Instant gastrointestinal filling developer as well as preparation method and application thereof

Abstract

The invention relates to an instant gastrointestinal filling developer as well as a preparation method and application thereof. The instant gastrointestinal filling developing agent is an instant gastrointestinal ultrasonic developing aid and comprises the following components in percentage by weight: 25%-35% of rice, 25%-35% of corn, 5% of pericarpium citri reticulatae, 15%-25% of semen coicis, 5%-15% of Chinese yam and 5% of edible starch. The preparation method comprises the following steps: S1, pretreatment; s2, weighing and frying; s3, crushing and screening; s4, mixing and granulating; s5, drying and selecting granules; and S6, sub-packaging and sealing. Hot water with the weight being 9 times that of the developing agent is added into the developing agent during oral administration, and hot water with the weight being 15 times that of the developing agent is added into the developing agent during enema. According to the preparation method, a traditional curing mode is adopted for stir-frying, so that faint scent and good taste can be better highlighted; boiling drying is adopted during processing, so that uniformity and high efficiency are achieved; after being dissolved, the product is uniformly pasty and can be quickly filled into gastral cavity and enteric cavity, so that pictures under ultrasonic images are clearer.

Description

Technical Field

[0001] The invention relates to the technical field of imaging reagents attached to ultrasonic imaging diagnosis, and in particular to a fast-dissolving gastrointestinal filling developer and a preparation method and application thereof. Background Art

[0002] In gastrointestinal ultrasound examination, the use of gastrointestinal filling contrast agent has many advantages: 1. It can avoid the interference of differences in food residues in the gastrointestinal tract and the presence of gas, which may interfere with the refraction and scattering of ultrasound on the displayed image; 2. It can avoid the situation that cannot be clearly explored due to collapse and folds in the digestive tract, such as the gastric vault, posterior wall of the stomach, colon curvature, anorectal area, etc.; 3. Compared with asking patients to drink an appropriate amount of water to fill the gastrointestinal tract before ultrasound examination, there can be more time for the operator to perform ultrasound examination; 4. It helps to establish standardized examination procedures to avoid imaging errors and artifacts during examination, and misdiagnosis and missed diagnosis of diseases.

[0003] Chinese invention patent CN1231927A discloses "Instant Gastrointestinal Ultrasound Aid and Its Preparation Method", the technical scheme of which is to mix part of fat-containing plant protein with rice flour starch, puff it, and then crush and sieve it; ripen part of fat-containing plant protein with rice kernel and tangerine peel, crush and sieve it; dry yam at low temperature, crush and sieve it; then mix the above-mentioned crushed raw materials, add flavoring agent and mix well, and finally add water to make granules and dry them.

[0004] Chinese invention patent CN1231927A discloses "A gastrointestinal ultrasound developer and its preparation method and application". Its technical solution is to take rice, soybeans, black corn, coix seeds and tangerine peel according to the formula, screen and wash them, and then blend them evenly; drain the water, steam them, dry them at low temperature, cool them to room temperature, mix and grind them into a mixed powder with a particle size of 30-50μm; add mannitol and polypeptide to the mixed powder, mix them evenly, and package them to obtain a gastrointestinal filling developer.

[0005] The product prepared by the above patent has the problem of uneven particle size screening due to the limitations of material selection, formula and preparation process. Different depths of sedimentation can be observed after ten minutes of modulation. When used as a developer, the image under ultrasound imaging will not be detailed enough, and the time for doctors to observe is not sufficient, which affects the accuracy of diagnosis. Summary of the invention

[0006] In order to overcome the deficiencies of the prior art, the present invention provides a fast-dissolving gastrointestinal filling contrast agent and a preparation method and application thereof. When performing gastrointestinal ultrasound angiography, the fast-dissolving contrast agent is easy to use, can be quickly dissolved, and has a slow sedimentation rate after modulation. When used, the gastrointestinal tract of the patient is filled with a contrast agent with uniform particles, and the ultrasound image is clearer, thereby reducing misdiagnosis and missed diagnosis caused by unclear images and insufficient observation time for doctors. In addition, the contrast agent has a pleasant smell and a good taste when taken.

