Multi-channel suction and injection mechanism and multi-channel pipetting device

Abstract

The utility model provides a multichannel sucking and injecting mechanism and a multichannel pipetting device, the multichannel sucking and injecting mechanism comprises a sucking and injecting driving device, a driving rod, a push seat, at least two sucking and injecting assemblies and needle removing assemblies arranged in one-to-one correspondence with the sucking and injecting assemblies, the push seat is connected to the driving rod, each needle removing assembly comprises a needle removing rod and a needle removing sleeve, the needle removing sleeve is arranged outside the corresponding suction and injection assembly in a sliding and sleeving manner, the needle removing rod is arranged between the push seat and the needle removing sleeve, and the push seat can push the needle removing rod under the driving of the suction and injection driving device so as to push the needle removing sleeve to move towards the needle removing position; the distances from the needle removing parts of the needle removing sleeves to the needle removing positions are the same, and the at least two needle removing rods push the corresponding needle removing sleeves to move to the needle removing positions in sequence, so that the at least two suction and injection assemblies are subjected to needle removing in sequence; the multi-channel pipetting device comprises a multi-channel suction and injection mechanism and a moving mechanism for moving the multi-channel suction and injection mechanism, and the multi-channel pipetting device disclosed by the utility model can realize needle removal in batches, and is beneficial to saving labor and reducing the power of a motor.

Description

Technical Field

[0001] The utility model relates to the field of liquid transfer devices, in particular to a multi-channel suction and injection mechanism and a multi-channel liquid transfer device. Background Art

[0002] A pipette is a measuring tool that transfers liquid from an original container to another container within a certain range. It is widely used in biology, chemistry and other fields. When using a pipette, the pipette needs to be equipped with a pipette tip. First, the liquid is extracted into the pipette tip of the pipette, and then the liquid in the pipette tip is delivered to other containers that need to be dripped.

[0003] The existing patent CN217578843U discloses a multi-channel integrated sample loading device, which realizes multi-channel needle removal, liquid aspiration, liquid injection, needle removal and other operations through the overall coordination of the Z-axis drive device, the first motor, the piston assembly and the gun discharge module. However, when the sample loading device is in the needle removal operation, the needle removal plate moves downward to push down multiple disposable sample loading needles at the same time, thereby completing the needle removal action, resulting in a large thrust to push the needle removal plate and a high power required by the motor. Utility Model Content

[0004] The first purpose of the utility model is to provide a multi-channel suction and injection mechanism capable of removing the needle in stages.

[0005] The second object of the utility model is to provide a multi-channel liquid transfer device comprising a multi-channel aspiration mechanism.

[0006] In order to achieve the above-mentioned first purpose, the utility model provides a multi-channel injection suction mechanism, including an injection suction drive device, a drive rod, a push seat, at least two injection suction components and needle removal components arranged one by one corresponding to the injection suction components, the push seat is connected to the drive rod, the needle removal component includes a needle removal rod and a needle removal sleeve, the needle removal sleeve sliding sleeve is arranged outside the corresponding injection suction component, the needle removal rod is arranged between the push seat and the needle removal sleeve, and the push seat can push the needle removal rod under the drive of the injection suction drive device, and then push the needle removal sleeve to move to the needle removal position; the distance from the needle removal part of the needle removal sleeve to the needle removal position is the same, and at least two needle removal rods successively push their corresponding needle removal sleeves to move to the needle removal position, so that at least two of the injection suction components remove the needles in turn.

[0007] It can be seen from the above scheme that at least two suction and injection components are provided to perform pipetting operations on at least two groups of liquids at the same time; a pipetting tip is connected to the suction and injection component during suction and injection, and the needle removal sleeve is used to separate the suction and injection component from the pipetting tip after the suction and injection is completed; when the distance from the needle removal part of the needle removal sleeve to the needle removal position is the same, at least two needle removal rods are provided to successively push the two corresponding needle removal sleeves to move to the needle removal position, so that at least two suction and injection components can remove the needles in turn; compared with removing the needles of all suction and injection components at the same time, removing the needles in batches is beneficial to reducing the driving force required for needle removal, thereby reducing the required power of the driving device when removing the needles.

[0008] A further solution is that the lengths of the needle removing rods are the same, there is a first spacing between the push seat and the needle removing rod, the first spacing is greater than or equal to 0, there is a second spacing between the needle removing sleeve and the needle removing rod, the second spacing is greater than or equal to 0; the sum of the first spacing and the second spacing of at least two needle removing rods is different, such as the sum of the first spacing and the second spacing of the needle removing component A is not equal to the sum of the first spacing and the second spacing of the needle removing component B.

[0009] Specifically, when the lengths of the needle stripping rods are the same, they include:

[0010] a) The push seat and the needle removing rod are fixedly connected, and the second abutting surfaces of at least two needle removing sleeves have a height difference in the direction of movement of the push seat, so that the distances between at least two needle removing rods and the second abutting surfaces of the corresponding needle removing sleeves are different.

