Method for processing genomic data

A genome and genome sequence technology, applied in the field of gene expression data, which can solve problems such as improving the possibility of diagnosis and hindering the possibility of diagnosis by professionals

Inactive Publication Date: 2013-09-25
KONINKLIJKE PHILIPS ELECTRONICS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this context, most genome sequence data obtained during whole genome sequencing rounds will hamper, rather than improve, the professional's diagnostic possibilities.

Method used

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  • Method for processing genomic data
  • Method for processing genomic data
  • Method for processing genomic data

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Embodiment Construction

[0034] The inventors of the present invention have developed mechanisms and methods that allow reducing the complexity and / or amount of the genomic sequence of a subject and allowing it to be stored in a form that enables rapid retrieval.

[0035] While the invention will be described with respect to particular embodiments, this description should not be construed in a limiting sense.

[0036] Before describing the exemplary embodiments of the present invention in detail, definitions important for understanding the present invention will be given.

[0037] As used in this specification and the appended claims, the article "a" and "a" in the singular also include the corresponding plural unless the context clearly dictates otherwise.

[0038] In the context of the present invention, the words "about" and "approximately" denote an interval of accuracy that a person skilled in the art will understand and still ensure the technical effect of the feature in question. The words gen...

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Abstract

The present invention relates to a method for processing a subject's genomic data comprising (a) obtaining a subject's genomic sequence; (b) reducing the complexity and / or amount of the genomic sequence information; and (c) storing the genomic sequence information of step (b) in a rapidly retrievable form. The present invention further relates to a method wherein the step of reducing the complexity and / or amount of the genomic sequence information is carried out by cropping said genomic sequence information except for signature data pertaining to a disease or disorder, or by aligning a subject's genomic sequence with a reference sequence comprising signature data pertaining to a disease or disorder. Furthermore, the invention relates to a method wherein the use of a subject's functional genetic information, in particular gene expression data is included, as well as to a method, wherein the information is encoded in matrices and decoded and represented based on Markov chain processes. The obtained information can also be used for diagnosing, detecting, monitoring or prognosticating a disease and / or for the preparation of a subject's molecular history. In addition, a corresponding clinical decision support and storage system, preferably in the form of an electronic picture / data archiving and communication system, is provided.

Description

technical field [0001] The present invention relates to a method of processing a subject's genomic data, comprising (a) obtaining a subject's genome sequence; (b) reducing the complexity and / or amount of genome sequence information; and (c) enabling rapid retrieval The genome sequence information of step (b) is stored in the form of . The present invention also relates to a method wherein, by clipping the genome sequence information in addition to the characteristic data associated with the disease or disorder, or by combining the subject's genome sequence with a reference including characteristic data associated with the disease or disorder Sequence alignment, to perform steps to reduce the complexity and / or amount of genomic sequence information. Furthermore, the present invention relates to a method comprising the use of functional genetic information of a subject, especially gene expression data; and a method wherein the information is encoded into a matrix based on a Mar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06F19/22G16B20/20G16B20/10G16B20/40G16B30/10
CPCG16B30/00G16B20/00G16B30/10G16B20/40G16B20/10G16B20/20
Inventor V·V·马卡帕蒂N·迪米特罗娃R·辛格S·K·亚格兰
Owner KONINKLIJKE PHILIPS ELECTRONICS NV
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