2 results about "Phospholipid vesicles" patented technology

The application discloses an ultrasonic-temperature double-triggered double-liquid gas phase change contrast agent and a preparation method thereof. The preparation steps comprise the following steps: adding an isotonic buffer solution into a prepared composite phospholipid film, oscillating after ultrasonic dispersion, obtaining a targeted phospholipid vesicle dispersion; then high-pressure double-liquid co-loading is carried out, and the phase change temperature and the ultrasonic response are calibrated; filtering through a filter membrane, collecting the precipitate after centrifugation, adding a protective solution after washing with a PBS buffer solution, and sealing and storing to obtain the double-liquid gas phase change contrast agent. After the contrast agent enters the body, under the ultrasonic double triggering of the physiological temperature and an ultrasonic imaging instrument, the double-liquid gas synchronously phase changes into a gaseous state, drives the contrast agent to rapidly expand from a nano-sized particle into a micron-sized microbubble, realizes ultrasonic enhanced imaging, and has a significant clinical application value.

The invention belongs to the technical field of membrane modification, and particularly relates to a reverse osmosis membrane and a preparation method thereof. The preparation method comprises the following steps: firstly, carrying out hydration reaction on dispersion liquid containing carboxylated single-walled carbon nanotubes and a phospholipid layer to form phospholipid vesicle dispersion liquid in which the carbon nanotubes are vertically embedded; then taking an ultrafiltration membrane as a base membrane, breaking the phospholipid vesicles through suction filtration, forming a phospholipid bilayer structure on the surface of the base membrane, and vertically arranging the carbon nanotubes between the phospholipid bilayers to construct a phospholipid-carbon nanotube composite intermediate layer; and finally, forming a cross-linked polyamide layer on the surface of the composite intermediate layer through an interfacial polymerization reaction, and vertically fixing the carbon nanotubes in the membrane structure to complete the preparation of the reverse osmosis membrane. According to the method, the carbon nano tube is really used as a water channel, and the water molecule permeation rate of the reverse osmosis membrane is remarkably improved.