Gastric targeted drug carrier and preparation method thereof
The technology of a drug and a carrier is applied in the field of stomach-targeted drug carrier and its preparation, which can solve the problems such as failure to achieve drug sustained-release performance, loss of targeting effect, and inability to satisfy the stomach-targeted drug delivery carrier, etc. Biocompatibility, Stabilized Autofluorescence, Improved Embedding Rate
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Embodiment 1
[0057] Accurately weigh chitosan (molecular weight 50,000), chitosan quaternary ammonium salt (quaternary ammonium substitution degree 50%, molecular weight 50,000), sodium glycerophosphate and dissolve it in 1% acetic acid aqueous solution, and make it fully dissolve under magnetic stirring to obtain The acetic acid aqueous solution of chitosan, chitosan quaternary ammonium salt, sodium glycerophosphate, its total concentration is 2.5wt%, wherein the concentration of chitosan, chitosan quaternary ammonium salt is respectively 0.5wt%, the concentration of sodium glycerophosphate The mass ratio of chitosan and chitosan quaternary ammonium salt is 1:1, and the mass ratio of chitosan and chitosan quaternary ammonium salt to sodium glycerophosphate is 2:3. The solution was centrifuged at 8000 rpm to remove insoluble impurities, and the supernatant was retained as the aqueous phase for subsequent use. Take 400 μL of 10 mg / mL rapamycin solution O 1 (rapamycin is dissolved in chloro...
Embodiment 2
[0059] Accurately weigh chitosan (molecular weight 50,000), chitosan quaternary ammonium salt (quaternary ammonium substitution degree 50%, molecular weight 50,000), sodium glycerophosphate and dissolve it in 1% acetic acid aqueous solution, and make it fully dissolve under magnetic stirring to obtain The acetic acid aqueous solution of chitosan, chitosan quaternary ammonium salt, sodium glycerophosphate, its total concentration is 2.5wt%, wherein the concentration of chitosan, chitosan quaternary ammonium salt is respectively 0.5wt%, the concentration of sodium glycerophosphate The mass ratio of chitosan and chitosan quaternary ammonium salt is 1:1, and the mass ratio of chitosan and chitosan quaternary ammonium salt to sodium glycerophosphate is 2:3. This solution was centrifuged at 8000rpm to remove insoluble impurities, then added 20 wt% gentamicin sulfate (stomach medicine) of the total dry weight of chitosan and chitosan quaternary ammonium salt and fully dissolved for fu...
Embodiment 3
[0061] Accurately weigh chitosan (molecular weight 50,000), chitosan quaternary ammonium salt (quaternary ammonium substitution degree 70%, molecular weight 100,000), sodium glycerophosphate and dissolve it in 1% acetic acid aqueous solution, and make it fully dissolve under mechanical stirring to obtain The acetic acid aqueous solution of chitosan, chitosan quaternary ammonium salt, sodium glycerophosphate, its total concentration is 2.5wt%, wherein the concentration of chitosan, chitosan quaternary ammonium salt is respectively 0.5wt%, the concentration of sodium glycerophosphate The mass ratio of chitosan and chitosan quaternary ammonium salt is 1:1, and the mass ratio of chitosan and chitosan quaternary ammonium salt to sodium glycerophosphate is 2:3. The solution was centrifuged at 8000 rpm to remove insoluble impurities, and the supernatant was retained as the aqueous phase for subsequent use. Take 400 μL of 10 mg / mL rapamycin solution O 1 (rapamycin is dissolved in chl...
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