Pharmaceutical composition of olopatadine or salts of olopatadine, and preparation method thereof

A technology for olopatadine and composition, which is applied in the field of pharmaceutical compositions of olopatadine or its salts and its preparation field, can solve problems such as eye damage, adverse reactions of antihistamine active substances and the like, and achieve irritant Small size, long surface residence time, and improved bioavailability
CN103202833AInactive Publication Date: 2013-07-17JIANGSU YABANG AIPUSEN PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
JIANGSU YABANG AIPUSEN PHARMA
Publication Date
2013-07-17
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a pharmaceutical composition of olopatadine or salts of olopatadine for treating allergic conjunctivitis, and a preparation method thereof. The composition mainly comprises the olopatadine or the salts of the olopatadine, and polycarbophil or polycarbophil salt or carbomer. The preparation method comprises firstly fully swelling the polycarbophil or the polycarbophil salt or the carbomer with a proper amount of pure water, and secondly adding the olopatadine or the salts of the olopatadine and other accessories.
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Description

technical field

[0001] The invention relates to a pharmaceutical composition of olopatadine or a salt thereof for treating allergic conjunctivitis and a preparation method thereof Background technique

[0002] A doxepin derivative represented by olopatadine is a mast cell stabilizer with antihistamine activity. For the prevention or treatment of allergic eye disease. The marketed product Olopatadine Hydrochloride Eye Drops, the trade name is Patanol, its ingredients are mainly composed of Olopatadine Hydrochloride, bacteriostatic agent, and pH regulator. 3 to 4 times a day, once every 6 to 8 hours. Its side effects include headache, fatigue, blurred vision, burning or stinging sensation, cold syndrome, dry eyes, foreign body sensation, congestion, allergies, keratitis, eyelid edema, nausea, pharyngitis, itching, rhinitis, sinusitis, and taste perversion Wait. As conventional sterile pure aqueous eye drops, due to the existence of the corneal barrier, the inversion of tea...

Claims

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