Preparation method of Shuangjiang stomachache tablet and application of Shuangjiang stomachache tablet in preparing drugs for inhibiting mouse anus sarcoma cell S-180 from cell proliferation

A technology of double ginger Weitong and turmeric, applied in the preparation of drugs for inhibiting the proliferation of mouse anal sarcoma cell S-180 cells, the field of preparation of Shuangjiang Weitong Tablets, which can solve the problems of many impurities, backwardness, and large dosage for patients

Inactive Publication Date: 2014-05-07
JINAN XINQIDIAN MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the extraction and preparation of Shuangjiang Weitong Tablets using microwave technology and macroporous resin adsorption technology. However, traditional Chinese medicine is directly powdered and extracted. The process is rough and backward, and there are many impurities, which leads to excessive dosage for patients and is inconvenient. Taking it seriously affects the clinical application of this product

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Take 200g of turmeric, 200g of purple ginger, 200g of Dirong, 200g of Shichangpu, and 200g of bitter rapeseed, crush the five medicinal materials, add 5L of 70% ethanol, and put it into a microwave extraction device for microwave extraction. The extraction power is 700W, and the extraction is performed twice. Each time for 8 minutes, the extracts were combined, concentrated, added to a Diaion HP-10 macroporous adsorption resin column, eluted with 70% ethanol, collected 5 times the column volume eluate, recovered ethanol under reduced pressure, concentrated and dried to obtain Microwave extract, mix the microwave extract with starch and 70% ethanol to make granules, dry, and compress into 500 tablets, each weighing 0.3g.

[0022] After testing, the content of curcumin in the finished product is 5.92mg / tablet.

Embodiment 2

[0024] Take 200g of turmeric, 200g of purple ginger, 200g of Dirong, 200g of Shichangpu, and 200g of bitter rapeseed, crush the five medicinal materials, add 5L of 70% ethanol, and put it into a microwave extraction device for microwave extraction. The extraction power is 600W, and the extraction is performed twice. The extracts were combined for 5 minutes each time, concentrated, added to a Diaion HP-10 macroporous adsorption resin column, eluted with 70% ethanol, collected 5 times the column volume eluate, recovered ethanol under reduced pressure, concentrated and dried to obtain Microwave extract, mix the microwave extract with starch and 70% ethanol to make granules, dry, and compress into 500 tablets, each weighing 0.3g.

[0025] After testing, the content of curcumin in the finished product is 3.66mg / tablet.

Embodiment 3

[0027] Take 200g of turmeric, 200g of purple ginger, 200g of Dirong, 200g of Shichangpu, and 200g of bitter rapeseed, crush the five herbs, add 5L of 70% ethanol, and put them into a microwave extraction device for microwave extraction. , extraction power 800W, extraction 2 times, 10 minutes each time, combined extracts, concentrated, added to Diaion HP-10 macroporous adsorption resin column, eluted with 70% ethanol, collected 5 times of column volume eluate, reduced The ethanol was recovered by pressure, concentrated and dried to obtain the microwave extract, which was mixed with starch and 70% ethanol to make granules, dried, and pressed into tablets to make 500 tablets, each weighing 0.3g.

[0028] After testing, the content of curcumin in the finished product is 4.58mg / tablet.

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PUM

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Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly provides a preparation method and application of a Shuangjiang stomachache tablet. The preparation method comprises the following steps: by using 200g of curcuma, 200g of Zingiber purpureum Rosc., 200g of delavay stephania root, 200g of Japanese sweetflag and 200g of semen integrifoliae as active pharmaceutical ingredients, carrying out microwave extraction and macroporous resin adsorption so that the curcumin content is greatly enhanced. The invention also provides application of the Shuangjiang stomachache tablet in preparing drugs for inhibiting mouse anus sarcoma cell S-180 from cell proliferation.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a preparation method of Shuangjiang Weitong Tablet and its application in the preparation of a medicine for inhibiting the proliferation of mouse anal sarcoma cell S-180 cells. Background technique [0002] The standard number of Shuangjiang Weitong Pills is WS-11105 (ZD-1105)-2002, which is recorded in the Spleen and Stomach Subvolume of the National Compilation of Chinese Patent Medicine Standards. It is made of 200g of turmeric, 200g of purple ginger, 200g of dirong, 200g of Shichangpu, and 200g of bitter rapeseed as raw materials. It has the effects of regulating qi and relieving pain, and regulating the stomach. It is used for patients with epigastric fullness and pain caused by qi stagnation in the middle energizer, belching and acid regurgitation, and chronic superficial gastritis with the above syndromes. [0003] In the prior art, there ...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): A61K36/9068A61K9/20A61P35/00
Inventor孙波
OwnerJINAN XINQIDIAN MEDICAL TECH