Chromatographic column for drug detection

Abstract

The utility model discloses a chromatographic column for drug detection, which comprises a main body assembly, a plurality of chromatographic columns and a plurality of chromatographic columns, the movable assembly comprises a sliding rail, a sliding rod, a sliding groove, a first fixing frame, a first fixing hole, a mounting plate, a side plate and a second fixing hole; sliding rails are fixed to the two sides of the upper surface of the fixing ring, a sliding rod penetrates through the upper surfaces of the sliding rails, a sliding groove is formed in the middle of the lower surface of the sliding rod, a first fixing frame is fixed to one side of the upper surface of the sliding rod, a first fixing hole is formed in one side of the outer surface of the first fixing frame, and a mounting plate is suspended in the middle of the first fixing frame. A side plate is fixed to one side of the upper surface of the mounting plate. The chromatographic column disclosed by the utility model solves the problems that an opening at the top end of the existing chromatographic column is relatively small, the operation is inconvenient when a sample is added or eluent is collected due to the relatively small opening, the difficulty and the time consumption of experimental operation are increased, and the sample is overflowed or splashed due to the relatively small opening when the sample is added if the operation is improper, so that the loss of the sample is caused.

Description

Technical Field

[0001] The utility model relates to the technical field of chromatography columns, in particular to a chromatography column for drug detection. Background Art

[0002] The chromatography column for drug testing is a device used to separate and purify chemical compounds. The detection process mainly includes steps such as column loading and column washing. The chromatography column is a key component in chromatographic analysis. It is usually made of metal or glass and includes a column tube, a pressure cap, a sealing ring, a sieve plate and other parts. In drug testing, the chromatography column is used to separate different components in a complex mixture for qualitative or quantitative analysis. Depending on the application requirements, there are different types of chromatography columns, such as adsorption chromatography columns, ion exchange chromatography columns and gel chromatography columns, which are suitable for different separation mechanisms.

[0003] However, it still has the following disadvantages in actual use:

[0004] The opening at the top of the existing chromatography column is small. The small opening will cause inconvenience in adding samples or collecting eluent, increase the difficulty and time consumption of experimental operations, and when adding samples, if the operation is improper, the small opening will cause sample overflow or splashing, resulting in sample loss.

[0005] Therefore, a new chromatography column for drug testing is proposed to solve the above problems. Utility Model Content

[0006] The utility model aims to provide a chromatography column for drug testing, so as to solve the problem raised in the above-mentioned background technology that the top opening of the existing chromatography column is small, and the small opening will lead to inconvenience in adding samples or collecting eluents, increase the difficulty and time consumption of experimental operations, and when adding samples, if the operation is improper, the small opening will cause sample overflow or splashing, thereby causing sample loss.

[0007] In order to solve the above technical problems, the utility model is realized by the following technical solutions:

[0008] The utility model is a chromatography column for drug detection, comprising:

[0009] a main body assembly, the main body assembly comprising a retaining ring;

[0010] A movable assembly, the movable assembly comprising a slide rail, a slide rod, a slide groove, a first fixing frame, a first fixing hole, a mounting plate, a side plate, and a second fixing hole;

[0011] Slide rails are fixed on both sides of the upper surface of the fixing ring, a slide rod passes through the upper surface of the slide rails, a slide groove is opened in the middle of the lower surface of the slide rod, a first fixing frame is fixed on one side of the upper surface of the slide rod, a first fixing hole is opened on one side of the outer surface of the first fixing frame, a mounting plate is suspended in the middle of the first fixing frame, a side plate is fixed on one side of the upper surface of the mounting plate, and four second fixing holes are opened on the side wall of the outer surface of the side plate.

[0012] Furthermore, the main body component also includes a chromatography column, a control valve, a discharge pipe, and a feed port;

[0013] A control valve is fixed at the lower end of the chromatography column, a discharge pipe is connected to the lower surface of the control valve, and a feed port is connected to the upper end of the chromatography column.

[0014] Furthermore, the movable assembly also includes a limiting column, a funnel, a connecting pipe, a mounting groove, a connecting shaft, and a circular plate;

[0015] The second fixing hole and the first fixing hole are fixed with a limiting column, a funnel is installed at the center of the upper surface of the mounting plate, a connecting pipe is connected to the lower end of the funnel, a mounting groove is opened on the outer surface side wall of the connecting pipe, a connecting shaft is installed inside the mounting groove, and a circular plate is fixed to the outer surface of one end of the connecting shaft.

[0016] Furthermore, the slide bar moves horizontally on the slide rail, and the circular plate is installed inside the connecting pipe, and the connecting pipe passes through the mounting plate.

