58 results about "Low weight birth" patented technology

The invention discloses a sow-milk-substitute fodder for piglets, comprising expanded corns, lactose and / or a whey powder, soy protein isolate, carried compound multivitamin carriers, and supported compound multi-mineral for piglets. The sow milk substitute has the advantages that the nutritional requirements of piglets are sufficiently satisfied for the improved digestive rate by utilizing simulation milk nutritional ingredients in line with the digestive psychology of piglets; growth problems of weak piglets caused by low birth weight, inadequate sow milk and low weaning weight are solved; since the weight and health level of the weak piglets can reach or approach to the growth standard like normal piglets after feeding by the milk substitute, the survival rate of piglets is improved, thus the annual marketing rate in hogpens is correspondingly increased.

The subject invention provides methods for reducing or preventing villous atrophy and feeding intolerance in infants, particularly low birth weight and / or preterm infants, by enterally administering granulocyte-colony stimulating factor (G-CSF), erythropoietin (Epo), or both G-CSF and Epo. The subject invention also provides compositions that comprise G-CSF and / or Epo that may be administered to infants in need thereof. In one embodiment, the composition of the subject invention comprises recombinant G-CSF, recombinant Epo, and one or more electrolyte additives. In a specific embodiment, the electrolyte additive is selected from the group consisting of sodium chloride, sodium acetate, and potassium chloride.

A nutritional composition for very low birth weight infants which comprises 26 5 to 38 g / l of a source of hypoallergenic hydrolysed whey protein with a degree of hydrolysis between 8 and 20, 37 to 46 g / l of a fat source of which 20 to 50% is medium chain triglycerides and which has an n6:n3 ratio between 6 and 12 and 50 to 100 g / l of a carbohydrate source which composition contains between 3.2 and 4.0 grams of protein per 100 kcal.

A multi-nutrient fortifier Total Randomized for supplementing breastfed infants is provided. The fortifier can be sterilized and can be formulated for delivery after hospital discharge. The fortifier is designed to supplement infants to meet the specific needs such as maintaining appropriate and safe levels of fat soluble vitamins and minerals, to incorporate vitamins normally requiring additional supplementation, such as vitamins A, D, E or iron for breastfed infants, to facilitate delivery of calcium and phosphorous salts. According to an embodiment of the invention, the fortifier can be in a concentrated liquid form, is sterile, and delivers greater than about 44% protein, by weight, and greater than about 17% protein, by weight, when analyzed in combination with breast milk. The fortifier can be used to improve growth and body composition of a breastfed infant post hospital discharge, such as a low birth weight infant, a post-surgical infant, or an ill term-born infant.

A method for determining the effect of critical glyconutrient dietary supplements in premature and term infants on growth, health, and brain function during early childhood development is described. The method comprises determining a critical target nutrient profile in typical samples of preterm and mother's milk, developing a supplement of the missing critical target nutrients to simulate mother's milk, performing an evaluation of early child development by correlating physiologic brain function with cognitive / behavioral brain function in low birth weight premature and term infants, assessing family influence and home environment on developmental outcome on infants under treatment, and comparing term siblings of low birth weight premature vs. term babies. A composition having the critical nutrients, an algorithm for screening and treatment, and a useful kit for employing the above are also described.

The invention discloses the therapeutic and prophylactic administration of leptin to (i) an infant of low birth weight for age; (ii) a nursing mother of an infant, the infant having low birth weight for age; or (iii) a pregnant female predisposed to giving birth to an infant of low birth weight for age; for the prevention or treatment, in later life of the infant, of a metabolic disorder or other condition associated with low birth weight, such as type 2 diabetes, obesity, cardiovascular disease, gestational diabetes, impaired glucose tolerance, insulin resistance, hypertension or syndrome X. It is thought that the beneficial properties of leptin may be due at least in part to an effect on glucocorticoid metabolism, in particular to an increase in type 2 11β-hydroxysteroid dehydrogenase activity.

Methods for diagnosis of sepsis very low birth weight (VLBW) infants are disclosed. The diagnostic methods for sepsis are based on determining whether a bodily fluid sample, such as a urine sample, contains an amount of neutrophil gelatinase-associated lipocalin (NGAL) protein that exceeds or is less than a certain threshold level, or that falls within a certain range. The present invention also provides methods for monitoring the progression of sepsis, methods for monitoring sepsis treatment, methods of distinguishing between true-positive and false culture-positive sepsis, and kits for diagnosing sepsis in VLBW infants.

This invention pertains to the discovery that agents which inhibit the binding of cortisol to its receptors can be used in methods for preventing neurological damage associated with glucocorticoid therapy in ventilator-dependent low birth weight preterm infants. Mifepristone, a potent glucocorticoid receptor antagonist, can be used in these methods.

The present invention relates to compositions and methods for enhancing the growth of infants. Particularly, the present invention discloses the use of insulin for promoting the growth of low birth weight infants, including preterm infants and small for gestational age (SGA) infants over the expected rate.

