This application discloses a method, device, medium, and program product for managing
plasma donor fatigue
recovery, addressing the problem in existing technologies where individual
physiological responses of different
plasma donors during
plasma donation are not considered, leading to fatigue
recovery predictions that deviate from individual realities and a lack of targeted intervention timing and content. The method includes: acquiring
stressor time-
series data and individual digital profiles of plasma donors; characterizing the donor's sensitivity to
anticoagulant metabolism and fatigue
recovery ability based on the
stressor time-
series data and individual digital profiles; predicting the plasma donor's fatigue recovery trajectory after plasma donation based on the
stressor time-
series data and individual digital profiles; determining at least one intervention time point based on the fatigue recovery trajectory, and pushing fatigue recovery guidance information to the plasma donor at the intervention time point.