[0017] Furthermore, it also includes a feeding assembly;

[0018] The feeding assembly includes a second fixing frame, a fixing plate, a through slot, a hollow tube, and a feeding hopper;

[0019] A second fixing frame is fixed to the other side of the upper surface of the slide rod, a fixing plate is fixedly installed on the upper surface of the second fixing frame, a through groove is opened at the center of the fixing plate, a hollow tube penetrates the through groove, and a feed hopper is fixedly connected to the upper end of the hollow tube.

[0020] Furthermore, the hollow tube is connected to the feed hopper, and the lower end of the hollow tube penetrates into the interior of the chromatography column.

[0021] Compared with the prior art, the advantages of the present invention are:

[0022] 1. The utility model, through the set slide rail, slide bar, slide groove, first fixing frame, first fixing hole, mounting plate, side plate, second fixing hole, limit column, funnel, connecting pipe, mounting groove, connecting shaft, circular plate, when testing drugs, first fill silica gel into the inside of the chromatography column, to prevent silica gel from spilling out of the column, the staff can push the slide bar to the left side so that the connecting pipe is facing the feed port, then adjust the height of the side plate, take out the limit column, move the mounting plate downward, drive the funnel and the connecting pipe to move downward, when the end of the connecting pipe goes deep into the feed port When inside, stop and then insert the limit column into the appropriate second fixing hole and the first fixing hole to fix the height of the mounting plate. Then the staff pours the silicone material into the funnel, and then holds the connecting shaft and rotates the connecting shaft. The connecting shaft drives the circular plate to rotate inside the connecting tube, and the silicone material in the funnel is leaked into the chromatography column below to avoid silicone spillage, thereby improving the efficiency and accuracy of column loading. By rotating the connecting shaft to control the inflow speed of the silicone material, more precise control can be achieved to avoid uneven filling due to excessive flow rate.

[0023] 2. Based on beneficial effect 1, by setting up the second fixed frame, fixed plate, through-groove, hollow tube, and feed hopper, when liquid needs to be added, the staff pushes the slide bar to the right to mobilize the second fixed frame to move to the right. When the fixed plate is directly above the feed port, the staff passes the hollow tube through the through-groove. At this time, pour the eluent into the feed hopper, and the eluent will flow into the chromatography column along the hollow tube, which can reduce the splashing of liquid during the transfer process, reduce experimental errors, and improve the safety of the experiment.

[0024] Of course, any product implementing the present invention does not necessarily need to achieve all of the advantages described above at the same time. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] In order to more clearly illustrate the technical solutions of the embodiments of the utility model, the drawings required for describing the embodiments are briefly introduced below. Obviously, the drawings described below are only some embodiments of the utility model. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0026] Figure 1 This is a schematic diagram of the main components of the utility model;

[0027] Figure 2 It is a schematic diagram of the active components of the utility model;

[0028] Figure 3 An exploded view of the active components of the utility model;

[0029] Figure 4 It is a structural diagram of the feeding assembly of the utility model.

[0030] In the accompanying drawings, the components represented by the reference numerals are listed as follows:

[0031] 11. Chromatographic column; 12. Control valve; 13. Discharge pipe; 14. Fixed ring; 15. Feed inlet;

[0032] 21. Slide rail; 22. Slide rod; 23. Slide groove; 24. First fixing frame; 241. First fixing hole; 25. Mounting plate; 26. Side plate; 261. Second fixing hole; 27. Limiting column; 28. Funnel; 281. Connecting pipe; 282. Mounting groove; 29. ​​Connecting shaft; 291. Round plate;

[0033] 31. Second fixed frame; 32. Fixed plate; 33. Through slot; 34. Hollow tube; 35. Feed hopper. DETAILED DESCRIPTION

[0034] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the specific implementation methods of the present invention are described in detail below with reference to the accompanying drawings.

[0035] In the following description, many specific details are set forth to facilitate a full understanding of the present invention, but the present invention may also be implemented in other ways different from those described herein, and those skilled in the art may make similar generalizations without violating the connotation of the present invention. Therefore, the present invention is not limited to the specific implementation methods disclosed below.

[0036] Secondly, the present invention is described in detail with reference to the schematic diagram. When describing the implementation of the present invention, for the sake of convenience, the cross-sectional diagram showing the device structure will not be partially enlarged according to the general scale, and the schematic diagram is only an example, which should not limit the scope of protection of the present invention. In addition, in actual production, the three-dimensional dimensions of length, width and depth should be included.

[0037] In order to make the purpose, technical solution and advantages of the present invention more clear, the implementation mode of the present invention will be further described in detail below with reference to the accompanying drawings.

