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Application of bufotalin std. in preparing medicament for treating lung tumors
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A technology of bufatalin and tumor drug, which is applied to the application field of bufatalin in the preparation of drugs for treating lung tumors
Inactive Publication Date: 2011-11-16
SHANGHAI MODERN PHARMA ENG INVESTIGATION CENT
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Abstract
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[0008] The therapeutic effect, toxicity and patient tolerance of existing chemotherapeutic drugs place great expectations on the emergence of new chemotherapeutic drugs
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Embodiment 1
[0020] Separation and purification of the compound bufotolin
[0021] Crush the toad venom medicinal material into fine particles with a pulverizer, weigh 300g and place it in a 5L round bottom flask, add 3L of ethanol with a volume concentration of 95%, heat and reflux in a water bath for 6 hours, and filter the extract; The concentration is 95% ethanol and the same operation as above, a total of 3 extractions, all the filtrates are combined, and when concentrated in a water bath at 55°C to 250ml, transfer to a large pear-shaped bottle, add 500ml of pure water, add 500ml of chloroform, shake the cap and ultrasonic After 2h, let stand overnight to separate the layers, and separate the chloroform layer; add chloroform to the remaining water layer and perform the same operation as above, and extract several times in total. All the chloroform layers were combined and concentrated to dryness under reduced pressure to obtain a solid.
[0022] Take the chloroform extract, dissolve ...
Embodiment 2
[0024] Preparation of Bufatalin Injection:
[0025] Formula: (by weight ratio)
[0026] 1-10 copies of bufotolin,
[0027] Pharmaceutical grade ethanol 5-100 parts
[0028] Cremophor EL 5~100 parts.
[0029] Vitamin C 0.001~2 parts.
[0030] It is prepared as an injection by a known method.
Embodiment 3
[0032] Tablet: (by weight ratio)
[0033] 1-10 copies of bufotoxin
[0034] Starch 5-100 parts
[0035] Hypromellose 0.1-10 parts
[0036] Micropowder silica gel 0.01-0.5 part
[0037] Magnesium stearate 0.01-0.5 parts
[0038] Tablets are prepared by known methods.
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Abstract
The invention discloses an application of bufotalin std. in preparing a medicament for treating lung tumors. Proved by in vitro anti-tumor experiments of the bufotalin std., the concentration of medicaments of the animal lungs is higher than the concentration of effecting medicaments, and the bufotalin std. has stronger activity inhibition effect on human non-small cell lung cancer and other lungtumor cell stains, wherein the IC50 is 15-200ng / ml, and the bufotalin std. has good dose-response relationship. Shown as experimental results, the tumor growth inhibition effect of the bufotalin std.is superior to that of medicaments clinically applied at present, and the bufotalin std. has great development and application prospects.
Description
technical field [0001] The present invention relates to a new application of bufatolin, in particular to the application of bufatolin and its composition in the preparation of medicines for treating lung tumors. Background technique [0002] Lung cancer is the most common primary malignant tumor of the lung. The vast majority of lung cancers originate from the bronchial mucosal epithelium, so it is also called bronchial lung cancer. Over the past 50 years, the morbidity and mortality of lung cancer have risen rapidly in countries all over the world, especially in industrialized countries, and lung cancer has ranked first among male patients who died of cancer. [0003] In the late stage of lung cancer, metastases to different organs can occur, which can cause corresponding symptoms, often bring great pain to patients, and even threaten their lives. The most common clinical metastasis of lung cancer is the brain, bone, liver, kidney and adrenal gland. [0004] There are two...
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Application Information
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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/585A61P35/00
Inventor 侯惠民于垂亮
Owner SHANGHAI MODERN PHARMA ENG INVESTIGATION CENT
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