Application of pollen pini and extract thereof in treating inflammatory bowel disease and method for preparing extract

Abstract

The invention discloses application of pollen pini, a pollen pini extract and a medicinal composition comprising the pollen pini extract in treating the inflammatory bowel disease and a method for preparing the medicinal composition comprising the pollen pini extract. In the preparation method, the pollen pini is extracted by using water, alcohol or a mixture of water and alcohol. Preferably, thealcohol comprises methanol and ethanol, and the concentration of the alcohol is preferably between 40 and 99 percent, and is further preferably 80 percent. During extraction, solvent amount is 5 to 15 times (volume / weight, ml / g) of the weight of an original medicament, and is preferably 10 times in volume. An extraction temperature is between room temperature (such as 20 DEG C) and a solvent reflux temperature, and is preferably a reflux temperature. The extraction can be repeated for 1 to 4 times, each time for 0.5 to 2 hours, preferably for 1 hour. After a previous step is completed, filtrate is combined, dregs of a decoction are filtered and concentrating under reduced pressure, evaporating to dryness or spray drying processes are performed to obtain the pollen pini extract.

Description

technical field [0001] The present invention relates to the field of medical applications, in particular to the use of pine pollen, pine pollen extract and a pharmaceutical composition comprising the pine pollen extract in the treatment of inflammatory bowel disease and the preparation of the pharmaceutical composition comprising the pine pollen extract method. Background technique [0002] Inflammatory bowel disease (IBD) is a group of chronic intestinal inflammatory diseases of unknown etiology, including ulcerative colitis (UC) and Crohn's disease (CD). In recent years, the incidence of IBD at home and abroad is on the rise. Its etiology and pathogenesis are caused by many factors, that is, on the basis of genetic material, due to antigen stimulation and activation of the immune system in the body, various environmental factors interact. Chronic intestinal inflammation. At present, the exact etiology and pathogenesis are still not very clear, and the complexity of its p...

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