[0011] b) The needle removal sleeve and the needle removal rod are fixedly connected, and the first abutment surfaces of at least two push seats have a height difference in the direction of movement of the push seats, so that the distances between at least two needle removal rods and the first abutment surfaces of the corresponding push seats are different.

[0012] c) There is a first distance between the needle removing rod and the push seat, and there is a second distance between the needle removing rod and the needle removing sleeve, and the sum of the first distance and the second distance of at least two needle removing components is different.

[0013] Furthermore, in the case where the lengths of at least two needle-removing rods are different, the distance between the push seat and the needle-removing sleeve can be adjusted to achieve needle removal of at least two groups of suction and injection assemblies at different times:

[0014] As an embodiment of the present invention, at least two needle-removing rods have different lengths, and when the needle-removing rods are fixedly connected to the corresponding push seats, different distances are set between at least two needle-removing rods and the needle-removing sleeves, so that at least two groups of suction and injection components can remove needles at different times.

[0015] As an embodiment of the utility model, when the lengths of at least two needle-removing rods are different, and there is a spacing between the needle-removing rod and the needle-removing sleeve, and there is a spacing between the needle-removing rod and the pushing seat, the spacing between the needle-removing sleeve and the pushing seat is set to be the same, so that at least two groups of suction and injection components can remove needles at different times.

[0016] As an embodiment of the utility model, when the lengths of at least two needle-removing rods are different, there is a spacing between the needle-removing rod and the needle-removing sleeve, there is a spacing between the needle-removing rod and the push seat, the spacing between the needle-removing sleeve and the push seat is different, and the length difference of needle-removing rods with different lengths is different from the corresponding spacing difference between the needle-removing sleeve and the push seat, so that at least two groups of suction and injection components can remove needles at different times.

[0017] As a preferred embodiment of the utility model, at least two needle-removing rods have different lengths, and when the needle-removing rods are fixedly connected to the corresponding needle-removing sleeves, different distances are set between at least two needle-removing rods and the push seat, so that at least two groups of suction and injection components can remove needles at different times.

[0018] A further solution is that the suction and injection assembly includes a sleeve, a piston rod and an adapter, the first end of the piston rod is fixedly connected to the push seat, the second end of the piston rod is inserted into the sleeve through the first end of the sleeve, the adapter is connected to the second end of the sleeve, and the suction and injection driving device drives the push seat to move along the direction of movement of the push seat through the driving rod, thereby driving the piston rod to move back and forth in the corresponding sleeve; the distance between the needle stripping rod and the push seat needs to be greater than the stroke required for the push seat to push the piston rod for complete injection.

[0019] In the utility model, the piston rod and the needle removal rod are pushed by the push seat, that is, the same driving device is used to drive the suction and injection and the needle removal assembly to remove the needle, and the structure is simpler and more compact. When the suction and injection and needle removal processes are controlled by the push seat at the same time, it should be noted that the distance between the needle removal rod and the push seat must be greater than the stroke required for the push seat to push the piston rod to complete the injection, that is, the push seat must complete the injection operation before the needle removal operation can be performed.

[0020] A further solution is that the multi-channel suction injection mechanism also includes a sleeve fixing seat, the suction injection assembly passes through the sleeve fixing seat along the direction of movement of the push seat, the first end of the sleeve is fixedly connected to the sleeve fixing seat, and the needle stripping rod passes through the sleeve fixing seat along the direction of movement of the push seat and is movably connected to the sleeve fixing seat.

[0021] A further solution is that a limiting portion is provided at one end of the needle removing rod close to the pushing seat, the limiting portion abuts against the sleeve fixing seat, a needle removing connecting rod sleeve is provided on the needle removing sleeve, and the end of the needle removing rod away from the pushing seat is connected to the needle removing connecting rod sleeve, the limiting portion and the needle removing connecting rod sleeve are respectively arranged on both sides of the sleeve fixing seat, and the distance from the limiting portion to the needle removing connecting rod sleeve is greater than the width of the sleeve fixing seat in the movement direction of the pushing seat.

[0022] It can be seen from the above scheme that by respectively arranging the limiting part and the needle-removing connecting rod sleeve on both sides of the sleeve fixing seat, the moving distance of the needle-removing rod can be limited to avoid separation from the sleeve fixing seat due to excessive moving distance.

[0023] A further solution is that a first mounting groove and a piston fixing seat for connecting with the piston rod are provided in the push seat, the piston fixing seat is provided in the first mounting groove, and the piston fixing seat can adjust its position in the first mounting groove along a direction not parallel to the movement of the push seat.

