamping rotating rod 121, and the bottom of the clamping rotating rod 121 is rotatably connected to a clamping rotating rod 121. The top of the clamping bucket 122 is rotatably connected with a clamping support block 123, and the rotating motor 107 drives the rotating worm 108 to rotate. The rotating worm 108 and the rotating worm wheel 109 are meshed and connected, so that the rotating worm wheel 109 drives the sampling tube 110 to rotate, which can not only fully mix the mobile phase, but also clean the residual raw materials inside the clamping bucket 122 to avoid the phenomenon of waste of raw materials. The sampling piston 113 is driven by the sampling cylinder 112 to move up and down inside the sampling tube 110, so as to The sampling needle 125 is used to sample the liquid solution. When the sampling piston 113 moves up and down, the sampling piston 113 drives the connecting rope 115 to move. The limiting sliding sleeve 118 can be lifted and lowered through the limiting fixed pulley 114. The limiting sliding sleeve 118 drives the connecting rotating rod 120 and the clamping rotating rod 121 to rotate, so as to realize the rotation of the clamping bucket 122. The clamping bucket 122 can be used to clamp the white crystalline powder of pioglitazone hydrochloride, so that the pioglitazone hydrochloride can be clamped into the mobile phase for mixing.

[0047] A clamping sleeve 124 is fixedly installed on the top of the clamping support block 123, a sampling needle tube 125 is fixedly installed inside the clamping sleeve 124, the sampling needle tube 125 is fixedly connected to the sampling tube 110, the clamping sleeve 124 is rotatably connected to the clamping rotating rod 121, a magnetic suction block 126 is symmetrically installed on one side of the clamping bucket 122, a lifting top plate 128 is fixedly installed on the top of the lifting fixed rod 127, a motor cover 129 is fixedly installed on one side of the top of the lifting top plate 128, a lifting motor 130 is fixedly installed on one side of the motor cover 129, the output end of the lifting motor 130 is fixedly connected to a sprocket transmission assembly 131, and a lifting threaded rod 132 is symmetrically installed on the bottom of the sprocket transmission assembly 131. The outer sides are both threadedly connected with lifting thread sleeves 133, a lifting plate 134 is fixedly installed between the two lifting thread sleeves 133, a lifting sliding sleeve 135 is symmetrically installed on the side of the lifting plate 134 away from the lifting thread sleeve 133, a lifting sliding rod 136 is slidably connected inside the lifting sliding sleeve 135, and a longitudinal sliding groove 137 is symmetrically opened at the bottom of the lifting sliding rod 136, a longitudinal fixing bracket 138 is fixedly installed at the bottom of the lifting plate 134, a longitudinal motor 139 is fixedly installed on one side of the longitudinal fixing bracket 138, a longitudinal bidirectional threaded rod 140 is fixedly connected to the output end of the longitudinal motor 139, a longitudinal bidirectional threaded rod 140 is symmetrically threadedly connected to the outer side of the longitudinal bidirectional threaded rod 140, and the outer side of the longitudinal thread sleeve 141 is rotatably connected to The longitudinal rotating rod 142, the end of the longitudinal rotating rod 142 is rotatably connected with the longitudinal sliding sleeve 143, the longitudinal sliding sleeve 143 is slidably connected with the longitudinal sliding rod 144, the outer side of the longitudinal sliding rod 144 is fixedly installed with a longitudinal sliding bracket 145, the top of the longitudinal sliding bracket 145 is symmetrically installed with a longitudinal slider 146, the longitudinal slider 146 is slidably connected with the longitudinal slide groove 137, the longitudinal sliding bracket 145 is fixedly connected with the horizontal moving bracket 101, the magnetic suction block 126 inside the clamping bucket 122 is used to clamp the clamping bucket 122, the lifting motor 130 drives the sprocket transmission assembly 131 and the lifting threaded rod 132 to rotate, so that the lifting threaded sleeve 133 and the lifting sliding sleeve 135 drive the lifting plate 134 to move up and down. The longitudinal motor 139 drives the longitudinal bidirectional threaded rod 140 to rotate so that the two longitudinal threaded sleeves 141 move relatively on the outside of the longitudinal bidirectional threaded rod 140, and at the same time drives the longitudinal rotating rod 142 to rotate, so that the longitudinal sliding sleeve 143 slides relatively on the outside of the longitudinal sliding rod 144, and the longitudinal sliding bracket 145 realizes the longitudinal movement of the sampling tube 110 under the limiting action of the longitudinal slider 146, thereby realizing all-round sampling and placing. The sampling tube 110 and the clamping bucket 122 can not only realize the clamping of the white crystalline powder of pioglitazone hydrochloride, but also can sample the fluidity formed by mixing pioglitazone hydrochloride with the corresponding reagent, so as to facilitate the detection of pioglitazone hydrochloride.

