Double-layer tablet tabletting device for processing morphone hydrochloride sustained-release preparation

Abstract

The utility model discloses a double-layer tablet tabletting device for processing a morphine hydrochloride sustained-release preparation, relates to the technical field of medicament tabletting machines, and aims to solve the problems that when the existing morphine hydrochloride sustained-release preparation is processed, the medicament is of a double-layer structure and needs to be subjected to double-layer pressing, and a tabletting machine on the market is relatively low in efficiency when being subjected to double-layer pressing, so that the working efficiency is relatively high. The problems that in the prior art, the pressing efficiency cannot be effectively guaranteed in the production process, so that the pharmaceutical process is long and tedious are solved. The rotating ring is arranged at the upper end of the base, the upper end and the lower end of the rotating ring are open, a motor is arranged at the bottom of the base, a rotating rod is arranged at the upper end of the motor, and the rotating rod penetrates through the base and is connected with the rotating ring; and the motor drives the rotating rod to drive the rotating ring to rotate on the surface of the base in the horizontal direction, and a scraping plate is arranged in the rotating ring.

Description

Technical Field

[0001] The utility model relates to the technical field of pharmaceutical tablet pressing machines, in particular to a double-layer tablet pressing device for processing morphine hydrochloride sustained-release preparations. Background Art

[0002] Morphine hydrochloride sustained-release tablets, according to the requirements of the three-step cancer pain treatment program proposed by the World Health Organization and the State Food and Drug Administration, morphine is a representative drug for the treatment of severe cancer pain. Morphine hydrochloride sustained-release tablets are powerful analgesics, mainly suitable for analgesia in advanced cancer patients, and the drug usually requires a tablet press to press the drug powder into shape. The tablet press is mainly used for tablet process research in the pharmaceutical industry. The tablet press is an automatic continuous production equipment that presses granular materials into round, special-shaped and sheet-shaped materials with text, symbols, and graphics with a diameter not exceeding 13mm. Some pharmaceutical tablet presses have burrs and dust when tablets are pressed. They should be equipped with a tablet screen for dust removal at the same time, and must meet GMP specifications.

[0003] When processing morphine hydrochloride sustained-release preparation, since the preparation has a double-layer structure, double-layer compression is required. However, the tablet presses on the market have low efficiency when performing double-layer compression and cannot effectively guarantee the compression efficiency during the production process, which results in a long and cumbersome pharmaceutical process. Therefore, we propose a double-layer tablet pressing device for processing morphine hydrochloride sustained-release preparations to solve the above-mentioned problems. Utility Model Content

[0004] The utility model aims to provide a double-layer tablet pressing device for processing morphine hydrochloride sustained-release preparations, so as to solve the problem that when processing morphine hydrochloride sustained-release preparations, since the preparations have a double-layer structure, double-layer pressing is required, and the tablet pressing machines on the market have low efficiency when performing double-layer pressing, and cannot effectively guarantee the pressing efficiency during the production process, which leads to a long and complicated pharmaceutical process.

[0005] To achieve the above-mentioned purpose, the utility model provides the following technical solutions: a double-layer tablet pressing device for processing morphine hydrochloride sustained-release preparations, comprising a base;

[0006] Also includes:

[0007] A rotating ring is arranged at the upper end of the base, and both upper and lower ends of the rotating ring are open-type. A motor is arranged at the bottom of the base, and a rotating rod is arranged at the upper end of the motor. The rotating rod passes through the base and is connected to the rotating ring, and the motor drives the rotating rod to drive the rotating ring to rotate horizontally on the surface of the base. A scraper is arranged inside the rotating ring, and eight scrapers are arranged and evenly installed inside the rotating ring in a circular array. The scraper divides the inside of the rotating ring into a pressing space, a first medicine space, and a second medicine space. Four pressing spaces are arranged and evenly arranged inside the rotating ring in a circular array. Two first medicine spaces and two second medicine spaces are arranged and respectively arranged on the left and right sides of the pressing space.

