The invention provides a method for testing the sealing integrity of a
medicine packaging container by an improved color water intrusion method, and particularly relates to the technical field of sample pretreatment of medicines. The method comprises the steps of preparing a 1%
sodium fluorescein solution, and putting the 1%
sodium fluorescein solution into a sealing cavity of a sealing tester; inverting a prepared
positive sample, submerging an inserted capillary tube by sterile
powder, keeping the capillary tube immersed in a dye solution, and tightly covering the sealing cavity; and takingout the inverted
positive sample after the invasion procedure is finished; adopting a
sodium hydroxide solution with a concentration of 1 [mu] g / mL as a
diluent; taking sterile
powder for injection, which is not subjected to capillary
insertion and color water invasion, fully redissolving the sterile
powder by using the
diluent, transferring the sterile powder into a clean
centrifuge tube, and fixing the volume to 20mL; after the invasion procedure is finished, fully redissolving each
bottle by using the
diluent, transferring into a clean
centrifuge tube, and fixing the volume to 20mL; and observing the dye invasion condition by naked eyes. According to the invention, the sensitivity of
naked eye observation and detection can be significantly improved, the specificity is high, the anti-interference ability is strong, the detection efficiency is high, and the labor cost is saved.