Magnetic resonance imaging detectable liquid embolism composition and preparation and application thereof

Abstract

The invention discloses a magnetic resonance imaging (MRI) detectable liquid embolism composition which comprises the following components: an MRI water-soluble or water-insoluble contrast medium, an embolism material, a physiological acceptable water-soluble organic solvent and water. The following components can be added according to the treatment goal and the clinical demand: an X ray-impermeable water-soluble or water-insoluble contrast medium and/or drugs. The MRI detectable liquid embolism composition disclosed by the invention has the characteristics of low viscosity, no toxicity, low cost and fast curing, can be injected, and is mainly used in local embolism treatment and relevant imageological examination of tumors, vascular malformation and hemostasis.

Description

technical field [0001] The invention relates to a magnetic resonance imaging-detectable liquid embolism composition used in the field of medical interventional therapy, which is mainly used for embolization therapy of vascular malformation, hemangioma, liver cancer, kidney cancer and lung cancer. Background technique [0002] Interventional therapy was developed in the 1970s. It is an interdisciplinary subject that combines medical imaging and clinical therapy. It has the characteristics of minimally invasive, fast recovery, and good curative effect. It has opened up new possibilities for previously incurable or intractable diseases. way of treatment. At present, it has become the three most important therapeutic disciplines along with internal medicine and surgery. Interventional embolization therapy is an important part of interventional therapy. With the guidance of imaging equipment, the doctor injects embolic material through a precise catheter and blocks local blood v...

AI Technical Summary

Problems solved by technology

However, the above embolic materials all have certain defects: that is, they cannot be directly detected by existing clinical detection methods.

Incomplete embolization will lead to persistence or recurrence of symptoms, and excessive injection of embolic agents may cause ectopic embolization, resulting in damage to normal tissues

However, the current clinical method of detecting the blood flow of the embolized vessel by DSA to judge the end point of embolism is not very accurate, and there will be certain errors.

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