Oral cavity adhesive bandage with double-layer structure

Abstract

The utility model relates to an oral cavity adhesive bandage with a double-layer structure. The oral cavity adhesive bandage comprises a near-wound layer and a protective layer, wherein the near-wound layer is directly attached to a wound surface; the protective layer is adhered to the outer side of the near-wound layer; the area of the protective layer is larger than or equal to that of the near-wound layer, so that the near-wound layer is located in the covering surface of the protective layer; the near-wound layer and the protective layer are hydrophilic structure layers; the near-wound layer is an absorptive application pad, and the protective layer is an anti-adhesion layer. The near-wound layer can be completely attached to the surface of a wound, the outer layer structure also has certain tissue adhesion, the tissue adhesion performance of the adhesive bandage is greatly improved, and the problem that an existing product is prone to slipping off is solved; meanwhile, the hydrophilic structure of the protective layer on the outer layer of the adhesive bandage can be dissolved, so that the safety problem after an existing product is mistakenly swallowed can be solved; by adding a specific high polymer material, the dissolution time of the product is remarkably prolonged, tissue healing can be promoted, breeding of oral pathogenic bacteria can be inhibited, and good safety is achieved.

Description

Technical Field

[0001] The utility model belongs to the technical field of oral medicine products, and in particular relates to an oral wound patch with a double-layer structure. Background Art

[0002] The wound surface of oral trauma has the characteristics of irregular shape and inconsistent degree, and the internal environment of the oral cavity is complex and difficult for doctors to operate, which makes the requirements for the product itself very high. Therefore, it is particularly important to develop an oral trauma treatment product that can adapt to the internal environment of the oral cavity and is easy to operate. Based on this, it is necessary to design an ideal mucosal wound dressing that plays the role of an "oral Band-Aid" and plays the role of protecting the wound surface, isolating bacteria, preventing infection and relieving pain. Considering the intraoral use environment, the wound dressing needs to be soft and comfortable, easy for doctors to operate, strong adhesion, and able to withstand frequent eating, swallowing, pronunciation and other movements in the mouth.

[0003] Some "oral bandages" products are composed of a double-layer composite structure, such as the patent with publication number CN111617058A, which includes a hydrophilic ointment and a hydrophobic film, that is, a hydrophilic layer that plays an adhesive role and a hydrophobic layer that plays an isolating role; the problem is that the hydrophobic isolation layer is not sticky in the mouth. When the hydrophilic layer dissolves, the hydrophobic isolation layer will reduce the adhesion to the oral wound to a certain extent, causing it to fall off naturally, and then there will be safety problems such as swallowing, which also shortens the efficacy time and weakens the efficacy; some other documents or patented products are single-layer hydrophilic structures, which are easily soluble in the oral environment, greatly shortening the protection time of the wound.

[0004] To this end, it is urgent to design an ideal band-aid that is soft and comfortable, easy for doctors to operate, has strong adhesion, delays dissolution time, is risk-free after dissolution, and can withstand frequent movements in the mouth such as eating, swallowing, and pronunciation. Utility Model Content

[0005] The purpose of the utility model is to provide an oral wound patch with a double-layer structure. The utility model cleverly designs an oral wound patch with a double-layer hydrophilic structure, wherein the near-wound layer structure has good oral adhesion, and the protective layer structure can not only perform physical isolation, but also has a soluble property, so that it avoids some safety issues caused by swallowing and other reasons, and can be used to treat all types of oral wounds, injuries and ulcers of the gums and oral mucosa, including oral inflammation, minor abrasions and traumatic ulcers, abrasions caused by braces and inappropriate dentures, and injuries related to oral surgery.

[0006] In order to solve the above technical problems, the utility model is achieved as follows:

[0007] The utility model provides an oral wound patch with a double-layer structure, comprising:

[0008] A near-wound layer directly attached to the wound surface and a protective layer adhered to the outside of the near-wound layer;

[0009] The area of ​​the protective layer is greater than or equal to the area of ​​the near-wound layer, so that the near-wound layer is within the coverage of the protective layer;

[0010] The near-wound layer and the protective layer are both hydrophilic structural layers;

[0011] The near-wound layer is an absorbent pad, and the protective layer is an anti-adhesion layer.

