83 results about "Blood donor" patented technology

This invention discloses a donor blood donation and sampling system including a donor needle adapted for drawing blood from a body, a blood collection bag coupled to a blood collection conduit which is coupled to the donor needle, a blood sampling conduit also coupled to the donor needle, and a sampling tube assembly arranged for selectable fluid engagement with the blood sampling conduit and for selectable clamping engagement with at least said blood collection conduit. A donor blood donation and sampling method is also disclosed.

A blood component collection system with data manipulation and optimization capabilities. The system comprises a central database, a data manipulation device, and a communication subsystem connected to the central database and the data manipulation device, and one or more extracorporeal blood processing machines. The central database maintains records of total donation volumes contributed by a donor during selected time periods as communicated by the blood processing machine and as determined by the data manipulation device. The records comprise a total red blood cell donation volume and a total plasma donation volume.

Automated systems and method for processing blood and other fluids are disclosed. The systems and methods utilize a disposable fluid circuit mounted on a re-usable hardware component or module. The system withdraws blood from a donor or patient, separates the blood into two or more components and further processes or treats the separated component.

A circuit for collecting a blood component includes a blood collection device provided with a blood collection needle through which blood is collected from a blood donor, a blood separator in which the blood collected by the above blood collection device is separated, a blood component collection bag in which a predetermined blood component separated by the above blood separator is collected, a blood line in which the blood collection needle is connected to an inlet of the blood separator, a line for removing an initial blood flow, which branches from a first branching portion formed in the blood line, and in which an initial flow of blood collected from the blood donor is removed, and an anticoagulant-injection line that branches from a second branching portion, formed in the line for removing the initial blood flow, and into which an anticoagulant is injected.

The invention belongs to the technical field of immunologic diagnosis, in particular to a treponema pallidum antibody diagnostic kit by a chemiluminescence method and a preparation method thereof. The kit comprises an anti-TP test reaction plate, an anti-TP test enzyme complex, chemiluminescence substrate liquid, concentrated washing liquor, a negative contrast and a positive contrast. The invention also discloses a preparation method of the diagnostic kit, which adopts a chemiluminescence immunoassay technology; compared with ELISA (enzyme-linked immuno sorbent assay), the method has higher sensitivity and specificity, is suitable for the auxiliary diagnosis of clinical syphilis and screening of blood donors and fills a blank of the production of a treponema pallidum antibody diagnostic reagent detected by the domestic chemiluminescence method.

Microfluidic cartridges or devices for serum separation and blood cross-match analysis are provided. The devices may include a serum separation subcircuit alone or in combination with a solute mixing subcircuit. The serum separation subcircuit promotes on-cartridge clotting of a blood sample and manipulates the flow of the separated serum sample for subsequent cross-match analysis with a second blood sample, for example. The solute mixing subcircuit includes at least two intake channels, one for a whole blood sample from, for example, a blood donor and the other for the separated serum sample from, for example, a transfusion recipient. The solute mixing subcircuit further includes a serpentine mixing channel conjoined to a downstream channel. Under vacuum generated by a conjoined finger pump, the two input streams fill the serpentine mixing and downstream channels due to capillary action, enabling visualization of an agglutination reaction.

The invention relates to a reagent erythrocyte preserving fluid and a preparing method thereof, and belongs to the field of medical examination. The preserving fluid comprises distilled water and sodium chloride. The preserving fluid and the method are characterized in that: the preserving fluid also comprises sodium citrate, ammonium chloride, disodium hydrogen phosphate, glucose, mannitol, adenine, chloramphenicol, sodium azide and amino acids, and the weight ratio of the distilled water, the sodium citrate, the ammonium chloride, the disodium hydrogen phosphate, the glucose, the mannitol, the adenine, the chloramphenicol, the sodium azide, the amino acids and the sodium chloride is 100 : 2-3 : 0.5-1 : 0.1-0.2 : 4-5 : 1-2 : 0.1-0.2 : 0.15-0.2 : 0.001-0.0025 : 1-2 : 2-3. By using the preserving agent for reagent erythrocyte preservation, the storage lifetime of the reagent erythrocytes is largely prolonged and can reach 90 days, thus largely facilitating fully-automatic micro-plate scan detection of reverse ABO typing for a large number of blood donors in a blood station, and carrying out of hemolytic disease of the newborn and difficult blood matching which are caused by incompatibility of blood group between the mother and fetus, and other works, and laying good foundations for serology examination and research on erythrocyte blood types.

