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Composition containing 3-methyl-1-phenyl-2-pyrazoline-5-ketone

A technology of composition and pyrazoline, which is applied in the direction of active ingredients of hydroxyl compounds, medical preparations containing active ingredients, drug combinations, etc., can solve problems such as unknown degree, and achieve the effect of reducing toxicity and increasing drug efficacy

Inactive Publication Date: 2009-09-09
JIANGSU SIMCERE PHARMACEUTICAL R & D CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, studies have found that it has certain side effects, such as acute renal failure of unknown degree, abnormal liver function, low platelet splash and disseminated intravascular coagulation and other adverse reactions

Method used

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  • Composition containing 3-methyl-1-phenyl-2-pyrazoline-5-ketone

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Get edaravone 2g, add in the propylene glycol solution of 200g, stir to make it dissolve completely, slowly add water for injection to make it dissolve and reach 1000ml, to obtain final product.

Embodiment 2

[0020] Take 2g of synthetic borneol, add to 200g of propylene glycol solution, stir to dissolve completely, slowly add water for injection to dissolve to 1000ml, to obtain.

Embodiment 3

[0022] Take 2g of natural borneol, add to 200g of propylene glycol solution, stir to dissolve completely, slowly add water for injection to dissolve to 1000ml, to obtain.

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Abstract

The invention relates to a composition comprising 3-methyl-1-phenyl-2-pyrazoline-5-ketone and borneol, and application thereof in preparing a medicine for treating cerebrovascular diseases, particularly ischemic cerebrovascular diseases. The typical ischemic cerebrovascular disease is cerebral infarction.

Description

technical field [0001] The invention relates to a composition containing 3-methyl-1-phenyl-2-pyrazolin-5-one and borneol, and their preparation for treating cerebrovascular diseases, especially ischemic cerebrovascular diseases in the application. Background technique [0002] Cerebrovascular disease is a group of diseases that seriously endanger human health, and has become one of the important causes of human disability and death. [0003] Cerebrovascular disease (CVD) refers to brain lesions caused by abnormalities in cerebral blood vessels. Stroke generally refers to acute cerebrovascular disease. [0004] Cerebrovascular diseases can be simply divided into two categories, one is ischemic cerebrovascular disease caused by the reduction or interruption of blood flow, and the other is hemorrhagic cerebrovascular disease caused by rupture of blood vessels. Ischemic cerebrovascular disease is mainly cerebral infarction (including cerebral thrombosis and cerebral embolism)...

Claims

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Application Information

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IPC IPC(8): A61K31/4152A61K31/045A61P9/10A61P9/00
CPCA61K31/045C07D231/22A61K31/4152A61P43/00A61P9/00A61P9/10
Inventor 殷晓进杨士豹李晓强江征和健张安元黄鑫
Owner JIANGSU SIMCERE PHARMACEUTICAL R & D CO LTD