[0024] It can be seen from the above scheme that by setting the piston fixing seat, the piston rod can move synchronously with the push seat in the direction of movement of the push seat; by setting the piston fixing seat in the first installation groove, its position can be adjusted along the direction not parallel to the movement of the push seat. The direction not parallel to the movement of the push seat is preferably perpendicular to the X and Y directions of the direction of movement of the push seat, and the X and Y directions are perpendicular to each other so that the piston rod can adaptively adjust its installation orientation, which is beneficial to ensure that the piston rod and the sleeve are coaxially arranged, so that the suction and injection of liquid is more stable and accurate.

[0025] In order to achieve the above-mentioned second purpose, the multi-channel pipetting device provided by the utility model includes a multi-channel aspiration mechanism and a moving mechanism for moving the multi-channel aspiration mechanism.

[0026] The utility model is conducive to realizing the function of multi-channel simultaneous pipetting by setting up a plurality of suction and injection components and needle removal components. When removing the needle, the plurality of needle removal components remove the needle in batches, which is conducive to saving labor and reducing the power of the motor. It has the advantages of compact structure, small size and easy use. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 It is a front view of an embodiment of the multi-channel liquid transfer device of the utility model.

[0028] Figure 2 It is a three-dimensional structural diagram of an embodiment of the multi-channel liquid transfer device of the utility model.

[0029] Figure 3 It is a three-dimensional structural diagram of the linear moving mechanism in the embodiment of the multi-channel liquid transfer device of the utility model.

[0030] Figure 4 It is an exploded view of the multi-channel suction and injection mechanism in the embodiment of the multi-channel pipetting device of the utility model.

[0031] Figure 5 It is a cross-sectional view of a multi-channel suction and injection mechanism in an embodiment of the multi-channel liquid transfer device of the utility model.

[0032] Figure 6 yes Figure 5 Enlarged view of point A in the middle.

[0033] Figure 7 yes Figure 6 Cross-sectional view of BB.

[0034] Figure 8 yes Figure 5 Enlarged view of point C in the middle.

[0035] In the figure: 1- multi-channel suction and injection mechanism;

[0036] 11-injection drive device, 111-drive device fixing seat, 112-coupling, 113-adjusting ring;

[0037] 12-driving rod;

[0038] 13-gun housing, 131-second guide rail, 132-second slide block;

[0039] 14-sleeve fixing seat, 141-third mounting groove, 142-sleeve fixing block, 143-sleeve fixing base plate, 144-first detector, 145-second detector, 146-air pressure sensor, 147-second mounting groove;

[0040] 15-push seat, 151-first mounting groove, 152-piston fixing seat, 153-first contact stopper;

[0041] 16-injection assembly, 161-sleeve, 162-piston rod, 163-adapter;

[0042] 17-needle removal assembly, 171-needle removal rod, 1711-annular flange, 1712-limiting portion, 172-needle removal sleeve, 1721-needle removal connecting rod sleeve, 173-elastic member, 174-second touch-blocking piece;

[0043] 18-puncture needle;

[0044] 19-seal assembly, 191-piston rod guide sleeve, 192-guide sleeve pressure plate, 193-first seal ring, 194-second seal ring, 195-third seal ring;

[0045] 2-linear moving mechanism, 21-mounting base, 211-first guide rail, 212-first slider, 22-linear moving driving device, 221-driving shaft, 23-third detector, 24-third touch-blocking piece;

[0046] 3- Pipette tips.

[0047] The present invention will be further described below with reference to the accompanying drawings and embodiments. DETAILED DESCRIPTION

[0048] See also Figures 1 to 3The multi-channel pipetting device provided in this embodiment includes a multi-channel suction and injection mechanism 1 and a moving mechanism for moving the multi-channel suction and injection mechanism. The multi-channel suction and injection mechanism 1 is arranged on the moving mechanism. The moving mechanism can be a linear moving mechanism 2 that can drive the multi-channel suction and injection mechanism to move back and forth along the Z direction, or it can be a manipulator. The manipulator includes but is not limited to: a four-axis manipulator or a six-axis manipulator. This embodiment is a linear moving mechanism 2. The Z direction is the vertical direction.

[0049] The linear motion mechanism 2 includes a mounting base 21 and a linear motion driving device 22. The mounting base 21 is provided with a first guide rail 211 and a first slider 212. The first guide rail 211 extends along the Z direction, and the first slider 212 is slidably connected to the first guide rail 211. The multi-channel suction injection mechanism 1 is arranged on the first slider 212. The driving end of the linear motion driving device 22 is connected with a driving shaft 221, and the driving shaft 221 is arranged parallel to the first guide rail 211. The first slider 212 is connected to the driving shaft 221. The linear motion driving device 22 can be a motor, a cylinder or a hydraulic cylinder. In this embodiment, it is preferably a motor. The driving shaft 221 is preferably a lead screw. The first slider 212 is provided with a thread and is screwed to the driving shaft 221. The linear motion driving device 22 drives the driving shaft 221 to rotate, thereby driving the first slider 212 and the multi-channel suction injection mechanism 1 to move along the extension direction of the first guide rail 211.