A nutritional composition for very low birth weight infants which comprises 26 5 to 38 g / l of a source of hypoallergenic hydrolysed whey protein with a degree of hydrolysis between 8 and 20, 37 to 46 g / l of a fat source of which 20 to 50% is medium chain triglycerides and which has an n6:n3 ratio between 6 and 12 and 50 to 100 g / l of a carbohydrate source which composition contains between 3.2 and 4.0 grams of protein per 100kcal.

The invention belongs to the technical field of functional food and food for special medical purposes and specifically relates to a breast milk nutritious supplementary agent for a premature infant or an infant with extremely low birth weight. The breast milk nutritious supplementary agent is used for supplementing nutrients required by the infant growth and development. The breast milk nutritious supplementary agent provided by the invention comprises the following components by weight percent: 10-14% of fresh milk (dry matter), 20-30% of whey protein powder, 2-4% of compound mineral substances, 1-3% of compound vitamins, 0.1-1% of iron compounds, 0.5-2% of breast milk nutrients and the balance of maltodextrin, or comprises the following components by weight percent: 5-15% of skim milk powder, 20-30% of whey protein powder, 2-4% of compound mineral substances, 1-3% of compound vitamins, 0.1-1% of iron compounds, 0.5-2% of breast milk nutrients and the balance of solid glucose syrup. The breast milk nutritious supplementary agent prepared in proportion according to the invention can guarantee the effects of all nutrients and all the nutrients have synergic effects, so that the healthy growth of the premature infant can be more effectively promoted.

The present invention relates to compositions for use in low-birth weight infants. In particular, the compositions are probiotic compositions which are used for achieving full enteral feeding in low birth weight infants. The invention is also concerned with the use of specific probiotics in the manufacture of low-birth weight infant formulations.

The invention discloses a nutritional supplement food formula for pregnant women and wet nurses. The nutritional supplement food formula comprises the following components by mass: 10-25g of alpha-whey protein, 6-15 [mu]g of nucleotide, 4-13 [mu]g of xanthophyll, 5-10g of lactose, 400-700 [mu]g of vitamin A, 1.3-4.8 [mu]g of vitamin B, 60-230 mg of vitamin C, 3-10 [mu]g of vitamin D, 140-400 [mu]gof folic acid, 5-14 mg of vitamin E, 26-80 mg of vitamin K, 2.8-12 mg of pantothenic acid and 200-840 mg of choline. The nutrients of the nutritional supplement food formula for pregnant women and wet nurses can meet nutrient requirements for bodies and foetuses, can promote proper development of the foetuses, can prevent and reduce complication during a pregnancy period, can solve the problems of low birth weight infants and the like, and can achieve a certain effect on improvement on nutrients of the pregnant women and wet nurses.

The invention relates to Lactobacillus reuteri DSM 17938, and compositions comprising Lactobacillus reuteri DSM 17938, for promoting the healthy development and / or repair of the enteric nervous system in mammals. Humans or animals and, in particular, a foetus, pre-term or term-born infant, toddler or child may benefit from the invention. The invention may be especially beneficial to those infants having experienced IUGR, or having a low, or very low birth weight, and / or suffered from enteric nervous system growth retardation either in utero or, during or after birth. The administration of to Lactobacillus reuteri DSM 17938 promotes normal and healthy neuronal and glial development. It also ensures healthy neuronal differentiation in the peripheral nervous system.

The invention discloses a low birth weight risk prediction system and a method for constructing the low birth weight risk prediction system. The low birth weight risk prediction system comprises an input device, a prediction device and an output device, wherein the input device is used for inputting an influencing parameter which influences the low birth weight; the prediction device is used for predicting the low birth weight risk on the basis of the input influencing parameter; and the output device is used for outputting a low birth weight risk prediction result. According to the low birth weight risk prediction system, a user can quickly and conveniently obtain a prediction result by simply inputting a relevant influencing parameter. On one hand, the time and the vigor of the user are saved, and on the other hand, the workload of technical service staff is reduced. Furthermore, the user can go to the hospital or consult experts for further diagnosis when the prediction result is unfavorable.

The invention provides a powdered formula for infants with premature birth / low birth weight. The powdered formula comprises the following components in percentage by mass: 40-50% of vegetable fat powder, 10-20% of desalted whey powder, 10-20% of skimmed milk powder, 5-10% of whey protein powder, 5-10% of medium-chain triglyceride, 1-5% of lactose, 1-5% of fructo-oligosaccharide, 3-10% of a nutrition enhancer, 1-3% of arachidonic acid and 0.5-1% of docosahexaenoic acid. According to the invention, the components are reasonably proportioned; aiming at the characteristics of premature infants / infants with low birth weight in a special period, various nutrients such as energy density and protein are increased to prevent lack or excess of various nutrients, the medium-chain fat easy to digest and absorb is adopted as a part of source of fat, the fructo-oligosaccharide improves immunity, the arachidonic acid and the docosahexaenoic acid promote brain and optic nerve development, and cholinepromotes brain development and improves memory.

