1 results about "Phospholipid vesicles" patented technology

The application discloses an ultrasonic-temperature double-triggered double-liquid gas phase change contrast agent and a preparation method thereof. The preparation steps comprise the following steps: adding an isotonic buffer solution into a prepared composite phospholipid film, oscillating after ultrasonic dispersion, obtaining a targeted phospholipid vesicle dispersion; then high-pressure double-liquid co-loading is carried out, and the phase change temperature and the ultrasonic response are calibrated; filtering through a filter membrane, collecting the precipitate after centrifugation, adding a protective solution after washing with a PBS buffer solution, and sealing and storing to obtain the double-liquid gas phase change contrast agent. After the contrast agent enters the body, under the ultrasonic double triggering of the physiological temperature and an ultrasonic imaging instrument, the double-liquid gas synchronously phase changes into a gaseous state, drives the contrast agent to rapidly expand from a nano-sized particle into a micron-sized microbubble, realizes ultrasonic enhanced imaging, and has a significant clinical application value.