[0050] Furthermore, a third detector 23 is provided on the mounting base 21, and the third detector 23 is preferably a photoelectric sensor. A third touch-blocking piece 24 is provided on the first slider 212 or the multi-channel injection mechanism 1. In this embodiment, the third touch-blocking piece 24 is preferably fixedly connected to the first slider 212, and the third touch-blocking piece 24 is correspondingly provided to the third detector 23. When the linear motion drive device 22 drives the first slider 212 back to the initial position, the third touch-blocking piece 24 can trigger the third detector 23 to send a return-to-position signal to the system control unit, which is conducive to ensuring that the first slider 212 accurately returns to the initial position.

[0051] See also Figures 4 to 7 The multi-channel injection mechanism 1 includes an injection driving device 11, a driving rod 12, a gun housing 13, a sleeve fixing seat 14, a push seat 15, at least two injection assemblies 16 and at least two needle removal assemblies 17. The number of the injection assemblies 16 and the needle removal assemblies 17 are equal, and the injection assemblies 16 and the needle removal assemblies 17 are arranged one by one.

[0052] This embodiment takes four suction injection assemblies 16 and four needle removal assemblies 17 as an example, each suction injection assembly 16 and needle removal assembly 17 extends along the z direction, and the four suction injection assemblies 16 are arranged along the x direction. The x direction is the horizontal direction.

[0053] A drive device fixing seat 111 is arranged outside one end of the discharge gun housing 13, and the suction and injection drive device 11 is arranged on the drive device fixing seat 111. The driving end of the suction and injection drive device 11 is connected with a driving rod 12, and the driving rod 12 extends into the discharge gun housing 13 along the z direction and is connected to a push seat 15 arranged in the discharge gun housing 13, so as to drive the push seat 15 to move back and forth along the z direction in the discharge gun housing 13. The suction and injection drive device 11 can be a motor, a cylinder or a hydraulic cylinder. In this embodiment, it is preferably a motor, and the driving rod 12 is preferably a lead screw. The driving end of the motor is connected to the driving rod 12 through a coupling 112. An adjusting ring 113 is also arranged between the coupling 112 and the driving rod 12, which is used to adjust the axial clearance between the driving rod 12 and the coupling 112, so as to compensate for the manufacturing error and installation error of the motor and the lead screw, and the position deviation caused by deformation or thermal expansion when the motor is working, which is conducive to mitigating impact and absorbing vibration, and is also conducive to the safety and reliability of the packaging equipment, so that the liquid transfer device has good strength and service life.

[0054] Two second guide rails 131 and two second sliders 132 are also provided in the volley gun housing 13. The second guide rails 131 extend along the Z direction. The two second guide rails 131 are preferably provided on both sides of the driving rod 12, respectively. The second sliders 132 are connected to the second guide rails 131. Specifically, the push seat 15 extends along the X direction. Both ends of the push seat 15 along the X direction are respectively connected to the two second sliders 132. The driving rod 12 is threadedly connected to the push seat 15. When the driving rod 12 rotates, the push seat 15 can be driven to move along the driving rod 12 and the second guide rails 131 along the Z direction.

[0055] The sleeve fixing seat 14 is connected to one end of the gun housing 13 away from the suction drive device 11. The sleeve fixing seat 14 includes a sleeve fixing block 142 and a sleeve fixing base plate 143. The sleeve fixing block 142 and the sleeve fixing base plate 143 are arranged opposite to each other along the Y direction. In this embodiment, the Y direction is a horizontal direction and is perpendicular to the X direction. The driving end of the driving rod 12 is connected to the connecting hole of the sleeve fixing seat 14.

[0056] Along the Z direction, the sleeve fixing seat 14 is provided with a plurality of through holes, which are used for installing the suction and injection assembly 16 and the needle removal rod 171 respectively.

[0057] The needle removal assembly 17 includes a needle removal rod 171 and a needle removal sleeve 172, wherein the needle removal rod 171 is located between the needle removal sleeve 172 and the push seat 15. The needle removal sleeve 172 is sleeved on the outer side of the corresponding sleeve 161. Since the cross-sectional area of ​​the liquid transfer head 3 plugged into the adapter 163 along the horizontal plane is larger than the cross-sectional area of ​​the sleeve 161 along the horizontal plane, the needle removal portion at the lower part of the needle removal sleeve 172 can directly abut against the liquid transfer head 3 to perform the needle removal operation.

