Glycyrrhetinic acid extraction device

Abstract

The utility model relates to the technical field of glycyrrhetinic acid production, in particular to a glycyrrhetinic acid extraction device. The glycyrrhetinic acid extraction device comprises an extraction tank, and a feed port of the extraction tank is connected with a glycyrrhetinic acid crude product input pipeline and a trichloromethane input pipeline; a discharge hole pipeline of the extraction tank is connected with an inlet of a crystallizer, and the discharge hole of the extraction tank is also connected with a middle-layer storage tank and a water-layer storage tank; the middle-layer storage tank is provided with an overflow pipe, and one end of the overflow pipe is connected with a feeding port of the water-layer storage tank. According to the glycyrrhetinic acid extraction device, an extraction tank is connected with a crystallizer, a middle-layer storage tank and a water-layer storage tank, liquid separation is carried out after extraction, raw materials of all parts can be effectively collected, trichloromethane is prevented from being discharged and exposed in the air, harm is reduced, meanwhile, the middle-layer storage tank is provided with an overflow pipeline, and the overflow pipeline is convenient to clean. A water layer on the upper side of the middle-layer storage tank can overflow into the water-layer storage tank, so that the final yield of glycyrrhetinic acid is guaranteed, and the yield is increased.

Description

Technical Field

[0001] The utility model relates to the technical field of glycyrrhetinic acid production, in particular to a glycyrrhetinic acid extraction device. Background Art

[0002] Licorice is a common food and medicine. Licorice extract is widely used in candy and canned food as a natural sweetener. The sweetness of licorice comes from glycyrrhizic acid and glycyrrhetinic acid. Glycyrrhizic acid is a type of triterpenoid saponin, accounting for about 4% to 5% of the dry weight of licorice root, and its sweetness is 50 times that of sucrose. Glycyrrhetinic acid is formed by the hydrolysis of glycyrrhizic acid to remove the sugar acid chain, and its sweetness is 250 times that of sucrose. Recent studies have shown that glycyrrhizic acid and glycyrrhetinic acid both have certain anti-cancer and anti-cancer effects, and glycyrrhetinic acid can inhibit the information transmission and gene expression of protocarcinoma cells. Glycyrrhizic acid has an inhibitory effect on malignant tumors in experimental animals induced by various carcinogens. Glycyrrhetinic acid also has an anti-viral effect, and has an inhibitory effect on carcinogenic viruses such as hepatitis virus, Epstein-Barr virus and HIV infection.

[0003] At present, in order to obtain glycyrrhizic acid with higher purity, it needs to be purified after hydrolysis of glycyrrhizic acid; in the extraction process, chloroform is often used as an extractant to dissolve the effective component of glycyrrhizic acid and extract and separate glycyrrhizic acid from water; in the extraction process, it is found that in addition to the lower chloroform layer containing the effective component and the upper water layer, there is also an intermediate layer between the upper and lower layers, and the intermediate layer contains chloroform and a part of the effective component of glycyrrhizic acid, and black residues with a density less than chloroform and greater than water are suspended. The conventional treatment method is to separate the chloroform layer of the lower layer and then discharge the middle layer and the water layer, which leads to a decrease in the yield of the glycyrrhizic acid product and also endangers the health of the operators.

[0004] In view of this, it is necessary to improve the extraction device of glycyrrhetinic acid. Utility Model Content

[0005] In order to overcome the above technical defects, the utility model provides an extraction device for glycyrrhetinic acid, in which an extraction tank is connected with a crystallizer, a middle storage tank and a water layer storage tank. Liquid separation after extraction can effectively collect raw materials from various parts, avoid chloroform discharge and exposure to the air, and reduce harm. At the same time, the middle storage tank is provided with an overflow pipe, which can allow the water layer on the upper side of the middle storage tank to overflow into the water layer storage tank, which is beneficial to ensure the final yield of glycyrrhetinic acid and improve production.

[0006] A glycyrrhetinic acid extraction device comprises an extraction tank, wherein the feed inlet of the extraction tank is connected to a crude glycyrrhetinic acid input pipeline and a chloroform input pipeline; the discharge port pipeline of the extraction tank is connected to the inlet of a crystallizer, and the discharge port of the extraction tank is also connected to a middle layer storage tank and a water layer storage tank; the middle layer storage tank is provided with an overflow pipe, and one end of the overflow pipe is connected to the feed inlet of the water layer storage tank.

[0007] Furthermore, the bottom discharge port of the middle storage tank is connected to the buffer tank through a discharge pipe.

[0008] The beneficial effect of adopting the above further technical solution is that the middle layer separated from the extraction tank can be subjected to secondary liquid separation in the middle layer storage tank, and the buffer tank can temporarily store the separated chloroform layer containing the effective ingredients.