[0007] The present invention is achieved in that: A fast-dissolving gastrointestinal filling developer, characterized in that it comprises, by weight percentage, 25%-35% of rice, 25%-35% of corn, 5% of tangerine peel, 15%-25% of coix seed, 5%-15% of yam, and 5% of edible starch.

[0008] Preferably, the instant gastrointestinal filling developer comprises, by weight percentage, 30% rice, 30% corn, 5% tangerine peel, 20% coix seed, 10% yam, and 5% edible starch.

[0009] Preferably, in the instant gastrointestinal filling developer, the edible starch is lotus root powder and / or sweet potato powder.

[0010] The method for preparing any of the aforementioned fast-dissolving gastrointestinal filling contrast agents comprises the following steps: S1 pretreatment: selecting, washing and drying tangerine peel, coix seed and yam; S2 weighing and frying: weigh rice, corn, and dried tangerine peel according to the weight ratio, put them into the frying machine to mix, set the temperature of the frying machine to 200-230℃, the speed to 30r / min, and fry for 25min; weigh dried coix seeds and yam according to the weight ratio, put them into the frying machine to mix, set the temperature of the frying machine to 200-230℃, the speed to 30r / min, and fry for 30min; S3 crushing and screening: mixing the raw materials fried in step S2, crushing them, passing them through a 60-mesh sieve, and processing them into 60-mesh mixed raw material fine powder; S4 Mixing and granulating: weigh edible starch according to the weight ratio; mix the mixed raw material fine powder obtained in step S3 and the edible starch evenly, add 40%-50% of the total weight of the material purified water, stir until the material is evenly moistened to prepare a soft material; use a swing granulator to prepare the soft material into 10 mesh granules; S5 drying and particle selection: putting the 10-mesh particles obtained in step S4 into a boiling drying oven and drying them at 80°C for 40-60 minutes; spreading the dried particles on the screen of a vibrating sieving machine for screening, and selecting 10-80-mesh particles as finished particles; S6: Packaging and sealing: sealing and packaging the finished particles obtained in step S5.

[0011] Preferably, in the method for preparing the instant gastrointestinal filling developer, the step S4 uses a trough mixer to mix the mixed raw material fine powder and edible starch for 10 minutes until they are uniform, and then adds purified water thereto and stirs for 15 minutes until they are uniformly wetted.

[0012] Preferably, in the method for preparing the instant gastrointestinal filling developer, the sealed packaging in step S6 produces final products in the following packaging specifications: 30 g / bag, 50 g / bag, 55 g / bag, 60 g / bag, 100 g / bag, and 150 g / bag.

[0013] The use of any of the aforementioned fast-dissolving gastrointestinal filling contrast agents in the preparation of reagents for abdominal gastrointestinal ultrasound examination.

[0014] Preferably, the use of the instant gastrointestinal filling developer comprises the following steps of preparing the developer reagent: pouring the instant gastrointestinal filling developer and 9 times its weight of hot water at a temperature above 90°C into a container, stirring into a uniform paste, and cooling to a suitable temperature for oral administration.

[0015] Preferably, the use of the instant gastrointestinal filling developer, the preparation of the developer reagent comprises the following steps: pouring the instant gastrointestinal filling developer and 15 times its weight of hot water above 90°C into a container, stirring into a uniform paste, and cooling to a suitable temperature for enema.