[0058] Specifically, Figure 5, the needle-removing rod 171 is movably inserted into the through hole of the sleeve fixing seat 14, and both ends of the needle-removing rod 171 pass through the sleeve fixing seat 14, one end of the needle-removing rod 171 is fixedly connected to the needle-removing connecting rod sleeve 1721 of the needle-removing sleeve 172, and the other end of the needle-removing rod 171 extends toward the push seat 15, and is provided with a limiting portion 1712. The spacing between the limiting portion 1712 and the needle-removing connecting rod sleeve 1721 is greater than the width of the sleeve fixing seat 14 in the Z direction, and the limiting portion 1712 and the needle-removing connecting rod sleeve 1721 do not abut against the upper and lower side walls of the sleeve fixing seat 14 at the same time to limit the moving distance of the needle-removing rod 171, and make the needle-removing rod 171 connected to the sleeve fixing seat 14 to avoid being separated from the sleeve fixing seat 14 when sliding. When the pipette tip 3 needs to be pushed away, the push seat 15 is driven downward by the suction drive device 11, and the push seat 15 abuts against and pushes the multiple needle removal rods 171 downward, thereby causing the needle removal rods 171 to push the needle removal sleeve 172 downward to realize the multi-channel needle removal operation.

[0059] In the present utility model, the distance between the needle removal part of each needle removal sleeve 172 and the needle removal position is the same, that is, the needle removal sleeve 172 can push the pipette tip 3 to separate from the adapter 163. Preferably, in this embodiment, when the pipette tip 3 is plugged into the adapter 163, the needle removal sleeve 172 abuts against the pipette tip 3, that is, the needle removal sleeve 172 moves downward to immediately separate the pipette tip 3 from the adapter 16. By adjusting the spacing between the push seat 15 and the needle removal rod 171, the spacing between the needle removal rod 171 and the needle removal sleeve 172, or the spacing between the push seat 15 and the needle removal sleeve 172, the push seat 15 can push different needle removal sleeves 172 not completely at the same time, thereby achieving incomplete simultaneous needle removal. The "incomplete simultaneous needle removal" mentioned here means that at least one needle removal sleeve 172 is not removed at the same time as other needle removal sleeves 172.

[0060] Specifically, taking the four needle-removing assemblies 17 as an example, in this embodiment, the distances between the push seat 15 and the four needle-removing sleeves 172 are the same. Since the needle-removing sleeve 172 is fixedly connected to the needle-removing rod 171, and the lengths of the four needle-removing rods 171 are different, the distances between the push seat 15 and the four needle-removing rods 171 are different. At this time, the push seat 15 moves toward each needle-removing rod 171, successively abutting against the four needle-removing rods 171, and the needle-removing rod 171 that contacts first is pushed first to perform the needle-removing action, and the needle-removing rod 171 that contacts later is pushed later to perform the needle-removing action. Since the needle-removing actions are not performed at the same time, the driving force required for needle-removing can be minimized.

[0061] Optionally, when the distances between the needle-removing rod 171 and the needle-removing sleeve 172 are the same, among the four needle-removing rods 171, only the distances from the abutting parts of two needle-removing rods 171 to the driving part of the push seat 15 are equal, and the distances from the other two needle-removing rods 171 to the push seat 15 are unequal. At this time, the push seat 15 can push the four needle-removing rods 171 to perform the needle-removing action in three batches, and the driving force required at this time is relatively small; or, among the four needle-removing rods 171, the distances from the two needle-removing rods 171 to the push seat 15 are equal, and the push seat 15 can push the four needle-removing rods 171 to perform the needle-removing action in two batches, that is, each batch pushes two needle-removing rods 171 to perform the needle-removing action, and the driving force required at this time is relatively large, but the driving force is smaller than the driving force required to drive the four needle-removing rods 171 to perform the needle-removing action at the same time in the prior art. This setting of setting needle-removing rods 171 of different lengths to achieve different needle-removing at the same time not only saves effort, but also reduces the power of the suction drive device 11.

[0062] Furthermore, combined with Figure 5 and Figure 8 An elastic member 173 is connected between the sleeve fixing seat 14 and the needle-removing rod 171. In a natural state, the elastic member 173 makes the needle-removing portion of the needle-removing sleeve 172 protrude from the needle-removing position at the lower part of the sleeve 161, and the suction and injection assembly 16 is in a needle-removing state.

[0063] Specifically, the sleeve fixing seat 14 is provided with a third mounting groove 141 at the lower end where it is connected to the needle-removing rod 171, and the third mounting groove 141 is provided with a notch downward; the needle-removing rod 171 is provided with an annular flange 1711 at the part of the third mounting groove 141, and the elastic member 173 is preferably a compression spring. The elastic member 173 is located in the third mounting groove 141 and is sleeved on the needle-removing rod 171, and the two ends of the elastic member 173 are respectively connected to the top wall of the third mounting groove 141 and the annular flange 1711, so that:

[0064] When the adapter 163 is plugged with the pipette tip 3, the elastic member 173 is compressed, and the elastic member 173 applies a downward elastic force F1 to the needle removal rod 171. The adapter 163 cooperates with the inner wall of the pipette tip 3, and the friction between the two is F2, F1 and gravity G are in the same direction, F1 and F2 are in opposite directions, and F2 = (elastic force F1 + gravity G), so that the pipette tip 3 can be firmly connected to the adapter 163. When the adapter 163 is not plugged with the pipette tip 3, the elastic member 173 is in a non-compressed state, so that the needle removal sleeve 172 moves downward beyond the needle removal position.