[0009] Furthermore, the bottom of the middle storage tank is conical.

[0010] The beneficial effect of adopting the above further technical solution is that the bottom of the middle storage tank is conical, which is conducive to secondary liquid separation.

[0011] Furthermore, a first liquid separation sight glass is provided on the discharge pipe.

[0012] The beneficial effect of adopting the above further technical solution is that the first liquid separation mirror is helpful for observing the state of the fluid medium passing through during the liquid separation process, thereby facilitating the liquid separation.

[0013] Furthermore, the discharge port of the buffer tank is connected to the glycyrrhizic acid input pipeline via a liquid return pipeline.

[0014] The beneficial effect of adopting the above further technical solution is that the liquid return pipe can facilitate the chloroform containing effective ingredients collected in the buffer tank to flow back to the extraction tank for secondary extraction, which is beneficial to reduce the loss of effective ingredients.

[0015] Furthermore, a liquid return pump is connected between the liquid return pipeline and the buffer tank, the discharge port of the buffer tank is connected to the input end of the liquid return pump, and the liquid return pipeline is connected to the output end of the liquid return pump.

[0016] The beneficial effect of adopting the above further technical solution is that the liquid return pump can reflux the chloroform containing the effective ingredients into the extraction tank.

[0017] Furthermore, the extraction tank is provided with a stirrer.

[0018] The beneficial effect of adopting the above further technical solution is that the agitator can facilitate the chloroform extractant to fully contact with glycyrrhetinic acid and promote the dissolution of glycyrrhetinic acid in chloroform, so that the extraction is more efficient.

[0019] Furthermore, the bottom of the extraction tank is conical.

[0020] The beneficial effect of adopting the above further technical solution is that the bottom of the extraction tank is conical, which is conducive to liquid separation after extraction.

[0021] Furthermore, a second liquid separation sight glass is connected to the bottom discharge port of the extraction tank.

[0022] The beneficial effect of adopting the above further technical solution is that the use of the second liquid separation mirror is conducive to observing the liquid separation after extraction.

[0023] Furthermore, a U-shaped bend is provided on the overflow pipe.

[0024] The beneficial effect of adopting the above further technical solution is that the U-shaped bend forms a certain gas phase sealing effect between the middle storage tank and the water layer storage tank. At the same time, when the material in the middle storage tank exceeds the overflow height, the water layer above it overflows into the water layer storage tank first. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1 This is a schematic diagram of the glycyrrhetinic acid extraction device of the utility model.

[0026] In the accompanying drawings, the components represented by the reference numerals are listed as follows:

[0027] 1. Extraction tank; 2. Middle layer storage tank; 3. Water layer storage tank; 4. Crystallizer; 5. Buffer tank; 6. Glycyrrhetinic acid crude product input pipeline; 7. Discharge pipeline; 8. Liquid return pipeline; 9. Overflow pipe. DETAILED DESCRIPTION

[0028] In order to make the purpose, technical solution and advantages of the utility model clearer, the technical solution of the utility model will be described in detail below. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments of the utility model, all other implementation methods obtained by ordinary technicians in this field without creative work belong to the scope of protection of the utility model.

[0029] Based on the attached Figure 1 A glycyrrhetinic acid extraction device comprises an extraction tank 1, the feed inlet of the extraction tank 1 is connected to a crude glycyrrhetinic acid input pipeline 6 and a chloroform input pipeline; the discharge port pipeline of the extraction tank 1 is connected to the inlet of a crystallizer 4, and the discharge port of the extraction tank 1 is also connected to a middle layer storage tank 2 and a water layer storage tank 3; the middle layer storage tank 2 is provided with an overflow pipe 9, and one end of the overflow pipe 9 is connected to the feed inlet of the water layer storage tank 3.

[0030] It should be noted that the material input into the extraction tank 1 through the crude glycyrrhizic acid input pipe 6 is the crude glycyrrhizic acid obtained by hydrolysis of glycyrrhizic acid, so water is introduced; the chloroform input pipe introduces chloroform to extract the crude glycyrrhizic acid, and after the extraction is completed, the crude glycyrrhizic acid is allowed to stand and separate into layers, the upper layer is the water layer, the lower layer is the chloroform layer containing glycyrrhizic acid, and the middle layer contains black residue, chloroform and glycyrrhizic acid components.

[0031] Preferably, the bottom discharge port of the middle storage tank 2 is connected to the buffer tank 5 through a discharge pipe 7.

[0032] Preferably, the bottom of the middle storage tank 2 is conical.

[0033] Preferably, a first liquid separation sight glass is provided on the discharge pipe 7 .

[0034] Preferably, the discharge port of the buffer tank 5 is connected to the glycyrrhetinic acid input pipeline via the liquid return pipeline 8 .

