Indometacin and albuterol suppository, preparation method, detection method and application thereof

A technology of indomethacin and salbutamol, which is applied in the direction of suppository delivery, anti-inflammatory agents, measuring devices, etc. It can solve the problems of sedimentation stratification, influence on curative effect and safe medication, patient discomfort, etc., and achieve the effect of ensuring safety
CN102670593BActive Publication Date: 2013-11-20LIVZON GROUP LIVZON PHARMA FACTORY +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
LIVZON GROUP LIVZON PHARMA FACTORY
Publication Date
2013-11-20

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Abstract

The invention provides an indometacin and albuterol suppository and a preparation method of the suppository; the suppository comprises effective dose of indometacin, effective dose of albuterol, a dispersing agent, emulsifier and a molding agent. The preparation method comprises the steps of dissolving the indometacin and the albuterol in the dispersing agent, then mixing with the molten molding agent and the emulsifier, and homogenizing to obtain the suppository. The suppository provided by the invention is featured with smooth production and uniform quality; and auxiliary materials do not influence content detection; wherein content detection recovery rate of the albuterol reaches 97%, and content uniformity A+1.8S is less than 10, and is superior to a requirement that content uniformity A+1.8S of a suppository is less than 25 (Department 2 of Chinese Pharmacopoeia 2005 edition, Page 75 of Appendix XE); and layering and precipitation do not appear after the suppository is subjected to a challenge test at 45 degrees centigrade for 72 hr.
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Description

technical field

[0001] The invention relates to an indomethacin salbutamol suppository, its preparation method, detection method and application. Background technique

[0002] Indomethacin salbutamol suppository has a significant curative effect on both primary dysmenorrhea and secondary dysmenorrhea; it also has outstanding curative effect on pain caused by abortion, post-operation, and urinary stones. Before 2002, the conventional prescription was produced with a mixture of PEG (polyethylene glycol) 400-PEG6000 as the matrix. Indomethacin and salbutamol were well dissolved and dispersed in the matrix, but PEG400-PEG6000 matrix had a strong dehydration effect And mucous membrane irritation, rectal or cavity administration brings discomfort to patients, and the incidence of side effects is high. In 2003, with the renewal of the document number and the completion of the national standard upgrade, the new national standard requires the use of "fatty matrix" based on mixed fat...

Claims

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