[0008] The bracket is arranged on the right side of the upper end of the base, and a hydraulic cylinder is arranged on the upper end of the bracket, and a lifting rod is arranged at the bottom of the hydraulic cylinder, and the hydraulic cylinder drives the lifting rod to move up and down, and a pressing head is arranged at the bottom of the lifting rod, and a pressing hole is arranged on the surface of the base, and the pressing hole is located on one side of the bottom of the rotating ring, the pressing hole and the pressing head are on the same vertical line, and the pressing head is movably engaged inside the pressing hole, and an electric push rod is arranged at the bottom of the base, and a push rod is arranged above the electric push rod, and the push rod is located inside the pressing hole, and the electric push rod drives the push rod to move up and down in the pressing hole.

[0009] Preferably, a collecting plate is disposed inside the rotating ring, and four collecting plates are provided and are installed inside the first medicine space and the second medicine space respectively.

[0010] Preferably, a material discharge box is provided on the left side of the upper end of the base, a storage box is provided on the upper end of the material discharge box, two storage boxes are provided, and the storage boxes are connected with the interior of the material discharge box, a cover plate is provided on the upper end surface of the storage box, and the cover plate is opened and closed at the upper end of the storage box through a connecting piece.

[0011] Preferably, an output pipe is provided at the front end of the discharge box, the discharge port of the output pipe is located on the upper side of the rotating ring, two output pipes are provided and are respectively connected to two storage boxes, and the discharge box discharges the pharmaceutical powder inside the storage box from the output pipe through the internal vacuum pump.

[0012] Preferably, a connecting block is fixedly installed on the outer bottom side of the lifting rod, a movable hose is provided on one side of the connecting block, and when the lifting rod is lifted or lowered, the front end of the movable hose is driven to be lifted or lowered synchronously, a suction nozzle is provided at the bottom of the front end of the movable hose, a fan is provided inside the bracket, and the other end of the movable hose is connected to the fan.

[0013] Preferably, a collecting bag is provided at the rear end of the bracket, and the collecting bag is fixed to the rear end of the bracket by means of a connecting ring at the front end being threadedly connected to the rear end of the bracket.

[0014] Preferably, the pressure head and the lifting rod are installed and fixed via a threaded connection.

[0015] Compared with the prior art, the beneficial effects of the utility model are:

[0016] 1. A rotating ring is arranged at the upper end of the base, and a plurality of scrapers are arranged inside the rotating ring, and the scrapers divide the inside of the rotating ring into a pressing space and two medicine spaces, and two layers of different medicine powders are respectively placed in the two medicine spaces, and the rotating ring is started, and the first layer of medicine can be pushed into the pressing hole under the action of the scraper, and the first layer is pressed by the hydraulic pressure head, and then the push rod is lowered to reserve space for the second layer of medicine in the pressing hole, and then the rotating ring is rotated to push the medicine powder of the second layer into the reserved hole, and the second layer of medicine is pressed by the hydraulic pressure head, so that a complete morphine hydrochloride sustained-release preparation can be obtained, and the production efficiency of the medicine is effectively improved.

[0017] 2. By arranging a feeding mechanism of a feed box and a storage box at the upper end of the base, two layers of different medicine powders can be added to the two medicine spaces in turn while the rotating ring rotates, so that the medicine powder is adequately added, ensuring that there is enough medicine powder inside the two medicine spaces for pressing when they pass through the pressing holes, and a suction structure such as a suction nozzle is arranged on one side of the lifting rod, so that each time the lifting rod is lowered for pressing, the excess powder around the outside of the pressing hole can be sucked away by the suction nozzle, thereby keeping the area around the pressing hole clean. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 It is a schematic diagram of the overall structure of the utility model;

[0019] Figure 2 It is a front cross-sectional view of the overall structure of the utility model;