[0048] The fixed structure 2 includes a sampling workbench 201, a first mounting base 202 is fixedly installed on the top of the sampling workbench 201, a test tube holder 203 is symmetrically installed on the top of the first mounting base 202, a plurality of test tube limiting holes 204 are opened inside the test tube holder 203, a plurality of test tube mounting bases 205 are fixedly installed on the top of the first mounting base 202, a limiting base 206 is fixedly installed on the inner side of the bottom of the test tube mounting base 205, a limiting clamping rod 207 is rotatably connected to the inner periphery of the limiting base 206, a second limiting spring 208 is fixedly installed at the inner center position of the limiting base 206, a limiting conical block 209 is fixedly connected to the top of the second limiting spring 208, and the limiting conical block 209 is fixedly connected to the upper side of the limiting spring 208. 09, the limiting connecting rod 210 is fixedly installed around the top of the limiting conical block 209, the limiting connecting rod 210 is fitted and connected with the surface of the limiting clamping rod 207, the limiting support plate 211 is fixedly installed on the top of the limiting conical block 209, and the top of the limiting support plate 211 is provided with a test tube body 212, and the test tube limiting hole 204 inside the test tube holder 203 is used to perform preliminary limiting on the test tube body 212, and the limiting support plate 211 and the second limiting spring 208 are squeezed by the gravity of the test tube body 212 itself, so that the limiting conical block 209 drives the limiting connecting rod 210 to descend, and drives the limiting clamping rod 207 to rotate, thereby limiting the bottom of the test tube body 212 and improving the placement stability of the test tube body 212.

[0049] The beaker fixing seat 213 is symmetrically installed on the top of the sampling workbench 201. A fixing sleeve 214 is fixedly installed at the inner center position of the sampling workbench 201. Fixed horizontal grooves 215 are provided on both sides of the fixing sleeve 214. A fixed spring buckle 216 is fixedly installed on one side of the fixed horizontal groove 215. A locking slider 217 is slidably connected inside the fixed horizontal groove 215. A first locking sliding rod 218 is fixedly installed between the two locking sliders 217. A non-slip rotating disk 219 is fixedly connected to the top of the first locking sliding rod 218. A locking rotating rod 220 is rotatably connected to the top of the locking rotating rod 220. A locking sliding sleeve 221 is rotatably connected to the top of the locking rotating rod 220. A second locking sliding rod 222 is slidably connected to the inside of the locking sliding sleeve 221. A locking spring 223 is fixedly connected to one side of the locking sliding sleeve 221. A locking clamping plate 224 is fixedly installed on the top of the locking sliding sleeve 221, a beaker body 225 is arranged on the top of the anti-skid rotating disk 219, and a clamping bracket 226 is fixedly installed on the outer side of the second locking sliding rod 222. By placing the beaker body 225 on the anti-skid rotating disk 219 and pressing the clamping bracket 226 downward, under the action of the locking rotating rod 220, the locking sliding sleeve 221 can drive the locking clamping plate 224 to move relatively, thereby clamping and fixing the beaker body 225, and by rotating the beaker body 225, the anti-skid rotating disk 219 and the first locking sliding rod 218 are driven to rotate, so that the locking sliders 217 on both sides of the bottom of the first locking sliding rod 218 slide inside the fixed horizontal groove 215 and are fixed by the fixed spring buckle 216, thereby realizing the locking clamping plate 224, which is convenient for taking and placing the locked beaker body 225.