The invention relates to a traditional Chinese medicinal ointment rubbing agent for promoting growth of premature low-birth-weight children, and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicinal ointment rubbing agent comprises, by weight, 18-20 parts of prepared rehmannia root, 9-10 parts of Chinese yam, 9-10 parts of Cornus officinalis, 7-8 parts of Poria cocos, 7-8 parts of Rhizoma Alismatis, 7-8 parts of Cortex Moutan, 9-11 parts of white vaseline, 11-12 parts of stearic acid, 1.8-2.5 parts of lanolin, 6-7 parts of glyceryl monostearate, 14-16 parts of glycerin, 2.5-3.5 parts of tween80, 50-55 parts of water, 2-3 parts of azone and 0.2-0.3 parts of ethyl p-hydroxybenzoate. The traditional Chinese medicinal ointment rubbing agent can effectively promote the growth of premature low-birth-weight children, has the advantages of no side effects and low cost, and is suitable for being used by general poor families.

The present invention relates to a protein fortifier for use in varying the amount of protein in preterm infant nutrition, thereby adapting the formula or human milk to the nutritional needs of very low birth weight infants and extremely low birth weight infants.

This invention is directed to compositions and methods for treating (e.g., prophylactically and / or therapeutically) infection in a preterm infant. In particular, the invention provides anti-lipoteichoic acid (LTA) antibody compositions and methods of administering the same to a preterm infant (e.g., a low birth weight preterm infant (e.g., a very low birth weight preterm infant)) under conditions to establish anti-LTA antibody serum concentrations effective to kill and / or prevent growth of bacteria (e.g., Staphylococci). Compositions and methods of the invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine) and research applications.

The present invention relates to the use of nutritional compositions enriched in glutamineto improve structural brain development in preterm and / or low birth weight infants.

The invention provides a method for the diagnosis of brain damage in a neonate. The method comprises a step of analyzing the level of alpha-B crystallin in a tissue or body fluid sample obtained fromthe neonate. The method is particularly useful for diagnosing preterm infants or neonates with a low birth weight.

The present invention relates to a protein fortifier for use in varying the amount of protein in preterm infant nutrition, thereby adapting the formula or human milk to the nutritional needs of very low birth weight infants and extremely low birth weight infants.

The invention discloses a sow-milk-substitute fodder for piglets, comprising expanded corns, lactose and / or a whey powder, soy protein isolate, carried compound multivitamin carriers, and supported compound multi-mineral for piglets. The sow milk substitute has the advantages that the nutritional requirements of piglets are sufficiently satisfied for the improved digestive rate by utilizing simulation milk nutritional ingredients in line with the digestive psychology of piglets; growth problems of weak piglets caused by low birth weight, inadequate sow milk and low weaning weight are solved; since the weight and health level of the weak piglets can reach or approach to the growth standard like normal piglets after feeding by the milk substitute, the survival rate of piglets is improved, thus the annual marketing rate in hogpens is correspondingly increased.

The invention discloses specially-compounded liquid for VLBWI (Very low birth weight infant) nutrition management and a preparation method and application of the specially-compounded liquid. The preparation method comprises the step of mixing fat emulsion with amino acids, glucose, ionogram and vitamins under the aseptic condition so as to obtain the specially-compounded liquid for VLBWI (Very lowbirth weight infant) nutrition management, wherein the fat emulsion is a long-chain fat emulsion. A new scheme is provided for nutrition management of clinical premature very low birth weight infants. The specially-compounded liquid disclosed by the invention can reduce the occurrence rate of PNAC, NEC, BPD, hypoglycemia, ROP, late-onset type septicaemia and BIPI, is good in safety, besides, canreduce the occurrence rate of EUGR, can shorten hospital stays and can optimize the life quality of child patients.

The invention discloses food capable of improving pregnancy reproductive performance of pets and a preparation method thereof. The food capable of improving the pregnancy reproductive performance of pets is prepared from the following components in parts by weight: 30-40 parts of corn flour, 5-20 parts of wheat flour, 5-20 parts of rice meal, 1-3 parts of beer yeast powder, 20-40 parts of meat meal, 8-20 parts of compound oil, 0.3-0.6 part of a womb nutrient regulator, 1.4-3.1 parts of an immunomodulator, 1.2-3.2 parts of a flavoring agent, 0.2-0.5 part of table salt, 1-2 parts of multiple vitamins, 1-2 parts of multiple minerals and 1-2 parts of a diluent. The food capable of improving the pregnancy reproductive performance of pets can effectively solve the problems of high still birth rate of pregnant pets and low birth weight of young pets, and achieve the objects of reducing the still birth rate and ensuring the birth weight of pets.

The present invention relates to compositions for use in low-birth weight infants. In particular, the compositions are probiotic compositions which are used for achieving full enteral feeding in low birth weight infants. The invention is also concerned with the use of specific probiotics in the manufacture of low-birth weight infant formulations.