10 results about "Fertility preservation" patented technology

The present invention discloses a comprehensive methodology for engineering a functional artificial ovary through precision tissue engineering approaches, specifically designed to overcome the limitations of current fertility preservation techniques. The present invention specifically targets the fabrication of a biomimetic artificial ovary using decellularization-recellularization technology

The utility model provides a portable testicular tissue sampling and freezing device, and belongs to the field of medical instruments. The sampling and freezing device comprises a sampling component, a freezing component and a freezing component, wherein the sampling component is used for sampling testicular tissues to be treated; the processing assembly is used for washing and fixing the testicular tissues sampled by the sampling assembly; the cooling assembly is used for cooling the testicular tissue treated by the treatment assembly; the freezing assembly is used for cryopreserving the testicular tissue cooled by the cooling assembly, and the sampling assembly, the processing assembly, the cooling assembly and the freezing assembly are all stored in a portable transfer box. According to the portable testicular tissue sampling and freezing device, the problem of emergency fertility preservation of soldiers can be solved, the device is portable, testicular tissue samples of rescued objects can be rapidly collected in time, and the testicular tissues can be rapidly frozen and stored for fertility preservation.

The invention discloses a prediction method and device for complete remission of an endometrial cancer patient, a medium and a product, and relates to the technical field of biologication.The method comprises the steps that feature extraction is conducted on an obtained data set, and a plurality of radiomics features are obtained; establishing an MR scoring model according to the plurality of radiomics features; performing prediction effectiveness evaluation on the MR scoring model to obtain an MR score; performing normal distribution test on the plurality of radiomics characteristics to obtain a plurality of radiomics characteristics converted into normal distribution; carrying out variance homogeneity analysis on the plurality of radiomics characteristics converted into normal distribution, and determining the difference of the plurality of radiomics characteristics converted into normal distribution and prediction factors related to complete remission of the patient; and constructing a column graph model according to the MR score and the prediction factor. According to the method, young EC patients suitable for retaining fertility can be accurately identified, the accuracy of a clinical decision-making process is improved, and unnecessary uterine cavity invasive operation is reduced.

The application relates to application of FOS / AP-1 inhibitors in preparation of drugs for improving vitrification freezing damage of ovary tissues. The application provides a new concept and intervention target for female fertility preservation based on ovary vitrification freezing, and has a good application prospect.

The application relates to an ovary organ chip, a manufacturing method and application thereof. The ovary organ chip is sealed by a four-layer structure from top to bottom, and comprises an upper ovary chip layer, a follicle culture layer, a porous filter membrane layer and a lower ovary chip layer. An upper end of an upper culture medium perfusion chamber of the upper ovary chip layer is communicated with an upper inlet pool through an upper perfusion channel, and a lower end of the upper culture medium perfusion chamber is communicated with an upper outlet pool through the upper perfusion channel. An upper end of a lower culture medium perfusion chamber of the lower ovary chip layer is communicated with a lower inlet pool through a lower perfusion channel, and a lower end of the lower culture medium perfusion chamber is communicated with a lower outlet pool through the lower perfusion channel. The follicle culture layer is provided with a round hole or a cylinder. The ovary organ chip is constructed to simulate the physiological environment and pathological changes of substantial cells in an ovary in vitro, so that researches on hormone synthesis, ovary development and maturation, disease occurrence mechanism, tumor occurrence, development, invasion and metastasis and the like are carried out, and the ovary organ chip is used for researching and developing drugs, individualized treatment of tumors and fertility preservation.

The invention belongs to the technical field of culture media, and discloses a culture medium for in-vitro culture of cynomolgus monkey testicular tissue. Through an innovative culture technology and in combination with a culture formula of adding ANGPTL4 and IGF1, the survival rate and spermatogenesis efficiency of testis tissues are optimized, an efficient and reliable technical means is provided for reproductive medicine research and fertility preservation, and the method is particularly suitable for pre-adolescent individuals or wild protection animals or humans needing to preserve fertility potential. The innovative rotary culture technology and the culture scheme that 20 ng / mL of ANGPTL4 and 20 ng / mL of IGF1 are additionally supplemented are beneficial to the integrity of testicular tissues in the in-vitro culture process and promote proliferation and differentiation of germ cells, and the spermatogenesis efficiency is improved. And a feasible technical scheme and a new insight can be provided for the research of male animal in-vitro spermatogenesis.

The application provides application of pyridoxamine in sperm of oligospermia, preferably and / or in a freezing and resuscitation operation, pyridoxamine is added in a sperm operation liquid or a semen freezing liquid, and the following shortcomings of patients with oligospermia are effectively improved: (1) the ratio of sperm forward motility; (2) the ratio of sperm forward motility after semen freezing and resuscitation; (3) the sperm DNA fragmentation rate after semen freezing and resuscitation; (4) the sperm acrosome enzyme content after semen freezing and resuscitation; in summary, pyridoxamine can be added in the sperm operation liquid or the semen freezing liquid as a natural semen protective agent, the sperm selection treatment and the freezing and resuscitation effect of patients with oligospermia are obviously improved, and the application is suitable for application of patients with oligospermia in assisted reproductive treatment and fertility preservation.

The invention relates to the field of fertility preservation and protection before adolescence, in particular to a transition culture method before immature testicular tissue transplantation. In a transition culture process before immature testicular tissue transplantation, coexistence states (such as FSH and testosterone continuously exist in a male body) of various growth factors and hormones in an in-vivo microenvironment are simulated, or in-vivo physiological dynamic changes are simulated. According to the transition culture method disclosed by the invention, the huge environmental difference caused by transplanting the testicular tissue before adolescence to the mature testicular tissue is reduced, the proliferation of spermatogonium and the maturation of supporting cells are remarkably promoted, the survival rate of the spermatogonium after transplantation is improved, and a foundation is laid for spermatogenesis after transplantation.

The invention provides an application of pyridoxamine in sperm optimization and / or freezing recovery operation of asthenospermia, pyridoxamine is added in sperm operation liquid or sperm freezing liquid, and the following shortages of asthenospermia patients are effectively improved: (1) the ratio of sperm forward motility sperms; (2) determining the ratio of forward motility sperms after the semen is frozen and resuscitated; (3) determining the sperm DNA fragment rate after the sperm is frozen and resuscitated; (4) determining the content of sperm acrosomal enzyme after the sperm is frozen and resuscitated; in conclusion, the pyridoxamine can be added into sperm operating fluid or sperm refrigerating fluid as a natural sperm protective agent, the sperm optimization treatment and freezing resuscitation effects of the asthenospermia patient are obviously improved, and the pyridoxamine is suitable for being applied to assisted reproductive therapy and fertility preservation of the asthenospermia patient.

Disclosed are compositions and methods including Anti-Müllerian Hormone (AMH) receptor binding peptides. The AMH receptor binding peptides can be used, for example, to modify the activity of the AMH receptor. For example, the AMH receptor binding peptides can activate the AMH receptor, such as the AMH receptor 2, thereby mimicking the function of AMH. In other examples, the AMH receptor binding peptides function as AMH receptor antagonists, thereby interfering with the function of endogenous AMH. By modifying the activity of the AMH receptor, the peptides have multiple applications, including for example modification of treatment of precocious puberty in females, delay of natural menopause, preservation of ovarian follicular reserve, contraception, fertility preservation after ovarian cortex transplant, treatment of endometriosis, treatment of cancer and / or cancer prevention, and treatment of polycystic ovary syndrome (PCOS).