The invention relates to a blood specimen management method based on RFID tags. The method comprises the steps of generating information tables and the RFID tags according to identity information of blood donors; determining whether or not the blood donors meet blood collection conditions; if yes, collecting blood and generating blood drawing status information; pasting the RFID tags to blood bagsand test tubes; sending and storing the identity information and blood drawing status information of the blood donors; judging whether or not the information meets the conditions; if yes, testing theblood in the test tubes, and generating test results; sending and storing the identity information and test results of the blood donors; determining whether or not storage conditions are met; if yes,storing the identity information and blood bags of the blood donors. Since the RFID tags can be automatically identified, processes of blood collection, blood detection and blood storage can be automatically identified, no manual operation is required, errors of information verification are reduced, and an automated management system can be formed.

The invention relates to a method for the unified registration and identification of blood donors, comprising: generation of a donor profile associated with a non-transferable identification code, filing of the profile in a portable electronic device and storage of same in a database that can be accessed by different centres; identification of the donor by the centre with the code in order to access the profile, generation of an alarm in the event of an impediment, and automatic updating of the profile in the database; optionally, acquisition of analysis results, storage of same in the database and user notification, acquisition of relevant information from other medical centres and incorporation of said information into the profile, detection of the presence of users at donation points and notification of same, verification of the accuracy of the profile data and updating of same.

The invention relates to an intelligent control method of blood specimens and a system thereof. The method includes the steps of checking information of blood donors, carrying out blood collection, conducting labeling and sample remaining on collected blood, inputting the blood into a system, and obtaining the blood specimens; conducting sample remaining on the blood specimens; automatically putting and storing the blood specimens after sample remaining in a warehouse, and detecting the temperature of the storage environment in real time; checking the stored blood specimens again, and obtaining information of the blood specimens; scrapping due blood specimens; conveying the blood specimens, and monitoring the conveying process. Through the adoption of the intelligent control method of the blood specimens and the system thereof, the intelligentized quality control of the blood specimens of a blood center and / or a blood station is achieved in the whole process of collecting, conveying, handing over, storing and scrapping, the intelligentization degree of the whole process is improved, and the fine and complete closed-loop control is achieved.

The invention discloses an ELISA detection chip based on nucleotide sequence coding and preparation and application thereof.The preparation of the chip includes the steps that coded nucleic acid and captured molecules are immobilized to the surfaces of micro-nano beads to form a micro-nano bead compound; targeted markers and marked detection molecules are immobilized to the surface of the obtained micro-nano bead compound to form a micro-nano bead complex; a substrate with distributed micro-nano pit arrays is loaded with the obtained micro-nano bead complex to prepare the ELISA detection chip; ELISA detection and coded nucleic acid decoding are carried out.Compared with the prior art, numerous samples and multiple markers can be detected at the same time on one chip, ELISA detection is carried out in micro-nano pits, the reaction volume can be below the 10-24 L level, and thus the reagent dosage can be greatly reduced.The ELISA detection chip can be applied to clinical medicine detection, blood donor detection, physical examinations, detection of toxins in agricultural and sideline products, detection of illegal food additives and environmental pollution detection.

The invention discloses a multifunctional blood collection and transfusion machine, aiming at solving the technical problems of achieving integrated blood collection, sample storage and blood donor identification so as to realize the safe and efficient purpose. The multifunctional blood collection and transfusion machine comprises a blood collection needle, wherein an outlet of a blood collection bag is connected with a second catheter, the second catheter is connected with an inlet of a blood plasma storage bag and an outlet of storage liquid through a first three-way tube, a fourth catheter and a fifth catheter, a first switch clip is arranged on the fifth catheter, more than two separable blood sample collection tubes are connected between the blood collection needle and the blood collection bag through a shunt, a second switch clip is arranged on a sixth catheter between the shunt and the blood sample collection tube, a third switch clip is arranged on the first catheter between the shunt and an inlet of the blood collection bag, a sampling needle is arranged on the blood sample collection tube, and the sampling needle is connected with the sixth catheter. Compared with the prior art, the shunt is arranged between the blood collection needle and the blood collection bag to shunt a blood sample so as to achieve the functions of reserving the initially collected blood and the blood retained in the catheter after the blood collection is stopped.

Method of optimization of blood and system for customizing blood for future use of an individual which includes: obtaining a unique blood volume measurement from the individual or a potential blood donor; administering an epoetin alfa medication to the individual or potential blood donor for stimulating bone marrow to increase production of red blood cells in accordance with information obtained from the measurement of the blood volume of the individual or the potential blood donor; and storage of blood obtained from the individual or potential blood donor if the blood donor is qualified in accordance with acceptable medical procedures to donate blood.

The invention relates to a high-titer human tetanus immunological blood plasma and a preparation process of the high-titer human tetanus immunological blood plasma. The blood plasma is obtained by the following steps: immunizing a health blood donor with tetanus toxoid; when the antibody in the blood donor is more than 12 international units per mL, collecting the blood plasma of the blood donor alone; and freezing and preserving the collected immunological blood plasma after being detected regularly. The immunological blood plasma obtained by the method of the invention has the advantages of high titer, high specificity, high safety, long durable time in the body and so on, prolongs protected period of a wounded person and enhances immunity preventive effect.