[0012] In an embodiment of the present invention, the protective layer presents a structural form that gradually becomes thinner from the center to the periphery.

[0013] Preferably, the near-wound layer and the protective layer are both composed of water-soluble compounds.

[0014] More preferably, in the utility model, the near-wound layer is added with at least oxidized sodium alginate.

[0015] Preferably, the near-wound layer is a blend comprising a hydrophilic polymer compound, a surfactant, a plasticizer, a disintegrant, and a drug, or a re-blend of the blend and oxidized sodium alginate.

[0016] More preferably, the near-wound layer is a blend comprising a hydrophilic polymer compound, a surfactant, a plasticizer, a disintegrant, a softener, and a drug, or a re-blend of the blend and oxidized sodium alginate.

[0017] Preferably, the protective layer is a blend including a hydrophilic polymer compound, a surfactant and a softener.

[0018] Preferably, the oral wound covering is attached to a polyethylene terephthalate film (PET film) through the proximal wound layer.

[0019] Preferably, the thickness of the near-wound layer and the protective layer are both 0.2-0.5 mm, preferably 0.35-0.45 mm.

[0020] Compared with the prior art, the utility model has the following beneficial effects:

[0021] 1. The wound dressing of the utility model comprises a near-wound layer directly attached to the wound surface and a protective layer adhered to the outer side of the near-wound layer, wherein both the near-wound layer and the protective layer are hydrophilic structural layers; since both layers are hydrophilic structural layers, both have high adhesion, when the near-wound layer is dissolved, the protective layer will further adhere to the wound surface, thereby further playing the role of protecting the wound surface;

[0022] 2. In the utility model, the area of ​​the protective layer is greater than or equal to the area of ​​the near-wound layer, so that the near-wound layer is within the coverage of the protective layer. This arrangement not only allows the wound patch to be attached to the wound through the near-wound layer, but also further attaches to the wound through the circumferential surface layer of the protective layer, further enhancing the attachment strength of the wound patch and greatly prolonging the protection time for the wound surface;

[0023] 3. The protective layer of the utility model presents a structural form that gradually becomes thinner from the center to the periphery, so that the protective layer has a stronger adhesion to the wound surface in the circumferential direction;

[0024] 4. The near-wound layer and the protective layer of the utility model are both made of materials that can be dissolved in the body, so that the wound dressing does not have to worry about the safety problem of accidental swallowing due to shedding;

[0025] 5. The utility model also adds oxidized sodium alginate to the near-wound layer, which contains more carboxyl and aldehyde groups in its molecules, thus having higher hydrophilicity, adhesion and gelation, and having better stability under acid-base conditions and a slower dissolution rate, so that the utility model wound dressing can have a sufficiently long fitting time and better effect;

[0026] 6. The utility model wound dressing has good usability and operability;

[0027] 7. In the present invention, oxidized sodium alginate is added to the near-wound layer. The oxidized sodium alginate molecules contain more carboxyl and aldehyde groups, which make them more hydrophilic, adhesive and gelling, and have better stability under acid-base conditions. The wide application of oral bandages requires good tissue adhesion to ensure that the bandage product is in close contact with the wound surface, and it needs to exert certain biological activities such as hemostasis and antibacterial effects to promote wound healing and prevent wound infection. Therefore, the addition of oxidized sodium alginate plays a very important role in improving the effectiveness of the bandage itself, especially prolonging the use time of the bandage.

[0028] 8. The inner layer structure (near-wound layer) of the wound patch of the utility model can completely fit the wound surface, and the outer layer structure (protective layer) also has a certain tissue adhesion, which greatly improves the tissue adhesion performance of the wound patch to overcome the problem of easy slipping of existing products on the market; compared with traditional wound patches, the hydrophilic structure of the outer layer of the wound patch of the utility model is soluble, which can solve the safety problems of existing products after accidental swallowing; by adding specific polymer materials, the dissolution time of the product is significantly prolonged, which can promote tissue healing, inhibit the growth of oral pathogens and have good safety. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Figure 1 This is a structural schematic diagram of Embodiment 1 of the present utility model;

[0030] Figure 2 This is a structural schematic diagram of Embodiment 2 of the present utility model;

[0031] Figure 3 This is a structural schematic diagram of Embodiment 3 of the present utility model;

[0032] Figure 4 It is a schematic diagram of the plane design structure of the protective layer of the utility model.