[0050] Working principle: Before using the sampling device for pioglitazone hydrochloride and its method of use, it is necessary to first check the overall condition of the device to ensure that it can work normally. Figure 1 - Fig.11As shown, first, the test tube limiting hole 204 inside the test tube holder 203 is used to perform preliminary limiting on the test tube body 212, and the test tube body 212 is squeezed by its own gravity to limit the support plate 211 and the second limiting spring 208, so that the limiting conical block 209 drives the limiting connecting rod 210 to descend, and drives the limiting clamping rod 207 to rotate, thereby limiting the bottom of the test tube body 212, improving the placement stability of the test tube body 212, and placing the beaker body 225 on the anti-slip rotating disk 219, and pressing the clamping bracket downward. 226, under the action of the locking rotating rod 220, the locking sliding sleeve 221 can drive the locking clamping plate 224 to move relatively, so as to clamp and fix the beaker body 225, and the anti-slip rotating disk 219 and the first locking sliding rod 218 are driven to rotate by rotating the beaker body 225, so that the locking sliders 217 on both sides of the bottom of the first locking sliding rod 218 slide inside the fixed horizontal groove 215, and are fixed by the fixed spring buckle 216, so as to realize the locking clamping plate 224, which is convenient for taking and placing the locked beaker body 225.

[0051] Secondly, the lifting motor 130 drives the sprocket drive assembly 131 and the lifting threaded rod 132 to rotate, so that the lifting threaded sleeve 133 and the lifting sliding sleeve 135 drive the lifting plate 134 to move up and down, so that the sampling and detection of pioglitazone hydrochloride can be carried out. The longitudinal motor 139 drives the longitudinal bidirectional threaded rod 140 to rotate so that the two longitudinal threaded sleeves 141 move relative to each other on the outside of the longitudinal bidirectional threaded rod 140, and at the same time drives the longitudinal rotating rod 142 to rotate, so that the longitudinal sliding sleeve 143 slides relative to each other on the outside of the longitudinal sliding rod 144, so that the longitudinal sliding bracket 145 can realize the longitudinal movement of the sampling tube 110 under the limiting action of the longitudinal slider 146, thereby realizing all-round sampling and placing. The sampling tube 110 and the clamping bucket 122 can not only realize the clamping of the white crystalline powder of pioglitazone hydrochloride, but also can realize the sampling of the fluidity formed by mixing pioglitazone hydrochloride with the corresponding reagent, so as to facilitate the detection of pioglitazone hydrochloride.

[0052] Finally, the horizontal threaded rod 103 is driven to rotate by the horizontal moving motor 102, so that the horizontal threaded sleeve 104 drives the electric telescopic rod 105 to move horizontally, and the horizontal position of the sampling tube 110 can be adjusted, thereby realizing uninterrupted sampling and setting out. The rotating motor 107 drives the rotating worm 108 to rotate, and the rotating worm 108 and the rotating worm wheel 109 are meshed and connected, so that the rotating worm wheel 109 drives the sampling tube 110 to rotate, which can not only fully mix the mobile phase, but also clean the residual raw materials in the clamping bucket 122 to avoid the phenomenon of raw material waste. The sampling piston 113 is driven by the sampling cylinder 112 to move in the sampling tube 1 10 is lifted and moved inside, so that the sampling needle tube 125 is used to sample the liquid solution. At the same time, when the sampling piston 113 is lifted and moved, the sampling piston 113 drives the connecting rope 115 to move, and the lifting and moving of the limiting sliding sleeve 118 can be realized through the limiting fixed pulley 114. The limiting sliding sleeve 118 drives the connecting rotating rod 120 and the clamping rotating rod 121 to rotate, and the rotation of the clamping bucket 122 can be realized. The clamping bucket 122 can be used to clamp the white crystalline powder of pioglitazone hydrochloride, which is convenient for clamping the pioglitazone hydrochloride into the mobile phase for mixing. At the same time, the magnetic suction block 126 inside the clamping bucket 122 is used to clamp the clamping bucket 122.