[0020] Figure 3 This is a front view of the pressing structure and the air suction structure of the utility model;

[0021] Figure 4 It is a top view of the rotating ring structure of the utility model;

[0022] In the figure: 1. base; 2. rotating ring; 3. scraper; 4. pressing space; 5. first medicine space; 6. second medicine space; 7. collecting plate; 8. pressing hole; 9. push rod; 10. electric push rod; 11. motor; 12. rotating rod; 13. cover plate; 14. unloading box; 15. storage box; 16. output pipe; 17. bracket; 18. hydraulic cylinder; 19. lifting rod; 20. pressure head; 21. connecting block; 22. movable hose; 23. suction nozzle; 24. fan; 25. collecting bag. DETAILED DESCRIPTION

[0023] The technical solutions in the embodiments of the present invention will be described clearly and completely below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all of the embodiments.

[0024] See also Figure 1-4 , an embodiment provided by the utility model: a double-layer tablet pressing device for processing morphine hydrochloride sustained-release preparation, comprising a base 1;

[0025] Also includes:

[0026] A rotating ring 2 is arranged at the upper end of the base 1, and both upper and lower ends of the rotating ring 2 are open-type. A motor 11 is arranged at the bottom of the base 1, and a rotating rod 12 is arranged at the upper end of the motor 11. The rotating rod 12 passes through the base 1 and is connected to the rotating ring 2, and the motor 11 drives the rotating rod 12 to drive the rotating ring 2 to rotate horizontally on the surface of the base 1. A scraper 3 is arranged inside the rotating ring 2, and the scraper 3 is provided with eight pieces and is evenly installed in the rotating ring 2 in a circular array. The scraper 3 divides the inside of the rotating ring 2 into a pressing space 4, a first medicine space 5 and a second medicine space 6. The pressing space 4 is provided with four pieces and is evenly arranged in a circular array inside the rotating ring 2. The first medicine space 5 and the second medicine space 6 are each provided with two pieces and are respectively arranged on the left and right sides of the pressing space 4;

[0027] The bracket 17 is arranged on the right side of the upper end of the base 1, and a hydraulic cylinder 18 is arranged on the upper end of the bracket 17. A lifting rod 19 is arranged at the bottom of the hydraulic cylinder 18, and the hydraulic cylinder 18 drives the lifting rod 19 to move up and down. A pressing head 20 is arranged at the bottom of the lifting rod 19. A pressing hole 8 is arranged on the surface of the base 1, and the pressing hole 8 is located on one side of the bottom of the rotating ring 2. The pressing hole 8 and the pressing head 20 are on the same vertical line, and the pressing head 20 is movably engaged in the inside of the pressing hole 8. An electric push rod 10 is arranged at the bottom of the base 1, and a push rod 9 is arranged above the electric push rod 10, and the push rod 9 is located in the inside of the pressing hole 8, and the electric push rod 10 drives the push rod 9 to move up and down in the pressing hole 8.

[0028] A rotating ring 2 is arranged at the upper end of the base 1, and a plurality of scrapers 3 are arranged inside the rotating ring 2, and the scrapers 3 divide the inside of the rotating ring 2 into a pressing space 4 and two medicine spaces. Two layers of different medicine powders are respectively put into the two medicine spaces, and the rotating ring 2 is started, so that the pressing space 4, the first medicine space 5 and the second medicine space 6 can pass through the surface of the pressing hole 8 in sequence, so that double-layer pressing can be performed and the efficiency is improved.

[0029] See also Figure 4A collecting plate 7 is provided inside the rotating ring 2, and four collecting plates 7 are provided and are respectively installed inside the first medicine space 5 and the second medicine space 6, so as to collect the excess medicine powder.