[0033] Reference numerals:

[0034] 1: Protective layer; 2: Near-wound layer. DETAILED DESCRIPTION

[0035] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments of the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0036] It should be understood that the references to "one embodiment" or "an embodiment" throughout the specification mean that the specific features, structures, or characteristics associated with the embodiment are included in at least one embodiment of the present invention. Therefore, the references to "in one embodiment" or "in an embodiment" appearing throughout the specification do not necessarily refer to the same embodiment. In addition, these specific features, structures, or characteristics may be combined in any suitable manner in one or more embodiments.

[0037] Embodiment 1:

[0038] See also Figure 1 , including a near-wound layer directly bonded to the wound skin, the thickness of the near-wound layer is preferably between 0.2 and 0.5 mm, and in this embodiment it is between 0.35 and 0.45 mm. Such a thickness, on the one hand, can make the oral cavity feel comfortable from the perspective of softness and comfort, and will not cause great rejection due to foreign matter; on the other hand, it can also improve its adhesion or adhesion at the wound, so that it can more fully play the role of drug treatment of the wound; further, this structure can make the entire bandage product able to tolerate frequent eating, swallowing, pronunciation and other movements in the mouth. It should be emphasized that: this bandage product is suitable for oral ulcers at the root of the gums and other parts, and can especially improve its tolerance to frequent eating, swallowing and other movements in the mouth.

[0039] The material of the near-wound layer can be a blend of one or more of a hydrophilic polymer compound, a surfactant, a plasticizer, a disintegrant, a softener, a drug, and a solvent; the hydrophilic polymer compound is selected from any one or more of carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, sodium alginate, oxidized sodium alginate, calcium alginate, polyvinyl pyrrolidone, xanthan gum, poloxamer, carbomer, and polyvinyl alcohol; the surfactant is selected from one or more of Tween 80, sodium lauryl sulfate, sodium dodecylpropane sulfonate, and monoglyceride of fatty acids; the plasticizer is selected from one or more of silicone oil, paraffin, triethyl citrate, and acetyl triethyl citrate; the disintegrant is selected from one or more of glycerol, polyethylene glycol, and sorbitol ; The drug is selected from one or more of vitamin E, dexamethasone, and dibucaine hydrochloride; the softener is selected from one or more of glycerol, paraffin, and triethyl citrate; the solvent is one or more of water, anhydrous ethanol, and acetone; in this embodiment, the hydrophilic polymer compounds used are carboxymethyl cellulose and oxidized sodium alginate, the surfactant is Tween 80, the plasticizer is silicone oil, the disintegrant is glycerol, the drugs are vitamin E, dexamethasone, and dibucaine hydrochloride, and the solvent is water; specifically, during the operation, the above ingredients are mixed and dissolved, and then moved to a mold, and dried at a temperature of 30°C to 90°C for 3-5 hours to form a near-wound layer; it should be noted that the near-wound layer is the absorbent pad, which is a key part for drug treatment.

[0040] A protective layer is also bonded to the outer surface of the near-wound layer, which is an anti-adhesion layer. The thickness of the protective layer is 0.3 to 0.5 mm. In this embodiment, the protective layer and the near-wound layer are of the same size. It should be noted here that the outer side refers to the side away from the wound, and the inner side refers to the side close to the wound.

[0041] The material of the protective layer is a blend of one or more of a hydrophilic polymer compound, a softener, a surfactant, and a solvent; wherein the hydrophilic polymer compound is selected from one or more of oxidized sodium alginate, ethyl cellulose, polyvinyl alcohol, and polyvinyl acetate; the surfactant is selected from one or more of Tween 80, sodium dodecyl sulfate, sodium dodecyl propane sulfonate, and monoglycerides of fatty acids; the softener is selected from one or more of triethyl citrate, dibutyl sebacate, and acetyl triethyl citrate; the solvent is selected from one or more of water, anhydrous ethanol, and acetone; the protective layer of this embodiment is a blend formed by mixing oxidized sodium alginate, polyvinyl alcohol, triethyl citrate, sodium dodecyl sulfate, triethyl citrate, and water. In this embodiment, the above blend is fully dissolved until a uniform transparent solution is formed, which is evenly poured on the upper surface of the near-wound layer, and dried at a temperature of 30°C-90°C for 3-5 hours to form a protective layer (anti-adhesion layer).