[0065] Furthermore, the corresponding detection component can monitor whether the adapter 163 is plugged with the pipette tip 3. The detection mechanism for monitoring whether the adapter 163 is plugged with the pipette tip 3 is as follows:

[0066] refer to Figure 4, each needle removal sleeve 172 is connected to a second touch-blocking piece 174, and the second touch-blocking piece 174 can move synchronously with the needle removal sleeve 172, and is preferably arranged on the needle removal connecting rod sleeve 1721. The sleeve fixed bottom plate 143 is correspondingly provided with four second detectors 145. The second detector 145 is preferably a photoelectric sensor. After taking the pipette tip 3, the needle removal sleeve 172 moves upward, driving the needle removal connecting rod sleeve 1721 to move upward, and allowing the second touch-blocking piece 174 to stably trigger the second detector 145, indicating that the needle removal is successful, otherwise the needle removal fails; the elastic member 173 can also effectively ensure that after the needle is removed, the second touch-blocking piece 174 remains away from the second detector 145 to avoid false detection.

[0067] The suction and injection assembly 16 includes a sleeve 161, a piston rod 162 and an adapter 163. The sleeve 161 extends along the Z direction, the first end of the sleeve 161 is fixedly connected to the sleeve fixing seat 14, the second end of the piston rod 162 is movably inserted from the first end of the sleeve 161 into the sleeve 161, and can slide along the inner wall of the sleeve 161, the first end of the piston rod 162 is connected to the push seat 15; the second end of the sleeve 161 is connected to the adapter 163. The adapter 163 is connected by plugging with the liquid transfer tip 3 - the inner wall of the connecting end of the liquid transfer tip 3 abuts against the outer side of one end of the adapter 163, and the friction force of the liquid transfer tip 3 makes it overcome gravity to be connected to the adapter 163. A through hole extending along the Z direction is opened in the middle of the adapter 163, and the interior of the sleeve 161 is connected to the interior of the liquid transfer tip 3 through the through hole, and the liquid transfer tip 3 is used for suction or injection. When aspirating, the push seat 15 is driven upward by the suction and injection driving device 11, thereby driving the piston rod 162 upward, forming negative pressure, and the liquid is aspirated by the liquid pipette tip 3. When injecting, the push seat 15 is driven downward by the suction and injection driving device 11, thereby driving the piston rod 162 downward, and positive pressure is used to push out the liquid in the liquid pipette tip 3.

[0068] Since the push seat 15 is used to control the process of aspirating and injecting liquid and removing the needle at the same time, the multi-channel aspirating and injecting mechanism 1 of this embodiment has a compact structure, reduces the use of parts, and saves costs. It should be noted that the distance between the needle-removing rod 171 and the push seat 15 must be greater than the stroke required for the push seat 15 to push the piston rod 162 to complete the injection, that is, the push seat 15 must complete the injection operation before the needle removal operation can be performed.

[0069] Further integration Figure 5 and Figure 8The multi-channel injection mechanism 1 of this embodiment also includes four sealing components 19, and the four sealing components 19 are arranged in a one-to-one correspondence with the four injection components 16. The sealing component 19 includes a piston rod guide sleeve 191, a guide sleeve pressure plate 192, a first sealing ring 193 and a second sealing ring 194. A second mounting groove 147 is provided in the sleeve fixing seat 14, and the connection between the piston rod 162 and the sleeve 161 is located in the second mounting groove 147. The upper part of the piston rod 162 extends from the upper notch of the second mounting groove 147, and the lower part of the sleeve 161 extends from the lower notch of the second mounting groove 147. The second mounting groove 147 is connected to the inside of the sleeve 161 through the upper end of the sleeve 161. The sealing component 19 is used to ensure the sealing between the piston rod 162 and the upper notch of the second mounting groove 147 to ensure smooth injection.

[0070] Specifically, see Figure 8 The piston rod guide sleeve 191 is sleeved on the piston rod 162 and extends into the second mounting groove 147 along the upper notch of the second mounting groove 147. The guide sleeve pressure plate 192 is arranged at the upper notch of the second mounting groove 147 and abuts against the protrusion of the piston rod guide sleeve 191 to prevent the piston rod guide sleeve 191 from being separated from the second mounting groove 147. Furthermore, a partition for separating the upper end of the sleeve 161 and the guide sleeve pressure plate 192 is also provided in the second mounting groove 147. The upper end of the sleeve 161 abuts against the lower end of the partition. A first sealing ring 193 and a second sealing ring 194 are also provided between the lower end of the guide sleeve pressure plate 192 and the partition. The first sealing ring 193 is sleeved on the outer side of the piston rod 162, and the first sealing ring 193 and the piston rod 162 are transitionally matched to improve the sealing between the first sealing ring 193 and the piston rod 162. The second sealing ring 194 is sleeved on the outer side of the piston rod 162 and abuts against the first sealing ring 193 and the partition, and the second sealing ring 194 is loosely matched with the piston rod 162. In the Z direction, the guide sleeve pressing plate 192 presses the piston rod guide sleeve 191 into the second installation groove 147, so that the first sealing ring 193 and the second sealing ring 194 are sealed and abutted. The first sealing ring 193 is made of elastic plastic, and the second sealing ring 194 is made of silicone.