An enzyme ¿C linked immune detection method of patient blood platelet and cross ¿C match includes obtaining multiple clone antibody from blood platelet film antigen composite immune abimal and using it to carry out encapsulation then carry out closing, washing plate, adding patient sample, washing plate, adding substrate for color developing and stopping reaction.

The invention relates to a granulocyte separating and purifying method, and especially relates to a novel granulocyte preparation method without damaging the activity of granulocytes, and a cancer-killing assay (CKA) method of the granulocytes. The CKA method comprises the following steps: 1, acquiring 2ml of the peripheral blood of a blood donor, and carrying out heparin anticoagulation; 2, mixing the blood with a precipitation liquid prepared through using a precipitation liquid (LIFT-001) formula developed by the applicant according to a volume ratio of the blood to the precipitation liquid of 5:1; 3, transferring the supernatant of a mixture obtained in step 2 to a centrifuge tube added with LIFT-002, centrifuging, and taking a buffy coat; 4, adding a culture medium, and counting for obtaining effector cells; incubating the effector cells and target cells; and 5, carrying out CKA detection. CKA experiment results show that the granulocytes of some healthy adults can effectively kill Hela tumor cells. Cell real-time monitoring system results show that cancer cells are broken and killed by the granulocytes. Cancer killing activity assay allows efficient donors having high activities to be screened, and can be used for the cancer prevention and treatment, and the management of dangerous factors.

A blood plasma for human use pooled from donors which belong to 10% or more to a non-Caucasian population, the plasma obtainable by mixing blood or blood plasma of blood groups A and B, optionally AB without admixing substantial amounts of blood or blood plasma of blood group 0 characterized in that four to eight parts of blood or blood plasma from donors having the blood group A, more than three parts to seven parts of blood or blood plasma from donors having the blood group B, zero to two parts of blood or blood plasma from donors having the blood group AB.

The invention discloses a preparing method for platelet-rich gel. The preparing method for the platelet-rich gel includes the following steps that (1) a blood sampling connecting bag is taken and ready for blood sampling; (2) whole blood of blood donors is collected through a blood sampling device; (3) a whole blood bag is centrifuged, standing is carried out after centrifugation, and a plasma layer located on an upper layer, a PRP layer located on a middle layer and an erythrocyte layer located on a lower layer are formed; (4) plasma in the plasma layer flows into a plasma transferring bag through a first conduit, a fluid director and a third conduit in sequence, and then enters a plasma transferring illumination bag through a methylene blue releaser, and therefore plasma is prepared; (5)PRP in the PRP layer flows into a PRP bag through the first conduit, the fluid director and a second conduit in sequence, then an activating agent in an activating agent bag is added into the PRP bag, and therefore the platelet-rich gel is prepared. The preparing method is combined with blood sampling, the preparing amount is large, the possibility of blood pollution is reduced, the preparation procedure is simple, and time of workers is saved.

The invention aims to provide an SNP (Single nucleotide polymorphism) site for detecting O-type variation of an ABO blood group system. In a coding region of a novel O-type variation gene, gtgacgctg basic groups are deleted from 484 to 492 sites from an initiation codon. The invention provides a novel O-type variation gene, so that an ABO gene bank is perfected, and a way for rapid genediagnosis, gene screening and genetic counseling is provided. An application effect shows that the SNP site and a detection primer of the gene provided by the invention can be effectively applied to rapid detection of a novel O-type variation gene mutation site in peripheral blood of blood donors and clinical patients.

The invention provides a multidigit integrated intelligent blood sampling device with a multimedia function. The multidigit integrated intelligent blood sampling device comprises a frame, at least two or more blood sampling components arranged on the frame, a PLC, an operation display screen and multimedia display screens. Each blood sampling component comprises a blood sampling scale and a blood trail control switch controlling connection and disconnection of a blood transfusion path, the PLC is electrically collected with the blood sampling scales and the blood train control switches respectively, the operation display screen is arranged on the frame and electrically connected the PLC, the number of the multimedia display screen is equal to that of the blood components, and the multimedia display screens are arranged on the frame by adjustable angle. The multidigit integrated intelligent blood sampling device is provided with a plurality of blood sampling mechanisms, operators can supply services for multiple blood donors on one station, and work efficiency is effectively improved; the multimedia display screens allows the blood donors to see multimedia videos, and the blood donors are effectively distracted during blood sampling.