[0042] Furthermore, it should be noted that after the above-mentioned wound dressing is manufactured, it can be attached to a PET film, and the PET film is a polyethylene terephthalate film.

[0043] Embodiment 2:

[0044] See also Figure 2 The difference between this embodiment and embodiment 1 is that the area of ​​the protective layer is larger than the area of ​​the near-wound layer, so that the near-wound layer is within the coverage surface of the protective layer, and the circumferential area of ​​the protective layer extends outward by a certain distance. The purpose of this arrangement is that after the near-wound layer is attached to the wound, the circumferential surface of the protective layer is further attached and fixed to the wound surface, ensuring that the bandage of this embodiment can be more stably attached to the wound and prolong the duration of drug action.

[0045] Embodiment 3:

[0046] See also Figure 3 The difference between this embodiment and embodiment 2 is that the protective layer is made into a curved surface structure that gradually becomes thinner from the middle to the two ends, or a structure that is thick in the middle and thin at both ends, and can be made into a structure that conforms to the physiological curvature of the oral skin; on the one hand, it ensures that the protective layer can fit the skin to the greatest extent and improve comfort; on the other hand, it ensures that the two ends of the protective layer can better bond with the wound surface and prolong its adhesion time.

[0047] Embodiment 4:

[0048] See also Figure 4 This embodiment is optimized on the basis of the above three embodiments, and the overall wound dressing is designed in a structural form, which is wide in the middle and narrow at both ends. The advantages of this form of design are: it makes the wound dressing of the utility model have better tension and better fit, and is particularly suitable for fitting treatment of gum root ulcers, etc.

[0049] It should be noted that the design of this embodiment is an optimized design for improving the overall fit of the bandage, which does not essentially affect the layered structure of the present application; if the protective layer is cut into a form that is wide in the middle and narrow at both ends, then the near-wound layer can also be cut into this shape, or it can be cut into other shapes, such as rectangles, squares, circles, diamonds, etc. Of course, the area of ​​the near-wound layer is less than or equal to the area of ​​the protective layer to ensure that when the bandage is applied to the wound, the near-wound layer can be fully covered to achieve a better therapeutic effect. It should be noted that the shape and size of the PET film are consistent with the shape and size of the protective layer.

[0050] It should be noted that the various embodiments in this specification are described in a progressive manner, and each embodiment focuses on the differences from other embodiments. The same or similar parts between the various embodiments can be referenced to each other.

[0051] Although the optional embodiments of the utility model embodiments have been described, those skilled in the art, once knowing the basic creative concept, can make other changes and modifications to these embodiments. Therefore, the appended claims are intended to be interpreted as including optional embodiments and all changes and modifications falling within the scope of the utility model embodiments.

[0052] Finally, it should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity from another entity, and do not necessarily require or imply any such actual relationship or order between these entities. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that an article or terminal device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such article or terminal device. In the absence of further restrictions, the elements defined by the sentence "including one..." do not exclude the existence of other identical elements in the article or terminal device including the elements.

[0053] The technical solution provided by the present invention is introduced in detail above. Specific examples are used in this article to illustrate the principle and implementation method of the present invention. At the same time, for those skilled in the art, according to the principle and implementation method of the present invention, there will be changes in the specific implementation method and application scope. In summary, the content of this specification should not be understood as a limitation on the present invention.

Claims

1. An oral wound dressing with a double-layer structure, characterized in that: include: A proximal wound layer directly attached to the wound surface and a protective layer adhered to the outer side of the proximal wound layer; The area of ​​the protective layer is greater than or equal to the area of ​​the proximal wound layer; The near-wound layer and the protective layer are both hydrophilic structural layers; The near-wound layer is an absorbent pad, and the protective layer is an anti-adhesion layer; The protective layer presents a structure that gradually becomes thinner from the center to the periphery; the near-wound layer and the protective layer are both composed of water-soluble compounds; The oral wound patch is attached to the polyethylene terephthalate film through the proximal wound layer.

2. The oral wound dressing with a double-layer structure according to claim 1, characterized in that: The thickness of the near-wound layer and the protective layer are both 0.2-0.5 mm.

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