[0071] In order to further improve the sealing performance, the third sealing ring 195 is provided in the first sealing ring 193 in this embodiment. Specifically, an annular groove is provided in the middle of the first sealing ring 193, and the third sealing ring 195 is provided in the annular groove and at least part of the third sealing ring 195 protrudes out of the notch of the annular groove, so that the third sealing ring 195 is sealed and connected between the annular groove and the groove wall of the second mounting groove 147.

[0072] Combination Figures 5 to 7Since there are manufacturing errors and assembly errors between the piston rod 162 and the sleeve 161, in order to ensure that the piston rod 162 and the sleeve 161 are coaxially arranged and to ensure that the suction and injection assembly 16 can more stably and accurately suck and inject liquid, the piston rod 162 of this embodiment is movably connected to the push seat 15. Specifically:

[0073] The push seat 15 is provided with a first mounting groove 151 and a piston fixing seat 152 corresponding to each piston rod 162. The piston fixing seat 152 is provided in the first mounting groove 151, and the upper part of the piston rod 162 is connected to the piston fixing seat 152. In the X direction, the groove width W2 of the first mounting groove 151 is greater than the width W1 of the piston fixing seat 152, so that the piston fixing seat 152 can adjust its position in the first mounting groove 151 along the X direction. In the Y direction, the depth L2 of the first mounting groove 151 is greater than the thickness L1 of the piston fixing seat 152, so that the piston fixing seat 152 can adjust its position in the first mounting groove 151 along the Y direction. Since the push seat 15 is to push the piston rod 162 to move along the Z direction, in the Z direction, the height H1 of the first mounting groove 151 is substantially equal to the height H2 of the piston fixing seat 152, so that when the push seat 15 moves, it can synchronously drive the piston fixing seat 152 and the piston rod 162 to move together.

[0074] See also Figure 4 and Figure 5 In the embodiment, the push seat 15 is connected with a first stopper 153 , and the first stopper 153 can move synchronously with the push seat 15 .

[0075] A first detector 144 is arranged on the sleeve fixed base plate 143, and the first detector 144 and the first touch-blocking piece 153 are arranged correspondingly in the Z direction. The first detector 144 is preferably a photoelectric sensor. When the push seat 15 drives the first touch-blocking piece 153 to move downward in the Z direction by a first preset distance, the needle removal sleeve 172 pushes the pipette tip 3 to separate from the adapter 163, and at this time, the first touch-blocking piece 153 can trigger the first detector 144 to send a needle removal signal to the system control unit. Multiple first detectors 144 and corresponding first touch-blocking pieces 153 can be set according to the positions of different needle removal groups 17 for needle removal; preferably, only one set of needle removal monitoring is set, and the needle removal monitoring is set according to the position of the push seat 15 required for the needle removal group 17 to remove the needle last.

[0076] Four air pressure sensors 146 are also provided on the sleeve fixing seat 14. The four air pressure sensors 146 are respectively provided in one-to-one correspondence with the four suction and injection components 16. The air pressure sensors 146 are provided on the sleeve fixing base plate 143. The detection end of the air pressure sensor 146 is connected to the inside of the sleeve 161 of each suction and injection component 16 to detect the air pressure in the sleeve 161 in real time and feedback the current air pressure to the system control unit. When the current air pressure is the first preset threshold, the system determines that the suction and injection component 16 is in the liquid suction state; when the current air pressure is the second preset threshold, the system determines that the suction and injection component 16 is in the liquid injection state; when the current air pressure is the third preset threshold, the system determines that the suction and injection component 16 is in the air leakage state, and when the current air pressure is the fourth preset threshold, the system determines that the suction and injection component 16 is in the needle blocking state. The first preset threshold, the second preset threshold, the third preset threshold and the fourth preset threshold can be constant values ​​or range values; the specific values ​​of the first preset threshold, the second preset threshold, the third preset threshold and the fourth preset threshold can be measured through multiple tests.

