Application of hollow nano-particles in preparation of medicine for treating osteoporosis

A hollow nanotechnology, therapeutic drug technology, applied in nanomedicine, drug combination, nanotechnology and other directions, can solve problems such as OP fractures that have not yet been seen, and achieve the effects of avoiding systemic side effects, improving local bone density, and improving local concentration.

Active Publication Date: 2021-04-20
THE THIRD MEDICAL CENT OF THE CHINESE PEOPLES LIBERATION ARMY GENERAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are foreign studies using ESW to mediate the release of anti-tumor drug-encapsulated nanoparticles at the therapeutic target site of tumor tissue, but there is no research on the prevention of OP fractures at home and abroad.

Method used

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  • Application of hollow nano-particles in preparation of medicine for treating osteoporosis
  • Application of hollow nano-particles in preparation of medicine for treating osteoporosis
  • Application of hollow nano-particles in preparation of medicine for treating osteoporosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Preparation of hollow nano-hydroxyapatite particles with in vitro shock wave responsive zoledronic acid as the framework component:

[0043] Required Components: Zoledronic Acid, Calcium Chloride, DOPA, OH-PEG-PA.

[0044] Preparation:

[0045] The synthesis was carried out in a 300 ml glass flask, which was washed with a small amount of glacial acetic acid, rinsed 5 times with hot tap water, 2 times with deionized water, rinsed with acetone, 5 times with hot tap water, and 5 times with deionized water , and dried in an oven at 60°C for 2 hours. Liposome templates were prepared by extruding a total of 6 mg of DOPA lipid in 6 mL of deionized water through a 100-nm PC filter at room temperature until the average size distribution as measured by dynamic light scattering (DLS) was uniform. After extrusion, allow liposomes to sit for at least 1 hour and use within 48 hours of extrusion. 100 mL of deionized water was mixed with 3 mL (24 mg) of ZOL in water and 300 μL of 1M...

Embodiment 2

[0047] Preparation of hollow nano-hydroxyapatite particles with in vitro shock wave responsive zoledronic acid as the framework component:

[0048] Required Components: Zoledronic Acid, Calcium Chloride, DOPA, OH-PEG-PA.

[0049] Preparation:

[0050] The synthesis was carried out in a 300 ml glass flask, which was washed with a small amount of glacial acetic acid, rinsed 5 times with hot tap water, 2 times with deionized water, rinsed with acetone, 5 times with hot tap water, and 5 times with deionized water , and dried in an oven at 60°C for 2 hours. Liposome templates were prepared by extruding a total of 6 mg of DOPA lipid in 6 mL of deionized water through a 100-nm PC filter at room temperature until the average size distribution as measured by dynamic light scattering (DLS) was uniform. After extrusion, allow liposomes to sit for at least 1 hour and use within 48 hours of extrusion. 100 mL of deionized water was mixed with 3 mL (24 mg) of ZOL in water and 300 μL of 1M...

Embodiment 3

[0052] Preparation of hollow nano-hydroxyapatite particles with in vitro shock wave responsive zoledronic acid as the framework component:

[0053] Required Components: Zoledronic Acid, Calcium Chloride, DOPA, OH-PEG-PA.

[0054] Preparation:

[0055] The synthesis was carried out in a 300 ml glass flask, which was washed with a small amount of glacial acetic acid, rinsed 5 times with hot tap water, 2 times with deionized water, rinsed with acetone, 5 times with hot tap water, and 5 times with deionized water , and dried in an oven at 60°C for 2 hours. Liposome templates were prepared by extruding a total of 6 mg of DOPA lipid in 6 mL of deionized water through a 100-nm PC filter at room temperature until the average size distribution as measured by dynamic light scattering (DLS) was uniform. After extrusion, allow liposomes to sit for at least 1 hour and use within 48 hours of extrusion. 100 mL of deionized water was mixed with 3 mL (24 mg) of ZOL in water and 300 μL of 1M...

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Abstract

The invention discloses application of hollow nano-particles in preparation of a medicine for treating osteoporosis, and belongs to the technical field of medical medicine preparation. Firstly, the invention provides the application of the hollow nano-particles which take extracorporeal shock wave response type zoledronic acid as a skeleton ingredient in the preparation of the medicine for treating the osteoporosis. Secondly, the invention provides the application of the hollow nano-particles which take zoledronic acid and / or a composition containing the zoledronic acid as the skeleton ingredient in the preparation of the medicine for treating the osteoporosis, in the application, an extracorporeal shock wave is adopted to carry out intervention on the hollow nano-particles, and specifically, the extracorporeal shock wave is used for carrying out local in-situ breaking on the hollow nano-particles so as to perform an obvious osteoporosis treatment effect. The shell thickness of a hollow nano-hydroxyapatite particle is controlled, the responsiveness of the extracorporeal shock wave of the particle can be enhanced, local release control is realized, the particles can be broken in a specific bone zone, local bone density is improved, and an osteoporosis treatment purpose is performed.

Description

technical field [0001] The invention belongs to the technical field of medical drug preparation, and in particular relates to the application of an extracorporeal shock wave as an intervention method in the preparation of drugs for the treatment of osteoporosis by locally crushing hollow nanoparticles in situ. Background technique [0002] Osteoporotic fractures are fragility fractures caused by low-energy or non-violent factors. They are a serious consequence of osteoporosis (OP) and are extremely harmful. They are one of the main causes of disability and death in middle-aged and elderly patients. Therefore, how to prevent OP fractures is not only a medical problem to be solved urgently, but also one of the serious social problems. [0003] Thankfully, pharmacological interventions for OP have advanced rapidly and dramatically over the past half century. Current clinical treatments for OP mainly include estrogens, bisphosphonates and selective estrogen receptor modulators....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/675A61K41/00A61K47/02A61P19/10B82Y5/00B82Y40/00
Inventor 邢更彦梁豪君陈奎邢更妹
Owner THE THIRD MEDICAL CENT OF THE CHINESE PEOPLES LIBERATION ARMY GENERAL HOSPITAL
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