Device for detecting fluidity of blue copper peptide slow-release gel

Abstract

A blue copper peptide slow-release gel fluidity detection device comprises a liquid dropping tank, a liquid receiving measuring cup and a timer, a liquid dropping opening is formed in the bottom of the liquid dropping tank, and the liquid dropping opening is located above the liquid receiving measuring cup; the liquidity detection device further comprises a constant-temperature water tank and a plunger, and the plunger is used for blocking or opening the liquid dropping opening; a bottom hole is formed in the bottom of the constant-temperature water tank, the liquid dropping tank is arranged in the constant-temperature water tank, a liquid dropping opening of the liquid dropping tank is located in the bottom hole, and a sealing ring is arranged between the bottom hole and the liquid dropping opening. The liquidity detection device is provided with the constant-temperature water tank, the temperature of the blue copper peptide slow-release gel in the liquid dropping tank is kept consistent with the water temperature through heat transfer, and a precondition is provided for testing accuracy. The fluidity detection device has multiple purposes, not only can accurately detect the fluidity of the blue-copper peptide slow-release gel, but also can detect the density of the blue-copper peptide slow-release gel, and provides a basis for measuring the crosslinking degree of blue-copper peptide and a poloxamer base.

Description

Technical Field

[0001] The utility model relates to the technical field of blue copper peptide sustained-release gel, in particular to a blue copper peptide sustained-release gel fluidity detection device. Background Art

[0002] Blue copper peptide is a powerful skin regeneration agent, which is very effective in treating skin damage. It can not only reduce the formation of scar tissue, but also stimulate the skin to heal itself. However, blue copper peptide has poor hydrophilicity and is difficult to be directly absorbed by the skin. Moreover, blue copper peptide is easily affected by temperature and pH value and denatured and inactivated, making it difficult to exert its efficacy. The latest technology is to embed blue copper peptide into the gel network of poloxamer through cross-linking technology to form a sustained-release gel containing blue copper peptide. The gel structure not only serves as a delivery carrier for blue copper peptide, but also provides a three-dimensional scaffold that can promote the attachment and proliferation of skin cells on the three-dimensional scaffold, supporting the reconstruction and repair of skin tissue.

[0003] The blue copper peptide sustained-release gel is sensitive to temperature. At 5-10°C, the blue copper peptide sustained-release gel is in liquid state. When the temperature rises and approaches human body temperature, the blue copper peptide sustained-release gel gradually changes from liquid state to semi-solid state or gel state. In the production process of the blue copper peptide sustained-release gel, the degree of cross-linking between the blue copper peptide and the poloxamer group can be reflected by testing the fluidity and density. However, the fluidity of the blue copper peptide sustained-release gel is greatly affected by temperature. The higher the temperature, the worse the fluidity. Existing fluidity tests usually measure the volume of material flow per unit time. However, the temperature of the material cannot be kept constant during the test, and the measurement loses its practical significance. Therefore, it is necessary to improve the existing fluidity detection device. Utility Model Content

[0004] In order to overcome the shortcomings of the background technology, the utility model discloses a blue copper peptide sustained-release gel fluidity detection device, which adopts the following technical solutions:

[0005] A blue copper peptide sustained-release gel fluidity detection device comprises a dripping tank, a liquid receiving measuring cup and a timer, wherein a dripping port is arranged at the bottom of the dripping tank, and the dripping port is located above the liquid receiving measuring cup; the fluidity detection device also comprises a constant temperature water tank and a plunger, wherein the plunger is used for blocking or opening the dripping port; a bottom hole is arranged at the bottom of the constant temperature water tank, the dripping tank is arranged in the constant temperature water tank, the dripping port is located in the bottom hole, and a sealing ring is arranged between the bottom hole and the dripping port.

[0006] To further improve the technical solution, the fluidity detection device also includes a base, the base has a support column, and the support column is used to support the constant temperature water tank.

[0007] To further improve the technical solution, the timer is arranged on the base.

[0008] To further improve the technical solution, an electronic scale is arranged on the base, and the liquid receiving measuring cup is placed on the electronic scale.

[0009] To further improve the technical solution, water, a heater and a temperature sensor are arranged in the constant temperature water tank.