[0038] See also Figure 1-Figure 3 As shown, this embodiment is a chromatography column for drug detection, comprising:

[0039] A main body component, the main body component includes a fixing ring 14;

[0040] The main component also includes a chromatography column 11, a control valve 12, a discharge pipe 13, and a feed port 15;

[0041] A control valve 12 is fixed to the lower end of the chromatography column 11, a discharge pipe 13 is connected to the lower surface of the control valve 12, and a feed port 15 is connected to the upper end of the chromatography column 11;

[0042] The chromatography column 11 is the main part of the experiment, which is used to fill the stationary phase such as silica gel or other adsorption materials, and the separation and purification process of the sample is carried out inside it. The control valve 12 is located at the lower end of the chromatography column 11, which is used to control the speed of liquid flow. The feed port 15 is located at the upper end of the chromatography column 11, which is used to add the sample to be separated and the eluent;

[0043] The movable assembly includes a slide rail 21, a slide bar 22, a slide slot 23, a first fixing frame 24, a first fixing hole 241, a mounting plate 25, a side plate 26, and a second fixing hole 261;

[0044] Slide rails 21 are fixed on both sides of the upper surface of the fixing ring 14, a slide bar 22 penetrates the upper surface of the slide rail 21, a slide groove 23 is provided in the middle of the lower surface of the slide bar 22, a first fixing frame 24 is fixed on one side of the upper surface of the slide bar 22, a first fixing hole 241 is provided on one side of the outer surface of the first fixing frame 24, a mounting plate 25 is suspended in the middle of the first fixing frame 24, a side plate 26 is fixed on one side of the upper surface of the mounting plate 25, and four second fixing holes 261 are provided on the outer surface side wall of the side plate 26;

[0045] The slide rails 21 are fixed on both sides of the upper surface of the fixing ring 14, and are used to guide the movement of the slide bar 22, ensuring that the slide bar 22 can slide smoothly along the slide rails 21. The first fixing hole 241 is opened on one side of the outer surface of the first fixing frame 24, corresponding to the second fixing hole 261, and is used to insert and fix the limiting column 27, and fix the height of the mounting plate 25;

[0046] The movable assembly also includes a limiting column 27, a funnel 28, a connecting pipe 281, a mounting groove 282, a connecting shaft 29, and a circular plate 291;

[0047] The second fixing hole 261 and the first fixing hole 241 are penetrated and fixed with a limiting column 27, a funnel 28 is installed at the center of the upper surface of the mounting plate 25, a connecting pipe 281 is connected to the lower end of the funnel 28, a mounting groove 282 is opened on the outer side wall of the connecting pipe 281, a connecting shaft 29 is installed inside the mounting groove 282, and a circular plate 291 is penetrated and fixed to the outer surface of one end of the connecting shaft 29;

[0048] The funnel 28 is mounted at the center of the upper surface of the mounting plate 25 and is used to pour silica gel or other filling materials. The connecting tube 281 is used to guide the materials poured into the funnel 28 into the interior of the chromatography column 11. The connecting shaft 29 is used to control the rotation of the circular plate 291. The circular plate 291 is used to rotate inside the connecting tube 281 to control the inflow speed and amount of the materials.

[0049] Working principle:

[0050] When testing drugs;

[0051] First, fill the silica gel into the chromatography column 11. To prevent the silica from spilling out, the staff can push the slide bar 22 to the left so that the connecting tube 281 faces the feed port 15.

[0052] Next, adjust the height of the side plate 26, remove the limit column 27, move the mounting plate 25 downward, and drive the funnel 28 and the connecting pipe 281 to move downward.

[0053] When the end of the connecting pipe 281 penetrates into the feed port 15, stop and then insert the limiting column 27 into the appropriate second fixing hole 261 and the first fixing hole 241 to fix the height of the mounting plate 25.

[0054] Then the staff pours the silica gel into the funnel 28, and then holds the connecting shaft 29 and rotates the connecting shaft 29. The connecting shaft 29 drives the circular plate 291 to rotate inside the connecting tube 281, and the silica gel in the funnel 28 is leaked into the chromatography column 11 below.

[0055] This step prevents silica gel from spilling out, thereby improving the efficiency and accuracy of column packing. By rotating the connecting shaft 29 to control the inflow speed of the silica gel material, more precise control can be achieved to avoid uneven filling caused by excessive flow rate.

