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Polymorphic sites of obsessive-compulsive disorder related gene GalR1 (Galanin Receptor 1) and application thereof

A locus and gene technology, applying situ gene mutation, GalR1 gene single nucleotide polymorphism in the field of diagnosis of obsessive-compulsive disorder, can solve the report that there is no correlation between GalR1 gene polymorphism site and obsessive-compulsive disorder, No research report on GalR1 gene and obsessive-compulsive disorder

Inactive Publication Date: 2013-06-26
QINGDAO UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] After searching the domestic and foreign literature of the prior art, there has been no research report on the relationship between GalR1 gene and obsessive-compulsive disorder, and there is no report on the correlation between GalR1 gene polymorphism site and obsessive-compulsive disorder

Method used

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  • Polymorphic sites of obsessive-compulsive disorder related gene GalR1 (Galanin Receptor 1) and application thereof
  • Polymorphic sites of obsessive-compulsive disorder related gene GalR1 (Galanin Receptor 1) and application thereof
  • Polymorphic sites of obsessive-compulsive disorder related gene GalR1 (Galanin Receptor 1) and application thereof

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[0019] Below in conjunction with specific embodiment, to further illustrate the present invention. It should be understood that the following examples are only used to illustrate the present invention and are not intended to limit the scope of the present invention. After reading the following contents of the present invention, those skilled in the art can make various changes or modifications to the present invention, but the changes or modifications Equivalents also fall within the scope of the invention.

[0020] 1. Technical route

[0021] (1) In the present embodiment, at first carry out the collection of sample and genomic DNA extraction:

[0022] A total of 224 patients with sporadic obsessive-compulsive disorder were collected from Qingdao, Shandong, with an average age of 29.36±14.67 years (standard deviation), 85 of whom were female; all patients met the DSM-IV (diagnostic and statistical manual of mental disorders, fourth edition) diagnostic criteria, each patient...

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Abstract

The invention discloses a detection method of mononucleotide polymorphic sites of an obsessive-compulsive disorder related gene GalR1 (Galanin Receptor 1) and an application thereof in the aspect of diagnosing obsessive-compulsive disorders. According to the invention, the mononucleotide polymorphic sites of the GalR1 gene comprise rs1944545 as a G allelic site, a C allelic site on a DNA (Deoxyribonucleic Acid) complementary chain, and haplotype AACTTG composed of SNP (Single Nucleotide Polymorphism) sites on the gene consisting of rs4621062, rs11662010, rs5373, rs5374, rs4890921 and rs1944545. By utilizing the obsessive-compulsive disorder related gene and nucleotide sequences of the polymorphic sites of the obsessive-compulsive disorder related gene disclosed by the invention, a kit for carrying out genetic diagnosis on obsessive-compulsive disorders is established; and the kit can be applicable to auxiliary diagnosis of obsessive-compulsive disorders and judgment whether individuals have susceptibility of obsessive-compulsive disorders and is beneficial to prevention, early diagnosis and treatment of diseases and development of new drugs.

Description

technical field [0001] The invention belongs to the gene field of biotechnology. Specifically, the invention relates to a gene GalR1 related to obsessive-compulsive disorder and its polymorphic site. The invention also relates to a method for analyzing the allelic mutation of the GalR1 gene, and the Use of genetic single nucleotide polymorphisms in the diagnosis of obsessive-compulsive disorder. Background technique [0002] Obsessive-compulsive disorder is a common mental illness with a prevalence rate of 1.8-3.0% in the population. The main clinical manifestations of the patient are obsessive thoughts or compulsive behaviors, which cause significant distress to the patient, and spend a lot of time (more than 1 hour per day), or seriously interfere with the patient's daily life, occupational (study) function , social activities or relationships. According to the data released by the World Health Organization, the disability rate of obsessive-compulsive disorder ranks amon...

Claims

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Application Information

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IPC IPC(8): C12N15/12C12Q1/68C12N15/11
Inventor 张心华于春燕段妮
Owner QINGDAO UNIV
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