Application of bufotalin std. in preparing medicament for treating lung tumors
A technology of bufatalin and tumor drug, which is applied to the application field of bufatalin in the preparation of drugs for treating lung tumors
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Embodiment 1
[0020] Separation and purification of the compound bufotolin
[0021] Crush the toad venom medicinal material into fine particles with a pulverizer, weigh 300g and place it in a 5L round bottom flask, add 3L of ethanol with a volume concentration of 95%, heat and reflux in a water bath for 6 hours, and filter the extract; The concentration is 95% ethanol and the same operation as above, a total of 3 extractions, all the filtrates are combined, and when concentrated in a water bath at 55°C to 250ml, transfer to a large pear-shaped bottle, add 500ml of pure water, add 500ml of chloroform, shake the cap and ultrasonic After 2h, let stand overnight to separate the layers, and separate the chloroform layer; add chloroform to the remaining water layer and perform the same operation as above, and extract several times in total. All the chloroform layers were combined and concentrated to dryness under reduced pressure to obtain a solid.
[0022] Take the chloroform extract, dissolve ...
Embodiment 2
[0024] Preparation of Bufatalin Injection:
[0025] Formula: (by weight ratio)
[0026] 1-10 copies of bufotolin,
[0027] Pharmaceutical grade ethanol 5-100 parts
[0028] Cremophor EL 5~100 parts.
[0029] Vitamin C 0.001~2 parts.
[0030] It is prepared as an injection by a known method.
Embodiment 3
[0032] Tablet: (by weight ratio)
[0033] 1-10 copies of bufotoxin
[0034] Starch 5-100 parts
[0035] Hypromellose 0.1-10 parts
[0036] Micropowder silica gel 0.01-0.5 part
[0037] Magnesium stearate 0.01-0.5 parts
[0038] Tablets are prepared by known methods.
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