A method and system for genetic principal component analysis of non-European and East Asian populations on individuals of unknown origin

A technology of population genetics and principal component analysis, which is applied in biochemical equipment and methods, microbiological determination/inspection, DNA/RNA fragments, etc. It can solve the problems that are difficult to popularize and use, and difficult to build a complex amplification detection system.

Active Publication Date: 2016-06-22
INST OF FORENSIC SCI OF MIN OF PUBLIC SECURITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, due to the large number of sites contained in the existing AIMs site combinations, it is not easy to construct a multiplex amplification detection system, and due to the limitation of the SNP detection platform, it is difficult to popularize these established detection systems

Method used

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  • A method and system for genetic principal component analysis of non-European and East Asian populations on individuals of unknown origin
  • A method and system for genetic principal component analysis of non-European and East Asian populations on individuals of unknown origin
  • A method and system for genetic principal component analysis of non-European and East Asian populations on individuals of unknown origin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Example 1 Using the method and system of the present invention for conducting genetic principal component analysis of non-European and East Asian populations on individuals of unknown origin to infer the origin of individuals of unknown origin

[0051] figure 1 For the 27 SNP sites in the scheme of this application, STRUCTURE software was used to analyze the results of the group composition of 14 populations STRUCTURE (K=3). figure 1 The results show that this group of loci can effectively distinguish the genetic principal components of the three major populations of Africa, Europe, and East Asia and their mixed populations.

[0052] The method and system of the present invention were used to infer the origin of the individuals in Case 1 and Case 2. The skeletal remains found in case 1 in Northeast China, (the skeletal fragments in case 1 have been handed over to the U.S., and the identity has been confirmed as the U.S. Air Force pilot who fell 56 years ago, and the ...

Embodiment 2

[0096] Using the same method and system as in Example 1, the same steps were used to analyze the composition of the genetic principal components of the population using the method and system of the present invention for randomly selected samples from Africans, Europeans, and Asians.

[0097] The samples drawn are the following 5 copies: Figure 6A For African samples YRI330, Figure 6B For the European sample CEU998, Figure 6C For South Asian (African, European, East Asian mixed) sample GIH1179, Figure 6D For East Asian sample CHN870, Figure 6E It is the sample CUX1066 of Central Asians (European and East Asian mixed). The results are shown in Figure 6, and the pie charts represent the proportions of genetic principal components of individual non-, European, and East Asian populations. The possible population origin of the individual is represented by the value from large to small, and it can be seen that the analysis result of the population genetic principal component...

Embodiment 3

[0099] Utilize method and system of the present invention to carry out race origin inference again to 422 samples of known sources selected in the HapMap database, to check the accuracy of above-mentioned non, Europe, East Asia and its mixed race inference system, the results are shown in Table 4 Shown:

[0100] Table 4 Inference results of 422 samples selected by the African, European and East Asian race inference system

[0101]

[0102]

[0103] Among them, 422 samples are known, African samples (sample size 84), European samples (sample size 85), East Asian samples (sample size 86), Central Asian (European and East Asian mixed) samples (sample 165 people)

[0104] Through the principal component analysis of the above 422 samples by the method and system of the present invention, all the African samples can be inferred as Africans, all the European samples can be inferred as Europeans, all East Asian samples can be inferred as East Asians, and all the samples of Cent...

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Abstract

The invention provides a method and a system for performing African, European and East Asian population genetic principal component analysis to an unknown-source individual. The method includes following steps: extracting DNA from the unknown-source individual; obtain 27 genotypes of specific locus of African, European and East Asian populations; and obtaining a population genetic principal component analysis result of the genotypes of the specific locus through STRUCTURE software. By means of the scheme in the invention, the African, European and East Asian population genetic principal component analysis of the unknown-source individual can be achieved and data support for inferring African, European and East Asian population sources of the unknown-source individual is provided.

Description

technical field [0001] The present invention relates to a method and system for inferring the origin of unknown individuals, in particular to a method and system for analyzing the genetic principal components of non-European and East Asian populations for individuals of unknown origin. Background technique [0002] With economic globalization, the flow of people between different countries and regions has increased, and complex cases such as foreign-related, anti-terrorism, and cross-regional flow crimes have continued to increase, making case investigation more and more difficult. For example, foreign-related cases often occur in big cities such as Beijing, Shanghai, and Guangdong. At present, the international races are mainly divided into the three major races of Europe, Africa and East Asia and the mixed races formed by these races. The mixed races in my country mainly include the Uyghurs, Kazakhs, Kirgizs and other European and East Asian mixed races in Xinjiang. . [...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/68C12N15/11
CPCC12Q1/6888C12Q2600/156
Inventor 李彩霞魏以梁叶健
Owner INST OF FORENSIC SCI OF MIN OF PUBLIC SECURITY
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