[0056] See also Figure 4 As shown, this embodiment is based on the above embodiment 1 and also includes:

[0057] Loading components;

[0058] The feeding assembly includes a second fixing frame 31, a fixing plate 32, a through slot 33, a hollow tube 34, and a feeding hopper 35;

[0059] A second fixing frame 31 is fixed to the other side of the upper surface of the slide bar 22, a fixing plate 32 is fixedly installed on the upper surface of the second fixing frame 31, a through slot 33 is opened at the center of the fixing plate 32, a hollow tube 34 penetrates the through slot 33, and a feed hopper 35 is fixedly connected to the upper end of the hollow tube 34;

[0060] The fixed plate 32 serves as a mounting base for the feed hopper 35. One end of the hollow tube 34 is connected to the feed hopper 35, and the other end extends into the feed port 15 of the chromatography column 11. The hollow tube 34 allows liquid to directly enter the chromatography column 11 through the pipeline, thereby reducing leakage and waste.

[0061] Working principle:

[0062] When liquid needs to be added;

[0063] First, the staff pushes the slide bar 22 to the right to move the second fixing frame 31 to the right. When the fixing plate 32 is directly above the feed port 15,

[0064] The staff member passes the hollow tube 34 through the through slot 33. At this time, the eluent is poured into the feed hopper 35. The eluent flows into the chromatography column 11 along the hollow tube 34.

[0065] This step can reduce splashing of liquid during the transfer process, reduce experimental errors, and improve the safety of the experiment.

[0066] In the description of the present invention, it is also necessary to explain that, unless otherwise clearly specified and limited, the terms "set", "install", "connect", and "connect" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0067] Finally, it should be noted that the above description is only a preferred embodiment of the utility model and is not intended to limit the utility model. Although the utility model is described in detail with reference to the above embodiments, those skilled in the art can still modify the technical solutions recorded in the above embodiments or replace some of the technical features therein by equivalents. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the utility model shall be included in the protection scope of the utility model.

Claims

1. A chromatography column for drug detection, characterized in that: include: A main body assembly, the main body assembly comprising a fixing ring (14); A movable assembly, the movable assembly comprising a slide rail (21), a slide rod (22), a slide groove (23), a first fixing frame (24), a first fixing hole (241), a mounting plate (25), a side plate (26), and a second fixing hole (261); Slide rails (21) are fixed on both sides of the upper surface of the fixing ring (14), a slide rod (22) passes through the upper surface of the slide rail (21), a slide groove (23) is provided in the middle of the lower surface of the slide rod (22), a first fixing frame (24) is fixed on one side of the upper surface of the slide rod (22), a first fixing hole (241) is provided on one side of the outer surface of the first fixing frame (24), a mounting plate (25) is suspended in the middle of the first fixing frame (24), a side plate (26) is fixed on one side of the upper surface of the mounting plate (25), and four second fixing holes (261) are provided on the side wall of the outer surface of the side plate (26).

2. A chromatography column for drug detection according to claim 1, characterized in that: The main body component also includes a chromatography column (11), a control valve (12), a discharge pipe (13), and a feed port (15); A control valve (12) is fixed to the lower end of the chromatography column (11), a discharge pipe (13) is connected to the lower surface of the control valve (12), and a feed port (15) is connected to the upper end of the chromatography column (11).

3. A chromatography column for drug detection according to claim 1, characterized in that: The movable assembly further comprises a limiting column (27), a funnel (28), a connecting pipe (281), a mounting groove (282), a connecting shaft (29), and a circular plate (291); A limiting column (27) is fixedly passed through the second fixing hole (261) and the first fixing hole (241); a funnel (28) is installed at the center of the upper surface of the mounting plate (25); a connecting pipe (281) is connected to the lower end of the funnel (28); a mounting groove (282) is provided on the side wall of the outer surface of the connecting pipe (281); a connecting shaft (29) is installed inside the mounting groove (282); and a circular plate (291) is fixedly passed through the outer surface of one end of the connecting shaft (29).

4. A chromatography column for drug detection according to claim 1, characterized in that: The slide bar (22) moves horizontally on the slide rail (21), and the circular plate (291) is installed inside the connecting pipe (281), and the connecting pipe (281) passes through the mounting plate (25).

5. A chromatography column for drug detection according to claim 1, characterized in that: Also included is a loading assembly; The feeding assembly comprises a second fixing frame (31), a fixing plate (32), a through groove (33), a hollow tube (34), and a feeding hopper (35); A second fixing frame (31) is fixed on the other side of the upper surface of the slide bar (22), a fixing plate (32) is fixedly installed on the upper surface of the second fixing frame (31), a through groove (33) is opened at the center of the fixing plate (32), a hollow tube (34) penetrates the interior of the through groove (33), and a feed hopper (35) is fixedly connected to the upper end of the hollow tube (34).

6. A chromatography column for drug detection according to claim 5, characterized in that: The hollow tube (34) is connected to the feed hopper (35), and the lower end of the hollow tube (34) penetrates into the interior of the chromatography column (11).

Images