[0010] To further improve the technical solution, the liquid receiving measuring cup is a transparent glass product; the liquid receiving measuring cup is composed of a flared portion, a thin neck and a cavity portion from top to bottom, and a scale line is provided on the thin neck.

[0011] After implementing the above technical solution, compared with the background technology, the beneficial effects produced by the utility model are:

[0012] The fluidity testing device is provided with a constant temperature water tank, which makes the temperature of the blue copper peptide sustained-release gel in the drip tank consistent with the water temperature through heat transfer, thus providing a prerequisite for the accuracy of the test.

[0013] The fluidity detection device is a multi-purpose device, which can not only accurately detect the fluidity of the blue copper peptide sustained-release gel, but also detect the density of the blue copper peptide sustained-release gel, providing a basis for measuring the degree of cross-linking between the blue copper peptide and the poloxamer group. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] Attached Figure 1 Shown is a schematic diagram of the overall structure of the fluidity detection device.

[0015] Attached Figure 2 Shown is a schematic diagram of the structure of a drip tank and a constant temperature water tank.

[0016] Attached Figure 3 What is shown is the structural schematic diagram of the liquid receiving measuring cup.

[0017] Attached Figure 4 Shown is a schematic diagram of the fluidity detection device in a testing state.

[0018] In the attached figure: 1. dripping tank; 11. dripping port; 12. plunger; 2. liquid receiving measuring cup; 21. flared part; 22. narrow neck; 23. cavity part; 24. scale line; 3. constant temperature water tank; 31. water; 32. heater; 33. temperature sensor; 34. sealing ring; 4. base; 5. support column; 6. electronic scale; 7. timer; 8. weighing display screen; 9. blue copper peptide sustained-release gel. DETAILED DESCRIPTION

[0019] The preferred embodiments of the present invention are described below with reference to the accompanying drawings. It should be understood by those skilled in the art that these embodiments are only used to explain the technical principles of the present invention and are not intended to limit the scope of protection of the present invention. It should be noted that in the description of the present invention, the terms "front", "rear", "up", "down", "left", "right", "vertical", "horizontal", "inside", "outside" and the like indicating directions or positional relationships are based on the directions or positional relationships shown in the accompanying drawings, which are only for the convenience of description, rather than indicating or implying that the device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation of the present invention. It should also be noted that in the description of the present invention, unless otherwise clearly specified and limited, the terms "installed", "connected" and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be directly connected, or indirectly connected through an intermediate medium, or the internal connection of two components. For those skilled in the art, the specific meanings of the above terms in the present invention can be understood according to the specific circumstances.

[0020] As attached Figure 1 As shown, a blue copper peptide sustained-release gel fluidity detection device comprises a dripping tank 1, a liquid receiving measuring cup 2, a timer 7, a constant temperature water tank 3 and a plunger 12. The structure and function thereof are described in detail below.

[0021] See attached Figure 2 The dripping tank 1 is used to hold the blue copper peptide sustained-release gel. A dripping port 11 is provided at the bottom of the dripping tank 1. The inner diameter of the dripping port 11 is 5 mm. The dripping port 11 is the key to measuring the fluidity of the blue copper peptide sustained-release gel.

[0022] In order to keep the temperature of the blue copper peptide sustained-release gel constant during the test, a bottom hole is provided at the bottom of the constant temperature water tank 3, the dripping tank 1 is arranged in the constant temperature water tank 3, the dripping port 11 of the dripping tank 1 is located in the bottom hole, and a sealing ring 34 is provided between the bottom hole and the dripping port 11. In this way, a cavity is formed between the dripping tank 1 and the constant temperature water tank 3.

[0023] See attached Figure 1 Before the test, water 31 of a certain temperature (test temperature) is poured into the constant temperature water tank 3, and the temperature of the blue copper peptide sustained-release gel 9 in the drip tank 1 is kept consistent with the temperature of the water 31 through heat transfer, providing a prerequisite for the accuracy of the test.

[0024] The lower end of the plunger 12 has a rubber plug, and the plunger 12 is used to block or open the dripping port 11. Heat conduction takes time, and the function of the plunger 12 is to ensure that the blue copper peptide sustained-release gel 9 cannot drip from the dripping port 11 before the temperature of the blue copper peptide sustained-release gel is consistent with the water temperature.

