The invention discloses a traditional Chinese medicine for curing a hand-foot-mouth disease syndrome. The traditional Chinese medicine for curing the hand-foot-mouth disease syndrome is prepared by medical materials of honeysuckle, fructus forsythiae, radix rehmanniae, raw rhubarb, yarrow, cape jasmine, honeysuckle stem, raw gypsum, rhizoma coptidis, poria cocos, coix seed, rush, immature bitter orange, medicated leaven, endothelium corneum gigeriae galli, tangerine peel, hawthorn, schizonepeta, melampyrum roseum maxim, sarel spleenwort herb, mint, ixeris chinensis, herb of sessilefruit chinaure, duchesnea indica, serissa serissoide, snakegourd fruit, magnoliae officinalis, paris polyphylla, kalimeris lautureana, herba eupatorii, agastache rugosa, bamboo leaf, radix scrophulariae, radix isatidis, folium isatidis, evodia lepta, cogongrass rhizome, talcum powder, radix sileris, semen cassiae, rhizoma cimicifugae, rhizoma smilacis glabrae, radix tetrastigme, dendrobium stem, trollius chinensis bunge, cortex dictamni, melaleuca leucadendra linn, epipremnum pinnata, flos paulowniae, periostracum cicadae, fructus kochiae, rhizoma paridis, fructus arctii, platycodon grandiflorum, red peony root, dendrobium, charred triplet, medicated leaven and malt culms, fermented soybean, picrorhiza, nacre and cornu bubali. The clinical trials prove that the traditional Chinese medicine for curing the hand-foot-mouth disease syndrome is effective and safe in curing the hand-foot-mouth disease syndrome.