[0030] See also Figure 2 A material discharge box 14 is arranged on the left side of the upper end of the base 1, and a storage box 15 is arranged on the upper end of the material discharge box 14. Two storage boxes 15 are arranged, and the storage boxes 15 are connected with the inside of the material discharge box 14. A cover plate 13 is arranged on the upper end surface of the storage box 15, and the cover plate 13 is opened and closed at the upper end of the storage box 15 through a connecting piece, so that two layers of different pharmaceutical powders can be added into the storage box 15 to facilitate subsequent pressing processing.

[0031] See also Figure 2 An output pipe 16 is provided at the front end of the discharge box 14, and the discharge port of the output pipe 16 is located on the upper side of the rotating ring 2. Two output pipes 16 are provided and are respectively connected to the two storage boxes 15. The discharge box 14 discharges the medicinal powder inside the storage box 15 from the output pipe 16 through the internal vacuum pump, which is convenient for adding the medicinal powder in the two medicinal spaces.

[0032] See also Figure 3 A connecting block 21 is fixedly installed on the outer bottom side of the lifting rod 19, and a movable hose 22 is arranged on one side of the connecting block 21. When the lifting rod 19 is lifted and moved, the front end of the movable hose 22 is driven to be lifted and moved synchronously. A suction nozzle 23 is arranged on the bottom of the front end of the movable hose 22. A fan 24 is arranged inside the bracket 17, and the other end of the movable hose 22 is connected to the fan 24, so that the suction nozzle 23 can be moved according to the height of the lifting rod 19, so as to facilitate the suction of excess residual medicine powder produced by pressing around the outside of the pressing hole 8, and keep the surface of the base 1 clean.

[0033] See also Figure 3 A collecting bag 25 is provided at the rear end of the bracket 17, and the collecting bag 25 is fixed to the rear end of the bracket 17 by threaded connection with the rear end of the bracket 17 through a connecting ring at the front end, so as to collect the residual pharmaceutical powder.

[0034] See also Figure 3 The pressure head 20 and the lifting rod 19 are installed and fixed by threaded connection, which makes it easy to disassemble the pressure head 20.

[0035] Working principle: two layers of different pharmaceutical powders are added to the interior of the storage box 15 respectively, and the vacuum pump inside the discharge box 14 is started to output the two layers of different pharmaceutical powders to the first pharmaceutical space 5 and the second pharmaceutical space 6 in turn. At the same time, the rotating ring 2 is started to facilitate the output of the pharmaceutical powders to the interior of the pharmaceutical space. Then, the rotating ring 2 is started, and the first layer of pharmaceutical powder is pushed into the pressing hole 8 through the scraper 3, so that the pressing space 4 is located above the pressing hole 8. The rotating ring 2 is stopped, and the pressure head 20 is started to descend and enter the pressing hole 8 to press the first layer of medicine. Then, the pressure head 20 is raised and the push rod 9 is lowered to reserve space for the second layer of medicine in the pressing hole 8. The rotating ring 2 is rotated again to push the second layer of pharmaceutical powder into the pressing hole 8. The second layer of medicine is pressed by lowering the pressure head 20, and a complete morphine hydrochloride sustained-release preparation can be obtained.

[0036] It is obvious to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above, and that the present invention can be implemented in other specific forms without departing from the spirit or essential features of the present invention. Therefore, the embodiments should be regarded as exemplary and non-restrictive from any point of view, and the scope of the present invention is defined by the appended claims rather than the above description, and it is intended that all changes falling within the meaning and scope of the equivalent elements of the claims be included in the present invention. Any reference numeral in a claim should not be regarded as limiting the claim to which it relates.

