Lactobacillus reuteri dsm 17938 for the development of the enteric nervous system

A technology of DSM17938, Lactobacillus reuteri, applied in the field of neuronal health

Inactive Publication Date: 2014-12-24
BIOGAIA AB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0018] To date, there have been no reports of the effects of probiotics on neuronal development in neonates

Method used

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  • Lactobacillus reuteri dsm 17938 for the development of the enteric nervous system
  • Lactobacillus reuteri dsm 17938 for the development of the enteric nervous system
  • Lactobacillus reuteri dsm 17938 for the development of the enteric nervous system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0115] Animal studies (feeding and sacrifice):

[0116] Animal experiments were carried out under authorization n° 2120 licensed by the Office Vétérinaire Cantonal, Etat de Vaud. Two month old female Sprague-Dawley rats were obtained from Harlan, Barcelona after one week of gestation. On the day of their arrival, dams were housed in individual cages and randomized into control (CTRL) or protein-restricted (PR) groups. Animals received food and water ad libitum and were maintained on a 12 hour light / dark cycle.

[0117] Diets for CTRL and PR dams are detailed in Table 1. CTRL dams received a control diet containing 20% ​​protein (casein) matching standard rat protein requirements during pregnancy (Reeves et al., 1993). PR dams received a PR diet containing 10% protein (casein). Both diets were isocaloric, and protein deficiency was balanced by the addition of cornstarch.

[0118] Table 1: Composition Diets of Control (CTRL) and Protein Restricted (PR) AIN-93G Diets

[0...

Embodiment 2

[0143] Examples of the composition of infant formulas for use according to the invention are given below. The composition is given by way of example only. The protein source is a regular blend of whey and casein.

[0144]

[0145]

[0146] Lactobacillus reuteri L. reuteri DSM 17938 was deposited in the German Culture Collection of Microorganisms DSMZ on January 30, 2006.

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Abstract

The invention relates to Lactobacillus reuteri DSM 17938, and compositions comprising Lactobacillus reuteri DSM 17938, for promoting the healthy development and / or repair of the enteric nervous system in mammals. Humans or animals and, in particular, a foetus, pre-term or term-born infant, toddler or child may benefit from the invention. The invention may be especially beneficial to those infants having experienced IUGR, or having a low, or very low birth weight, and / or suffered from enteric nervous system growth retardation either in utero or, during or after birth. The administration of to Lactobacillus reuteri DSM 17938 promotes normal and healthy neuronal and glial development. It also ensures healthy neuronal differentiation in the peripheral nervous system.

Description

technical field [0001] The present invention relates generally to the fields of neuronal health, neuronal protection and neuronal development. The present invention specifically relates to the administration of probiotics capable of promoting the development of enteric neurons in infants, particularly premature infants and low birth weight infants. Background technique [0002] The nervous system is a highly complex network composed of neurons and glial cells. It is present in all mammalian species and consists of the central nervous system (brain and spinal cord) as well as the peripheral nervous system (somatic, autonomic and enteric nervous systems). [0003] The central nervous system drives cognitive functions (memory, attention, perception, movement, etc.). Together with the peripheral nervous system, it has a fundamental role in the control of behavior. The somatic nervous system is responsible for coordinating body movements (under conscious control). The autonom...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/30A61K35/74A23L33/00A61K35/747
CPCA23L33/135A61K35/747A23V2002/00A61K2035/115A23V2400/173A23V2200/322A23L33/40A61P1/00A61P1/04A61K35/742A61K45/06
Inventor 加芙列拉·贝尔贡齐立-德蒙马加利·福尔尼科尔·库施
Owner BIOGAIA AB
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