Gastric targeted drug carrier and preparation method thereof

The technology of a drug and a carrier is applied in the field of gastric targeted drug carrier and its preparation, which can solve the problems of losing the targeting effect, unable to satisfy the gastric targeted drug delivery carrier, unable to achieve the drug sustained-release performance, etc., and achieves stability Autofluorescence, good biocompatibility, the effect of improving the embedding rate
CN102652833AInactive Publication Date: 2012-09-05INST OF PROCESS ENG CHINESE ACAD OF SCI
2 Cites 4 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
INST OF PROCESS ENG CHINESE ACAD OF SCI
Publication Date
2012-09-05
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention relates to the field of drug carrier preparation, in particular to a gastric targeted drug carrier and a preparation method thereof. The gastric targeted drug carrier is prepared from the following raw materials: drug-containing emulsion and a crosslinking agent, wherein the drug-containing emulsion contains chitosan, chitosan quaternary ammonium salt and sodium glycerophosphate; and the crosslinking agent is used for crosslinking the emulsion into microspheres. The preparation method comprises the following steps: 1) preparing the drug-containing emulsion: with a aqueous solution of chitosan, chitosan quaternary ammonium salt and sodium glycerophosphate as an aqueous phase W, preparing the drug-containing emulsion with the aqueous phase, drugs and an oil phase containing anemulsifying agent; and 2) heating and stirring the drug-containing emulsion prepared in the step 1), crosslinking the chitosan quaternary ammonium salt and sodium glycerophosphate contained in the drug-containing emulsion to obtain gel microsphere suspension, heating the suspension and adding the crosslinking agent to carry out secondary crosslinking to solidify the gel microspheres. The drug carrier has the advantages of uniform and controllable grain size, high embedding rate and good dispersibility and simultaneously meets the requirements of the gastric targeted drug delivery carrier.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to the field of drug carrier preparation, in particular, the invention relates to a stomach-targeting drug carrier and a preparation method thereof. Background technique

[0002] Chitosan is a polysaccharide composed of glucosamine and N-acetylglucosamine copolymer, which is the product of deacetylation of chitin. Chitosan can be dissolved in dilute acid solution due to the free amino group on the molecular chain, so It has a wider range of uses than chitin. As a cationic biopolymer, chitosan has bioadhesion, biocompatibility and biodegradability, and its degradation products are non-toxic, non-immunogenic and non-carcinogenic. These unique properties of chitosan Its uniqueness makes it a biomedical carrier with broad application prospects. In the literature Chitosan-cellulose composite membrane for affinity purification of biopolymers and immunoadsorption, Journal of Membrane Science, 2002, 197: 185-197. L. Yang, W. W. Hsiao, P....

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More