The invention provides a preparation method of dry red wine containing onion, allium macrostemon and ginseng. The preparation method comprises the following steps: pulverizing, primary fermentation, secondary fermentation and the like. In a process of primary fermentation, special yeast freeze-dried powder for red wine and special pectinase are added; in a process of secondary fermentation, lactobacillus is added; and after secondary fermentation is finished, 100% onion juice, a ginseng extracting solution and an allium macrostemon extract are added in the obtained dry wine, and are mixed with the dry wine to obtain the dry red wine containing the onion, the allium macrostemon and the ginseng. In the fermentation process, by the added pectinase, nutritional substances of peel and pulp are released to a maximum extent, and by lactic acid fermentation, wild grape wine is complete and is good in flavor. The onion, the allium macrostemon and the ginseng are added according to a certain propprtion, so that the conventional wild grape wine has functions of reducing blood pressure, resisting ageing, resisting arteriosclerosis and improving immunity; the health-care effect on heart and cerebral vessels is improved in a maximum extent; meanwhile, the dry red wine tastes mellow; and the stability of the production can further be improved.