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Preparation method of radix arnebiae seu lithospermi phenolic acids, adjuvant resistant to early pregnancy

A technology of shikonolic acid and auxiliary drugs, which can be applied to pharmaceutical formulations, medical preparations containing active ingredients, and drug combinations, etc., can solve the problems of difficult preparation process, difficulty in research and development of new drugs, and difficulty.

Inactive Publication Date: 2015-04-01
武汉康鸿达科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, according to the requirements for the application of the new preparations of the 5 types of traditional Chinese medicines, the content of the effective parts must reach more than 50%. As far as Xinjiang Zicao is concerned, the total phenolic acid content must reach more than 50%. The preparation process is difficult, and the pharmacodynamic experiment is also difficult. , it is very difficult to complete the research and development of new drugs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A preparation method of anti-early pregnancy auxiliary drug shikonolic acid is prepared according to the following steps:

[0031] ①After crushing 10 kg of comfrey, 100 kg of water was extracted twice, the water was ordinary pure water, and the extraction time was 1.5 hours. The extract was concentrated under reduced pressure, and the filtrate was concentrated to a relative density of 1.22 (measured at 40 °C) ;

[0032] 2. Wash the super-macroporous resin of the concentrated solution in step 1 with 10 kg of 10% ethanol until it is colorless, and use 20 kg of 40% ethanol to elute, collect, and continue to concentrate until the relative density is 1.18 (measured at 40 °C);

[0033] ③ The concentrate of step ② was washed with 12 kg of MCI gel CHP 20P column distilled water until the compound rabdosiin dipotassium salt appeared, and then eluted with 15 kg of 30% ethanol, and the fraction containing the compound rabdosiin dipotassium salt was collected and washed with 30% et...

Embodiment 2

[0037] A preparation method of anti-early pregnancy auxiliary drug shikonolic acid is prepared according to the following steps:

[0038] ① After crushing 10 kg of comfrey, 100 kg of water was extracted twice, the water was ordinary pure water, and the extraction time was 1.5 hours. The extract was concentrated under reduced pressure, and the filtrate was concentrated to a relative density of 1.23 (measured at 40 °C) ;

[0039] 2. Wash the super-macroporous resin of the concentrated solution in step ① with 10 kg of 10% ethanol until it is colorless, elute with 20 kg of 40% ethanol, collect, and continue to concentrate until the relative density is 1.21 (measured at 40 °C);

[0040]③ The concentrate of step ② was washed with 12 kg of MCI gel CHP 20P column distilled water until the compound rabdosiin dipotassium salt appeared, and then eluted with 15 kg of 30% ethanol, and the fraction containing the compound rabdosiin dipotassium salt was collected and washed with 30% ethanol....

Embodiment 3

[0044] A preparation method of anti-early pregnancy auxiliary drug shikonolic acid is prepared according to the following steps:

[0045] ① After crushing 10 kg of comfrey, 100 kg of water was extracted twice, the water was ordinary pure water, and the extraction time was 1.5 hours. The extract was concentrated under reduced pressure, and the filtrate was concentrated to a relative density of 1.25 (measured at 40 °C) ;

[0046] 2. Wash the super-macroporous resin of the concentrated solution in step 1 with 10 kg of 10% ethanol until it is colorless, elute with 20 kg of 40% ethanol, collect, and continue to concentrate until the relative density is 1.23 (measured at 40 °C);

[0047] ③ The concentrate of step ② was washed with 12 kg of MCI gel CHP 20P column distilled water until the compound rabdosiin dipotassium salt appeared, and then eluted with 15 kg of 30% ethanol, and the fraction containing the compound rabdosiin dipotassium salt was collected and washed with 30% ethanol...

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PUM

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Abstract

The invention discloses a preparation method of lithospermum phenolic acids, adjuvant resistant to early pregnancy. The method comprises the steps of smashing natural lithospermum, extracting for two times (1.5 hours for each time) through water, concentrating extracted solution in decompression mode, enabling the extracted solution to go through macroporous resin, washing the extracted solution with ethanol to be colorless, eluting with the ethanol, collecting, continuously concentrating, washing concentrate in MCI gel CHP20P column stilled water until occurrence of chemical compound dipotassium salt, eluting with the ethanol, collecting the chemical compound dipotassium salt and 30% ethanol eluting part, and obtaining eluant of lithospermum phenolic acids effective parts. The lithospermum phenolic acids made in the preparation method can directly kill chorionic villus cells, obviously enhances contractility of ingravidation uterus muscles, improves complete abortion rates of mifepristone, and is effective adjuvant resistant to early pregnancy.

Description

technical field [0001] The invention relates to the technical field of pharmacy, in particular to a preparation method of an anti-early pregnancy auxiliary drug shikonolic acid. Background technique [0002] According to WHO statistics, more than 50 million women in the world undergo pregnancy termination operations every year, and 200,000 of the 500,000 maternal deaths per year die from complications of abortion. More than 10 million women in China undergo legal abortions every year. In order to eliminate the harm of surgical abortion, medical abortion has gradually emerged in recent years. Among them, mifepristone combined with misoprostol medical abortion has become the main clinical anti-early pregnancy method because of its safety and effectiveness. However, there are still obvious deficiencies in medical abortion. The incomplete abortion rate is as high as 5-9%. Due to the residual villi in the uterus, the uterine bleeding time is longer and the bleeding volume is lar...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/30A61P15/04
Inventor 廖矛川王丽君廖元
Owner 武汉康鸿达科技股份有限公司
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