7results about How to "Avoid systemic side effects" patented technology

The invention relates to the technical field of nano biological medicines, and discloses a photo-thermal-enzyme catalysis nano-particle as well as a preparation method and application thereof. The photo-thermal-enzyme catalysis nano-particles are constructed by crosslinking water-soluble self-doped polyaniline nano-particles, human serum albumin, lactate oxidase and collagenase through a thioacetal linker capable of being split by active oxygen. Collagenase and lactate oxidase (LOx) are integrated into the same nanoparticle system through a thioacetal (TK) linker, the TK linker is split under the action of tumor microenvironment active oxygen (ROS) and H2O2 generated by catalysis of the LOx, the activity of the two enzymes is synchronously activated, a collagen matrix (physical barrier) is degraded, lactic acid (chemical barrier) is removed, the tumor microenvironment is efficiently remodeled, and the tumor microenvironment can be effectively inhibited. The problems that the regulation effect of a single barrier is limited, and the tumor microenvironment is difficult to improve are solved.

This invention relates to the field of traditional Chinese medicine preparation technology, and particularly to a traditional Chinese medicine composition for treating cancer pain and numbness, as well as its preparation and application. This invention designs a traditional Chinese medicine composition for cancer pain and numbness, comprising: *Houttuynia cordata*, *Aconitum carmichaelii*, processed *Aconitum carmichaelii*, centipede, *Astragalus membranaceus*, *Ephedra sinica*, clove, frankincense, ephedra, menthol, and azone. The scientifically formulated combination of principal, assistant, and adjuvant herbs allows for multi-target action on both "cancer pain" (inflammation, compression, nerve infiltration) and "CIPN" (nerve damage), resulting in a superior analgesic effect, while also possessing anti-inflammatory, anti-swelling, potential tumor-suppressing, and nerve-repairing effects. The traditional Chinese medicine composition is prepared into a traditional Chinese medicine ointment, which is administered transdermally, allowing a high concentration of the drug to act directly on the lesion, avoiding the systemic side effects (addiction, constipation, etc.) associated with oral opioids. This is especially suitable for patients who cannot take oral opioids or cannot tolerate them.

The invention relates to the technical field of traditional Chinese medicine, in particular to anti-inflammatory and analgesic external traditional Chinese medicine powder for osteoarthritis and a preparation method thereof, and the powder is prepared from the following raw materials in parts by weight: 6.7 parts of mirabilite, 2 parts of borneol, 1 part of fructus gardeniae, 0.7 part of rhizoma paridis, 0.7 part of radix aconiti, 0.7 part of radix aconiti agrestis, 0.6 part of caulis spatholobi, 1.3 parts of rheum officinale, 0.4 part of cassia twig and 0.6 part of radix achyranthis bidentatae. The preparation method comprises the following steps: weighing the medicinal materials according to the proportion, mixing, grinding at low temperature, controlling the temperature to be below 40 DEG C until uniform and fine powder is formed, and sieving, so as to obtain the traditional Chinese medicine powder. The powder has the effects of clearing away heat and toxic materials, promoting blood circulation to remove blood stasis, relieving swelling and pain, dispelling wind and eliminating dampness, and warming and activating meridians; the traditional Chinese medicine composition has the advantages of quick effect, exact curative effect, convenience in use and high safety on osteoarthritis (especially patients with red, swollen and heat pain symptoms). The preparation method is simple in process, easy to control and suitable for industrial production.

The invention relates to the technical field of medicine, in particular to application of a compound in treatment of psoriasis, the compound is an AMPK activator Aldometanib, and the chemical structural formula of the compound is as shown in Figure 1. The research result shows that the Aldometanib can effectively relieve the psoriasis-like phenotype of mice, the erythema of the mice is converted from bright red to light red, the area is reduced, silver-white scales attached to the skin surface are thinned, and the psoriasis area and severity index (PASI) score is remarkably reduced. The mouse back skin lesion tissue is subjected to HE dyeing, the visible epidermis thickness is recovered to be close to the normal level through microscopic observation, inflammatory cell infiltration lesions on the superficial layer of dermis and around blood vessels are reduced, and the number is remarkably reduced. A mouse serum ELISA detection result shows that the expression of pro-inflammatory cytokines TNF alpha, IL-1beta and IL-6 is reduced. The Aldometanib disclosed by the invention is remarkable in anti-psoriasis effect, safe and non-toxic, and is expected to become a novel therapeutic drug for psoriasis.

The application discloses a tretinoin-matrine ionic liquid photocured hydrogel microneedle patch and a preparation method and application thereof, relates to the technical field of medical materials.The microneedle patch of the application takes methacrylated hyaluronic acid (HAMA) and polyether F127 diacrylate (F127DA) as a mixed matrix, and encapsulates tretinoin-matrine ionic liquid (RA-Mat IL) as an active ingredient; the preparation process comprises the following steps: ionic liquid preparation, needle tip layer and backing layer solution preparation, mold filling and drying, integrated photocuring and demolding, and the like.The microneedle patch can be directly attached to the skin surface, can effectively treat mild to moderate psoriasis and repair damaged skin barrier, and has a good application prospect in the fields of inflammatory skin disease treatment and wound repair.

This invention discloses the application of Z944 in the preparation of drugs for treating knee osteoarthritis. Z944 can simultaneously promote the repair of knee cartilage and inhibit neuropathic pain, overcoming the shortcomings of existing KOA therapies, such as single target, limited efficacy, and inability to block the core pathological cycle of the disease. The mechanism of action of Z944 lies in its ability to simultaneously inhibit abnormal discharge of pain neurons and block the catabolism signals of chondrocytes, thereby fundamentally intervening in the vicious cycle of cartilage degeneration and pain transmission in knee osteoarthritis. Compared with existing therapies that target only a single pathological link, this invention achieves a synergistic therapeutic effect greater than the sum of its parts (1+1>2). Its efficacy stems from blocking the core mechanism of the disease, thus being more fundamental and lasting.

The invention provides application of indoleacetic acid or pharmaceutically acceptable salt or ester thereof in preparation of drugs for preventing, relieving and / or treating neurodegenerative diseases, and belongs to the technical field of neuroprotection. The invention provides application of indoleacetic acid or pharmaceutically acceptable salt or ester thereof in preparation of drugs or cognitive function protective agents for preventing, relieving and / or treating neurodegenerative diseases. The neurodegenerative disease is a neurodegenerative disease caused by exposure of environmental pollutants. A novel prevention and treatment strategy for relieving the DEP exposure induced cognitive impairment is provided through an endogenous metabolite indoleacetic acid (IAA), low-toxic-side-effect intervention is achieved, systematic side effects of traditional nerve drugs are avoided, the compensatory protection effect of the IAA in DEP induced nerve injury is defined, and the application of the IAA in the DEP induced nerve injury is promoted. The application potential of an endogenous metabolite IAA as a neuroprotective agent in neurodegenerative diseases is expanded.