[0025] In order to keep the water temperature constant, in addition to the requirements for the ambient temperature of the laboratory, a heater 32 and a temperature sensor 33 are also provided in the constant temperature water tank 3. The temperature sensor 33 is used to measure the water temperature. Once the water temperature is lower than the required value, the heater 32 starts heating to keep the water temperature constant.

[0026] See attached Figure 3 The liquid-receiving measuring cup 2 is a transparent glass product, and is composed of a flared portion 21, a narrow neck portion 22, and a cavity portion 23 from top to bottom, and a scale line 24 is provided on the narrow neck portion 22. The flared portion 21 is used to receive the dripping liquid from the dripping port 11, and the scale line 24 on the narrow neck portion 22 is conducive to observing the volume of the dripping liquid and reducing the measurement error.

[0027] See attached Figure 4 During the test, the plunger 12 is pulled upwards to allow the blue copper peptide sustained-release gel 9 to drip from the dripping port 11 and enter the liquid receiving measuring cup 2, and the dripping time is timed. When the liquid level of the blue copper peptide sustained-release gel reaches the scale line 24, the timing is stopped, and then the fluidity of the blue copper peptide sustained-release gel at this temperature is calculated.

[0028] To further improve the technical solution, the fluidity detection device further includes a base 4 having a support column 5, and the support column 5 is used to support the constant temperature water tank 3. In this way, the liquid receiving measuring cup 2 can be located below the dripping port 11 to receive the blue copper peptide sustained-release gel dripping from the dripping port 11.

[0029] To further improve the technical solution, the timer 7 is arranged on the base 4. The timer 7 is a necessary tool for the fluidity test, and the timer 7 is arranged on the base 4 to facilitate the timing operation.

[0030] To further improve the technical solution, an electronic scale 6 is provided on the base 4, and a weighing display screen 8 is provided on the base 4. During the test, the liquid measuring cup 2 is placed on the electronic scale 6. The liquid measuring cup 2 can measure the volume of the blue copper peptide sustained-release gel dripping, and the electronic scale 6 can measure the weight of the blue copper peptide sustained-release gel dripping, so the density of the blue copper peptide sustained-release gel dripping can be calculated.

[0031] In addition to fluidity, density is also an important indicator for measuring the degree of cross-linking between blue copper peptide and poloxamer. In this way, the fluidity detection device can not only accurately detect the fluidity of blue copper peptide sustained-release gel, but also detect the density of blue copper peptide sustained-release gel, which is a multi-purpose device.

[0032] Although the embodiments of the present invention have been shown and described, it is understood by those skilled in the art that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principles and spirit of the present invention, and the protection scope of the present invention is defined by the attached claims and their equivalents.

Claims

1. A blue copper peptide sustained-release gel fluidity detection device, comprising a dripping tank, a liquid receiving measuring cup and a timer, wherein a dripping port is provided at the bottom of the dripping tank, and the dripping port is located above the liquid receiving measuring cup, and is characterized in that: The fluidity detection device also includes a constant temperature water tank and a plunger, wherein the plunger is used to block or open the dripping port; a bottom hole is provided at the bottom of the constant temperature water tank, the dripping tank is arranged in the constant temperature water tank, and its dripping port is located in the bottom hole, and a sealing ring is arranged between the bottom hole and the dripping port.

2. A blue copper peptide sustained-release gel fluidity detection device as claimed in claim 1, characterized in that: The fluidity detection device also includes a base, the base has a support column, and the support column is used to support the constant temperature water tank.

3. A blue copper peptide sustained-release gel fluidity detection device as claimed in claim 2, characterized in that: The timer is arranged on the base.

4. A blue copper peptide sustained-release gel fluidity detection device as claimed in claim 2, characterized in that: An electronic scale is arranged on the base, and the liquid receiving measuring cup is placed on the electronic scale.

5. A blue copper peptide sustained-release gel fluidity detection device as claimed in claim 1, characterized in that: Water, a heater and a temperature sensor are arranged in the constant temperature water tank.

6. A blue copper peptide sustained-release gel fluidity detection device as claimed in claim 1, characterized in that: The liquid receiving measuring cup is a transparent glass product; the liquid receiving measuring cup is composed of a flared portion, a thin neck and a cavity portion from top to bottom, and a scale line is arranged on the thin neck.

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