[0053] Although the present invention has been described in detail with reference to the aforementioned embodiments, it is still possible for those skilled in the art to modify the technical solutions described in the aforementioned embodiments, or to make equivalent substitutions for some of the technical features therein. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A sampling device for pioglitazone hydrochloride, comprising a sampling mechanism (1), and a lifting and fixing rod (127) installed around the bottom of the sampling mechanism (1); A fixing structure (2) is provided at the bottom of the sampling mechanism (1), and a beaker fixing seat (213) is symmetrically mounted on one side of the top of the fixing structure (2); It is characterized in that Also includes: The sampling mechanism (1) comprises a horizontal movable bracket (101), a horizontal movable motor (102) is fixedly mounted on one side of the horizontal movable bracket (101), a horizontal threaded rod (103) is fixedly connected to the output end of the horizontal movable motor (102), a horizontal threaded sleeve (104) is threadedly connected to the outer side of the horizontal threaded rod (103), and an electric telescopic rod (105) is fixedly mounted on the bottom of the horizontal threaded sleeve (104); A rotating bracket (106) is symmetrically mounted on one side of the bottom of the electric telescopic rod (105); a rotating motor (107) is fixedly mounted on one side of the rotating bracket (106); a rotating worm (108) is fixedly connected to the output end of the rotating motor (107); and a rotating worm gear (109) is meshedly connected to one side of the rotating worm gear (108); The rotating worm gear (109) is rotationally connected to the electric telescopic rod (105), a sampling tube (110) is fixedly installed at the bottom of the rotating worm gear (109), a sampling scale (111) is arranged on the outside of the sampling tube (110), and a sampling cylinder (112) is fixedly installed on the inside of the top of the sampling tube (110).

2. A sampling device for pioglitazone hydrochloride according to claim 1, characterized in that: A sampling piston (113) is fixedly connected to the bottom of the sampling cylinder (112), and the sampling piston (113) is closely connected to the inner wall of the sampling tube (110). Position-limiting fixed pulleys (114) are symmetrically installed on both sides of the bottom of the sampling tube (110) close to the sampling cylinder (112). A connecting rope (115) is slidably connected to the outer side of the position-limiting fixed pulley (114), and one end of the connecting rope (115) is fixedly connected to the sampling piston (113).

3. A sampling device for pioglitazone hydrochloride according to claim 2, characterized in that: The limiting brackets (116) are symmetrically installed on both sides of the bottom of the sampling tube (110), and the limiting sliding rod (117) is fixedly installed inside the limiting bracket (116). The outer side of the limiting sliding rod (117) is slidably connected to the limiting sliding sleeve (118), and the top of the limiting sliding sleeve (118) is fixedly installed with a first limiting spring (119). The limiting sliding sleeve (118) is fixedly connected to the connecting rope (115), and one side of the bottom of the limiting sliding sleeve (118) is rotatably connected to a connecting rotating rod (120), and the top of the connecting rotating rod (120) is rotatably connected to a clamping rotating rod (121).

4. A sampling device for pioglitazone hydrochloride according to claim 3, characterized in that: The bottom of the clamping rotating rod (121) is rotatably connected to a clamping bucket (122), the top of the clamping bucket (122) is rotatably connected to a clamping support block (123), the top of the clamping support block (123) is fixedly installed with a clamping sleeve (124), the interior of the clamping sleeve (124) is fixedly installed with a sampling needle tube (125), the sampling needle tube (125) is fixedly connected to the sampling tube (110), the clamping sleeve (124) is rotatably connected to the clamping rotating rod (121), and a magnetic suction block (126) is symmetrically installed on one side of the clamping bucket (122).

5. A sampling device for pioglitazone hydrochloride according to claim 4, characterized in that: A lifting top plate (128) is fixedly mounted on the top of the lifting fixed rod (127), a motor cover (129) is fixedly mounted on one side of the top of the lifting top plate (128), a lifting motor (130) is fixedly mounted on one side of the inside of the motor cover (129), an output end of the lifting motor (130) is fixedly connected to a sprocket transmission assembly (131), lifting threaded rods (132) are symmetrically mounted on the bottom of the sprocket transmission assembly (131), the outer sides of the two lifting threaded rods (132) are both threadedly connected to lifting threaded sleeves (133), and a lifting plate (134) is fixedly mounted between the two lifting threaded sleeves (133).