The invention belongs to the application field of biotechnology, relates to human medicine and veterinary medicine, and includes the detection of RNA viruses in various biological products, blood donors, patient blood samples and the like. Specifically, the enzyme-linked-loop-mediated isothermal amplification technique (E-LAMP) was used to analyze the conserved and virus-specific gene sequences of the HCV RNA virus through computer software, and six primers were designed to completely match the eight binding regions in the identified target sequence. , just one step to complete the cyclic displacement amplification reaction in an isothermal environment. At the same time, the common enzyme-linked immunosorbent technique is organically combined with RT-LAMP, and the intermediate product of RT-LAMP is solid-phased by biotin-labeling different primers. On a microwell reaction plate coated with streptavidin, the HRP enzyme-labeled anti-Digoxin antibody specifically binds to Digoxin labeled on another primer to finally present a color reaction. The entire detection process from amplification to result presentation is realized in a single tube. Compared with the traditional RT-PCR method, it has the advantages of safety, specificity, sensitivity and convenience.

The invention discloses an electronic blood matching method and relates to a technology of medical treatment information diagnosis. Confirmation and information recording are conducted twice on blood types of a blood donator and a patient to sufficiently confirm the matching condition of the blood types of the blood donator and the patient, antibody screening experiments are conducted on the blood donator and the patient to further ensure blood type matching safety and accuracy, and the method greatly improves blood matching efficiency.

The invention discloses a blood transfusion management method including: scanning patient information and information of a blood donor on a blood preparation into a patient information database of a hospital; primarily checking the patient information before collecting a blood sample of a patient; secondarily checking the patient information before a blood bank detects the blood sample; and tertiarily checking the patient information before the patient is in blood transfusion. By the blood transfusion management method, an electronic identifier is used for respectively checking the patient information in a blood collection phase, a blood bank blood detection phase and a blood transfusion phase, so that blood transfusion management level in hospitals is improved, and various errors possibly caused during blood management are reduced.

The invention relates to a fluorescent quantitative PCR kit for simultaneous detection of hepatitis B virus, hepatitis C virus and human immunodeficiency virus. The kit comprises HBV, HCV and HIV-1, the sequence of which is shown in SEQ ID NO. 1 to SEQ ID NO. 9. The kit provided by the invention adopts a multiplex fluorescent PCR method, and can realize DNA virus HBV and RNA virus HCV and HIV-1 atthe same time, and the amplification of one virus nucleic acid will not affect the other two, has the advantages of high sensitivity, strong specificity, good repeatability, short detection time, lowdetection cost, low technical requirements and less pollution, etc. for blood donors in blood centers or blood stations of HBV, HCV and HIV-1 simultaneous detection of the three viruses has importantsignificance and high application value.

The invention discloses a hydraulic wrist developer. The hydraulic wrist developer comprises an elastic cavity, a signal control assembly arranged in the elastic cavity, and a force application mechanism used for switching on or off the signal control assembly. The signal control assembly controls switch-on and switch-off of a prompt signal. The force application mechanism comprises a hydraulic buffer, a reset spring and a stress support. According to the hydraulic wrist developer, light emitted by a vibrating light-emitting diode is adopted as the prompt signal, whether the grasping force of a blood donor is proper or not is visible, and the blood donor can timely adjust the force; the interval at which the reset spring drives a buffer rod of the hydraulic buffer to slowly retract is adopted as the frequency at which the blood donor grasps the wrist developer, thus, the blood donor can accurately apply force, vasospasm is avoided, and the blood drawing efficiency in a hospital is improved.

The present invention relates to a method for producing fibrin colloid and preparing platelet gel by using human thrombosin, in particular it utilizes ingle blood donor or self-body thrombin to produce fibrin colloid and platelet gel with bio-compatibility and bio-degradability. Said invented preparation method can reduce viral infection and antigenic hazard, and can raise application of fibrin colloid in the fields of medicine and cell culture.

The invention discloses a plasma separating bag which is matched with a blood separating machine to be used, and the plasma separating bag is mainly used to separate components from the blood of a blood donor; the invention comprises an airlocked bag body, a whole blood inlet opening, a poor component plasma outlet opening and a rich component plasma outlet opening. The internal space of the bag body is divided into an upper cavity and a lower cavity through an L-shaped thermal synthesis separation line in the bag body, the upper cavity and the lower cavity are integrally communicated, the other ends of the upper cavity and the lower cavity are insolated, the rich component plasma outlet opening is positioned on the end part of the lower cavity, namely, the tail end of a rich component plasma flow route, the whole blood inlet opening and the poor component plasma outlet opening are positioned at the upper end of the upper cavity, the internal space of the bag body is divided into the upper cavity and the lower cavity through the L-shaped thermal synthesis separation line in the bag body, the separating structure can well and effectively separate the poor component plasma and the rich component plasma, and the structure is simpler and more compact; in addition, the invention changes the original two time separation way to lead the once separation of the blood to be accomplished and to greatly reduce the separating time.