[0016] In order to overcome the defects of the existing fast-dissolving gastrointestinal ultrasound assistant, the present invention provides a fast-dissolving gastrointestinal filling developer, i.e., a fast-dissolving gastrointestinal ultrasound assistant, which is made of rice, corn, lotus root powder, coix seed and other materials for daily use, which are washed, dried, fried, crushed, weighed, mixed, granulated, dried and selected to become granular edible products. The raw materials are all selected from materials for dual use of medicine and food, which are safe and have no toxic side effects. High-quality starch such as rice, corn and yam contains high viscosity factor, forms relative isotropic acid with gastrointestinal mucosa, has natural adsorption effect with gastrointestinal mucosa, small lesions can be fully adhered, and the display rate is high. The chyme feces in the gastrointestinal tract are completely wrapped by the fast-dissolving gastrointestinal filling developer, and the gastric acid and gastric juice will be suspended on it like grease under the pressure correction of the fast-dissolving gastrointestinal filling developer, which improves the internal environment of gastrointestinal ultrasound imaging, enables the sound beam to penetrate smoothly, and the gastrointestinal cavity after filling completely improves the coherence between the entire abdominal organs. The brewing liquid prepared by the present invention is a material that imitates human soft tissue in terms of ultrasonic propagation characteristics. After being combined with several different materials, it is closest to the normal sound velocity, sound attenuation and sound impedance indexes in the human body structure, so that the brewed liquid is most suitable for ultrasonic transmission. The brewing liquid is uniform and fine, and settles slowly, which can effectively assist gastrointestinal ultrasonic examination, make up for the deficiencies in conventional examinations, improve the accuracy of ultrasonic examinations, and also reduce the difficulty of ultrasonic examinations and the requirements for auxiliary operators.

[0017] The developer of the present invention contains 5% starch. After being mixed with hot water above 90°C, "gelatinization" occurs. The starch expands and becomes a viscous translucent paste, which is thick and swollen. The water content is between 10-15%. After repeated tests, we determined that the starch addition ratio is 5%, which is most conducive to the product being in a paste state after mixing. Lotus root starch and sweet potato starch both show good effects when used alone or in combination as starch.

[0018] In the preparation process of the present invention, it is considered that boiling drying after wet granulation may cause particle damage, and 10 mesh granulation is adopted, and then through particle selection, large particles larger than 10 mesh and fine powder smaller than 80 mesh are removed, so as to ensure uniform dispersion of the product of the present invention after dissolution.

[0019] Compared with the prior art, the preparation process of the present invention adopts the traditional cooking method to fry, which can highlight the fragrance and good taste; the boiling drying is used in the processing, which is more uniform and efficient; after the process of the present invention is improved, the product is in a uniform paste after dissolving, and there is no obvious sedimentation of the product of the present invention after modulation for ten minutes, providing doctors with sufficient observation time. The product can quickly fill the stomach cavity and intestinal cavity, so that the medium surface forms the best acoustic impedance difference, eliminates the reverberation effect generated in the ultrasonic examination, the artifacts and graphic distortion caused by the high and low attenuation areas of the medium, and other ultrasonic artifacts and interference, thereby improving the sound and image clarity of the examined part and the surrounding organs, and significantly enhancing the sound and image resolution of the lesion, so that it can adapt to the ultrasonic examination and diagnosis of the gastrointestinal tract, making the picture under the ultrasonic image clearer. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 This is a picture showing the effect of ultrasound examination of gastric filling of the product of the present invention; Figure 2 This is the ultrasound examination effect diagram of gastric filling of control product 1; Figure 3 This is the ultrasound examination effect diagram of gastric filling of control product 2; Figure 4 This is the ultrasound examination effect diagram of gastric filling of control product 3. DETAILED DESCRIPTION

[0021] The present invention is further described below in conjunction with specific embodiments. The following embodiments are only preferred embodiments of the present invention, not all. Based on the embodiments in the implementation mode, other embodiments obtained by those skilled in the art without creative work all belong to the protection scope of the present invention. The experimental methods in the following embodiments, unless otherwise specified, are conventional methods, and the materials, reagents, etc. used in the following embodiments, unless otherwise specified, can be obtained from commercial sources.