6. A sampling device for pioglitazone hydrochloride according to claim 5, characterized in that: A lifting sliding sleeve (135) is symmetrically installed on one side of the lifting plate (134) away from the lifting threaded sleeve (133); a lifting sliding rod (136) is slidably connected inside the lifting sliding sleeve (135); a longitudinal sliding groove (137) is symmetrically opened at the bottom of the lifting sliding rod (136); a longitudinal fixing bracket (138) is fixedly installed at the bottom of the lifting plate (134); a longitudinal motor (139) is fixedly installed on one side of the longitudinal fixing bracket (138); a longitudinal bidirectional threaded rod (140) is fixedly connected to the output end of the longitudinal motor (139); and a longitudinal bidirectional threaded rod (140) is symmetrically threadedly connected to the outer side of the longitudinal bidirectional threaded rod (140). The longitudinal threaded sleeve (141) is rotatably connected to a longitudinal rotating rod (142) on the outside of the longitudinal threaded sleeve (141); the end of the longitudinal rotating rod (142) is rotatably connected to a longitudinal sliding sleeve (143); the inside of the longitudinal sliding sleeve (143) is slidably connected to a longitudinal sliding rod (144); a longitudinal sliding bracket (145) is fixedly installed on the outside of the longitudinal sliding rod (144); a longitudinal sliding slider (146) is symmetrically installed on the top of the longitudinal sliding bracket (145); the longitudinal sliding slider (146) is slidably connected to the longitudinal sliding groove (137); and the longitudinal sliding bracket (145) is fixedly connected to the horizontal movable bracket (101).

7. A sampling device for pioglitazone hydrochloride according to claim 6, characterized in that: The fixed structure (2) comprises a sampling workbench (201), a first mounting base (202) is fixedly mounted on the top of the sampling workbench (201), a test tube holder (203) is symmetrically mounted on the top of the first mounting base (202), a plurality of test tube limiting holes (204) are provided inside the test tube holder (203), a plurality of test tube mounting bases (205) are fixedly mounted on the top of the first mounting base (202), a limiting base (206) is fixedly mounted on the inner side of the bottom of the test tube mounting base (205), and the limiting base (206) is rotatably connected to the inner periphery of the inner periphery. A limit clamping rod (207) is connected, a second limit spring (208) is fixedly installed at the inner center position of the limit base (206), the top of the second limit spring (208) is fixedly connected to a limit conical block (209), a limit connecting rod (210) is fixedly installed around the top of the limit conical block (209), the limit connecting rod (210) is fitted and connected with the surface of the limit clamping rod (207), a limit support disk (211) is fixedly installed on the top of the limit conical block (209), and a test tube body (212) is arranged on the top of the limit support disk (211).

8. A sampling device for pioglitazone hydrochloride according to claim 7, characterized in that: The beaker fixing seat (213) is symmetrically installed on the top of the sampling workbench (201); a fixed sleeve (214) is fixedly installed at the inner center position of the sampling workbench (201); fixed horizontal grooves (215) are provided on both sides of the interior of the fixed sleeve (214); a fixed spring buckle (216) is fixedly installed on one side of the fixed horizontal groove (215); a locking slider (217) is slidably connected inside the fixed horizontal groove (215); a first locking sliding rod (218) is fixedly installed between the two locking sliding rods (217); and a non-slip rotating disk (219) is fixedly connected to the top of the first locking sliding rod (218).

9. A sampling device for pioglitazone hydrochloride according to claim 8, characterized in that: The top of the beaker fixing seat (213) is rotatably connected to a locking rotating rod (220), the top of the locking rotating rod (220) is rotatably connected to a locking sliding sleeve (221), the interior of the locking sliding sleeve (221) is slidably connected to a second locking sliding rod (222), one side of the locking sliding sleeve (221) is fixedly connected to a locking spring (223), the top of the locking sliding sleeve (221) is fixedly installed with a locking clamping plate (224), the top of the anti-slip rotating disk (219) is provided with a beaker body (225), and the outer side of the second locking sliding rod (222) is fixedly installed with a clamping bracket (226).

