Atropine eyewater in low concentration for restraining increase of degree of short sight and preparing method
A manufacturing method and low-concentration technology, which can be used in pharmaceutical formulation, drug delivery, drug combination, etc., can solve problems such as poor compliance and difficulty in use, and achieve the effects of improving pupil dilation and photophobia, strengthening compliance and return visit rate
Inactive Publication Date: 2007-10-10
CHANG GUNG MEMORIAL HOSPITAL
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Problems solved by technology
[0004] In 1999, Dr. Shi Yongfeng of National Taiwan University published a study (Shih YF, Chen CH, Chou AC, et al. Effects of different concentrations of atropine on controlling myopia inmyopic children. J Ocul Pharmacol Ther 1999; 15: 85-90.), showing 0.5% atropine (atropine) is the most effective, although many countries use more potent 1% atropine (atropine) or the 0.5% atropine (atropine) that Taiwan uses at present, it is effective, but it is clinically used. Quite difficult, mainly because they will be sensitive to light all day long after administering the medicine, and primary school children cannot attend physical education classes, so the compliance rate is poor and the rate of giving up treatment is high
Method used
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Embodiment 1
[0045] The preparation of the medicament of the present invention is to dilute the atropine medicine with a distillate to become a medicament with a concentration of atropine less than 0.1% by weight.
Embodiment 2
[0047]The medicament of the present invention can be prepared by diluting the atropine medicament with physiological salt to obtain the medicament of atropine at a concentration of 0.1% by weight.
Embodiment 3
[0049] The preparation of the medicament of the present invention is to dilute the atropine medicine with a distillate to become a medicament with a concentration of 0.05% by weight atropine.
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Description
technical field [0001] The invention relates to a low-concentration atropine medicament for inhibiting the increase of myopia degree and a manufacturing method thereof, and mainly relates to a medicine invention for treating deterioration of myopia in human eyes in the field of human medicine. Background technique [0002] Myopia is an important eye disease, especially high myopia (myopia over 600 degrees), which can lead to many complications, such as young cataract, glaucoma, retinal detachment, macular hemorrhage, retinal degeneration, and even blindness. In Taiwan, myopia has become the second leading cause of blindness in the elderly, so it is very important to prevent high myopia. The prevention of high myopia must start with children. In Asian children, the increase is about 75-100 degrees per year, and in Western children, it is about 50 degrees per year. Once a child is myopic, the degree will continue to increase until the end of puberty. Children suffering from my...
Claims
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IPC IPC(8): A61K9/08A61P27/10
Inventor 吴佩昌郭锡恭方博泂李仲哲陈志信
Owner CHANG GUNG MEMORIAL HOSPITAL
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