[0022] The invention discloses a quick-dissolving gastrointestinal filling developer, comprising, by weight percentage, 25%-35% of rice, 25%-35% of corn, 5% of tangerine peel, 15%-25% of coix seed, 5%-15% of yam, and 5% of edible starch. Example 1

[0023] Prepare the fast-dissolving gastrointestinal filling contrast agent as follows: S1 Pretreatment: Select, wash and dry rice, corn, tangerine peel, coix seed and yam; S2 weighing and frying: weigh 1200 g of dried rice, 1200 g of corn, and 200 g of dried tangerine peel, mix them, set the temperature of the frying machine to 200-230°C, the speed to 30r / min, and fry for 25min; weigh 800 g of dried coix seeds and 400 g of yam, mix them, set the temperature of the frying machine to 200-230°C, the speed to 30r / min, and fry for 30min; S3 crushing and screening: the raw materials fried in step S2 are mixed, crushed, passed through a 60-mesh sieve, and processed into 60-mesh mixed raw material particles; S4 Mixing and granulation: weigh 200 g lotus root starch; use a trough mixer to mix the raw material particles with the lotus root starch for 10 min until uniform, add 1600 g purified water, stir for 15 min until uniformly moistened, and make a soft material; use a swing granulator to make the soft material into 10 mesh particles; S5 drying and particle selection: putting the 10-mesh particles obtained in step S4 into a drying oven and drying them at 80°C for 40 minutes; spreading the dried particles on the screen of a vibrating sieving machine for screening, and selecting particles with 10-80 mesh as finished particles; S6: Packaging and sealing: the finished granules obtained in step S5 are packaged and sealed at 50 g / bag.

[0024] The finished product in step S6 can also be packaged in amounts of 30 g / bag, 55 g / bag, 60 g / bag, 100 g / bag, or 150 g / bag, which is convenient for use.

[0025] The use of the instant gastrointestinal filling developer in the preparation of reagents for abdominal gastrointestinal ultrasound examination requires the preparation of reagents. The product of the present invention is used for the examination of gastric cavity and surrounding organ diseases in an oral manner, with adults taking 50g each time and children taking less. Pour 450 grams of hot water above 90°C and 50 grams of instant gastrointestinal filling developer into a container, stir continuously into a uniform paste, and take it orally after the temperature is suitable, and then an ultrasound examination can be performed. The product of the present invention is used for the examination of intestinal cavity and surrounding organ diseases in an enema manner, with adults taking 100g each time and children taking less. Pour 1500 grams of hot water above 90°C and 100 grams of instant gastrointestinal filling developer into a container, stir continuously into a uniform paste, and take an enema after the temperature is suitable, and then an ultrasound examination can be performed.

[0026] We conducted two experiments to compare the product of the present invention with gastrointestinal filling contrast agents commonly used in the medical market.

[0027] Experiment 1: Sedimentation velocity comparison experiment. Since ultrasonic examination requires a certain amount of observation time, the sedimentation velocity of the developer used requires no obvious sedimentation within ten minutes after modulation. We compared the product of the present invention with three groups of control products. Different depths of sedimentation can be observed in the three groups of control products after modulation for ten minutes, while the product of the present invention has no obvious sedimentation.

[0028] Experiment 2: Comparative experiment on the effect of gastric filling ultrasound examination. In addition to the designer of the experiment, two people were blindly selected to conduct on-site observations, and each of them gave their observation opinions according to the design requirements. The subjects were selected to be of similar body shape and age. Figure 1-4 , the observers reached a consistent conclusion that, compared with the control products 1, 2, and 3, the image of the product of the present invention is uniform and delicate during use, and can well set off the lesions. Figure 2 , 3 In 4, particles can be seen in the image due to uneven sedimentation or dissolution of the control group product. Example 2

[0029] The raw materials weighed in this embodiment are: 1000 grams of rice, 1000 grams of corn, 200 grams of tangerine peel, 1000 grams of coix seeds, 600 grams of yam, and 200 grams of sweet potato starch.

[0030] Step S4: 2000 g of purified water was added during the mixing and granulation.

[0031] The rest of the contents are the same as in Example 1.