10. A method for using a sampling device for pioglitazone hydrochloride, using the sampling device for pioglitazone hydrochloride as claimed in claim 9, and the steps of using the method are as follows: Step 1: Use the test tube limiting hole (204) inside the test tube support (203) to initially limit the test tube body (212), and use the gravity of the test tube body (212) to squeeze the limiting support plate (211) and the second limiting spring (208), so that the limiting conical block (209) drives the limiting connecting rod (210) to descend, and drives the limiting clamping rod (207) to rotate, thereby limiting the bottom of the test tube body (212) and improving the placement stability of the test tube body (212). By placing the beaker body (225) on the anti-slip rotating plate (219) and pressing the clamping support (219) downward, the beaker body (225) is placed on the anti-slip rotating plate (219). 26), under the action of the locking rotating rod (220), the locking sliding sleeve (221) can drive the locking clamping plate (224) to move relatively, so as to clamp and fix the beaker body (225), and the anti-skid rotating disk (219) and the first locking sliding rod (218) are driven to rotate by rotating the beaker body (225), so that the locking sliders (217) on both sides of the bottom of the first locking sliding rod (218) slide inside the fixed horizontal groove (215), and are fixed by the fixed spring buckle (216), so as to realize the locking clamping plate (224), which is convenient for taking and placing the locked beaker body (225); Step 2: The lifting motor (130) drives the sprocket drive assembly (131) and the lifting threaded rod (132) to rotate, so that the lifting threaded sleeve (133) and the lifting sliding sleeve (135) drive the lifting plate (134) to move up and down, so that the sampling and detection of pioglitazone hydrochloride can be performed, and the longitudinal motor (139) drives the longitudinal bidirectional threaded rod (140) to rotate so that the two longitudinal threaded sleeves (141) move relative to each other on the outer side of the longitudinal bidirectional threaded rod (140), while driving the longitudinal rotating rod (142) to rotate. The longitudinal sliding sleeve (143) is moved to slide relative to the outer side of the longitudinal sliding rod (144), so that the longitudinal sliding bracket (145) can realize the longitudinal movement of the sampling tube (110) under the limiting action of the longitudinal sliding block (146), thereby realizing all-round sampling and placing. The sampling tube (110) and the clamping bucket (122) can not only realize the clamping of the white crystalline powder of pioglitazone hydrochloride, but also can realize the sampling of the fluidity formed by mixing pioglitazone hydrochloride with the corresponding reagent, so as to facilitate the detection of pioglitazone hydrochloride; Step 3: Utilize the horizontal moving motor (102) to drive the horizontal threaded rod (103) to rotate, so that the horizontal threaded sleeve (104) drives the electric telescopic rod (105) to move horizontally, and the horizontal position of the sampling tube (110) can be adjusted, thereby realizing uninterrupted sampling and placing. The rotating motor (107) drives the rotating worm (108) to rotate, and utilizes the meshing connection between the rotating worm (108) and the rotating worm wheel (109) to drive the rotating worm wheel (109) to drive the sampling tube (110) to rotate, so that the mobile phase can be fully mixed, and the residual raw materials inside the clamping bucket (122) can be cleaned to avoid the phenomenon of raw material waste. The sampling cylinder (112) drives the sampling piston (113) in the sampling tube ( The interior of the sampler (110) is lifted and moved, so that the sampling needle tube (125) is used to sample the liquid solution. At the same time, when the sampling piston (113) is lifted and moved, the sampling piston (113) drives the connecting rope (115) to move, and the lifting and moving of the limiting sliding sleeve (118) can be realized through the limiting fixed pulley (114). The limiting sliding sleeve (118) drives the connecting rotating rod (120) and the clamping rotating rod (121) to rotate, so that the rotation of the clamping bucket (122) can be realized. The clamping bucket (122) can be used to clamp the white crystalline powder of pioglitazone hydrochloride, so that the pioglitazone hydrochloride is clamped into the mobile phase for mixing. At the same time, the magnetic suction block (126) inside the clamping bucket (122) is used to clamp the clamping bucket (122).

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