Claims

1. A double-layer tablet pressing device for processing a morphine hydrochloride sustained-release preparation, comprising a base (1); Features: Also includes: A rotating ring (2) is arranged at the upper end of the base (1), and the upper and lower ends of the rotating ring (2) are both open-type. A motor (11) is arranged at the bottom of the base (1), and a rotating rod (12) is arranged at the upper end of the motor (11). The rotating rod (12) passes through the base (1) and is connected to the rotating ring (2), and the motor (11) drives the rotating rod (12) to drive the rotating ring (2) to rotate horizontally on the surface of the base (1). A scraper (3) is arranged inside the rotating ring (2), and the scraper (3) is provided with eight pieces and is evenly installed in the rotating ring (2) in an annular array. The scraper (3) divides the interior of the rotating ring (2) into a pressing space (4), a first medicine space (5) and a second medicine space (6). The pressing space (4) is provided with four pieces and is evenly arranged in an annular array inside the rotating ring (2). The first medicine space (5) and the second medicine space (6) are each provided with two pieces and are respectively arranged on the left and right sides of the pressing space (4); A bracket (17) is arranged on the right side of the upper end of the base (1); a hydraulic cylinder (18) is arranged on the upper end of the bracket (17); a lifting rod (19) is arranged at the bottom of the hydraulic cylinder (18); the hydraulic cylinder (18) drives the lifting rod (19) to move up and down; a pressing head (20) is arranged at the bottom of the lifting rod (19); a pressing hole (8) is arranged on the surface of the base (1); the pressing hole (8) is located on one side of the bottom of the rotating ring (2); the pressing hole (8) and the pressing head (20) are on the same vertical line; the pressing head (20) is movably engaged inside the pressing hole (8); an electric push rod (10) is arranged at the bottom of the base (1); a push rod (9) is arranged above the electric push rod (10); the push rod (9) is located inside the pressing hole (8); and the electric push rod (10) drives the push rod (9) to move up and down in the pressing hole (8).

2. A double-layer tablet pressing device for processing a morphine hydrochloride sustained-release preparation according to claim 1, characterized in that: A collecting plate (7) is arranged inside the rotating ring (2), and four collecting plates (7) are arranged and are respectively installed inside the first medicine space (5) and the second medicine space (6).

3. A double-layer tablet pressing device for processing a morphine hydrochloride sustained-release preparation according to claim 1, characterized in that: A material discharge box (14) is arranged on the left side of the upper end of the base (1), and a storage box (15) is arranged on the upper end of the material discharge box (14). Two storage boxes (15) are arranged, and the storage boxes (15) are connected to the inside of the material discharge box (14). A cover plate (13) is arranged on the upper end surface of the storage box (15), and the cover plate (13) is opened and closed at the upper end of the storage box (15) through a connecting piece.

4. A double-layer tablet pressing device for processing a morphine hydrochloride sustained-release preparation according to claim 3, characterized in that: The front end of the discharge box (14) is provided with an output pipe (16), the discharge port of the output pipe (16) is located on the upper side of the rotating ring (2), two output pipes (16) are provided and are respectively connected to the two storage boxes (15), and the discharge box (14) discharges the medicine powder inside the storage box (15) from the output pipe (16) through the internal vacuum pump.

5. A double-layer tablet pressing device for processing morphine hydrochloride sustained-release preparation according to claim 1, characterized in that: A connecting block (21) is fixedly mounted on the outer bottom side of the lifting rod (19), a movable hose (22) is arranged on one side of the connecting block (21), and when the lifting rod (19) is lifted or lowered, the front end of the movable hose (22) is driven to be lifted or lowered synchronously, a suction nozzle (23) is arranged at the bottom of the front end of the movable hose (22), a fan (24) is arranged inside the bracket (17), and the other end of the movable hose (22) is connected to the fan (24).

6. A double-layer tablet pressing device for processing morphine hydrochloride sustained-release preparation according to claim 1, characterized in that: A collecting bag (25) is provided at the rear end of the bracket (17), and the collecting bag (25) is fixed to the rear end of the bracket (17) by means of a connecting ring at the front end being threadedly connected to the rear end of the bracket (17).

7. A double-layer tablet pressing device for processing morphine hydrochloride sustained-release preparation according to claim 1, characterized in that: The pressure head (20) and the lifting rod (19) are installed and fixed via a threaded connection.

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