[0032] Example 3

[0033] The raw materials weighed in this embodiment are: a starch mixture of 1400 grams of rice, 1400 grams of corn, 200 grams of tangerine peel, 600 grams of coix seeds, 200 grams of yam, 100 grams of lotus root powder and 100 grams of sweet potato starch.

[0034] Step S4: 1800 g of purified water was added during mixing and granulation.

[0035] The rest of the contents are the same as in Example 1.

Claims

1. A fast-dissolving gastrointestinal filling contrast agent, characterized in that: include: By weight percentage, 25%-35% rice, 25%-35% corn, 5% tangerine peel, 15%-25% coix seed, 5%-15% yam, and 5% edible starch.

2. The fast-dissolving gastrointestinal filling developer according to claim 1, characterized in that: include: By weight percentage, 30% rice, 30% corn, 5% tangerine peel, 20% coix seed, 10% yam, and 5% edible starch.

3. The fast-dissolving gastrointestinal filling contrast agent according to claim 1 or 2, characterized in that: The edible starch is lotus root powder and / or sweet potato powder.

4. The method for preparing the fast-dissolving gastrointestinal filling developer according to any one of claims 1 to 3, characterized in that: The following steps are involved: S1 pretreatment: selecting, washing and drying tangerine peel, coix seed and yam; S2 weighing and frying: weigh rice, corn, and dried tangerine peel according to the weight ratio, put them into the frying machine to mix, set the temperature of the frying machine to 200-230℃, the speed to 30r / min, and fry for 25min; weigh dried coix seeds and yam according to the weight ratio, put them into the frying machine to mix, set the temperature of the frying machine to 200-230℃, the speed to 30r / min, and fry for 30min; S3 crushing and screening: mixing the raw materials fried in step S2, crushing them, passing them through a 60-mesh sieve, and processing them into 60-mesh mixed raw material fine powder; S4 Mixing and granulating: weigh edible starch according to the weight ratio; mix the mixed raw material fine powder obtained in step S3 and the edible starch evenly, add 40%-50% of the total weight of the material purified water, stir until the material is evenly moistened to prepare a soft material; use a swing granulator to prepare the soft material into 10 mesh granules; S5 drying and particle selection: putting the 10-mesh particles obtained in step S4 into a boiling drying oven and drying them at 80°C for 40-60 minutes; spreading the dried particles on the screen of a vibrating sieving machine for screening, and selecting 10-80-mesh particles as finished particles; S6: Packaging and sealing: sealing and packaging the finished particles obtained in step S5.

5. The method for preparing the fast-dissolving gastrointestinal filling developer according to claim 4, characterized in that: In step S4, the mixed raw material fine powder and edible starch are mixed for 10 minutes using a trough mixer until they are uniform, and then purified water is added thereto and stirred for 15 minutes until they are uniformly wetted.

6. The method for preparing the fast-dissolving gastrointestinal filling developer according to claim 4 or 5, characterized in that: The step S6 is sealed and packaged, and the packaging specifications of the final product include 30g / bag, 50g / bag, 55g / bag, 60g / bag, 100g / bag, and 150g / bag.

7. Use of the fast-dissolving gastrointestinal filling contrast agent according to any one of claims 1 to 3, characterized in that: The instant gastrointestinal filling developer is used in preparing reagents for abdominal gastrointestinal ultrasound examination.

8. The use of the fast-dissolving gastrointestinal filling contrast agent according to claim 7, characterized in that: The preparation of the developer reagent comprises the following steps: pouring a fast-dissolving gastrointestinal filling developer and hot water above 90°C which is 9 times its weight into a container, stirring into a uniform paste, and cooling to a suitable temperature for oral administration.

9. The use of the fast-dissolving gastrointestinal filling developer according to claim 7, characterized in that: The preparation of the developer reagent comprises the following steps: pouring a fast-dissolving gastrointestinal filling developer and hot water above 90°C which is 15 times its weight into a container, stirring into a uniform paste, and cooling to a suitable temperature for enema.

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