Benzydamine Hcl soluble tablet and method for preparing the same

A technology of benzydamine hydrochloride and soluble tablet, applied in the field of medicine, achieves the effects of being convenient to carry, easy to operate, and shortening the disintegration time

Active Publication Date: 2011-06-01
CHONGQING SUCCEWAY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As a treatment for bacterial vaginosis, there is no clinical research report in China

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0105] Embodiment 1: a kind of benzydamine hydrochloride soluble tablet, it is composed of: benzydamine hydrochloride 250g, sodium chloride 100g, croscarmellose sodium 25g, leucine 40g, sodium lauryl sulfate 5g, Concentration is 30ml of 80% ethanol aqueous solution.

[0106] Preparation method: follow the steps below:

[0107] a) According to the above ratio, prepare benzydamine hydrochloride with 80% ethanol aqueous solution as a soft material, pass through a 20-mesh sieve to granulate, and ventilate and dry at 60-70° C. for 1 hour;

[0108] b) Pass the above-mentioned dried granules through a 30-mesh sieve for granulation, then add sodium chloride, croscarmellose sodium, sodium lauryl sulfate, and leucine in the above-mentioned proportions in sequence, and mix well;

[0109] c), measure the content of the above-mentioned mixture, calculate the weight of the tablet, and compress the tablet to obtain a finished product;

Embodiment 2

[0110] Embodiment 2: a kind of benzydamine hydrochloride soluble tablet, it is composed of: benzydamine hydrochloride 250g, sodium chloride 80g, croscarmellose sodium 30g, leucine 20g, concentration is 80% ethanol aqueous solution 40ml .

[0111]The preparation method is the same as in Example 1.

Embodiment 3

[0112] Embodiment 3: a kind of benzydamine hydrochloride soluble tablet, it is composed of: 250g of benzydamine hydrochloride, 150g of microcrystalline cellulose, 25g of sodium carboxymethylcellulose, 50g of leucine, 25ml of 80% ethanol aqueous solution.

[0113] The preparation method is the same as in Example 1.

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PUM

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Abstract

The invention provides a benzydamine hydrochloride soluble tablet, which is characterized in that: the benzydamine hydrochloride soluble tablet comprises effective dose of benzydamine hydrochloride and a filling agent, a disintegrating agent, a lubricant and a wetting agent in right amounts. The product of the invention used for the treatment of bacterial vaginosis has the effects of quick dissolution, quick release, high efficiency and safety. A preparation method of the benzydamine hydrochloride soluble tablet is also provided in the invention.

Description

technical field [0001] The invention relates to a benzydamine hydrochloride soluble tablet and a preparation method thereof, belonging to the field of medicine. Background technique [0002] Benzydamine hydrochloride is an antipyretic and analgesic drug, which has been used for many years at home and abroad. Ordinary tablets have been on the market in China, mainly for oral administration, and are mainly used for analgesia and anti-inflammation clinically. As a treatment for bacterial vaginosis, there is no clinical research report in China. Contents of the invention [0003] The object of the present invention is to provide a benzydamine hydrochloride soluble tablet that has good curative effect for external use in the treatment of bacterial vaginosis, is convenient for patients to use, has stable quality, and can ensure drug safety. [0004] Another object of the present invention is to provide a method for preparing the dissolvable tablet. [0005] The object of the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/416A61K9/20A61K47/02A61K47/16A61K47/26A61K47/32A61K47/36A61K47/38A61P15/02A61P31/04
Inventor 王建标汪渡方霜胡显刚银媛王怡
Owner CHONGQING SUCCEWAY PHARMA
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