[0035] Preferably, a liquid return pump is connected between the liquid return pipe 8 and the buffer tank 5, the discharge port of the buffer tank 5 is connected to the input end of the liquid return pump, and the liquid return pipe 8 is connected to the output end of the liquid return pump.

[0036] Preferably, the extraction tank 1 is provided with a stirrer.

[0037] Preferably, the bottom of the extraction tank 1 is conical.

[0038] Preferably, the bottom discharge port of the extraction tank 1 is connected to a second liquid separation sight glass.

[0039] Preferably, the overflow pipe 9 is provided with a U-shaped bend.

[0040] In the utility model, after the material in the extraction tank 1 is allowed to stand and stratify, the clean, colorless, chloroform layer containing the effective ingredient is first separated into a crystallizer 4, and a post-crystallization process is carried out to finally obtain a glycyrrhetinic acid product; the turbid middle layer is separated into a middle storage tank 2; finally, the upper water layer is separated into a water layer storage tank 3; the material in the middle storage tank 2 can be directly returned to the extraction tank 1 through a buffer tank 5 and a return liquid pump, or it can be extracted continuously for multiple times, the middle layer material is collected, and the liquid is separated again in the middle storage tank 2, so that the turbid material is retained in the middle storage tank 2, and the upper water layer is input into the water layer storage tank 3 through overflow; the utility model effectively solves the problem of the turbid middle layer containing black residues in the extraction process of glycyrrhetinic acid inside the equipment, and at the same time prevents the black residues from entering the crystallizer 4 to affect the crystallization of glycyrrhetinic acid, especially preventing the product after the crystallization of glycyrrhetinic acid from having color.

[0041] In the description of the present invention, it should be understood that the terms "center", "length", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "inside", "outside", "peripheral", "circumferential" and the like indicating orientations or positional relationships are based on the orientations or positional relationships shown in the accompanying drawings and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the referred system or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present invention.

[0042] In the description of the present invention, "plurality" means at least two, such as two, three, etc., unless otherwise clearly and specifically defined.

[0043] In the present invention, unless otherwise clearly specified and limited, the terms "installed", "connected", "connected", "fixed" and the like should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements, unless otherwise clearly defined. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0044] In the description of this specification, the description with reference to the terms "one embodiment", "some embodiments", "example", "specific example", or "some examples" etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the utility model. In this specification, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described may be combined in any one or more embodiments or examples in a suitable manner. In addition, those skilled in the art may combine and combine the different embodiments or examples described in this specification and the features of the different embodiments or examples, without contradiction.

[0045] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A device for extracting glycyrrhetinic acid, characterized in that: The invention comprises an extraction tank (1), wherein the inlet of the extraction tank (1) is connected to a crude glycyrrhetinic acid input pipeline (6) and a chloroform input pipeline; the outlet pipeline of the extraction tank (1) is connected to the inlet of a crystallizer (4), and the outlet of the extraction tank (1) is also connected to a middle-layer storage tank (2) and a water-layer storage tank (3); the middle-layer storage tank (2) is provided with an overflow pipe (9), and one end of the overflow pipe (9) is connected to the inlet of the water-layer storage tank (3).

2. The extraction device of glycyrrhetinic acid according to claim 1, characterized in that: The bottom discharge port of the middle storage tank (2) is connected to the buffer tank (5) via a discharge pipe (7).

3. The extraction device of glycyrrhetinic acid according to claim 2, characterized in that: The bottom of the middle storage tank (2) is conical.

4. The extraction device of glycyrrhetinic acid according to claim 2, characterized in that: The discharge pipe (7) is provided with a first liquid separation mirror.

5. The extraction device of glycyrrhetinic acid according to claim 2, characterized in that: The discharge port of the buffer tank (5) is connected to the glycyrrhizic acid input pipeline via a liquid return pipeline (8).

6. The extraction device of glycyrrhetinic acid according to claim 5, characterized in that: A liquid return pump is connected between the liquid return pipe (8) and the buffer tank (5), the discharge port of the buffer tank (5) is connected to the input end of the liquid return pump, and the liquid return pipe (8) is connected to the output end of the liquid return pump.

7. The extraction device for glycyrrhetinic acid according to any one of claims 1 to 6, characterized in that: The extraction tank (1) is provided with a stirrer.

8. The extraction device of glycyrrhetinic acid according to claim 7, characterized in that: The bottom of the extraction tank (1) is conical.

9. The extraction device of glycyrrhetinic acid according to claim 7, characterized in that: The bottom discharge port of the extraction tank (1) is connected to a second liquid separation sight glass.

10. The extraction device for glycyrrhetinic acid according to any one of claims 1 to 6, characterized in that: The overflow pipe (9) is provided with a U-shaped bend.

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