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Injection for treating cardiovascular or cerebrovascular disease and the preparing method and the quality control method

A technology for cardiovascular and cerebrovascular diseases and injections, which can be applied to cardiovascular system diseases, medical preparations containing active ingredients, and pharmaceutical formulas, etc., and can solve problems such as inconvenient use

Active Publication Date: 2011-12-07
INCREASEPHARM (ZHUHAI) PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Based on the good clinical basis of Guanxinning Injection and the existing deficiencies, the purpose of the present invention is to provide a new dosage form of the drug and a preparation method thereof. In order to make up for the deficiencies of the existing technology by making it into a new injection preparation for severe patients and other patients who need to be diluted for use, it also provides a preparation method for the preparation. The preparation method is mature and can be used directly. It is used to guide the production; at the same time, it also provides the quality control method of the preparation

Method used

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  • Injection for treating cardiovascular or cerebrovascular disease and the preparing method and the quality control method
  • Injection for treating cardiovascular or cerebrovascular disease and the preparing method and the quality control method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0086] Embodiment 1: Salvia miltiorrhiza 2000g Chuanxiong 2000g

[0087] Take Danshen and Chuanxiong medicinal materials, add 10 times the amount of water and decoct three times, the first time for 2 hours, the second and third times for 1.5 hours each, combine the decoction, filter, concentrate the filtrate, and use ethanol precipitation for two times. The alcohol content reaches 75%, and the alcohol content reaches 85% for the second time. After adding ethanol each time, place it in cold storage, filter, combine the filtrate, concentrate, dilute with water for injection, adjust the pH value to 3.2 with dilute hydrochloric acid, and refrigerate , filter, adjust the pH value to 6.8 with 10% sodium hydroxide solution, concentrate, refrigerate, filter, add mannitol solution (120mg / ml), then adjust the pH value to 6.8, boil for 30 minutes, add 1.0% needle for Activated carbon, slightly cooled, filtered, the filtrate adjusted to a pH value of 6.8, added with an appropriate amount ...

Embodiment 2

[0088] Embodiment 2: Salvia miltiorrhiza 2000g Chuanxiong 2000g

[0089] Take Danshen and Chuanxiong medicinal materials, add 8 times the amount of water to decoct three times, the first time for 2 hours, the second and third times for 1.5 hours each, combine the decoction, filter, concentrate the filtrate, and use ethanol precipitation for two times. The alcohol content reaches 75%, and the alcohol content reaches 85% for the second time. After adding ethanol each time, place it in cold storage, filter, combine the filtrate, concentrate, dilute with water for injection, adjust the pH value to 3.2 with dilute hydrochloric acid, and refrigerate , filter, adjust the pH value to 6.8 with 10% sodium hydroxide solution, concentrate, refrigerate, filter, then adjust the pH value to 6.8, boil for 30 minutes, add 0.2% activated carbon for needles, cool slightly, filter, and adjust the filtrate When the pH value reaches 6.8, add an appropriate amount of water for injection, and then ad...

Embodiment 3

[0090] Embodiment 3: Salvia miltiorrhiza 2000g Chuanxiong 2000g

[0091]Take Danshen and Chuanxiong medicinal materials, add 12 times the amount of water and decoct three times, the first time for 2 hours, the second and third times for 1.5 hours each, combine the decoction, filter, concentrate the filtrate, and use ethanol precipitation for two times. The alcohol content reaches 75%, and the alcohol content reaches 85% for the second time. After adding ethanol each time, place it in cold storage, filter, combine the filtrate, concentrate, dilute with water for injection, adjust the pH value to 3.2 with dilute hydrochloric acid, and refrigerate , filter, adjust the pH value to 6.8 with 10% sodium hydroxide solution, concentrate, refrigerate, filter, then adjust the pH value to 6.8, boil for 30 minutes, add 0.5% activated carbon for needles, cool slightly, filter, and adjust the filtrate When the pH value reaches 6.8, add an appropriate amount of water for injection, and then a...

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Abstract

The invention discloses a method for preparing an injection used to treat cardiovascular cerebrovascular disease, belonging to Chinese medicine, wherein the preparation comprises that preparing Danshen or relative extractive with chuanxiong rhizome or relative extractive, added with some findings. The inventive drug has the functions as activate blood circulation and remove stasis, while it can be made into freeze dried and vein injection. The invention can be used in production directly, provided with a quality control method which comprises check, content detection, and fingerprint spectrum, to supply data to production.

Description

technical field [0001] The invention relates to an injection for treating cardiovascular and cerebrovascular diseases, a preparation method and a quality control method thereof, and belongs to the technical field of traditional Chinese medicine. technical background [0002] Cardiovascular and cerebrovascular diseases have become the most important diseases that affect the health of residents. They are characterized by high disability rates, high morbidity rates, high recurrence rates, and high mortality rates. In China, there are about 2.6 million people every year, and about 7,000 people every day. People die from cardiovascular and cerebrovascular diseases. Among them, the average prevalence rate of coronary heart disease angina pectoris in China is about 6.49%, and the prevalence rate increases with age, which seriously threatens human life and health. There are more lesions inside the blood vessels but have not yet broken out, which brings great pain to individuals and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/537A61K9/08A61P9/10G01N30/90G01N33/15
Inventor 张保献
Owner INCREASEPHARM (ZHUHAI) PHARM CO LTD
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