[0077] exist Figure 1 In the embodiment, the multi-channel suction and injection mechanism 1 is also provided with a puncture needle 18, and the number of the puncture needles 18 can be set to one, two or more than three. In this embodiment, two puncture needles 18 are used as an example, and the two puncture needles 18 are arranged along the X direction, and each puncture needle 18 extends along the Z direction. The first end of the puncture needle 18 is fixedly connected to the sleeve fixing seat 14, and the second end of the puncture needle 18 is provided with a puncture tip, which is used to puncture the membrane of the bottle mouth of the reagent bottle.

[0078] Finally, it should be emphasized that the above are only preferred embodiments of the present invention and are not intended to limit the present invention. For those skilled in the art, the present invention may have various changes and modifications. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A multi-channel injection mechanism, comprising an injection drive device, a drive rod, a push seat, at least two injection assemblies and a needle removal assembly corresponding to the injection assemblies, wherein the push seat is connected to the drive rod, the needle removal assembly comprises a needle removal rod and a needle removal sleeve, the needle removal sleeve sliding sleeve is arranged outside the corresponding injection assembly, the needle removal rod is arranged between the push seat and the needle removal sleeve, and the push seat can push the needle removal rod under the drive of the injection drive device, thereby pushing the needle removal sleeve to move to the needle removal position; characterized in that: The distances from the needle removal portion of the needle removal sleeve to the needle removal position are the same, and at least two needle removal rods successively push the corresponding needle removal sleeves to move to the needle removal position, so that at least two suction and injection assemblies remove needles in sequence.

2. The multi-channel suction injection mechanism according to claim 1, characterized in that: The needle removing rods have the same length, a first spacing between the push seat and the needle removing rod is greater than or equal to 0, a second spacing between the needle removing sleeve and the needle removing rod is greater than or equal to 0; the sum of the first spacing and the second spacing of at least two needle removing rods is different.

3. The multi-channel suction injection mechanism according to claim 1, characterized in that: The needle-removing rod is fixedly connected to the corresponding pushing seat, at least two of the needle-removing rods have different lengths, and at least two of the needle-removing rods have different spacings from the needle-removing sleeve.

4. The multi-channel suction and injection mechanism according to claim 1, characterized in that: There is a distance between the needle removing rod and the needle removing sleeve, there is a distance between the needle removing rod and the pushing seat, the distances between the needle removing sleeve and the pushing seat are the same, and at least two of the needle removing rods have different lengths.

5. The multi-channel suction and injection mechanism according to claim 1, characterized in that: There is a distance between the needle removing rod and the needle removing sleeve, and there is a distance between the needle removing rod and the pushing seat. The distances between the needle removing sleeve and the pushing seat are different. The lengths of at least two needle removing rods are different, and the length difference between the needle removing rods with different lengths is different from the corresponding distance difference between the needle removing sleeve and the pushing seat.

6. The multi-channel suction and injection mechanism according to claim 1, characterized in that: The needle-removing rod is fixedly connected to the corresponding needle-removing sleeve, at least two needle-removing rods have different lengths, and at least two needle-removing rods have different spacings from the pushing seat.

7. The multi-channel suction and injection mechanism according to claim 6, characterized in that: The suction and injection assembly includes a sleeve, a piston rod and an adapter. The first end of the piston rod is fixedly connected to the push seat, the second end of the piston rod is inserted into the sleeve through the first end of the sleeve, and the adapter is connected to the second end of the sleeve. The suction and injection driving device drives the push seat through the driving rod, thereby driving the piston rod to move back and forth in the corresponding sleeve.

8. The multi-channel suction and injection mechanism according to claim 7, characterized in that: The multi-channel injection suction mechanism also includes a sleeve fixing seat, the injection suction assembly is arranged to pass through the sleeve fixing seat along the direction of movement of the push seat, the first end of the sleeve is fixedly connected to the sleeve fixing seat, and the needle-removing rod passes through the sleeve fixing seat along the direction of movement of the push seat and is movably connected to the sleeve fixing seat.

9. The multi-channel suction and injection mechanism according to claim 8, characterized in that: A limiting portion is provided at one end of the needle removing rod close to the pushing seat, a needle removing connecting rod sleeve is provided on the needle removing sleeve, and the end of the needle removing rod away from the pushing seat is connected to the needle removing connecting rod sleeve, the limiting portion and the needle removing connecting rod sleeve are respectively arranged on both sides of the sleeve fixing seat, and the distance from the limiting portion to the needle removing connecting rod sleeve is greater than the width of the sleeve fixing seat in the movement direction of the pushing seat.

10. The multi-channel suction injection mechanism according to claim 7, characterized in that: The push seat is provided with a first mounting groove and a piston fixing seat for connecting with the piston rod. The piston fixing seat is arranged in the first mounting groove. The piston fixing seat can adjust its position in the first mounting groove along a direction that is not parallel to the movement of the push seat.

11. A multi-channel liquid transfer device, characterized in that: It comprises the multi-channel suction injection mechanism as described in any one of claims 1 to 10 above, and a moving mechanism for moving the multi-channel suction injection mechanism.

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